Certificação de qualidade versus qualidade da informação financeira: estudo para empresas portuguesas

Com o estudo pretende-se analisar se as empresas que têm implementado um Sistema de Gestão da Qualidade e certificadas segundo a norma da International Organization for Standardization (ISO) 9001, apresentam também uma boa qualidade da informação financeira. Utiliza-se um modelo logit para testar a relação pretendida, tendo como variável dependente a variável binária relativa à certificação de qualidade e como principal variável explicativa a qualidade da informação financeira. Com base nos resultados obtidos foi possível verificar a existência de uma relação positiva e estatisticamente significativa entre certificação de qualidade das empresas e a sua qualidade da informação financeira.info:eu-repo/semantics/publishedVersio

Comparison of financial performance between branded and nonbranded hotel companies using composite indicator

The Hospitality industry is one of the main sectors of tourism activity, being important to assess the performance of the hotel companies. The aim of the present paper is to study the financial performance of 570 companies operating hotel units in Portugal, in 2017, allowing for comparison among companies with similar stars rating and market orientation to explore the question of branded and non-branded affiliation. This issue is studied using a methodology based on Data Envelopment Analysis to assess the overall performance for each company. The hotel company performance is assessed through the aggregation of multiple financial indicators using the composite indicator derived from the DEA model. The empirical results show that the hotel branded companies have, on average, significantly, higher overall financial performance than hotel non-branded companies. Although, the best practices are observed in hotel branded and non-branded companies. This analysis can support the strategic decision process of the hotel companies in choosing to operate independently or selecting a brand affiliation.info:eu-repo/semantics/draf

Using m-health apps in oncology : A review from 2015 to 2022

The increased use of smartphones and the COVID-19 pandemic directly influenced the development of remote tools in several areas. In the context of oncology, it was no different, as several studies address health care or services related to mobile devices. Apps aimed at the medical field (m-health) focus directly on monitoring symptoms and improving interaction between health professionals and patients, combined with the convenience of smartphones. In this context, this work aims to address recent studies on the use of m-health in the clinical practice of oncological diseases and report the characteristics of the apps involved. For this, a review of m-health focused on oncology was conducted using the PubMed and Science Direct databases. The investigation was carried out using tools inherent in international databases and was limited to articles published between 2015 and 2022. In total, 34 articles were analyzed, with a higher frequency of publications between 2019 and 2022. The resources observed were patient follow-up, prevention of signs and symptoms, monitoring of treatment and aid in prognosis and diagnosis of patients. It is concluded that a close collaboration among patients, health professionals, and information technology professionals is necessary to optimize symptom recognition and improve patientprofessional communication. Although the pandemic has intensified the increase in the use of m-health, its use is expected to increase in the post-pandemic scenario, bearing in mind the changes in social dynamics and the growing dissemination of technologies.This work has been supported by Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CeDRI (UIDB/05757/2020 and UIDP/05757/2020), SusTEC (LA/P/0007/2021) and NORTE-01-0247-FEDER-072598 iSafety: Intelligent system for occupational safety and wellbeing in the retail sector. Laíres A. Lima thanks the Fundação para a Ciência e Tecnologia (FCT), Portugal, for the Ph.D. Grant 2022.13393.BD.info:eu-repo/semantics/publishedVersio

Brand affiliation: portrait of hotel establishments in Portugal

A hotelaria é um dos setores mais importantes na atividade turística em Portugal. Conhecer as características e especificidades das unidades hoteleiras a operar em Portugal é importante para todos aqueles que tomam decisões sobre o investimento neste setor. Conhecer a realidade da afiliação dos estabelecimentos hoteleiros portugueses a uma marca é também uma questão de muito interesse para os hoteleiros no apoio à tomada de decisões estratégicas. Com recurso à análise do universo dos estabelecimentos hoteleiros existentes em Portugal, é feita a sua caracterização quanto às especificidades, instalações e equipamentos. Em termos metodológicos estima-se um modelo de regressão logística que permite discutir a afiliação dos estabelecimentos hoteleiros portugueses a uma marca. Os resultados permitem concluir que pouco mais de um terço dos estabelecimentos hoteleiros em Portugal são afiliados a uma marca, sendo esta afiliação mais frequente nas regiões mais turísticas. Os resultados permitem ainda verificar que os estabelecimentos hoteleiros afiliados possuem, em média, maior número de estrelas, maior capacidade e menor número de equipamentos que os estabelecimentos hoteleiros não afiliados.Hospitality is one of the most important sectors in the tourist activity in Portugal. Knowing the characteristics and features of the hotel units operating in Portugal is important for all those who make decisions about investment in this sector. Knowing the reality of brand affiliation of Portuguese hotel establishments is also a matter of great interest for hoteliers in supporting strategic decision-making. Performing the analysis of the universe of hotel establishments in Portugal, their characterization is made concerning their features, facilities and equipment. In addition, the reality of brand affiliation of Portuguese hotel establishments is analyzed and discussed through a logistic regression model. The results allow us to conclude that just over a third of hotel establishments in Portugal are brand affiliated and they are mostly located in the more touristic regions. The results also show that brand affiliated hotel establishments have, on average, a greater number of stars, greater capacity and a greater number of facilities than non-brand affiliated hotel establishments.info:eu-repo/semantics/publishedVersio

