Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Mine waste pollutes Mediterranean

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Key factors in developing controlled closed ecosystems for lunar missions

From Elsevier via Jisc Publications RouterHistory: accepted 2024-04-29, issued 2024-05-09Article version: AMPublication status: AcceptedThe utilization of in-situ resources will be crucial for the survival of astronauts in space. Therefore, plants and crops will be important for humans in space as they serve as food, provide oxygen, and remove carbon dioxide, enhancing habitability. The aim of this research is to explore the growth of crops on celestial bodies prior to human arrival. The paper outlines the creation of a novel capsule by Green Moon Project (GMP) designed to meet essential criteria for monitoring and enhancing crop cultivation on the lunar terrain, tackling key obstacles such as self-propagation, fluctuating light patterns, water provision, and monitoring germination and growth stages. The Center of Space Exploration (hereafter COSE) managed to sprout the first seed on another celestial body during the Chang’e 4 mission on the Moon in January 2019. This achievement means an important step in space agriculture and widens the biological research of crops that will sustain future crewed missions and human bases in space. Space farming requires greater understanding if humans are to survive in space without constant contact from Earth and that is why GMP goals are aligned COSE’s. Therefore, GMP and COSE work in synergy to boost the research of space farming, future crops, habitability, and close controlled environmental systems. Due to the similarities between both projects, both teams decided to join efforts and cooperate in future space missions. To provide scientific support and technical solutions for future long-term crewed exploration missions, it is mandatory to conduct ground verification experiments of controllable extraterrestrial ecosystems

Key factors in developing controlled closed ecosystems for lunar missions

From Elsevier via Jisc Publications RouterHistory: accepted 2024-04-29, epub 2024-05-23, issued 2024-06-30Article version: VoRPublication status: PublishedThe utilization of in-situ resources will be crucial for the survival of astronauts in space. Therefore, plants and crops will be important for humans in space as they serve as food, provide oxygen, and remove carbon dioxide, enhancing habitability. The aim of this research is to explore the growth of crops on celestial bodies prior to human arrival. The paper outlines the creation of a novel capsule by Green Moon Project (GMP) designed to meet essential criteria for monitoring and enhancing crop cultivation on the lunar terrain, tackling key obstacles such as self-propagation, fluctuating light patterns, water provision, and monitoring germination and growth stages. The Center of Space Exploration (hereafter COSE) managed to sprout the first seed on another celestial body during the Chang’e 4 mission on the Moon in January 2019. This achievement means an important step in space agriculture and widens the biological research of crops that will sustain future crewed missions and human bases in space. Space farming requires greater understanding if humans are to survive in space without constant contact from Earth and that is why GMP goals are aligned COSE’s. Therefore, GMP and COSE work in synergy to boost the research of space farming, future crops, habitability, and close controlled environmental systems. Due to the similarities between both projects, both teams decided to join efforts and cooperate in future space missions. To provide scientific support and technical solutions for future long-term crewed exploration missions, it is mandatory to conduct ground verification experiments of controllable extraterrestrial ecosystems

Discovering HIV related information by means of association rules and machine learning

Acquired immunodeficiency syndrome (AIDS) is still one of the main health problems worldwide. It is therefore essential to keep making progress in improving the prognosis and quality of life of affected patients. One way to advance along this pathway is to uncover connections between other disorders associated with HIV/AIDS-so that they can be anticipated and possibly mitigated. We propose to achieve this by using Association Rules (ARs). They allow us to represent the dependencies between a number of diseases and other specific diseases. However, classical techniques systematically generate every AR meeting some minimal conditions on data frequency, hence generating a vast amount of uninteresting ARs, which need to be filtered out. The lack of manually annotated ARs has favored unsupervised filtering, even though they produce limited results. In this paper, we propose a semi-supervised system, able to identify relevant ARs among HIV-related diseases with a minimal amount of annotated training data. Our system has been able to extract a good number of relationships between HIV-related diseases that have been previously detected in the literature but are scattered and are often little known. Furthermore, a number of plausible new relationships have shown up which deserve further investigation by qualified medical experts

How do women living with HIV experience menopause? Menopausal symptoms, anxiety and depression according to reproductive age in a multicenter cohort

CatedresBackground: To estimate the prevalence and severity of menopausal symptoms and anxiety/depression and to assess the differences according to menopausal status among women living with HIV aged 45-60 years from the cohort of Spanish HIV/AIDS Research Network (CoRIS). Methods: Women were interviewed by phone between September 2017 and December 2018 to determine whether they had experienced menopausal symptoms and anxiety/depression. The Menopause Rating Scale was used to evaluate the prevalence and severity of symptoms related to menopause in three subscales: somatic, psychologic and urogenital; and the 4-item Patient Health Questionnaire was used for anxiety/depression. Logistic regression models were used to estimate odds ratios (ORs) of association between menopausal status, and other potential risk factors, the presence and severity of somatic, psychological and urogenital symptoms and of anxiety/depression. Results: Of 251 women included, 137 (54.6%) were post-, 70 (27.9%) peri- and 44 (17.5%) pre-menopausal, respectively. Median age of onset menopause was 48 years (IQR 45-50). The proportions of pre-, peri- and post-menopausal women who had experienced any menopausal symptoms were 45.5%, 60.0% and 66.4%, respectively. Both peri- and post-menopause were associated with a higher likelihood of having somatic symptoms (aOR 3.01; 95% CI 1.38-6.55 and 2.63; 1.44-4.81, respectively), while post-menopause increased the likelihood of having psychological (2.16; 1.13-4.14) and urogenital symptoms (2.54; 1.42-4.85). By other hand, post-menopausal women had a statistically significant five-fold increase in the likelihood of presenting severe urogenital symptoms than pre-menopausal women (4.90; 1.74-13.84). No significant differences by menopausal status were found for anxiety/depression. Joint/muscle problems, exhaustion and sleeping disorders were the most commonly reported symptoms among all women. Differences in the prevalences of vaginal dryness (p = 0.002), joint/muscle complaints (p = 0.032), and sweating/flush (p = 0.032) were found among the three groups. Conclusions: Women living with HIV experienced a wide variety of menopausal symptoms, some of them initiated before women had any menstrual irregularity. We found a higher likelihood of somatic symptoms in peri- and post-menopausal women, while a higher likelihood of psychological and urogenital symptoms was found in post-menopausal women. Most somatic symptoms were of low or moderate severity, probably due to the good clinical and immunological situation of these women