General models in min-max continous location

In this paper, a class of min-max continuous location problems is discussed. After giving a complete characterization of th stationary points, we propose a simple central and deep-cut ellipsoid algorithm to solve these problems for the quasiconvex case. Moreover, an elementary convergence proof of this algorithm and some computational results are presented

Best approximation by downward sets with applications

We develop a theory of downward sets for a class of normed ordered spaces. We study best approximation in a normed ordered space X by elements of downward sets, and give necessary and sufficient conditions for any element of best approximation by a closed downward subset of X. We also characterize strictly downward subsets of X, and prove that a downward subset of X is strictly downward if and only if each its boundary point is Chebyshev. The results obtained are used for examination of some Chebyshev pairs (W,x), where x E X and W is a closed downward subset of X.C

The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala

In rodents, the medial nucleus of the amygdala receives direct inputs from the accessory olfactory bulbs and is mainly implicated in pheromone-mediated reproductive and defensive behaviors. The principal neurons of the medial amygdala are GABAergic neurons generated principally in the caudo-ventral medial ganglionic eminence and preoptic area. Beside GABAergic neurons, the medial amygdala also contains glutamatergic Otp-expressing neurons cells generated in the lateral hypothalamic neuroepithelium and a non-well characterized Pax6-positive population. In the present work, we describe a novel glutamatergic Ebf3-expressing neuronal subpopulation distributed within the periphery of the postero-ventral medial amygdala. These neurons are generated in a pallial domain characterized by high expression of Gdf10. This territory is topologically the most caudal tier of the ventral pallium and accordingly, we named it Caudo-Ventral Pallium (CVP). In the absence of Pax6, the CVP is disrupted and Ebf3-expressing neurons fail to be generated. Overall, this work proposes a novel model of the neuronal composition of the medial amygdala and unravels for the first time a new novel pallial subpopulation originating from the CVP and expressing the transcription factor Ebf3.This work was supported by Grants of the French National Research Agency (Agence Nationale de la Recherche; ANR) [ANR-13-BSV4-0011] and by the French Government through the ‘Investments for the Future’ LABEX SIGNALIFE [ANR-11-LABX-0028-01] to M.S., by the Spanish Government (BFU2007-60263 and BFU2010-17305) to A.F, and by the Medical Research Council (MR/K013750/1) to T.T. N.R.-R. is funded by a postdoctoral fellowship from the Ville de Nice, France (“Aide Individuelle aux Jeunes Chercheurs 2016”).Peer reviewe

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Yuan's alternative theorem and the maximization of the minimum eigenvalue function

International audienc

Axiomatic Characterizations of the Duality Correspondence in Theory.

economic models ; microeconomics ; economic theory ; consumers

Mission d'appui au laboratoire de recherches vétérinaires et zootechniques de Farcha (Tchad)

A la demande du laboratoire de Farcha, cette mission avait pour objectif d'identifier des pistes de recherche concernant la sécurisation des systèmes pastoraux, de discuter des perspectives de partenariat dans les différents domaines retenus, de se focaliser sur le rôle des dromadaires dans la dynamique des systèmes pastoraux et de proposer des pistes pour des projets au plan national et au plan régional dans le cadre du PRASAC. Les principales conclusions de la mission se résument en 5 points: (i) Evaluer la place du dromadaire dans l'économie de l'élevage tant au plan des ménages qu'au plan national, (ii) Mesurer l'impact des changements climatiques sur la dynamique des systèmes pastoraux basés sur l'élevage camelin, (iii) Explorer les voies d'une valorisation des produits de l'élevage camelin (lait et viande), (iv) Mettre en oeuvre les réseaux adéquats pour évaluer le poids des maladies émergentes chez le dromadaire face aux changements climatiques et la modification de leurs écosystèmes, (v) Développer une véritable expertise tchadienne en matière de camélologie et de développement de l'élevage camelin. (Résumé d'auteur