Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Clinical features and natural history of coronavirus disease 2019 (COVID-19) differ widely among different countries and during different phases of the pandemia. Here, we aimed to evaluate the case fatality rate (CFR) and to identify predictors of mortality in a cohort of COVID-19 patients admitted to three hospitals of Northern Italy between March 1 and April 28, 2020. All these patients had a confirmed diagnosis of SARS-CoV-2 infection by molecular methods. During the study period 504/1697 patients died; thus, overall CFR was 29.7%. We looked for predictors of mortality in a subgroup of 486 patients (239 males, 59%; median age 71 years) for whom sufficient clinical data were available at data cut-off. Among the demographic and clinical variables considered, age, a diagnosis of cancer, obesity and current smoking independently predicted mortality. When laboratory data were added to the model in a further subgroup of patients, age, the diagnosis of cancer, and the baseline PaO2/FiO2 ratio were identified as independent predictors of mortality. In conclusion, the CFR of hospitalized patients in Northern Italy during the ascending phase of the COVID-19 pandemic approached 30%. The identification of mortality predictors might contribute to better stratification of individual patient risk

Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19

The clinical course of Coronavirus Disease 2019 (COVID-19) is highly heterogenous, ranging from asymptomatic to fatal forms. The identification of clinical and laboratory predictors of poor prognosis may assist clinicians in monitoring strategies and therapeutic decisions

[Prognostic significance of desmoplasia in breast carcinoma. A preliminary clinical study].

this study carried on 61 patienets with brest cancer confirmed the biological assumption of a higher malignancy in tumors vith strong desmoplastic reation. Patients in stage II A, IIB and III presenting a marked despmoplastic reaction have a shorter DFS (deasise free survival). Therefore, desmoplastic reation may be considered a marker of local malignancy and metastatic process

IKKγ protein is a target of BAG3 regulatory activity in human tumor growth

BAG3, a member of the BAG family of heat shock protein (HSP) 70 cochaperones, is expressed in response to stressful stimuli in a number of normal cell types and constitutively in a variety of tumors, including pancreas carcinomas, lymphocytic and myeloblastic leukemias, and thyroid carcinomas. Down-regulation of BAG3 results in cell death, but the underlying molecular mechanisms are still elusive. Here, we investigated the molecular mechanism of BAG3-dependent survival in human osteosarcoma (SAOS-2) and melanoma (M14) cells. We show that bag3 overexpression in tumors promotes survival through the NF-κB pathway. Indeed, we demonstrate that BAG3 alters the interaction between HSP70 and IKKγ, increasing availability of IKKγ and protecting it from proteasome-dependent degradation; this, in turn, results in increased NF-κB activity and survival. These results identify bag3 as a potential target for anticancer therapies in those tumors in which this gene is constitutively expressed. As a proof of principle, we show that treatment of a mouse xenograft tumor model with bag3siRNA-adenovirus that down-regulates bag3 results in reduced tumor growth and increased animal survival

Apollo. A. 5(Gennaio 1965 - Dicembre 1984)

A. 5(gen.1965 - dic.1984): De Franciscis, A., Presentazione, P. 5 ; Panebianco, V., Ricordo di Antonio Marzullo, P. 7 ; Marzullo, B., Ricordo di Padre: Antonio Marzullo, P. 9 ; Gigante, M., Ricordo di Venturino Panebianco, P. 15 ; Nabers, N., A new hydria by the Pan Painter, P. 31 ; Trendall, A. D., A red-figured calyx-krater from Nocera, P. 47 ; Varone, A., Un miliario del Museo dell’Agro Nocerino e la via di Nocera al porto di Stabia (e al capo Ateneo), P. 59 ; Avagliano, G., Fratte di Salerno. Tomba VI/1971, P. 87 ; Fabbri, B., Guarino, D. P., e R. Maldera, Caratterizzazione tecnologica di un corredo ceramico della necropoli di Fratte, P. 95 ; Bignardi, M., Un ignoto salernitano della prima metà del quattrocento (l’affresco del vicolo dei Sediari), P. 127 ; Migliorini, P. M., La Certosa di Padula nella prima metà del ‘700 e le sue immagini, P. 133 ; D’Aniello, A., Contributo per la ricostruzione del disperso patrimonio della Certosa di S. Lorenzo diPadula, P. 145 ; Tamajo Contarini, M., Contributo alla conoscenza del patrimonio artistico della Certosa di Padula: il solimeniano Alessio D’Elia, P. 153 ; Samaritani, C., L’attività dei Musei Provinciali del Salernitano dal 1965 al 1984. P.165 ; Cipriani, M., Il Museo Archeologico Provinciale di Salerno, P. 183 ; Mangieri, G. L., Nota sulla Collezione Numismatica del Museo Archeologico Provinciale di S. Benedetto in Salerno, P. 187 ; Avagliano, G., La zona archeologica di Fratte, P. 191 ; Fiammenghi, C. A., Il Museo archeologico della Lucania Occidentale nella Certosa di Padula, P. 199 ; Varone, A., Il Museo dell’Agro Nocerino, P. 205 ; Iannelli, M. A., Il Museo della Ceramica Vietrese, P. 207 ; D’Andria, R., La sezione “Guido Gambone”: priorità di un’iniziativa, P. 215 ; Iacoe, A., La ceramica del Castello di Salerno, P. 221 ; Di Santo, A., Antiquarium di Sala Consilina, P. 223 ; Rota, L., Antiquarium di S. Marzano, P. 225 ; Falanga, L. Recenti contributi alla conoscenza di Salerno romana, P. 227 ; Compagnone, A., Profili storico della ceramica di Vietri, P. 249

Music in Classical Greek Drama

Si fornisce un quadro geenrale delle conoscenze relative al ruolo e alle modalit\ue0 di impiego della musica nel dramma greco d'et\ue0 classica, con analisi di alcuni casi (Eur. Or. 338-344, IA 1328-1335, Ar. Av. 227-262)