314 research outputs found
The nuclear to host galaxy relation of high redshift quasars
We present near-infrared imaging with ESO VLT+ISAAC of the host galaxies of
low luminosity quasars in the redshift range 1 < z < 2, aimed at investigating
the relationship between the nuclear and host galaxy luminosities at high
redshift. This work complements our previous study to trace the cosmological
evolution of the host galaxies of high luminosity quasars (Falomo et al. 2004).
The new sample includes 15 low luminosity quasars, nine radio-loud (RLQ) and
six radio-quiet (RQQ). They have similar distribution of redshift and optical
luminosity, and together with the high luminosity quasars they cover a large
range (~4 mag) of the quasar luminosity function. The host galaxies of both
types of quasars are in the range of massive inactive ellipticals between L*
and 10 L*. RLQ hosts are systematically more luminous than RQQ hosts by a
factor of ~2. This difference is similar to that found for the high luminosity
quasars. This luminosity gap appears to be independent of the rest-frame U-band
luminosity but clearly correlated with the rest-frame R-band luminosity. The
color difference between the RQQs and the RLQs is likely a combination of an
intrinsic difference in the strength of the thermal and nonthermal components
in the SEDs of RLQs and RQQs, and a selection effect due to internal dust
extinction. For the combined set of quasars, we find a reasonable correlation
between the nuclear and the host luminosities. This correlation is less
apparent for RQQs than for RLQs. If the R-band luminosity is representative of
the bolometric luminosity, and assuming that the host luminosity is
proportional to the black hole mass, as observed in nearby massive spheroids,
quasars emit with a relatively narrow range of power with respect to their
Eddington luminosity and with the same distribution for RLQs and RQQs.Comment: Accepted for publication in ApJ, 24 pages, 4 figure
Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis
Background: Multiple myeloma (MM) is a clonal plasma cell malignancy associated with osteolytic bone disease. Recently, the role of MM-derived exosomes in the osteoclastogenesis has been demonstrated although the underlying mechanism is still unknown. Since exosomes-derived epidermal growth factor receptor ligands (EGFR) are involved in tumor-associated osteolysis, we hypothesize that the EGFR ligand amphiregulin (AREG) can be delivered by MM-derived exosomes and participate in MM-induced osteoclastogenesis. Methods: Exosomes were isolated from the conditioned medium of MM1.S cell line and from bone marrow (BM) plasma samples of MM patients. The murine cell line RAW264.7 and primary human CD14 + cells were used as osteoclast (OC) sources. Results: We found that AREG was specifically enriched in exosomes from MM samples and that exosomes-derived AREG led to the activation of EGFR in pre-OC, as showed by the increase of mRNA expression of its downstream SNAIL in both RAW264.7 and CD14 + cells. The presence of neutralizing anti-AREG monoclonal antibody (mAb) reverted this effect. Consequently, we showed that the effect of MM-derived exosomes on osteoclast differentiation was inhibited by the pre-treatment of exosomes with anti-AREG mAb. In addition, we demonstrated the ability of MM-derived AREG-enriched exosomes to be internalized into human mesenchymal stromal cells (MSCs) blocking osteoblast (OB) differentiation, increasing MM cell adhesion and the release of the pro-osteoclastogenic cytokine interleukin-8 (IL8). Accordingly, anti-AREG mAb inhibited the release of IL8 by MSCs suggesting that both direct and indirect effects are responsible for AREG-enriched exosomes involvement on MM-induced osteoclastogenesis. Conclusions: In conclusion, our data indicate that AREG is packed into MM-derived exosomes and implicated in OC differentiation through an indirect mechanism mediated by OBs
Role of AR-V7 and AR-FL in resistance to hormonal therapy in mCRPC: Independent actors or reciprocal drivers? A translational study by Meet-Uro group
The late Pleistocene Po River lowstand wedge in the Adriatic Sea : Controls on architecture variability and sediment partitioning
The authors dedicate this study to their colleague Giovanni Bortoluzzi, who passed away in 2015. A special tanks is due to Marco Ligi and Nevio Zitellini for geophysical data acquisition and processing; Marco Pastore and Filippo D'Oriano for their support during the cruise LSD2014 and processing of geophysical data. Elisabetta Campiani provided additional support for processing the multibeam bathymetry. A particular thank goes to Cpt. Emanuele Gentile and the crew of the R/V Urania during cruise LSD 2014. We thank Ronald Steel and an anonymous Reviewer for their constructive comments. This project was funded by ExxonMobil Upstream Research Company and by the Flagship Project RITMARE–The Italian Research for the Sea. We acknowledge the European Union Project PROMESS-1 (contract EVR1-2001-41) for borehole PRAD 1-2. This is ISMAR-CNR contribution number 1959.Peer reviewedPostprin
Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice
Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures
