Altitude training and endurance and ultra-endurance performance

Background. Altitude training has been shown to improve endurance and ultra-en-durance performance at altitude, whereas the possible benefits from altitude/hypoxic training for competing at sea level have been, and still are, a matter for debate. Reasons for this discrepancy may result from the variety of protocols utilized in terms of alti-tude, natural or simulated, to which the athletes were exposed, and amount of the time spent at altitude. In order to conciliate previous findings and provide practical recommendations to athletes, the concept of optimal “hypoxic dose” has been defined. Methods. To perform a review of the literature concerning the effects of altitude training on athletic performance. Results. The dominant paradigm is that the improved performance at sea level is due primarily to an accelerated erythropoiesis due to the reduced oxygen available at alti-tude, leading to an increase in red cell mass. Indeed, in recent years it has become evident that other non-hematological factors (improved muscle efficiency, greater muscle buffering capacity, etc.), may contribute to improve athletic performance. Conclusions. Despite more than fifty years of research and studies, altitude training remains a controversial issue and yet, there are many unanswered questions

Seismic Ground Motion Amplifications Estimated by Means of Spectral Ratio Techniques: Examples for Different Geological and Morphological Settings

One of the most important issue in seismic hazard and microzonation studies is the evaluation of local site response (i.e. the tendency of a site to experience during an earthquake greater or lower levels of ground shacking with respect to another). In general site effects reflect all modifications (in amplitude, frequency content and duration) of a wave-field produced by a seismic source during the propagation near the surface, due to particular geologic (stratigraphy and morphology), geotechnical (mechanical properties of deposits) and physical (e.g. coupling of incident, diffracted and reflected seismic waves) conditions of a particular site. Actually local seismic amplification represents one of the main factors responsible for building damage during earthquakes: this statement is supported by well documented evidences of structural damages during past moderate to high energy events occurred both in Italy (e.g. 23th November 1980, Mw 6.9, Irpinia earthquake, Faccioli, 1986; 26th September 1997, Mw 6.0, Umbria-Marche earthquake, Caserta et al., 2000; the 31th October 2002, Mw 5.7, Molise earthquake, Strollo et al., 2007; 6th April 2009, Mw 6.3, L’Aquila earthquake, Cultrera et al., 2009) and in other worldwide countries (e.g. 3rd March 1985, Mw 7.8, Chile earthquake, Celebi, 1987; 17th August 1999, Mw 7.6, Izmit earthquake, Sadik Bakir et al., 2002). For this reason the site effects evaluation, performed by experimental methods but also through numerical simulations, has attracted the attention of engineering seismology and earthquake engineering communities. Of consequence, in the last decade many experiments were performed in correspondence of different setting such as alluvial basins (Parolai et al., 2001 and 2004; Ferretti et al., 2007; Massa et al., 2009; Bindi et al., 2009) or topographies (e.g. Pischiutta et al., 2010; Massa et al., 2010; Buech et al., 2010; Marzorati et al., 2011; Lovati et al., 2011). The present work has the aim to evaluate the capabilities of the most common passive methods at present used in seismology to evaluate the site response: HVSR (Horizontal to Vertical Spectral Ratio technique on seismic noise, Nakamura, 1989, or earthquakes, Lermo & Chavez Garcia, 1993) and SSR (Standard Spectral Ratio, Borcherdt, 1970).Published195-2184.1. Metodologie sismologiche per l'ingegneria sismicaope

Environmental factors shaping the ecological niches of ammonia-oxidizing archaea

For more than 100 years it was believed that bacteria were the only group responsible for the oxidation of ammonia. However, recently, a new strain of archaea bearing a putative ammonia monooxygenase subunit A (amoA) gene and able to oxidize ammonia was isolated from a marine aquarium tank. Ammonia-oxidizing archaea (AOA) were subsequently discovered in many ecosystems of varied characteristics and even found as the predominant causal organisms in some environments. Here, we summarize the current knowledge on the environmental conditions related to the presence of AOA and discuss the possible site-related properties. Considering these data, we deduct the possible niches of AOA based on pH, sulfide and phosphate levels. It is proposed that the AOA might be important actors within the nitrogen cycle in low-nutrient, low-pH, and sulfide-containing environments

Site Classification Assessment for Estimating Empirical Attenuation Relationships for Central-Northern Italy Earthquakes

The aim of this article is to investigate the ground motion attenuation of the most industrialized and populated regions of Italy, evaluating the capability of different approaches to estimate site dependent models. The 5.2 magnitude earthquake on November 24, 2004 shocked the areas of Northern Italy producing damage of about 215 million euros. The data set, including 243 earthquakes of local magnitude up to 5.2, has been collected in the period December 2002–October 2005 by 30 threecomponent seismic stations managed by Istituto Nazionale di Geofisica e Vulcanologia, Sezione of Milano (INGV-MI). Empirical attenuation relationships have been estimated for horizontal peak ground velocity (PGHV), acceleration (PGHA), displacement (PGHD), and for response spectral acceleration (SA) for periods between 0.1 and 1.5 s. To estimate suitable attenuation models, in particular for sites characterized by thick sedimentary geological formations, a soil discrimination based on EU8 code can lead to wrong evaluations. On the contrary, a classification based on H/V spectral ratios of seismic ambient noise (NHV) allows the models to fit better real and predicted data and to reduce the uncertainties of the process. For each receiver, NHV have been strengthened by additional H/V spectral ratio of earthquake data (EHV), calculated considering different portions of the analysed signals. In order to validate the PGHA attenuation relationship for greater magnitudes, accelerometric records, relative to Central-Northern Italy strong motions occurring in the last 30 years, have been collected and superimposed to our attenuation curves

