Movilidad sostenible en entornos turísticos. Singularidades y medidas

Las medidas orientadas a la movilidad sostenible se encuentran generalmente bien desarrolladas, al menos en el plano teórico, para entornos urbanos convencionales, esto es, para ciudades donde la movilidad sigue una pauta esencialmente recurrente y vinculada a motivos como el trabajo y el estudio. Sin embargo, en entornos donde el turismo es una componente predominante, la movilidad es claramente diferente. Las motivaciones de los viajes son diferentes, la valoración del tiempo es diferente, las pautas espacio-temporales son diferentes. Por tanto, las medidas para la sostenibilidad de la movilidad han de ser diferentes

A clinical phase III comparative, randomised, clinical trial to assess the safety and efficacy of a fixed dose of oral pyronaridine-artesunate granule formulation (60:20) (paediatric Pyramax®) versus artemether-lumefantrine (Coartem®) crushed tablets in infants and children with acute uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon

The study assessed the efficacy and safety of a fixed dose of oral pyronaridine-artesunate granule formulation (60:20) (paediatric Pyramax®) compared to artesunate-lumefantrine (Coartem®) crushed tablets in infants and children with acute uncomplicated P. falciparum malaria. The study was part of a multicenter, comparative, randomized, open-labeled, parallel group study on the efficacy, safety and pharmacokinetics of the investigational drug conducted in a total of 534 male and female infants and children (between ≥ 5 kg and < 25 kg body weight) suffering from acute symptomatic uncomplicated P. falciparum malaria recruited from study sites located in Africa and the Philippines. A total of 80 subjects with similar demographic and clinical characteristics at baseline were enrolled in the study. Fifty-three patients received pyronaridine-artesunate granule formulation (60:20 mg) daily for 3 days and 27 received artemether-lumefantrine crushed tablets as drug comparator. The primary outcome was achieved as the cure rate at Day 28 in the pyronaridine-artesunate group (PCR-corrected ACPR in the efficacy-evaluable population) was of 100%. Moreover, non-inferiority of the investigational drug compared to artemether-lumefantrine was demonstrated on Day 28 and on Day 42 in the efficacy-evaluable population. Furthermore, parasite clearance was significantly shorter with pyronaridine-artesunate. Overall adverse events incidence and severity were similar between groups. Neither serious nor adverse events leading to study neither drug discontinuation nor withdrawal occurred in the course of the study. Adverse events considered by investigators as drug related occurred in 11% of the patients receiving pyronaridine-artesunate and were mostly mild gastrointestinal disorders. Pyronaridine-artesunate pediatric granules were efficacious, safe and well tolerated in this study in children under 12 years of age with uncomplicated P. falciparum malaria. Pyronaridine-artesunate granule co-formulation appears to be a valuable ACT for use in children and infants with uncomplicated P. falciparum

waveSLAM: Empowering accurate indoor mapping using off-the-shelf millimeter-wave self-sensing

Proceedings of: 2023 IEEE 98th Vehicular Technology Conference: VTC2023-Fall, 10-13 October 2023, Hong Kong.This paper presents the design, implementation and evaluation of waveSLAM, a low-cost mobile robot system that uses the millimetre wave (mmWave) communication devices to enhance the indoor mapping process targeting environments with reduced visibility or glass/mirror walls. A unique feature of waveSLAM is that it only leverages existing Commercial-Off-The-Shelf (COTS) hardware (Lidar and mmWave radios) that are mounted on mobile robots to improve the accurate indoor mapping achieved with optical sensors. The key intuition behind the waveSLAM design is that while the mobile robots moves freely, the mmWave radios can periodically exchange angle and distance estimates between themselves (self-sensing) by bouncing the signal from the environment, thus enabling accurate estimates of the target object/material surface. Our experiments verify that waveSLAM can archive cm-level accuracy with errors below 22 cm and 20&#9702; in angle orientation which is compatible with Lidar when building indoor maps.This work has been partially funded by the European Union's Horizon Europe research and innovation program under grant agreement No 101095759 (Hexa-X-II) and the Spanish Ministry of Economic Affairs and Digital Transformation and the European Union-Next Generation EU through the UNICO 5G I+D 6G-EDGEDT

Dynamic nuclear polarization enhanced solid-state NMR studies of surface modification of gamma-alumina

