EFEITOS DA BENZOFENONA NAS PROPRIEDADES FÍSICO-QUÍMICAS DE RESINAS COMPOSTAS EXPERIMENTAIS COM DIFERENTES FOTOINICIADORES

O objetivo foi avaliar o potencial da benzofenona como fotoiniciador alternativo no grau de conversão (GC), densidade de ligações cruzadas (DLC), sorção de água (Ws) e solubilidade (S) de resinas compostas experimentais. Para isso, foram elaboradas quatro resinas com as mesmas concentrações de BisGMA, TEGDMA e partículas de carga, diferenciando apenas os fotoiniciadores: CQ/EDAB - 0,5% Canforoquinona + 1% EDAB (etil-dimetialmino benzoato, amina terciária), PPD- 2% PPD (1-fenil-1,2-propanodiona), PPD/EDAB – 2% de PPF e 4% EDAB, e BENZ - 1% de benzofenona (n,n-dietilamino) + 2% EDAB. Amostras cilíndricas foram preparadas e fotopolimerizadas com luz halógena (450 mW/cm2) por 40 segundos e foi avaliado o GC (n=3) com espectroscopia Micro Raman através dos picos 1608/1637 cm-1. A DLC (n=5) foi testada por microdureza antes e após imersão em etanol absoluto por 48h. Ws (n=5) e S (n=5) avaliado de acordo com a ISO 4049. Os resultados foram analisados com ANOVA e teste de Tukey (

Intervenciones farmacéuticas y factores asociados a su aceptación en unidades de cuidados intensivos en Brasil

Objective: The purpose of this study is to evaluate the pharmaceutical interventions (PI) performed in PRM and the factors associated with their acceptance. Method: This is a descriptive and cross-sectional study that analyzed PIs performed on adult patients from two ICUs in Fortaleza, Brazil, in 2019. PIs were analyzed in the categories quantity of drug and pharmacological strategy, using the classification proposed by Sabater et al. The drugs were also classified by the Anatomical, Therapeutic, and Chemical Classification System and by the High Surveillance Drugs (FAV) classification. Results: 305 patients were included, most of them male (55.1 %), elderly (52.8 %) and treated in the surgical ICU (51.4 %). 1,317 PIs were analyzed and 88.0 % were accepted, being to replace one or more drugs (28.0 %), to add one or more drugs (27.7 %) and to change the dose (24.8 %) the most frequent types. The most prevalent therapeutic class was anti-infectives for systemic use (24.1 %) and AVFs were involved in 21.7 % of the PIs. An association was observed between PIs accepted and admission to the clinical ICU (p<0.0001), AVF (p=0.0013), substitution of one or more drugs (p=0.0062) and the class of blood substitutes and perfusion solutions. (p= 0.0187). Conclusions: A high number of PIs were performed and accepted, which reinforces the importance of the pharmacist in the review of medical prescriptions in the ICU.Objetivo: El propósito de este estudio es evaluar las intervenciones farmacéuticas (IF) realizadas sobre PRM y los factores asociados a su aceptación. Método: Se trata de un estudio descriptivo y transversal que analizó las IF realizadas a pacientes adultos de dos UCI de Fortaleza, Brasil, en 2019. Las IF se analizaron en las categorías cantidad de fármaco y estrategia farmacológica, utilizando la clasificación propuesta por Sabater et al. Los fármacos se clasificaron además por el Sistema de Clasificación Anatómica, Terapéutica, Química y por la clasificación de Fármacos de Alta Vigilancia (FAV). Resultados: Se incluyeron 305 pacientes, siendo la mayoría del sexo masculino (55,1 %), ancianos (52,8 %) y atendidos en la UCI quirúrgica (51,4 %). Se analizaron 1.317 IF y se aceptaron el 88,0 %, siendo la sustitución de uno o más fármacos (28,0 %) y la adición de uno o más fármacos (27,7 %) las más frecuentes. La clase terapéutica más prevalente fue antiinfeccioso de uso sistémico (24,1 %) y los FAV estuvieron implicados en el 21,7 % de las IF. Se observó asociación entre las IF aceptadas e ingreso en UCI clínica (p<0,0001), FAV (p=0,0013), sustitución de uno o más fármacos (p=0,0062) y la clase sustitutos sanguíneos y soluciones de perfusión (p= 0,0187). Conclusiones: Se realizaron y aceptaron un elevado número de IF, lo que refuerza la importancia del farmacéutico en la revisión de las prescripciones médicas en UCI