Utilização de aplicativos m-health na oncologia: uma revisão sistemática

O presente trabalho consiste em uma revisão sistemática de literatura acerca de estudos recentes sobre aplicativos móveis relacionados com saúde (m-health) na prática clínica de doenças oncológicas para catalogação das principais características dos aplicativos desenvolvidos.info:eu-repo/semantics/publishedVersio

Developing tools for the e-learning platform mathE

MathE (mathe.pixel-online.org) is an e-learning platform for higher education developed and implemented by a consortium of seven institutional partners from five European countries. The aim of the project is to enhance the quality of teaching and improve pedagogies and assessment methods by facilitating the identification of students’ gaps in Math, providing appropriate digital tools and promoting self-evaluation with immediate feedback. The Polytechnic Institute of Bragança (IPB), in Portugal, is one of the consortium members: sixteen of its teachers collaborate in the development of this platform, being responsible for thirteen of the topics/subtopics in which the platform is structured. Such topics cover a wide range of contents, from linear transformations to integration, from graph theory to probabilities. The articulation of the topics of the MathE collection corresponds to the canonic mathematics content of engineering, business and education degrees. The MathE platform is organized into three main sections: Student´s Assessment, MathE Library and Community of Practice. So far, IPB has already developed a collection of around 800 questions for the student´s assessment section and is currently developing the MathE Library. More than 350 students from IPB are using the MathE platform; some offered as volunteers, whose role is testing the behavior of the platform as well as looking for bugs and other details that require improvement, while others are already using the platform in their study. The feedback received up until now is quite encouraging.info:eu-repo/semantics/publishedVersio

The Halogen Effect on the Magnetic Behaviour of Dimethylformamide Solvates in [Fe(halide-salEen)2]BPh4

Funding Research was funded by Fundação para a Ciência e a Tecnologia (FCT): projects UIDB/00100/2020, UIDP/00100/2020, LA/P/0056/2020, UIDB/04046/2020, UIDP/04046/2020, UIDB/50006/2020, UIDP/50006/2020 and LA/P/0008/2020, UIDB/04378/2020, UIDP/04378/2020, and LA/P/0140/2020, PTDC/QUI-QFI/29236/2017, PTDCQUI-QIN0252_2021, CEECIND/00509/2017; Fonds de la Recherche Scientifique (FNRS): PDR T.0095.21); Portugal2020: CENTRO-01-0145-FEDER-000018; Royal Society of Chemistry (RSC): R21-7511142525. Acknowledgments Centro de Química Estrutural (CQE) and Institute of Molecular Sciences (IMS) acknowledge the financial support of Fundação para a Ciência e a Tecnologia (FCT): Projects UIDB/00100/2020, UIDP/00100/2020, and LA/P/0056/2020, respectively. BioISI acknowledges FCT for financial support (UIDB/04046/2020, UIDP/04046/2020). This work was supported by the FNRS (PDR T.0095.21). Clara S. B. Gomes acknowledges the Associate Laboratory for Green Chemistry—LAQV, the Applied Molecular Biosciences Unit—UCIBIO and Associated Laboratory i4HB, which are financed by national funds from FCT (UIDB/50006/2020, UIDP/50006/2020 and LA/P/0008/2020, UIDB/04378/2020 and UIDP/04378/2020, and LA/P/0140/2020, respectively). Sónia Barroso thanks project SmartBioR for financial support (CENTRO-01-0145-FEDER-000018)and Centro de Química Estrutural for the access to crystallography facilities. Nuno A. G. Bandeira gratefully acknowledges the NanoBioSolutions FCT grant PTDC/QUI-QFI/29236/2017 for the computational infrastructure. Paulo N. Martinho thanks FCT and RSC for financial support (grants PTDCQUI-QIN0252_2021 and R21-7511142525). Paulo N. Martinho also thanks FCT for the contract CEECIND/00509/2017.Complexes [Fe(X-salEen)2]BPh4·DMF, with X = Br (1), Cl (2), and F (3), were crystallised from N,N′-dimethylformamide with the aim of understanding the role of a high boiling point N,N′-dimethylformamide solvate in the spin crossover phenomenon. The counter ion was chosen for only being able to participate in weak intermolecular interactions. The compounds were structurally characterised by single crystal X-ray diffraction. Complex 1 crystallised in the orthorhombic space group P212121, and complexes 2 and 3 in the monoclinic space group P21/n. Even at room temperature, low spin was the predominant form, although complex 2 exhibited the largest proportion of the high-spin species according to both the magnetisation measurements and the Mössbauer spectra. Density Functional Theory calculations were performed both on the periodic solids and on molecular models for complexes 1–3 and the iodide analogue 4. While all approaches reproduced the experimental structures very well, the energy balance between the high-spin and low-spin forms was harder to reproduce, though some calculations pointed to the easier spin crossover of complex 2, as observed. Periodic calculations with the functional PBE led to very similar ΔEHS-LS values for all complexes but showed a preference for the low-spin form. However, the single-point calculations with B3LYP* showed, for the model without solvate, that the Cl complex should undergo spin crossover more easily. The molecular calculations also reflected this fact, which was more clearly defined when the cation–anion–solvate model was used. In the other models there was not much difference between the Cl, Br, and I complexes.publishersversionpublishe

