Optimization of municipal solid waste management using externality costs

Economic and environmental impacts associated with solid waste management (SWM) systems should be considered to ensure sustainability of such systems. Societal life cycle costing (S-LCC) can be used for this purpose since it includes “budget costs” and “externality costs.” While budget costs represent market goods and services in monetary terms, i.e. economic impacts, externality costs include effects outside the economic system such as environmental impacts (translated in monetary terms).1 Numerous models have been developed to determine the environmental and economic impacts associated with SWM systems (e.g., EASETECH2) by using “what-if” scenario analyses. While these models are an essential foundation that enables a systematic integrated analysis of SWM systems, they do not provide information about the overall optimal solution as done with optimization models such as SWOLF.3 This study represents the first attempt to optimize SWM systems using externality costs in SWOLF. The assessment identifies the waste strategy that minimizes externality costs and other criteria (budget costs and landfilling) for a specific case study. The latter represents a hypothetical U.S. county with annual waste generation of 320,000 Mg. The externality cost includes the damage costs of fossil CO2, CH4, N2O, PM2.5, PM10, NOX, SO2 , VOC, CO, NH3, CO, Hg, Pb, Cd, Cr (VI), Ni, As, and dioxins. Table 1 shows the results of the optimization including: i) optimization criteria, ii) waste flows and iii) eco-efficiency indicator (ratio between externality costs and budget costs). Minimal externality costs are obtained when incinerating most of the waste (88%) and commingled collection of recyclables (12%). The eco-efficiency of this waste strategy corresponds to -0.6, i.e. its environmental benefits (negative externality costs) correspond to approximately half of its budget costs. On the other hand, there is the solution with minimal budget costs (100% of the waste is landfilled) in which the environmental load (positive externality cost) represent one third of the budget costs (positive eco-efficiency indicator). In between these options, there is a strategy with minimal landfilling in which the organic waste is sent to anaerobic digestion, the recyclables to a single stream MRF and the residual to a mixed waste MRF. Most of the externality costs of the three strategies stem from SO2, NOx and GHG as suggested by Woon & Lo.4 The case study shows that waste solutions identified by optimization modelling differ from common SWM systems selected for analysis in state-of-the-art accounting modelling Please click Additional Files below to see the full abstract

Evaluation of Externality Costs in Life-Cycle Optimization of Municipal Solid Waste Management Systems

The development of sustainable solid waste management (SWM) systems requires consideration of both economic and environmental impacts. Societal life-cycle costing (S-LCC) provides a quantitative framework to estimate both economic and environmental impacts, by including “budget costs” and “externality costs”. Budget costs include market goods and services (economic impact), whereas externality costs include effects outside the economic system (e.g., environmental impact). This study demonstrates the applicability of S-LCC to SWM life-cycle optimization through a case study based on an average suburban U.S. county of 500 000 people generating 320 000 Mg of waste annually. Estimated externality costs are based on emissions of CO₂, CH₄, N₂O, PM_2.5, PM₁₀, NO_<i>x</i>, SO₂, VOC, CO, NH₃, Hg, Pb, Cd, Cr (VI), Ni, As, and dioxins. The results indicate that incorporating S-LCC into optimized SWM strategy development encourages the use of a mixed waste material recovery facility with residues going to incineration, and separated organics to anaerobic digestion. Results are sensitive to waste composition, energy mix and recycling rates. Most of the externality costs stem from SO₂, NO_<i>x</i>, PM_2.5, CH₄, fossil CO₂, and NH₃ emissions. S-LCC proved to be a valuable tool for policy analysis, but additional data on key externality costs such as organic compounds emissions to water would improve future analyses

The transcribed ultraconserved region uc.160+ enhances processing and A-to-I editing of the miR-376 cluster : hypermethylation improves glioma prognosis

Transcribed ultraconserved regions (T-UCRs) are noncoding RNAs derived from DNA sequences that are entirely conserved across species. Their expression is altered in many tumor types, and, although a role for T-UCRs as regulators of gene expression has been proposed, their functions remain largely unknown. Herein, we describe the epigenetic silencing of the uc.160+ T-UCR in gliomas and mechanistically define a novel RNA-RNA regulatory network in which uc.160+ modulates the biogenesis of several members of the miR-376 cluster. This includes the positive regulation of primary microRNA (pri-miRNA) cleavage and an enhanced A-to-I editing on its mature sequence. As a consequence, the expression of uc.160+ affects the downstream, miR-376-regulated genes, including the transcriptional coregulators RING1 and YY1-binding protein (RYBP) and forkhead box P2 (FOXP2). Finally, we elucidate the clinical impact of our findings, showing that hypermethylation of the uc.160+ CpG island is an independent prognostic factor associated with better overall survival in lower-grade gliomas, highlighting the importance of T-UCRs in cancer pathophysiology.Peer reviewe

