TZ- VirtIO: Enabling Standardized Inter-Partition Communication in a Trustzone-Assisted Hypervisor

Virtualization technology allows the coexistence and execution of multiple operating systems on top of the same hardware platform. In the embedded systems domain, virtualization has been focused on the isolation of critical requirements like real-time, security and safety from non-critical characteristics. The strict confinement of guest partitions typically provided by virtualization does not suit the modular and inter-cooperative nature of embedded systems. The need for inter-partition communication has been addressed by multiple virtualization solutions, either to enable guest-level device para-virtualization or to ensure increased flexibility regarding cooperative partitions. However, the majority of existing approaches follow an ad hoc approach with limited to none applicability outside their solution's scope. This paper presents TZ-VirtIO, an asynchronous standardized inter-partition communication (IPC) mechanism on top of a TrustZone-assisted dual-OS hypervisor (LTZVisor). The implemented IPC uses the standard VirtIO transport layer. The experiments conducted on a physical platform show a scalable, high-bandwidth and low-overhead solution for both single-core and multi-core architectures.FCT - Fundação para a Ciência e a Tecnologia (UID/CEC/00319/2013

Stripes and spin-incommensurabilities are favored by lattice anisotropies

Structural distortions in cuprate materials give a natural origin for anisotropies in electron properties. We study a modified one-band t-J model in which we allow for different hoppings and antiferromagnetic couplings in the two spatial directions ($t_x \ne t_y$ and $J_x \ne J_y$). Incommensurate peaks in the spin structure factor show up only in the presence of a lattice anisotropy, whereas charge correlations, indicating enhanced fluctuations at incommensurate wave vectors, are almost unaffected with respect to the isotropic case.Comment: accepted for publication on Physical Review Letters, one color figur

Successful surgical management of an extrahepatic biliary cystadenocarcinoma

Extrahepatic bile duct cancer is an uncommon disease, and few cases are curable by surgery. We report a case of extrahepatic biliary cystadenocarcinoma (BCAC) associated with atrophy of the left hepatic lobe. A 54-year old male was admitted with painless obstructive jaundice and a hepatic palpable mass noticed one month before presentation. Liver functions tests were consistent with cholestatic damage and serum carbohydrate antigen 19.9 (CA 19-9) was increased before treatment. Magnetic resonance imaging (MRI) disclosed dilatation of the left hepatic bile duct with irregular wall thickening close to the hepatic confluence, and atrophy of left hepatic lobe. The patient was submitted to en bloc extended left hepatectomy with resection of caudate lobe, hilar lymphadenectomy, and suprapancreatic biliary tree resection. All surgical margins were grossly negative, and postoperative course was uneventful, except for a minor bile leak. The patient was discharged on the 15th postoperative day; he is alive without tumor recurrence one year after primary therapy. Although technically challenging, extended en bloc resection is feasible in adults with extrahepatic BCAC and can improve survival with acceptable and manageable morbidity

Efeito do gengibre no poder anaeróbico de membros inferiores de ginastas da seleção brasileira

Introduction: Aerobic gymnastics is a sport that has consistently grown over the previous decades, and its practice demands its athletes to perform complex and high-intensity movements. Objective: The study was to analyze whether ginger supplementation had an ergogenic effect on the anaerobic power of limbs (PAMI) in aerobic gymnastic athletes. Methods: A randomized double-blind placebo-controlled trial was conducted with nine athletes (23.11 + 4.14 years, 1.63 + 0.09 m, 60.51 + 7.38 kg) from the Brazilian National Team of Aerobic Gymnastics. After ingesting 400 mg of Zingiber officinale or placebo for seven days, the subjects underwent an anaerobic power test (RAST). Peak Velocity and Peak power (m/s and W), average and minimum power (W), and fatigue index (W/s and %) data were obtained from the RAST. Results: After verifying the no normality of the sample, the Mann-Whitney was applied, but no significant differences were found in the peak velocity of the ginger supplementation (6.28 ± 0.41 m/s; 445.28 ± 117.15 W) compared to placebo (6.22 ± 0.45 m/s; 425.95 ± 130.39 W). Conclusions: It is concluded that ingesting 400 mg of Z. officinale does not have an ergogenic effect on the anaerobic power of the lower limbs of aerobic gymnastic athletes.Introdução: a ginástica aeróbica é um esporte que tem crescido consistentemente nas últimas décadas, e sua prática exige que seus atletas realizem movimentos complexos e de alta intensidade. Objetivo: analisar se a suplementação com gengibre tem efeito ergogênico no poder anaeróbico dos membros (PAMI) em atletas de ginástica aeróbica. Métodos: foi realizado um estudo randomizado, duplo-cego, controlado por placebo, com nove atletas (23,11 + 4,14 anos, 1,63 + 0,09 m, 60,51 + 7,38 kg) da Seleção Brasileira de Ginástica Aeróbica. Após a ingestão de 400 mg de Zingiber officinale ou placebo por sete dias, os indivíduos foram submetidos a um teste de potência anaeróbica (RAST). Os dados de Velocidade de pico e Potência de pico (m/s e W), potência média e mínima (W) e índice de fadiga (W/s e %) foram obtidos no RAST. Resultados: Após verificar a não normalidade da amostra, foi aplicado o Mann-Whitney, mas não foram encontradas diferenças significativas na velocidade de pico da suplementação de gengibre (6,28 ± 0,41 m / s; 445,28 ± 117,15 W) em comparação ao placebo (6,22 ± 0,45 m / s; 425,95 ± 130,39 W). Conclusões: conclui-se que a ingestão de 400 mg de Z. officinale não exerce efeito ergogênico no poder anaeróbico dos membros inferiores de atletas de ginástica aeróbica