Crack consumption Characteristics of users undergoing treatment at a Psychosocial Alcohol-Drug Attention Center

The objective of this study was to characterize the sociodemographic and clinical profile of crack users attended at the Center for Psychosocial Care for Alcohol and Other Drugs (CAPS AD) of a municipality in the northwestern mesoregion in the state of Ceará. This is an exploratory-descriptive, documental and retrospective study of a quantitative approach, carried out in CAPS-AD, in 2014, using a form developed based on the CAPS-AD Reception Roadmap. The study found the majority of crack users were men, with an average age of 25 years, singles and had not finished elementary school. The present study contributes for the health professional to know the profile, reality and challenges to be faced for this population, in which these results are based on strategies for disease prevention, health promotion and interventions based on Harm Reduction Strategies.O objetivo deste estudo foi caracterizar o perfil sociodemográfico e clínico de usuários de crack atendidos no Centro de Atenção Psicossocial para Álcool e Outras Drogas (CAPS AD) de um município da mesorregião noroeste do Ceará. Trata-se de um estudo exploratório-descritivo, documental e retrospectivo de abordagem quantitativa, realizado no CAPS-AD, em 2014, utilizando-se de um formulário desenvolvido com base no Roteiro de Acolhimento do CAPS-AD. Constataram-se no estudo que a maior parte dos usuários de crack era homens, com média etária de 25 anos, solteiros e não haviam concluído o Ensino Fundamental. O presente estudo contribuiu para que o profisisonal de saúde conheça o perfil, realidade e desafios a serem enfrentados para esta população, no que pautam estes resultados para elaborar estratégias de prevenção de doenças, promoção da saúde, intervenções fundamentadas nas Estratégias de Redução de Danos.El objetivo de este estudio fue caracterizar el perfil sociodemográfico y clínico de usuarios de crack atendidos en el Centro de Atención Psicosocial para Alcohol y Otras Drogas (CAPS AD) de un municipio de la mesorregión en el noroeste del estado de Ceará. Se trata de un estudio exploratorio-descriptivo, documental y retrospectivo de abordaje cuantitativo, realizado en el CAPS-AD, en 2014, utilizando un formulario desarrollado con base en la Hoja de Acogida del CAPS-AD. Se constató en el estudio que la mayor parte de los usuarios de crack eran hombres, con edad promedio de 25 años, solteros y no habían concluido la Enseñanza Fundamental. El presente estudio contribuye para que el profesional de salud conozca el perfil, realidad y desafíos a ser enfrentados para esta población, en lo que pautan estos resultados para elaborar estrategias de prevención de enfermedades, promoción de la salud, intervenciones fundamentadas en las Estrategias de Reducción de Daños

Intervenciones farmacéuticas y factores asociados a su aceptación en unidades de cuidados intensivos en Brasil

