Deciphering the large-scale environment of radio galaxies in the local Universe: where do they born, grow and die?

The role played by the large-scale environment on the nuclear activity of radio galaxies (RGs), is still not completely understood. Accretion mode, jet power and galaxy evolution are connected with their large-scale environment from tens to hundreds of kpc. Here we present a detailed, statistical, analysis of the large-scale environment for two samples of RGs up to redshifts $z_\mathrm{src}$=0.15. The main advantages of our study, with respect to those already present in the literature, are due to the extremely homogeneous selection criteria of catalogs adopted to perform our investigation. This is also coupled with the use of several clustering algorithms. We performed a direct search of galaxy-rich environments around RGs using them as beacon. To perform this study we also developed a new method that does not appear to suffer by a strong $z_\mathrm{src}$ dependence as other algorithms. We conclude that, despite their radio morphological (FR\,I $vs$ FR\,II) and/or their optical (HERG $vs$ LERG) classification, RGs in the local Universe tend to live in galaxy-rich large-scale environments having similar characteristics and richness. We highlight that the fraction of FR\,Is-LERG, inhabiting galaxy rich environments, appears larger than that of FR\,IIs-LERG. We also found that 5 out of 7 FR\,II-HERGs, with $z_\mathrm{src}\leq$0.11, lie in groups/clusters of galaxies. However, we recognize that, despite the high level of completeness of our catalogs, when restricting to the local Universe, the low number of HERGs ($\sim$10\% of the total FR\,IIs investigated) prevent us to make a strong statistical conclusion about this source class.Comment: 21 pages, 25 figures, accepted for publication on the Astrophysical Journal Supplement Series - pre-proof versio

Performance of seven ECG interpretation programs in identifying arrhythmia and acute cardiovascular syndrome

Abstract Background No direct comparison of current electrocardiogram (ECG) interpretation programs exists. Objective Assess the accuracy of ECG interpretation programs in detecting abnormal rhythms and flagging for priority review records with alterations secondary to acute coronary syndrome (ACS). Methods More than 2,000 digital ECGs from hospitals and databases in Europe, USA, and Australia, were obtained from consecutive adult and pediatric patients and converted to 10 s analog samples that were replayed on seven electrocardiographs and classified by the manufacturers' interpretation programs. We assessed ability to distinguish sinus rhythm from non-sinus rhythm, identify atrial fibrillation/flutter and other abnormal rhythms, and accuracy in flagging results for priority review. If all seven programs' interpretation statements did not agree, cases were reviewed by experienced cardiologists. Results All programs could distinguish well between sinus and non-sinus rhythms and could identify atrial fibrillation/flutter or other abnormal rhythms. However, false-positive rates varied from 2.1% to 5.5% for non-sinus rhythm, from 0.7% to 4.4% for atrial fibrillation/flutter, and from 1.5% to 3.0% for other abnormal rhythms. False-negative rates varied from 12.0% to 7.5%, 9.9% to 2.7%, and 55.9% to 30.5%, respectively. Flagging of ACS varied by a factor of 2.5 between programs. Physicians flagged more ECGs for prompt review, but also showed variance of around a factor of 2. False-negative values differed between programs by a factor of 2 but was high for all (>50%). Agreement between programs and majority reviewer decisions was 46–62%. Conclusions Automatic interpretations of rhythms and ACS differ between programs. Healthcare institutions should not rely on ECG software "critical result" flags alone to decide the ACS workflow

The connection between radio and high energy emission in black hole powered systems in the SKA era