Influence of passage number on the impact of the secretome of adipose tissue stem cells on neural survival, neurodifferentiation and axonal growth

Mesenchymal stem cells (MSCs), and within them adipose tissue derived stem cells (ASCs), have been shown to have therapeutic effects on central nervous system (CNS) cell populations. Such effects have been mostly attributed to soluble factors, as well as vesicles, present in their secretome. Yet, little is known about the impact that MSC passaging might have in the secretion therapeutic profile. Our aim was to show how human ASCs (hASCs) passage number influences the effect of their secretome in neuronal survival, differentiation and axonal growth. For this purpose, post-natal rat hippocampal primary cultures, human neural progenitor cell (hNPCs) cultures and dorsal root ganglia (DRGs) explants were incubated with secretome, collected as conditioned media (CM), obtained from hASCs in P3, P6, P9 and P12. Results showed no differences when comparing percentages of MAP-2 positive cells (a mature neuronal marker) in neuronal cultures or hNPCs, after incubation with hASCs secretome from different passages. The same was observed regarding DRG neurite outgrowth. In order to characterize the secretomes obtained from different passages, a proteomic analysis was performed, revealing that its composition did not vary significantly with passage number P3 to P12. Results allowed us to identify several key proteins, such as pigment epithelium derived factor (PEDF), DJ-1, interleucin-6 (IL-6) and galectin, all of which have already proven to play neuroprotective and neurodifferentiating roles. Proteins that promote neurite outgrowth were also found present, such as semaphorin 7A and glypican-1. We conclude that cellular passaging does not influence significantly hASCs's secretome properties especially their ability to support post-natal neuronal survival, induce neurodifferentiation and promote axonal growth.Prémios Santa Casa Neurociências - Prize Melo e Castro for Spinal Cord Injury Research (MC-17-2013 and MC-04-2017), Canada Research Chair in Biomedical Engineering (LAB), Northern Portugal Regional Operational Programme (NORTE 2020),, European Regional Development Fund (FEDER), Competitiveness Factors Operational Programme (COMPETE), National Mass Spectrometry Network (RNEM)info:eu-repo/semantics/publishedVersio

Numerical convergence of the block-maxima approach to the Generalized Extreme Value distribution

In this paper we perform an analytical and numerical study of Extreme Value distributions in discrete dynamical systems. In this setting, recent works have shown how to get a statistics of extremes in agreement with the classical Extreme Value Theory. We pursue these investigations by giving analytical expressions of Extreme Value distribution parameters for maps that have an absolutely continuous invariant measure. We compare these analytical results with numerical experiments in which we study the convergence to limiting distributions using the so called block-maxima approach, pointing out in which cases we obtain robust estimation of parameters. In regular maps for which mixing properties do not hold, we show that the fitting procedure to the classical Extreme Value Distribution fails, as expected. However, we obtain an empirical distribution that can be explained starting from a different observable function for which Nicolis et al. [2006] have found analytical results.Comment: 34 pages, 7 figures; Journal of Statistical Physics 201

Chemotherapy with cisplatin and vinorelbine for elderly patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC)