The chemokine RANTES is critically involved in neuroinflammation and has been implicated in the pathophysiology of multiple sclerosis. We examined the possibility that activation of G-protein-coupled metabotropic glutamate (mGlu) receptors regulates the formation of RANTES in glial cells. A 15 hr exposure of cultured astrocytes to tumor necrosis factor-alpha and interferon-gamma induced a substantial increase in both RANTES mRNA and extracellular RANTES levels. These increases were markedly reduced when astrocytes were coincubated with l-2-amino-4-phosphonobutanoate (l-AP-4), 4-phosphonophenylglycine, or l-serine-O-phosphate, which selectively activate group III mGlu receptor subtypes (i.e., mGlu4, -6, -7, and -8 receptors). Agonists of mGlu1/5 or mGlu2/3 receptors were virtually inactive. Inhibition of RANTES release produced by l-AP-4 was attenuated by the selective group III mGlu receptor antagonist (R,S)-alpha-methylserine-O-phosphate or by pretreatment of the cultures with pertussis toxin. Cultured astrocytes expressed mGlu4 receptors, and the ability of l-AP-4 to inhibit RANTES release was markedly reduced in cultures prepared from mGlu4 knock-out mice. This suggests that activation of mGlu4 receptors negatively modulates the production of RANTES in glial cells. We also examined the effect of l-AP-4 on the development of experimental allergic encephalomyelitis (EAE) in Lewis rats. l-AP-4 was subcutaneously infused for 28 d by an osmotic minipump that released 250 nl/hr of a solution of 250 mm of the drug. Detectable levels of l-AP-4 ( approximately 100 nm) were found in the brain dialysate of EAE rats. Infusion of l-AP-4 did not affect the time at onset and the severity of neurological symptoms but significantly increased the rate of recovery from EAE. In addition, lower levels of RANTES mRNA were found in the cerebellum and spinal cord of EAE rats infused with l-AP-4. These results suggest that pharmacological activation of group III mGlu receptors may be useful in the experimental treatment of neuroinflammatory CNS disorders
Biopsy confirmation of metastatic sites in breast cancer patients:clinical impact and future perspectives
Determination of hormone receptor (estrogen receptor and progesterone receptor) and human epidermal growth factor receptor 2 status in the primary tumor is clinically relevant to define breast cancer subtypes, clinical outcome,and the choice of therapy. Retrospective and prospective studies suggest that there is substantial discordance in receptor status between primary and recurrent breast cancer. Despite this evidence and current recommendations,the acquisition of tissue from metastatic deposits is not routine practice. As a consequence, therapeutic decisions for treatment in the metastatic setting are based on the features of the primary tumor. Reasons for this attitude include the invasiveness of the procedure and the unreliable outcome of biopsy, in particular for biopsies of lesions at complex visceral sites. Improvements in interventional radiology techniques mean that most metastatic sites are now accessible by minimally invasive methods, including surgery. In our opinion, since biopsies are diagnostic and changes in biological features between the primary and secondary tumors can occur, the routine biopsy of metastatic disease needs to be performed. In this review, we discuss the rationale for biopsy of suspected breast cancer metastases, review issues and caveats surrounding discordance of biomarker status between primary and metastatic tumors, and provide insights for deciding when to perform biopsy of suspected metastases and which one (s) to biopsy. We also speculate on the future translational implications for biopsy of suspected metastatic lesions in the context of clinical trials and the establishment of bio-banks of biopsy material taken from metastatic sites. We believe that such bio-banks will be important for exploring mechanisms of metastasis. In the future,advances in targeted therapy will depend on the availability of metastatic tissue
SiOx/SiNy multilayers for photovoltaic and photonic applications
Microstructural, electrical, and optical properties of undoped and Nd3+-doped SiOx/SiNy multilayers fabricated by reactive radio frequency magnetron co-sputtering have been investigated with regard to thermal treatment. This letter demonstrates the advantages of using SiNy as the alternating sublayer instead of SiO2. A high density of silicon nanoclusters of the order 1019 nc/cm3 is achieved in the SiOx sublayers. Enhanced conductivity, emission, and absorption are attained at low thermal budget, which are promising for photovoltaic applications. Furthermore, the enhancement of Nd3+ emission in these multilayers in comparison with the SiOx/SiO2 counterparts offers promising future photonic applications
Cross section and transverse single-spin asymmetry of eta mesons in p up arrow plus p collisions at root s=200 GeV at forward rapidity
We present a measurement of the cross section and transverse single-spin asymmetry (AN) for. mesons at large pseudorapidity from root s = 200 GeV p up arrow + p collisions. The measured cross section for 0.5 \u3c p(T) \u3c 5.0 GeV/c and 3.0 \u3c vertical bar eta vertical bar \u3c 3.8 is well described by a next-to-leading-order perturbative-quantum-chromodynamics calculation. The asymmetries A(N) have been measured as a function of Feynman-x (x(F)) from 0.2 \u3c vertical bar x(F)vertical bar \u3c 0.7, as well as transverse momentum (p(T)) from 1.0 \u3c p(T) \u3c 4.5 GeV/c. The asymmetry averaged over positive x(F) is \u3c A(N)\u3e = 0.061 +/- 0.014. The results are consistent with prior transverse single-spin measurements of forward eta and pi(0) mesons at various energies in overlapping x(F) ranges. Comparison of different particle species can help to determine the origin of the large observed asymmetries in p up arrow + p collisions
Measurements of directed, elliptic, and triangular flow in Cu plus Au collisions at root sNN=200 GeV
Measurements of anisotropic flow Fourier coefficients (upsilon(n)) for inclusive charged particles and identified hadrons pi(+/-), K-+/-, p, and (p) over bar produced at midrapidity in Cu + Au collisions at root s(NN) = 200 GeV are presented. The data were collected in 2012 by the PHENIX experiment at the Relativistic Heavy-Ion Collider (RHIC). The particle azimuthal distributions with respect to different-order symmetry planes psi(n), for n = 1, 2, and 3 are studied as a function of transverse momentum p(T) over a broad range of collision centralities. Mass ordering, as expected from hydrodynamic flow, is observed for all three harmonics. The charged-particle results are compared with hydrodynamical and transport model calculations. We also compare these Cu + Au results with those in Cu + Cu and Au + Au collisions at the same root s(NN) and find that the upsilon(2) and upsilon(3), as a function of transverse momentum, follow a common scaling with 1/(epsilon N-n(part)1/3)
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