Study of the Interaction Between a High-Pressure Jet and Horizontal Tanks using CFD

Accidental high-pressure flammable gas releases are among the most relevant hazards in the process safety, and consequences could be severe. In the recent decades, there have been numerous efforts to study high-pressure jets in open field (i.e., free jets). Easy-to-use mathematical models have been developed, to rapidly assess the main physical variables involved in safety evaluations. However, in a realistic scenario, the accidental leak may involve either the ground or a piece of equipment. As demonstrated by recent works, when a jet interacts with an obstacle, its behavior can significantly change. Therefore, the mathematical models extrapolated for the free jet scenario could be a source of incorrect predictions. Focusing on the scenario of an accidental high-pressure unignited flammable jet, this work shows how the presence of one or two obstacles, placed at a different distance from the source of the leak, can influence the lower flammability limit cloud extent of methane. Varying the height of the source term, the effect of the interaction among the jet, both the obstacles, and the ground was systematically studied through a Computational Fluid Dynamics analysis

Editorial: Strategies to Fight Exercise Intolerance in Neuromuscular Disorders

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Dimensionality and Measurement Invariance of the Italian Version of the EORTC QLQ-C30 in Postoperative Lung Cancer Patients

Background: This study aims to validate and evaluate the psychometric properties and measurement invariance of the Italian version of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30), which is a measure of quality of life (QoL) for lung cancer patients after surgery. Methods: A total of 167 lung cancer patients completed the Italian version of the EORTC QLQ-C30 questionnaire at 30 days after they received a lobectomy. The factor structure of this scale was assessed by performing confirmatory factor analysis (CFA). Measurement invariance was evaluated by considering differential item functioning (DIF) due to age, gender, and type of surgery (i.e., robot- or not robot-assisted). Results: The CFA demonstrated the validity of the factor structure of the EORTC QLQ-C30 in assessing overall health and eight distinct subscales of adverse events and functioning. Moreover, the results highlighted a minimal DIF with only trivial consequences on measurement invariance. Specifically, the DIF did not affect the mean differences of latent scores of QoL between patients undergoing robot-assisted surgery or traditional surgery. Conclusion: These findings supported the validity and suitability of the EORTC QLQ-C30 for the assessment of QoL in lung cancer patients of diverse ages and genders undergoing lobectomy with or without robot-assisted surgery

Validation of the Italian version of the abbreviated expanded prostate Cancer index composite (EPIC-26) in men with prostate Cancer

Background: This study aims to validate and evaluate the psychometric properties and reliability of the Italian version of the Expanded Prostate Cancer Index Composite - Short Form (EPIC-26), a measure of quality of life (QoL) for prostate cancer patients. Methods: Two hundred and eighty-four prostate cancer patients completed the Italian version of the EPIC-26 questionnaire at 45 days (T1) and 3 months (T2) after robot-assisted radical prostatectomy (RARP). Psychometric properties were evaluated using structural equation modeling: the goodness of fit of the correlated five-factor model (CFFM) for the EPIC-26 was assessed using the confirmatory factor analysis (CFA), while longitudinal invariance was conducted to assess the ability of the EPIC-26 to measure QoL construct over time. Test-retest reliability was assessed as well by considering intraclass correlations. Results: At T1, the CFFM model displayed a good fit to data. Similarly, the model showed an adequate fit also at T2. Results of the reliability analysis attested the acceptable internal consistency and test-retest reliability of each dimension: all Cronbach's alphas could be classified as acceptable (i.e., above.65) except for low Cronbach's alpha for hormonal dysfunction at T1 (i.e.,.638) and urinary irritation at both waves. (i.e., respectively.585 and.518). Finally, psychometric properties were invariant over time and each of the five dimensions of QoL displayed from moderate (all ICCs above.500) to good test-retest reliability (i.e. ICC for urinary incontinence =.764). Conclusions: Results of the CFA and the measurement invariance analysis demonstrated the validity of the Italian version of the EPIC-26 to assess QoL in prostate cancer patients. Its reliability and good psychometric qualities are well-supported, thus providing a valid tool to assess health-related quality of life and its change over time in prostate cancer patients

Dimensionality and Measurement Invariance of the Italian Version of the EORTC QLQ-C30 in Postoperative Lung Cancer Patients

Background: This study aims to validate and evaluate the psychometric properties and measurement invariance of the Italian version of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30), which is a measure of quality of life (QoL) for lung cancer patients after surgery. Methods: A total of 167 lung cancer patients completed the Italian version of the EORTC QLQ-C30 questionnaire at 30 days after they received a lobectomy. The factor structure of this scale was assessed by performing confirmatory factor analysis (CFA). Measurement invariance was evaluated by considering differential item functioning (DIF) due to age, gender, and type of surgery (i.e., robot- or not robot-assisted). Results: The CFA demonstrated the validity of the factor structure of the EORTC QLQ-C30 in assessing overall health and eight distinct subscales of adverse events and functioning. Moreover, the results highlighted a minimal DIF with only trivial consequences on measurement invariance. Specifically, the DIF did not affect the mean differences of latent scores of QoL between patients undergoing robot-assisted surgery or traditional surgery. Conclusion: These findings supported the validity and suitability of the EORTC QLQ-C30 for the assessment of QoL in lung cancer patients of diverse ages and genders undergoing lobectomy with or without robot-assisted surgery