The authors are grateful for the contribution of the physicians, pharmacists and patients of the Walter Cantídio University Hospital who collaborated in the conduction of this study.Objetivo: El propósito de este estudio es evaluar las intervenciones farmacéuticas (IF) realizadas sobre PRM y los factores asociados a su aceptación. Método: Se trata de un estudio descriptivo y transversal que analizó las IF realizadas a pacientes adultos de dos UCI de Fortaleza, Brasil, en 2019. Las IF se analizaron en las categorías cantidad de fármaco y estrategia farmacológica, utilizando la clasificación propuesta por Sabater et al. Los fármacos se clasificaron además por el Sistema de Clas ificación Anatómica, Terapéutica, Química y por la clasificación de Fármacos de Alta Vigilancia (FAV). Resultados: Se incluyeron 305 pacientes, siendo la mayoría del sexo masculino (55,1 %), ancianos (52,8 %) y aten didos en la UCI quirúrgica (51,4 %). Se analizaron 1.317 IF y se aceptaron el 88,0 %, siendo la sustitución de uno o más fármacos (28,0 %) y la adición de uno o más fármacos (27,7 %) las más frecuentes. La clase terapéutica más prevalente fue antiinfeccioso de uso sistémico (24,1 %) y los FAV estuvieron implicados en el 21,7 % de las IF. Se observó asociación entre las IF aceptadas e ingreso en UCI clínica (p<0,0001), FAV (p=0,0013), sustitución de uno o más fármacos (p=0,0062) y la clase sustitutos sanguíneos y soluciones de perfusión (p= 0,0187). Conclusiones: Se realizaron y aceptaron un elevado número de IF, lo que refuerza la importancia del farmacéutico en la revisión de las prescripciones médicas en UCI.Objective: The purpose of this study is to evaluate the pharmaceutical interventions (PI) performed in PRM and the factors associated with their acceptance. Method: This is a descriptive and cross-sectional study that analyzed PIs performed on adult patients from two ICUs in Fortaleza, Brazil, in 2019. PIs were analyzed in the categories quantity of drug and pharmacological strategy, using the classification proposed by Sabater et al. The drugs were also classified by the Anatomical, Therapeutic, and Chemical Classification System and by the High Surveillance Drugs (FAV) classification. Results: 305 patients were included, most of them male (55.1 %), elderly (52.8 %) and treated in the surgical ICU (51.4 %). 1,317 PIs were analyzed and 88.0 % were accepted, being to replace one or more drugs (28.0 %), to add one or more drugs (27.7 %) and to change the dose (24.8 %) the most frequent types. The most prevalent therapeutic class was anti-infectives for systemic use (24.1 %) and AVFs were involved in 21.7 % of the PIs. An association was observed between PIs accepted and admission to the clinical ICU (p<0.0001), AVF (p=0.0013), substitution of one or more drugs (p=0.0062) and the class of blood substitutes and perfusion solutions. (p= 0.0187). Conclusions: A high number of PIs were performed and accepted, which reinforces the importance of the pharma cist in the review of medical prescriptions in the ICU

Crack consumption: characteristics of users undergoing treatment at a Psychosocial Alcohol-Drug Attention Center

Objectivo: caracterizar el perfil sociodemográfico y clínico de usuarios de crack atendidos en el Centro de Atención Psicosocial para Alcohol y Otras Drogas (Caps AD) de un municipio de la mesorregión en el noroeste del estado de Ceará. Metodo: estudio exploratorio-descriptivo, documental y retrospectivo de abordaje cuantitativo, realizado en el Caps AD, en 2014, utilizando un formulario desarrollado con base en la Hoja de Acogida del Caps AD. Resultados: se constató en el estudio que la mayor parte de los usuarios de crack eran hombres, con edad promedio de 25 años, solteros y no habían concluido la Enseñanza Fundamental. Conclusión: el presente estudio contribuye para que el profesional de salud conozca el perfil, realidad y desafíos a ser enfrentados para esta población, en lo que pautan estos resultados para elaborar estrategias de prevención de enfermedades, promoción de la salud, intervenciones fundamentadas en las Estrategias de Reducción de Daños.Objective: to characterize the sociodemographic and clinical profile of crack users attended at the Center for Psychosocial Care for Alcohol and Other Drugs (Caps AD) of a municipality in the northwestern mesoregion in the State of Ceará. Method: this is an exploratory-descriptive, documental and retrospective study of a quantitative approach, carried out in Caps AD, in 2014, using a form developed based on the Caps AD Reception Roadmap. Results: the study found the majority of crack users were men, with an average age of 25 years, singles and had not finished elementary school. Conclusion: the present study contributes for the health professional to know the profile, reality and challenges to be faced for this population, in which these results are based on strategies for disease prevention, health promotion and interventions based on Harm Reduction Strategies.Objetivo: caracterizar o perfil sociodemográfico e clínico de usuários de crack atendidos no Centro de Atenção Psicossocial Álcool e Drogas (Caps AD) de um município da mesorregião noroeste do Ceará. Método: estudo exploratório-descritivo, documental e retrospectivo, de abordagem quantitativa, realizado em 2014, utilizando um formulário desenvolvido a partir do roteiro de acolhimento do Caps AD. Resultados: constatou-se no estudo que a maior parte dos usuários de crack era do sexo masculino, com média etária de 25 anos, solteira e com Ensino Fundamental incompleto. Conclusão: o estudo contribuiu para que o profisisonal de saúde&nbsp;conheça o perfil, a realidade e os desafios enfrentados por esta população, elaborando estratégias de prevenção de doenças, promoção da saúde e intervenções fundamentadas nas estratégias de redução de danos

