614 research outputs found
Metabolic predispositions and increased risk of colorectal adenocarcinoma by anatomical locations: a large population-based cohort study in Norway
Whether different definitions of metabolic syndrome (MetS) are differently
associated with colorectal adenocarcinoma (CA) by anatomical location is unclear.
A population-based cohort study, the Cohort of Norway (CONOR) Study, was
conducted in Norway from 1995 to 2010. Anthropometric measurements, blood
samples, and lifestyle data were collected at recruitment. CAs were identified
through linkage to the Norwegian Cancer Register. A composite index of MetS as
defined by the International Diabetes Federation (IDF) or/and the National
Cholesterol Education Program's Adult Treatment Panel III (ATP III) and single
components of MetS, including anthropometric factors, blood pressure, lipids,
triglycerides, and glucose, were analyzed. Cox proportional hazards regression
was performed to estimate hazard ratios and 95% confidence intervals. Significant
associations between single MetS components and CA, except for reduced
high-density lipoprotein cholesterol and nonfasting glucose levels, were
observed. MetS defined by 2 criteria separately showed a similar association with
CA in general, and MetS defined by both the IDF and ATP III showed consistent
results. Stronger associations were observed in the proximal colon among men
(IDF: hazard ratio (HR) = 1.51, 95% confidence interval (CI): 1.24, 1.84; ATP
III: HR = 1.40, 95% CI: 1.15, 1.70) and in the rectum among women (IDF: HR =
1.42, 95% CI: 1.07, 1.89; ATP III: HR = 1.43, 95% CI: 1.08, 1.90).Swedish Society of MedicineKarolinska InstitutetSwedish Research CouncilAccepte
Пародонтопротекторное действие гексафторосиликатов 2-, 3-, 4-пиридинуксусной кислоты и 2,4-диамино-6-гидроксипиримидина у крыс
ФТОРПРЕПАРАТЫПИРИДИНУКСУСНАЯ КИСЛОТАГЕКСАФТОРОСИЛИКАТЫКАРИЕС ЗУБОВПЕРИОДОНТА БОЛЕЗНИДИСБИОЗЖИВОТНЫЕ ЛАБОРАТОРНЫЕКРЫСЫЭКСПЕРИМЕНТЫ НА ЖИВОТНЫХВ работе определяли пародонтопротекторное действие оральных аппликаций геля, содержащего гексафторосиликаты 2-пиридинуксусной кислоты (ГФС-2-ПУК), 3-пиридинуксусной кислоты (ГФС-3-ПУК), 4-пиридинуксусной кислоты (ГФС-4-ПУК) и 2,4-диамино-6-гидроксипиримидина (ГФС-ДАГП) у крыс, которых содержали на кариесогенном (высокосахарозном) рационе. Состояние десны оценивали по уровню маркеров воспаления (МДА, эластаза), микробной обсемененности (уреаза), неспецифического иммунитета (лизоцим), антиоксидантной защиты (каталаза), а также по степени дисбиоза и индекса АПИ. Результаты исследований показали, что КГР вызывает увеличение активности лизоцима и уреазы в десне, степени дисбиоза и снижение активности каталазы и индекса АПИ. Оральные аппликации гелей снижают в десне активность уреазы и содержание МДА. Таким образом, результаты изучения свойств гексафторосиликатов 2-, 3-, 4-пиридинуксусной кислоты свидетельствуют об их пародонтопротекторном действии, причем наиболее перспективным объектом дальнейшего изучения является ГФС-4-ПУК
Ökad jämställdhet genom ett kvinnligt nätverk? Om jämställdhetsarbete i ett företag i byggbranschen
I denna uppsats belyser vi hur jämställdhetsarbete kan bedrivas inom en organisation genom att studera ett kvinnligt nätverk hos ett stort svenskt företag i byggbranschen. Syftet med vårt arbete är att bidra med en kritisk diskussion om nytta och funktion av praktiskt jämställdhetsarbete i en samtida arbetslivskontext. Frågeställningen blir därmed: Hur fungerar jämställdhetsarbetet inom det undersökta kvinnliga nätverket; Vad är bra, vad är problematiskt, och hur kan det bli bättre? Uppsatsen baseras på en kvalitativ undersökning i form av semistrukturerade intervjuer gjorda med åtta kvinnliga anställda på företaget, samt på en analys av nätverkets projektplan. I arbetet kommer vi fram till att nätverket har en potential, då man från företagets sida satsar tid, pengar och kraft på nätverksarbetet. Dock identifierar vi en rad olika problem med hur nätverksarbetet bedrivs. Vi menar att sättet man bedriver nätverksarbetet på gör att det inte går att åstadkomma särskilt stora förändringar vad gäller jämställdheten i organisationen. För att en förändring ska ske föreslår vi att man hos nätverksmedlemmarna implementerar en teoretiskt förankrad grundförståelse för genusfrågor i organisationer. Samt att man fokuserar på att det kvinnliga nätverket kan fylla funktionen som ett socialt kapital där nätverksmedlemmarna drar nytta av varandras tillgångar
Anthropometry-based obesity phenotypes and risk of colorectal adenocarcinoma : a large prospective cohort study in Norway
BACKGROUND: It is unclear whether obesity phenotypes measured by different anthropometric indices are associated with a risk of colorectal adenocarcinoma by
anatomical location.