Strong evidence exists for a highly significant correlation between the radio flux density and gamma-ray energy flux in blazars revealed by Fermi. However, there are central issues that need to be clarified in this field: what are the counterparts of the about 30% of gamma-ray sources that are as yet unidentified? Are they just blazars in disguise or they are something more exotic, possibly associated with dark matter? How would they fit in the radio-gamma ray connection studied so far? With their superb sensitivity, SKA1-MID and SKA1-SUR will help to resolve all of these questions. Even more, while the radio-MeV/GeV connection has been firmly established, a radio-VHE connection has been entirely elusive so far. The advent of CTA in the next few years and the expected CTA-SKA1 synergy will offer the chance to explore this connection, even more intriguing as it involves the opposite ends of the electromagnetic spectrum and the acceleration of particles up to the highest energies. We are already preparing to address these questions by exploiting data from the various SKA pathfinders and precursors. We have obtained 18 cm European VLBI Network observations of E>10 GeV sources, with a detection rate of 83%. Moreover, we are cross correlating the Fermi catalogs with the MWA commissioning survey: when faint gamma-ray sources are considered, pure positional coincidence is not significant enough for selecting counterparts and we need an additional physical criterion to pinpoint the right object. It can be radio spectral index, variability, polarization, or compactness, needing high angular resolution in SKA1-MID; timing studies can also reveal pulsars, which are often found from dedicated searches of unidentified gamma-ray sources. SKA will be the ideal instrument for investigating these characteristics in conjunction with CTA. (abridged)Comment: 12 pages, to be published in the proceedings of "Advancing Astrophysics with the Square Kilometre Array", PoS(AASKA14)15

The populations of hard X- and {\gamma}-ray sources: a correlation study and new possible identifications

We present the results of our analysis devoted to the research of sources emitting in the energy bands surveyed by both the Swift-BAT and the Fermi-LAT telescopes. We cross-correlate the Fermi-LAT 1-year point source catalogue (1FGL) of {\gamma}-ray sources and the second Palermo BAT catalogue (2PBC) of hard X-ray sources, establishing a correspondence between sources when their error boxes overlap. We also extract the significance value in the BAT 15-150 keV map, obtained using a dedicated software for the reduction of BAT data, in the direction of the 1FGL sources and take into account those above the significance threshold {\sigma} = 3. We obtain a sample of common sources emitting in both the hard X- and the {\gamma}-ray energy bands and evaluate its content in galactic and extragalactic objects. We assess the fraction of unidentified sources and describe in greater detail the properties of two of them, 1FGL J0137.8+5814 and 1FGL J2056.7+4938, supporting their classification as blazars after the analysis of their broad-band spectral energy distribution. We discuss the blazar content of the collected 1FGL-2PBC sources: we build its redshift distibution and compare it with that of the whole blazar population as reported in the second edition of the BZCAT blazar catalogue.Comment: 12 pages, 5 figures, 5 table

Gene Therapy for Mitochondrial Diseases: Current Status and Future Perspective

Mitochondrial diseases (MDs) are a group of severe genetic disorders caused by mutations in the nuclear or mitochondrial genome encoding proteins involved in the oxidative phosphorylation (OXPHOS) system. MDs have a wide range of symptoms, ranging from organ-specific to multisystemic dysfunctions, with different clinical outcomes. The lack of natural history information, the limits of currently available preclinical models, and the wide range of phenotypic presentations seen in MD patients have all hampered the development of effective therapies. The growing number of pre-clinical and clinical trials over the last decade has shown that gene therapy is a viable precision medicine option for treating MD. However, several obstacles must be overcome, including vector design, targeted tissue tropism and efficient delivery, transgene expression, and immunotoxicity. This manuscript offers a comprehensive overview of the state of the art of gene therapy in MD, addressing the main challenges, the most feasible solutions, and the future perspectives of the field

Origin of TeV Galactic Cosmic Rays

We consider a possibility of identification of sources of cosmic rays (CR) of the energy above 1 TeV via observation of degree-scale extended gamma-ray emission which traces the locations of recent sources in the Galaxy. Such emission in the energy band above 100 GeV is produced by CR nuclei and electrons released by the sources and spreading into the interstellar medium. We use the data from the Fermi gamma-ray telescope to locate the degree-scale 100 GeV gamma-ray sources. We find that the number of such sources and their overall power match to those expected when CRs injection events happen every ~100 yr in portions of ~1e50 erg. We find that most of the sources are associated to pulsars with spin down age less than ~30 kyr and hence to the recent supernova explosions. This supports the hypothesis of supernova origin of Galactic CRs. We notice that the degree-scale extended emission does not surround shell-like supernova remnants without pulsars. Based on this observation, we argue that the presence of the pulsar is essential for the CR acceleration process. We expect that a significant fraction of the degree-scale sources should be detectable as extended sources with km3-scale neutrino detectors.Comment: 14 pages, 14 figures, accepted for publication in Phys.Rev.