Preclinical pharmacokinetics and biodistribution of anticancer dinuclear Palladium(II)-Spermine Complex (Pd2Spm) in mice

Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro activity against several therapy-resistant cancers. Using inductively coupled plasma-mass spectrometry, the kinetic profiles of palladium/platinum in serum, serum ultrafiltrate and tissues (kidney, liver, brain, heart, lungs, ovaries, adipose tissue and mammary glands) were studied in healthy female Balb/c mice after a single intraperitoneal bolus injection of Pd2Spm (3 mg/kg bw) or cisplatin (3.5 mg/kg bw) between 0.5 and 48 h post-injection. Palladium in serum exhibited biphasic kinetics with a terminal half-life of 20.7 h, while the free palladium in serum ultrafiltrate showed a higher terminal half-life than platinum (35.5 versus 31.5 h). Palladium was distributed throughout most of the tissues except for the brain, with the highest values in the kidney, followed by the liver, lungs, ovaries, adipose tissue and mammary glands. The in vitro cellular accumulation was also evaluated in breast cancer cells, evidencing a passive diffusion as a mechanism of Pd2Spm’s cellular entry. This study reports, for the first time, the favorable pharmacokinetics and biodistribution of Pd2Spm, which may become a promising pharmacological agent for cancer treatmentinfo:eu-repo/semantics/publishedVersio

Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

This deposit is composed by the main article and supplementary files of the publication.Studies of the role of actin in tumour progression have highlighted its key contribution in cell softening associated with cell invasion. Here, using a human breast cell line with conditional Src induction, we demonstrate that cells undergo a stiffening state prior to acquiring malignant features. This state is characterized by the transient accumulation of stress fibres and upregulation of Ena/VASP-like (EVL). EVL, in turn, organizes stress fibres leading to transient cell stiffening, ERK-dependent cell proliferation, as well as enhancement of Src activation and progression towards a fully transformed state. Accordingly, EVL accumulates predominantly in premalignant breast lesions and is required for Src-induced epithelial overgrowth in Drosophila. While cell softening allows for cancer cell invasion, our work reveals that stress fibre-mediated cell stiffening could drive tumour growth during premalignant stages. A careful consideration of the mechanical properties of tumour cells could therefore offer new avenues of exploration when designing cancer-targeting therapies.Bloomington Drosophila Stock Centre; Vienna Drosophila Research Center (VDRC); Developmental Studies Hybridoma Bank (DSHB); Fundação para a Ciência e Tecnologia (FCT) grant: (IF/01031/2012); Laço Grant in breast cancer 2015; Alexander von Humboldt Foundation grant: (Alexander von Humboldt Professorship); Liga Portuguesa contra o Cancro/Pfizer.info:eu-repo/semantics/publishedVersio

Machado-Joseph disease in a Nigerian family: mutational origin and review of the literature

Machado-Joseph disease (MJD) has been described in Africans, but no cases have been reported from Nigeria. Current MJD global distribution results from both the ancestral populations-of-origin and the founder effects of mutations, some as a consequence of the Portuguese sea travels in the 15th to 16th century. Two main ancestral haplotypes have been identified: the Machado lineage, which is more recent, predominant in families of Portuguese extraction, and the Joseph lineage, which is much older and worldwide spread, postulated to have an Asian origin. We report a Nigerian family with MJD from Calabar, once settled by Portuguese slave traders, and assessed its mutational origin. The proband was a 33-year-old man with progressive unsteady gait, weakness of all limbs, dysphagia, dysarthria, urinary frequency and diaphoresis. He had end-of-gaze nystagmus, spastic quadriparesis and atrophic small muscles of the hand. He showed fibrillation potentials on EMG, and nerve conduction studies suggested a central axonopathy without demyelination. This family bears the Joseph haplotype, which has a founder effect in the island of Flores, in the Azores (and their descendants in North-America), but is also the most common in non-Portuguese populations worldwide, with an estimated mutation age of around 7000 years.SM is the recipient of a scholarship (SFRH/BPD/77969/2011) from the Portuguese Foundation for Science and Technology (FCT); IPATIMUP is partially supported by FCT. This work was co-financed by the European Social Fund (Human Potential Thematic Operational Programme)