BACKGROUND: Although modest improvements in the survival of patients with non-small cell lung cancer (NSCLC) can be achieved with cisplatin-based chemotherapy (CT), its value is disputed in the geriatric setting. In this study, we evaluate the feasibility of vinorelbine/cisplatin CT for elderly NSCLC patients. METHODS: In this pilot phase I/II trial, all patients received CT with vinorelbine 25 mg/m(2), on day 1 and 8, and cisplatin on day 1, in 28 days-cycles. After stratification for age (up to 75 years), younger patients were sequentially allocated to moderate cisplatin doses (80 mg/m(2 )or 90 mg/m(2)), and older patients were allocated to lower cisplatin doses (60 mg/m(2 )or 70 mg/m(2)). We recruited patients aged over 70 years with newly diagnosed NSCLC, clinical stage III or IV, Karnofsky performance status ≥ 70%, normal serum creatinine, peripheral neuropathy ≤ grade 1, and no prior cancer therapy. RESULTS: Analysis was by intention to treat. Main toxicities (grade 3–4) was as follows: neutropenia, 20%; anemia, 11%; and thrombocytopenia, 2%; alopecia, 55%; fatigue, 11%; and peripheral neurotoxicity, 2%. No grade 3–4 emesis or renal toxicity occurred. Global median time to progression (TTP) and overall survival (OS) were 27.0 (95% CI: 10.1 to 43.7) weeks and 30.1 (95% CI: 24.4 to 35.8) weeks; 1- and 2-year survival rates were 36.3% and 13.2%, respectively. Overall response rate was 50.0% (95% CI: 35.4% to 64.5%), with 1 complete response; no difference on response rate was noticed according to cisplatin dose. Median overall survival was 30.1 weeks, with 1- and 2-year survival rates of 36.3% and 13.2%, respectively. CONCLUSION: Age does not preclude assessment on the role of cisplatin-vinorelbine CT for elderly NSCLC patients with good performance status and adequate bodily functions

Convergence of miRNA Expression Profiling, α-Synuclein Interacton and GWAS in Parkinson's Disease

miRNAs were recently implicated in the pathogenesis of numerous diseases, including neurological disorders such as Parkinson's disease (PD). miRNAs are abundant in the nervous system, essential for efficient brain function and play important roles in neuronal patterning and cell specification. To further investigate their involvement in the etiology of PD, we conducted miRNA expression profiling in peripheral blood mononuclear cells (PBMCs) of 19 patients and 13 controls using microarrays. We found 18 miRNAs differentially expressed, and pathway analysis of 662 predicted target genes of 11 of these miRNAs revealed an over-representation in pathways previously linked to PD as well as novel pathways. To narrow down the genes for further investigations, we undertook a parallel approach using chromatin immunoprecipitation-sequencing (ChIP-seq) analysis to uncover genome-wide interactions of α-synuclein, a molecule with a central role in both monogenic and idiopathic PD. Convergence of ChIP-seq and miRNomics data highlighted the glycosphingolipid biosynthesis and the ubiquitin proteasome system as key players in PD. We then tested the association of target genes belonging to these pathways with PD risk, and identified nine SNPs in USP37 consistently associated with PD susceptibility in three genome-wide association studies (GWAS) datasets (0.46≤OR≤0.63) and highly significant in the meta-dataset (3.36×10−4<p<1.94×10−3). A SNP in ST8SIA4 was also highly associated with PD (p = 6.15×10−3) in the meta-dataset. These findings suggest that several miRNAs may act as regulators of both known and novel biological processes leading to idiopathic PD

Improving Decision-Making for Population Health in Nonhealth Sectors in Urban Environments: the Example of the Transportation Sector in Three Megacities—the 3-D Commission.

Noncommunicable diseases (NCDs) represent a significant global public health burden. As more countries experience both epidemiologic transition and increasing urbanization, it is clear that we need approaches to mitigate the growing burden of NCDs. Large and growing urban environments play an important role in shaping risk factors that influence NCDs, pointing to the ineluctable need to engage sectors beyond the health sector in these settings if we are to improve health. By way of one example, the transportation sector plays a critical role in building and sustaining health outcomes in urban environments in general and in megacities in particular. We conducted a qualitative comparative case study design. We compared Bus Rapid Transit (BRT) policies in 3 megacities-Lagos (Africa), Bogotá (South America), and Beijing (Asia). We examined the extent to which data on the social determinants of health, equity considerations, and multisectoral approaches were incorporated into local politics and the decision-making processes surrounding BRT. We found that all three megacities paid inadequate attention to health in their agenda-setting, despite having considerable healthy transportation policies in principle. BRT system policies have the opportunity to improve lifestyle choices for NCDs through a focus on safe, affordable, and effective forms of transportation. There are opportunities to improve decision-making for health by involving more available data for health, building on existing infrastructures, building stronger political leadership and commitments, and establishing formal frameworks to improve multisectoral collaborations within megacities. Future research will benefit from addressing the political and bureaucratic processes of using health data when designing public transportation services, the political and social obstacles involved, and the cross-national lessons that can be learned from other megacities