3,347 research outputs found
Improved Photocatalytic Activity of Polysiloxane TiO2 Composites by Thermally Induced Nanoparticle Bulk Clustering and Dye Adsorption
Fine control of nanoparticle clustering within polymeric matrices can be tuned to enhance the physicochemical properties of the resulting composites, which are governed by the interplay of nanoparticle surface segregation and bulk clustering. To this aim, out-of-equilibrium strategies can be leveraged to program the multiscale organization of such systems. Here, we present experimental results indicating that bulk assembly of highly photoactive clusters of titanium dioxide nanoparticles within an in situ synthesized polysiloxane matrix can be thermally tuned. Remarkably, the controlled nanoparticle clustering results in improved degradation photocatalytic performances of the material under 1 sun toward methylene blue. The resulting coatings, in particular the 35 wt % TiO2-loaded composites, show a photocatalytic degradation of about 80%, which was comparable to the equivalent amount of bare TiO2 and two-fold higher with respect to the corresponding composites not subjected to thermal treatment. These findings highlight the role of thermally induced bulk clustering in enhancing photoactive nanoparticle/polymer composite properties
Políticas públicas orientadas a clubes. Rosario, noviembre 2022.
El presente informe tiene como principal objetivo difundir entre las instituciones deportivas de la ciudad de Rosario las iniciativas estatales de los tres niveles gubernamentales (nacional, provincial y local) que impulsan el desarrollo de clubes, tanto en infraestructura como en formación y en mejoras de las prestaciones deportivas y sociales.Universidad Nacional de Rosario. Área de Ciencia, Tecnología e Innovación para el Desarrollo; Argentin
First report of Berkeleyomyces basicola (synonymous: Thielaviopsis basicola) on roots of sweet potato (Ipomoea batatas (L.) Lam) in Argentina
Symptomatic sweet potato cv Arapey INIA samples were collected from a commercial production field in Colonia Molina, Guaymallén department, Mendoza province, Argentina. They showed dark rounded lesions, sometimes coalescing with white granular mycelium. Fungus was obtained from symptomatic sweet potatoes, which represented the generalized infection that affected the crop. They were seeded in PDA with streptomycin sulfate and incubated for seven days at 21°C, alternating white/black (UV400nm) light. Observations with an optical microscope revealed the presence of hyaline, not septated, cylindrical endoconidia with rounded ends. They were 8-16 μm length and 4–6 μm width. Phialides were 43-46 μm length, rounded bases (7-9 μm width) and tapering to the neck´s tip (4-6 μm width). Brown chlamydospores (aleuriospores), 9-13 μm length and 8-12 μm width, in chains of 2-8 spores were observed. For molecular identification, total genomic DNA was extracted. ITS fragment of 565 pb was amplified using ITS5/ITS4 primers and sequenced. The sequence indicated 99% identity with Berkeleyomyces basicola (synonymous: Thielaviopsis basicola). This was deposited in GenBank as (KX580957) (CBS: C430.74, Gen Bank accession number AF275482.1). This is the first report of B. basicola in sweet potato in Argentina, a potential threat to storage root yields.
Highlights:
Sweet potato black root rot, new disease in Argentina.
First report of Berkeleyomyces basicola causing black root rot on sweet potato in Mendoza, Argentina.Symptomatic sweet potato cv Arapey INIA samples were collected from a commercial production field in Colonia Molina, Guaymallén department, Mendoza province, Argentina. They showed dark rounded lesions, sometimes coalescing with white granular mycelium. Fungus was obtained from symptomatic sweet potatoes, which represented the generalized infection that affected the crop. They were seeded in PDA with streptomycin sulfate and incubated for seven days at 21°C, alternating white/black (UV400nm) light. Observations with an optical microscope revealed the presence of hyaline, not septated, cylindrical endoconidia with rounded ends. They were 8-16 μm length and 4–6 μm width. Phialides were 43-46 μm length, rounded bases (7-9 μm width) and tapering to the neck´s tip (4-6 μm width). Brown chlamydospores (aleuriospores), 9-13 μm length and 8-12 μm width, in chains of 2-8 spores were observed. For molecular identification, total genomic DNA was extracted. ITS fragment of 565 pb was amplified using ITS5/ITS4 primers and sequenced. The sequence indicated 99% identity with Berkeleyomyces basicola (synonymous: Thielaviopsis basicola). This was deposited in GenBank as (KX580957) (CBS: C430.74, Gen Bank accession number AF275482.1). This is the first report of B. basicola in sweet potato in Argentina, a potential threat to storage root yields.
Highlights:
Sweet potato black root rot, new disease in Argentina.
First report of Berkeleyomyces basicola causing black root rot on sweet potato in Mendoza, Argentina
Notas sobre lógica y grupos políticos
En estas notas nos enfrentamos a la complejidad del estudio del concepto de grupo político desde una doble perspectiva: jurídica y lógica.