SmartSantander: IoT experimentation over a smart city testbed

This paper describes the deployment and experimentation architecture of the Internet of Things experimentation facility being deployed at Santander city. The facility is implemented within the SmartSantander project, one of the projects of the Future Internet Research and Experimentation initiative of the European Commission and represents a unique in the world city-scale experimental research facility. Additionally, this facility supports typical applications and services of a smart city. Tangible results are expected to influence the definition and specification of Future Internet architecture design from viewpoints of Internet of Things and Internet of Services. The facility comprises a large number of Internet of Things devices deployed in several urban scenarios which will be federated into a single testbed. In this paper the deployment being carried out at the main location, namely Santander city, is described. Besides presenting the current deployment, in this article the main insights in terms of the architectural design of a large-scale IoT testbed are presented as well. Furthermore, solutions adopted for implementation of the different components addressing the required testbed functionalities are also sketched out. The IoT experimentation facility described in this paper is conceived to provide a suitable platform for large scale experimentation and evaluation of IoT concepts under real-life conditions.This work is funded by research project SmartSantander, under FP7-ICT-2009-5 of the 7th Framework Programme of the European Community. Authors would like to acknowledge the collaboration with the rest of partners within the consortium leading to the results presented in this paper

Effect of Continuous Positive Airway Pressure on Inflammatory, Antioxidant, and Depression Biomarkers in Women With Obstructive Sleep Apnea: A Randomized Controlled Trial

Study objectives: The effect of continuous positive airway pressure (CPAP) on mediators of cardiovascular disease and depression in women with obstructive sleep apnea (OSA) is unknown. We aimed to assess the effect of CPAP therapy on a variety of biomarkers of inflammation, antioxidant activity, and depression in women with OSA. Methods: We conducted a multicenter, randomized controlled trial in 247 women diagnosed with moderate-to-severe OSA (apnea-hypopnea index [AHI] ? 15). Women were randomized to CPAP (n = 120) or conservative treatment (n = 127) for 12 weeks. Changes in tumor necrosis factor ? (TNF?), interleukin 6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1), catalase (CAT), superoxide dismutase (SOD), and brain-derived neurotrophic factor (BDNF) were assessed. Additional analyses were conducted in subgroups of clinical interest. Results: Women had a median (25th-75th percentiles) age of 58 (51-65) years, body mass index 33.5 (29.0-38.3) kg/m2, and AHI 33.3 (22.8-49.3). No differences were found between groups in the baseline levels of the biomarkers. After 12 weeks of follow-up, there were no changes between groups in any of the biomarkers assessed. These results did not change when the analyses were restricted to sleepy women or to those with severe OSA. In women with CPAP use at least 5 hours per night, only TNF? levels decreased compared to the control group (-0.29 ± 1.1 vs -0.06 ± 0.53, intergroup difference -0.23 [95% CI = -0.03 to -0.50]; p = 0.043). Conclusions: Twelve weeks of CPAP therapy does not improve biomarkers of inflammation, antioxidant activity, or depression compared to conservative treatment in women with moderate-to-severe OSA

Neuronal and glial characterization in the rostrocaudal axis of the human anterior olfactory nucleus: Involvement in Parkinson’s disease

Hyposmia is one of the prodromal symptoms of Parkinson’s disease (PD) and a red flag in clinical diagnosis. Neuropathologically, this sign correlates with α-synuclein involvement in the anterior olfactory nucleus (AON). Neurodegeneration, microgliosis, and astrogliosis in AON are poorly studied, and bulbar AON is the focus of these studies with contradictory results. Additionally, male sex is a risk marker for developing PD, but sexual dimorphism of neural and glial populations in the AON has rarely been considered. The aim of this study was to analyze the density of NeuN, Iba-1, GFAP, and Lewy bodies (LBs), as well as the relationship of these cell type markers with pathology along the rostrocaudal axis of the AON (bulbar, retrobulbar, cortical anterior, and posterior divisions). Cavalieri, optical fractionator, and area fraction fractionator stereological approaches were used for the volume, cell populations and LBs densities, area fraction, and percentage of overlap. Iba-1 and α-syn intensities were measured using ImageJ. In non-PD (NPD) cases, the volume was lower in the AON at the extremes of the rostrocaudal axis than in the intermediate divisions. Cortical anterior AON volume decreased in PD compared with NPD cases. NeuN density decreased rostrocaudally in AON portions in NPD and PD cases. This occurred similarly in Iba-1 but only in PD samples. Iba-1 intensity significantly increased in bulbar AON between PD and NPD. No changes were found in astrocytes. Eight percent of NeuN, 0.1% of Iba-1, and 0.1% of GFAP areas overlapped with LBs area along the AON portions. The data indicate that bulbar AON, which is the most rostral portion in this axis, could play a major role in the pathology. This could be related to the larger area occupied by LBs in these divisions