0534: Antenatal echocardiographic parameters to predict postnatal outcome of neonates with Ebstein anomaly

Ebstein tricuspide valve anomaly is a rare CHD with uncertain postnatal prognosis. Criteria to predict outcome are still a matter of debate. The aim of this study was to determine antenatal echocardiographic predictive parameters.MethodsRetrospective multicentric analysis of fetus with diagnosis of Ebstein anomaly. Echocardiographic measurements of ventricles, atria, great vessels and tricuspid regurgitation were collected. Comparisons were made between group I (poor outcome= death occurred in utero or within the first 3 months of life) and group II (favourable outcome: postnatal survival >3 months).Results16 fetuses were included in the study: 10 in group I (62.5%: 2 TOP, 2 fetal deaths, 6 postnatal deaths) and 6 in group II (37.5%). Mean gestationnal age at diagnosis was 29weeks (22 to 38). The mean number of echocardiographic records per patient was 2 (1 to 6). LV to RV ratio, tricuspid valve regurgitation grade and retrograde or anterograde ductal flow did not differ between the 2 groups. Significative differences were found between groups I and II regarding the presence of pulmonary flow (none or mild RV to PA flow: 8 of 9 cases died= 89%), AO to PA ratio (75% death if > 97°p vs 25% if 3-97°p), RA diameter (77.3% death if > 97°p vs 0%), PA diameter (100% death if < 3°p) and pericardial effusion (80% death vs 0%). Only 1 case had arrhythmia and died.ConclusionThis small sample size study showed that the absence of RV to PA flow and/ or pulmonary valve opening, increased AO to PA ratio, RA and decreased PA diameter and the presence of pericardial effusion might represent prognosis factors in fetus with Ebstein anomaly. These results should be confirmed by large scale prospective study

The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design

Abstract Background Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management of PUV is prenatal prediction of postnatal renal function. Fetal ultrasound and fetal urine biochemistry are currently employed for this prediction, but clearly lack precision. We previously developed a fetal urine peptide signature that predicted in utero with high precision postnatal renal function in fetuses with PUV. We describe here the objectives and design of the prospective international multicentre ANTENATAL (multicentre validation of a fetal urine peptidome-based classifier to predict postnatal renal function in posterior urethral valves) study, set up to validate this fetal urine peptide signature. Methods Participants will be PUV pregnancies enrolled from 2017 to 2021 and followed up until 2023 in >30 European centres endorsed and supported by European reference networks for rare urological disorders (ERN eUROGEN) and rare kidney diseases (ERN ERKNet). The endpoint will be renal/patient survival at 2 years postnatally. Assuming α = 0.05, 1–β = 0.8 and a mean prevalence of severe renal outcome in PUV individuals of 0.35, 400 patients need to be enrolled to validate the previously reported sensitivity and specificity of the peptide signature. Results In this largest multicentre study of antenatally detected PUV, we anticipate bringing a novel tool to the clinic. Based on urinary peptides and potentially amended in the future with additional omics traits, this tool will be able to precisely quantify postnatal renal survival in PUV pregnancies. The main limitation of the employed approach is the need for specialized equipment. Conclusions Accurate risk assessment in the prenatal period should strongly improve the management of fetuses with PUV

Risque de tumeur trophoblastique gestationnelle après môle hydatiforme partielle (à propos d'une série de 15 cas)

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Légionellose maternelle en cours de grossesse (à propos d'un cas)

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Etat des lieux sur la pratique de la prescription du dépistage de la trisomie 21 par les médecins généralistes à Lyon

LYON1-BU Santé (693882101) / SudocSudocFranceF

Môle hydatiforme complète associée à une grossesse de développement normal (l'expérience du Centre de Référence des maladies trophoblastiques de l'Hôtel-Dieu [de Lyon])

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Risque de tumeur trophoblastique gestationnelle après môle hydatiforme partielle (à propos d'une série de 15 cas)

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Os longs courts isolés en échographie (inquiétude justifiée ou non ?)

LYON1-BU Santé (693882101) / SudocSudocFranceF

Contributions de la sociologie et de la science politique à la recherche sur la notion de service environnemental: Programme Serena

[Cd-Rom]. Paris : ANR, 36 p. Atelier Concept ANR-SERENA, 2010-02-02/2010-02-04, La Grande Motte, France.Rapport

Charge carrier transport and low electrical percolation threshold in multiwalled carbon nanotube polymer nanocomposites

International audienceElectrical transport properties of multiwalled carbon nanotube (MWCNT) polymer nanocomposites based on epoxy and high density polyethylene (HDPE) as matrices have been studied. The composites have been prepared from masterbatches by dilution. Low electrical percolation thresholds of 0.05 and 0.4 vol.% of carbon nanotubes in epoxy and HDPE matrices were found respectively. The analysis of the temperature dependence of dc-conductivity shows that the charge transport is fully described as the combination in series of one-dimensional (1-D) and three-dimensional (3-D) variable range hopping (VRH) regimes. The transport is limited by the 1-D VRH regime in the low temperatures limit and by the 3-D VRH regime at room temperature. The analysis of the VRH parameters when the overall volume fraction of MWCNT decreases reveals two distinct situations. In the epoxy the local characteristics of the masterbatch remain practically unchanged and a percolating network is maintained even at very low volume fractions; in the HDPE matrix, the density of the MWCNT bundles packing decreases as revealed by the strong variation of the Mott temperature parameter. Our results indicate that amorphous polymers matrices give lower percolation thresholds than semicrystalline ones when a masterbatch dilution process is used