Pretendemos abordar representaciones formales de creencias, objetivos, confianza, acciones y regulaciones en grupos que poseen una ideología, una actitud política, y llevan a cabo acción política.Sociedad Argentina de Informática e Investigación Operativ
Primer reporte de Berkeleyomyces basicola (sinónimo: Thielaviopsis basicola) en raíces de batata (Ipomoea batatas (L.) Lam) en Argentina
Muestras sintomáticas de batata cv Arapey INIA, fueron recolectadas en lotes de producción comercial en Colonia Molina, Guaymallén, Mendoza, Argentina. Estas presentaban lesiones redondeadas, oscuras, frecuentemente coalescentes, con micelio granuloso blanco. El hongo fue aislado a partir de batatas sintomáticas que representaban la infección generalizada del cultivo. Los aislamientos fueron sembrados en APG con sulfato de estreptomicina e incubados durante siete días a 21°C con alternancia de luz blanca/ luz negra (UV-400 nm). Las observaciones al microscopio óptico revelaron la presencia de endoconidios hialinos, no-septados, cilíndricos con extremos redondeados (8-16 x 4-6 µm), fiálides (43-46 µm de largo) de base redondeada (7-9 µm) y cuello que se estrecha hacia la punta (4-6 µm). También se observaron clamidosporas marrones (aleuriesporas) de 9-13 x 8-12 µm, en cadenas con 1-7 septos. El ADN genómico fue extraído para la identificación molecular. Un fragmento ITS de 565 pb fue amplificado usando los iniciadores ITS5/ ITS4 y secuenciado. La secuencia reveló 99 % de identidad con Berkeleyomyces basicola (sinónimo: Thielaviopsis basicola) y está depositada en el GenBank como KX580957 (CBS: C430.74, GenBank accession number AF275482.1). Esta constituye el primer reporte de B. basicola en el cultivo de batata en Argentina y una amenaza potencial para la producción de raíces reservantes.Symptomatic sweet potato cv Arapey INIA samples were collected from a commercial production field in Colonia Molina, Guaymallén department, Mendoza province, Argentina. They showed dark rounded lesions, sometimes coalescing with white granular mycelium. Fungus was obtained from symptomatic sweet potatoes, which represented the generalized infection that affected the crop. They were seeded in PDA with streptomycin sulfate and incubated for seven days at 21°C, alternating white/black (UV400nm) light. Observations with an optical microscope revealed the presence of hyaline, not septated, cylindrical endoconidia with rounded ends. They were 8-16 µm length and 4–6 µm width. Phialides were 43-46 µm length, rounded bases (7-9 µm width) and tapering to the neck´s tip (4-6 µm width). Brown chlamydospores (aleuriospores), 9-13 µm length and 8-12 µm width, in chains of 2-8 spores were observed. For molecular identification, total genomic DNA was extracted. ITS fragment of 565 pb was amplified using ITS5/ITS4 primers and sequenced. The sequence indicated 99% identity with Berkeleyomyces basicola (synonymous: Thielaviopsis basicola). This was deposited in GenBank as (KX580957) (CBS: C430.74, Gen Bank accession number AF275482.1). This is the first report of B. basicola in sweet potato in Argentina, a potential threat to storage root yields.Fil: Martino, Julia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; ArgentinaFil: Di Feo, Liliana del Valle. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Paccioretti, Mauro Andrés. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; ArgentinaFil: Contardi, Clara Adriana. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Mendoza-san Juan. Estacion Experimental Agropecuaria Mendoza. Agencia de Extension Rural Lujan de Cuyo.; ArgentinaFil: Sánchez, Miguel Alejandro. Instituto Nacional de Tecnologia Agropecuaria. Centro de Investigaciones Agropecuarias. Unidad de Estudios Agropecuarios. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Unidad de Estudios Agropecuarios.; ArgentinaFil: Ortega, Leandro Ismael. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Fisiología y Recursos Genéticos Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pastor, Silvina Estela. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; Argentin
A multimodal approach to the treatment of bilateral choroidal metastases from thyroid carcinoma
A 58-year old man, affected by metastatic thyroid carcinoma, experienced a progressive bilateral visual impairment. Ophthalmic examination revealed the presence of a choroidal mass with an associated exudative retinal detachment in both eyes. Twelve years before, a diagnosis of metastatic thyroid carcinoma had been established and the patient had been subject to several therapeutic procedures
Comparative Analysis for Direct Costs and Global Functions in Persons Affected By Bipolar Disorders I and II in Outpatient Treatment
Objetivo: Evaluar los costos directos, el nivel de funcionamiento y la tasa de empleo reportada en una muestra aleatoria de personas con trastorno bipolar (TB) I y II que se atienden en forma ambulatoria. Métodos: Se analizaron y compararon los costos directos de los tratamientos ambulatorios de 165 pacientes con diagnóstico de trastorno bipolar tipo I y II (el costo mensual del tratamiento farmacológico, el número de consultas mensuales, el número de internaciones y días de internación). Se estimó el funcionamiento global y se consignó la condición laboral. Resultados: El 51,5% (n=85) de los pacientes presentaba diagnóstico de TB tipo I y 48,5% (n=80) de TB tipo II. El 40,6% de los pacientes se encontraba desocupado; el puntaje de GAF fue 73 ± 12,59. Los costos mensuales del tratamiento farmacológico fueron de 350,4 por paciente sin diferencia entre los TB. Un mayor porcentaje de pacientes con TB I había tenido internaciones y recibía antipsicóticos, mientras que un mayor porcentaje de pacientes con TB II recibía