METHODS: We compiled harmonized population-based cohort
studies (Cohort of Norway, CONOR) with 143,477 participants that were conducted
between 1994 and 2010. General, abdominal, and gluteofemoral obesity were
assessed by body mass index (BMI, kg/m(2)), waist circumference (cm), and hip
circumference (cm). Other measures examined were waist to hip ratio, waist to
height ratio, and body adiposity index. We performed Cox proportional hazards
regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of
obesity relative to a risk of colorectal adenocarcinoma.
RESULTS: In total, 2,044
incident cases of colorectal adenocarcinoma were identified. We observed a
positive association between waist circumference (high versus low) and
adenocarcinoma in the proximal colon (HR = 1.9, 95% CI = 1.5, 2.5) and distal
colon (HR = 1.7, 95% CI = 1.3, 2.3) when adjusted for BMI. The association with
waist circumference was especially strong in men. BMI was not associated with
adenocarcinoma in the colon or rectum after adjusting for waist circumference. We
found no association between hip circumference and colorectal adenocarcinoma.
When adjusted for BMI plus waist circumference, body adiposity index was
negatively associated with adenocarcinoma in the proximal or distal colon.
CONCLUSION: Abdominal obesity, but not general or gluteofemoral obesity, was
associated with an increased risk of adenocarcinoma in the proximal and the
distal colon, especially in men. Muscularity may be negatively associated with
risk of colon adenocarcinoma.Swedish Research CouncilAccepte
Superiority of Serum Cystatin C Over Creatinine in Prediction of Long-Term Prognosis at Discharge From ICU
MB, BR, CRM and JM have received the Baxter “INVESTIGATOR INITIATED
RESEARCH ACUTE CARE GRANT”
The Importance of the Pathologist’s Role in Assessment of the Quality of the Mesorectum
Total mesorectal excision (TME) is considered standard of care for rectal cancer treatment. Failure to remove the mesorectal fat envelope entirely may explain part of observed local and distant recurrences. Several studies suggest quality of the mesorectum after TME surgery as determined by pathological evaluation may influence prognosis. We aimed to determine the prognostic value of the plane of surgery as well as factors influencing the likelihood of a high-quality specimen by reviewing the literature. A pooled meta-analysis of relevant outcome data was performed where appropriate. A muscularis propria resection plane was found to increase the risk of local recurrence (RR 2.72 [95 % CI 1.36 to 5.44]) and overall recurrence (RR 2.00 [95 % CI 1.17 to 3.42]) compared to an (intra)mesorectal plane. Plane of surgery is an important factor in rectal cancer treatment and the documentation by pathologists is essential for the improvement of TME quality and patient outcome
Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression
SummarySignaling proteins driving the proliferation of stem and progenitor cells are often encoded by proto-oncogenes. EphB receptors represent a rare exception; they promote cell proliferation in the intestinal epithelium and function as tumor suppressors by controlling cell migration and inhibiting invasive growth. We show that cell migration and proliferation are controlled independently by the receptor EphB2. EphB2 regulated cell positioning is kinase-independent and mediated via phosphatidylinositol 3-kinase, whereas EphB2 tyrosine kinase activity regulates cell proliferation through an Abl-cyclin D1 pathway. Cyclin D1 regulation becomes uncoupled from EphB signaling during the progression from adenoma to colon carcinoma in humans, allowing continued proliferation with invasive growth. The dissociation of EphB2 signaling pathways enables the selective inhibition of the mitogenic effect without affecting the tumor suppressor function and identifies a pharmacological strategy to suppress adenoma growth
The Effect of a Multidisciplinary Regional Educational Programme on the Quality of Colon Cancer Resection
Abstract: Mesocolic plane surgery with central vascular ligation produces an oncologically superior specimen following colon cancer resection and appears to be related to optimal outcomes. Aim: We aimed to assess whether a regional educational programme in optimal mesocolic surgery led to an improvement in the quality of specimens. Method: Following an educational programme in the Capital and Zealand areas of Denmark, 686 cases of primary colon cancer resected across six hospitals were assessed by grading the plane of surgery and undertaking tissue morphometry. These were compared to 263 specimens resected prior to the educational programme. Results: Across the region, the mesocolic plane rate improved from 58% to 77% (p<0.001). One hospital had previously implemented optimal surgery as standard prior to the educational programme and continued to produce a high rate of mesocolic plane specimens (68%) with a greater distance between the tumour and the high tie (median for all fresh cases: 113 vs. 82 mm) and lymph node yield (33 vs. 18) compared to the other hospitals. Three of the other hospitals showed a significant improvement in the plane of surgical resection. Conclusion: A multidisciplinary regional educational programme in optimal mesocolic surgery improved the oncological quality of colon cancer specimens as assessed by mesocolic planes, however, there was no significant effect on the amount of tissue resected centrally. Surgeons who attempt central vascular ligation continue to produce more radical specimens suggesting that such educational programmes alone are not sufficient alone to increase the amount of tissue resected around the tumour
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