Influence of violence on the mental health of brazilian immigrant women in Portugal

This study aimed to analyze the prevalence of violence against Brazilian immigrant women in Portugal since their arrival, and the consequences of this in their experience, specifically in health, perception of discrimination and loneliness. The sample comprised 682 Brazilian women, migrants, over 18 years old, living in Portugal for more than three months. Data collection was carried out online, through the Limasurvey Platform, and in person at the Brazilian General Consulate in Porto and Lisbon, at More Association (Associação Mais), in which the Discrimination Perceptions, Loneliness (ULS-6) and Mental Health Problems Scales were applied. The results suggest that Brazilian women who have been subjected to violence in Portugal have a worse perception of their health, a greater perception of discrimination, a higher level of loneliness and more mental problems. The study also shows that: the length of stay in Portugal is significantly associated with having been subjected to violence; there is a greater proportion of single women (31.5%) who have been subjected to violence; there is a marginally significant association with whom the immigrants live [χ2 (1, 671) = 2.86, p = 0.09]. Immigrants have some vulnerabilities in the host country, since violence has an adverse effect on their physical and mental health. It is believed to be crucial to create a policy of strengthening the citizen and collective conscience of these immigrant women.info:eu-repo/semantics/publishedVersio

Hanseníase na Amazônia central: um olhar epidemiológico

OBJECTIVE: To describe the epidemiology and clinical profile of leprosy in the western region of the state of Pará, Brazil, in the period from 2014 to 2020. METHODS: This is a cross-sectional, descriptive study. Data collection was performed from the Sistema de Informação de Agravos de Notificação (SINAN) of the Secretaria de Vigilância em Saúde (SVS) of the Brazilian Ministry of Health in the period from june 2021 to august 2021, and a literature review in the PUBMED database. RESULTS: 1764 cases were registered, with a prevalence of 17.5 per 10.000 inhabitants, 942 (53.5%) in the region of Tapajós and 822 (47.9%) in the region of Baixo Amazonas. There was a predominance in the age group of 40 to 49 years (20.6%); colour “Parda” (73.6%); Incomplete Primary Education (55.7%); male sex (66.3%); clinical form Dimorphic (54.5%); Multibacillary operational classification (82.3%); zero degree of functional disability (41.6%); type I reaction episodes (11.6%). In the literature review, 9 articles were included after applying the inclusion and exclusion criteria and reading the articles in full. CONCLUSION: There was a reduction in the number of leprosy cases in the Mesoregion in the studied period. However, there are still deficits in the strategies of screening, treatment and monitoring of cases of leprosy, with prevalence of highly transmissible and clinically severe cases, especially among men in economically active age. Thus, it is essential to adopt regional public policies to combat, control and prevent leprosy in the western region of the state of Pará.OBJETIVO: Descrever a epidemiologia e o perfil clínico da hanseníase na região oeste do estado do Pará, Brasil, no período de 2014 a 2020. MÉTODO: Trata-se de um estudo de corte transversal, descritivo. A coleta de dados foi realizada a partir do Sistema de Informação de Agravos de Notificação (SINAN) da Secretaria de Vigilância em Saúde (SVS) do Ministério da Saúde do Brasil no período de junho de 2021 a agosto de 2021, e uma revisão da literatura na base dados PUBMED. RESULTADOS: Foram registrados 1764 casos, com uma prevalência de 17,5 por 10.000 habitantes, sendo 942 (53,5%) na região do Tapajós e 822 (47,9%) na região do Baixo Amazonas. Houve predomínio na faixa etária de 40 a 49 anos (20,6%); cor “parda” (73,6%); escolaridade com Ensino Fundamental Incompleto (55,7%); sexo masculino (66,3%); forma clínica Dimorfa (54,5%); classificação operacional Multibacilar (82,3%); grau zero de incapacidade funcional (41,6%); episódios reacionais tipo I (11,6%). Na revisão de literatura, foram incluídos 9 artigos após aplicação dos critérios de inclusão e exclusão e leitura dos artigos na íntegra. CONCLUSÃO: Houve redução no número de casos de hanseníase na Mesorregião no período estudado. Todavia, ainda existem déficits nas estratégias de rastreio, tratamento e acompanhamento dos casos de hanseníase, com prevalência de casos altamente transmissíveis e clinicamente graves, especialmente entre homens em idade economicamente ativa. Dessa forma, faz-se essencial a adoção de políticas públicas regionais para combate, controle e prevenção da hanseníase na região Oeste do estado do Pará