antidepresivos y asistía al psicólogo. Discusión: Los pacientes con diagnóstico de TB I y TB II deben afrontar tratamientos farmacológicos que implican un costo promedio equivalente a un cuarto del ingreso mínimo en nuestro país, independientemente del tipo de trastorno bipolar que padezcan. Ambos grupos de pacientes presentaban una elevada tasa de desempleo y puntajes de funcionamiento global relativamente bajos.Objective: To evaluate the direct costs, the functional level and the employment rate reported for a random sample of people with Bipolar Disorders (BD) I and II that are cared for as outpatients. Methods: The direct costs of outpatient treatment for 165 patients diagnosed with types I and II bipolar disorders were compared and analyzed (the monthly cost of pharmacological treatments, the number of consultations per month, the number of hospitalizations and the days spent in hospital). Global functioning was estimated and their employment was recorded. Results: 51,5% (N=85) of the patients had been diagnosed with type I BD and 48.5% (N=80) with BD type II. 40,6% of the patients were unemployed; the GAF score was 73 ± 12,59. Monthly costs of pharmacological treatment were 350,4 per patient, with no difference between the type of BD. A larger percentage of type I BD patients had been hospitalized and received anti-psychotic drugs, whereas a greater percentage of BD II patients received anti-depressants and went to a psychologist. Discussion: Patients diagnosed with BDI and BD II must face pharmacological treatments that imply an average cost equal to one quarter of the minimum income in our country, independent of the type of bipolar disorder they suffer. Both groups of patients presented a high level of unemployment and relatively low global functioning scores.Fil: Igoa, Ana. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Khan, Clara. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; ArgentinaFil: Scchiavo, Patricia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; ArgentinaFil: Marengo, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Strejilevich, Sergio. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentin
Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects?
Abstract: Cardiovascular mortality is a major cause of death among in type 2 diabetes (T2DM).
Endothelial dysfunction (ED) is a well-known important risk factor for the development of diabetes
cardiovascular complications. Therefore, the prevention of diabetic macroangiopathies by preserving
endothelial function represents a major therapeutic concern for all National Health Systems.
Several complex mechanisms support ED in diabetic patients, frequently cross-talking each other:
uncoupling of eNOS with impaired endothelium-dependent vascular response, increased ROS production,
mitochondrial dysfunction, activation of polyol pathway, generation of advanced glycation
end-products (AGEs), activation of protein kinase C (PKC), endothelial inflammation, endothelial
apoptosis and senescence, and dysregulation of microRNAs (miRNAs). Metformin is a milestone
in T2DM treatment. To date, according to most recent EASD/ADA guidelines, it still represents
the first-choice drug in these patients. Intriguingly, several extraglycemic effects of metformin have
been recently observed, among which large preclinical and clinical evidence support metformin’s
efficacy against ED in T2DM. Metformin seems effective thanks to its favorable action on all the
aforementioned pathophysiological ED mechanisms. AMPK pharmacological activation plays a key
role, with metformin inhibiting inflammation and improving ED. Therefore, aim of this review is
to assess metformin’s beneficial effects on endothelial dysfunction in T2DM, which could preempt
development of atherosclerosis
Monitoring the 5'UTR landscape reveals isoform switches to drive translational efficiencies in cancer
Transcriptional and translational control are key determinants of gene expression, however, to what extent these two processes can be collectively coordinated is still poorly understood. Here, we use Nanopore long-read sequencing and cap analysis of gene expression (CAGE-seq) to document the landscape of 5' and 3' untranslated region (UTR) isoforms and transcription start sites of epidermal stem cells, wild-type keratinocytes and squamous cell carcinomas. Focusing on squamous cell carcinomas, we show that a small cohort of genes with alternative 5'UTR isoforms exhibit overall increased translational efficiencies and are enriched in ribosomal proteins and splicing factors. By combining polysome fractionations and CAGE-seq, we further characterize two of these UTR isoform genes with identical coding sequences and demonstrate that the underlying transcription start site heterogeneity frequently results in 5' terminal oligopyrimidine (TOP) and pyrimidine-rich translational element (PRTE) motif switches to drive mTORC1-dependent translation of the mRNA. Genome-wide, we show that highly translated squamous cell carcinoma transcripts switch towards increased use of 5'TOP and PRTE motifs, have generally shorter 5'UTRs and expose decreased RNA secondary structures. Notably, we found that the two 5'TOP motif-containing, but not the TOP-less, RPL21 transcript isoforms strongly correlated with overall survival in human head and neck squamous cell carcinoma patients. Our findings warrant isoform-specific analyses in human cancer datasets and suggest that switching between 5'UTR isoforms is an elegant and simple way to alter protein synthesis rates, set their sensitivity to the mTORC1-dependent nutrient-sensing pathway and direct the translational potential of an mRNA by the precise 5'UTR sequence
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