Soil erosion vulnerability in the southern part of the Meia Ponte watershed, Goias, Brazil

ABSTRACT Soil erosion is a serious environmental problem that can cause numerous types of damage to society and the environment, and thus require preventive measures. The objective of this study was to evaluate soil erosion vulnerability in the southern region of the Meia Ponte watershed, Goias, Brazil, considering two situations: natural and anthropic cover conditions. For the analysis, we used remote sensing data represented by several parameters: lithology, soil class, slope, rain intensity, vegetation index, vicinity of roads, and land use and occupation. For each variable, we established a scale of weights according to erosive susceptibility for natural and anthropogenic environments. Multicriteria analysis, which allows the combination of qualitative and quantitative information in the analysis of erosive susceptibility, was used through the relationship between soil use and land occupation. In the southern part of the Meia Ponte River watershed, the anthropic factor showed greater influence. The factors that increase erosive susceptibility were soil use and occupation, low vegetation index, and high slope. The southern part of the Meia Ponte watershed presents medium natural erosive susceptibility in most of the study area.RESUMEN La erosión de los suelos es un grave problema ambiental que puede ocasionar numerosos daños a la sociedad y al medio ambiente, siendo necesario la adopción de medidas preventivas. Este estudio tuvo por objetivo evaluar la vulnerabilidad erosiva de los suelos en la región sur de la cuenca Meia Ponte, Goiás, considerando dos situaciones: condiciones de cobertura natural y antrópica. Para la realización de los análisis, se utilizaron datos de sensoriamiento remoto representados por diversos parámetros: litología, clase de suelo, declividad, intensidad de lluvia, índice de vegetación, cercanías de vías y uso y ocupación del suelo. Se establecieron para cada variable, una escala de pesos de acuerdo con susceptibilidad erosiva para el medio natural y otra antrópica. Se utilizó el análisis multicriterio, por medio de la relación entre las actividades de uso y ocupación del suelo, la cual permite combinar informaciones cualitativas y cuantitativas en análisis en cuanto a la susceptibilidad erosiva. En la parte sur de la cuenca del Río Meia Ponte, el factor antrópico obtuvo mayor influencia. Los factores que aumentaron susceptibilidad erosiva fueron el uso y ocupación del suelo, bajo índice de vegetación y la alta declividad. La parte sur de la cuenca Media Ponte, presenta susceptibilidad erosiva natural media en la mayor parte del área de estudio

Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres

Background. Pancreatic acinar cell carcinoma (PACC) is a rare tumor. Surgical resection is the treatment of choice when feasible, but there are no clear recommendations for patients with advanced disease. Liver-directed therapy with Y-90 selective internal radiation therapy (SIRT) has been used to treat hepatic metastases from pancreatic tumors. We describe a case of PACC liver metastases treated with SIRT. Case Report. 59-year-old man was admitted with an infiltrative, solid lesion in pancreatic tail diagnosed as PACC. Lymph nodes in the hepatic hilum were enlarged, and many metastatic liver nodules were observed. After partial pancreatectomy, the left and right lobes of the liver were separately treated with Y-90 resin microspheres. Follow-up imaging revealed that all hepatic nodules shrank by at least 50%, and 3 nodules disappeared completely. Lipase concentration was 8407 U/L at baseline, rose to 12,705 U/L after pancreatectomy, and declined to 344 U/L after SIRT. Multiple rounds of chemotherapy in the subsequent year shrank the hepatic tumors further; disease then progressed, but a third line of chemotherapy shrank the tumors again, 16 months after SIRT treatment. Conclusion. SIRT had a positive effect on liver metastases from PACC. In conjunction with systemic therapy, SIRT can achieve sustained disease control