Dynamic nuclear polarization (DNP) gives large (>100-fold) signal enhancements in solid-state NMR spectra via the transfer of spin polarization from unpaired electrons from radicals implanted in the sample. This means that the detailed information about local molecular environment available for bulk samples from solid-state NMR spectroscopy can now be obtained for dilute species, such as sites on the surfaces of catalysts and catalyst supports. In this paper we describe a DNP-enhanced solid-state NMR study of the widely used catalyst gamma-alumina which is often modified at the surface by the incorporation of alkaline earth oxides in order to control the availability of catalytically active penta-coordinate surface Al sites. DNP-enhanced 27Al solid-state NMR allows surface sites in gamma-alumina to be observed and their 27Al NMR parameters measured. In addition changes in the availability of different surface sites can be detected after incorporation of BaO

Index of T-wave variation as a predictor of sudden cardiac death in chronic heart failure patients with atrial fibrillation

Chronic heart failure (CHF) and atrial fibrillation (AF) are worldwide leading causes of morbidity and mortality in elders, a large part due to sudden cardiac deaths (SCD). The high irregularity of ventricular response in AF patients makes the use of standard SCD-risk markers inappropriate in this target population. The aim of this study was twofold: i) to propose a new index, suitable for AF patients, able to quantify ventricular repolarization changes; and ii) to evaluate its prognostic value in a CHF population with AF. Holter ECG recordings from 176 consecutive CHF patients with AF (22 SCD) were analyzed. The index of T-wave variation (ITV), quantifying the average T-wave changes in pairs of consecutive beats under stable rhythm conditions, was computed using a fully-automatic method. Survival analysis was performed considering SCD as an independent endpoint. ITVwas higher for SCD than non-SCD victims (median (Q1;Q3): 24.9 (14.4;85.4) μV vs 17.1 (11.3;28.2) μV, p=0.06). In a survival analysis where the threshold was set on the third quartile of ITVvalues, ITV(+) outcome was successfully associated to SCD (Hazard Ratio (CI):3.22 (1.36, 7.58)per μV, p=0.008). In conclusion, we show in this work that Ijy stratifies CHF patients with AF according to their risk of SCD, with larger ITVassociated to lower survival probability

Index of T-wave variation as a predictor of sudden cardiac death in chronic heart failure patients with atrial fibrillation

Chronic heart failure (CHF) and atrial fibrillation (AF) are worldwide leading causes of morbidity and mortality in elders, a large part due to sudden cardiac deaths (SCD). The high irregularity of ventricular response in AF patients makes the use of standard SCD-risk markers inappropriate in this target population. The aim of this study was twofold: i) to propose a new index, suitable for AF patients, able to quantify ventricular repolarization changes; and ii) to evaluate its prognostic value in a CHF population with AF. Holter ECG recordings from 176 consecutive CHF patients with AF (22 SCD) were analyzed. The index of T-wave variation (ITV), quantifying the average T-wave changes in pairs of consecutive beats under stable rhythm conditions, was computed using a fully-automatic method. Survival analysis was performed considering SCD as an independent endpoint. ITV was higher for SCD than non-SCD victims (median (Q1;Q3): 24.9 (14.4;85.4) µV vs 17.1 (11.3;28.2) µV, p=0.06). In a survival analysis where the threshold was set on the third quartile of ITV values, ITV (+) outcome was successfully associated to SCD (Hazard Ratio (CI):3.22 (1.36, 7.58)per µV, p=0.008). In conclusion, we show in this work that Ijy stratifies CHF patients with AF according to their risk of SCD, with larger ITV associated to lower survival probability

Postextrasystolic T wave change to stratify risk of pump failure death in patients with chronic heart failure

The postextrasystolic T wave change (PEST) is an electrocardiographic phenomenon in which the morphology of the normal T wave is altered for a short time after a ventricular ectopic beat (VEB). It has been observed in patients with other cardiac pathologies but it has not been proposed as a risk index for cardiac death. Since PEST seems to be potentiated in patients with depression of myocardial contractility, we hypothesize that PEST could be used to predict pump failure death (PFD) in patients with chronic heart failure (CHF). For the purpose of quantifying PEST, the parameters morphological change onset (MCO) and morphological change slope (MCS) were introduced. MCO describes an initial morphological change of the T wave after a VEB, while MCS is responsible for the description of the restitution to its original shape. 537 records from the MUSIC study were separated according to their cause of death and comparisons against the others (including survivors) were carried out. In addition, receiver operating characteristic (ROC) curves were used to determine the optimal separating thresholds for MCO and MCS that maximized the sum of sensitivity and specificity for PFD risk prediction. The results showed that no significant differences could be established and the proposed parameters do not seem to be related to any kind of cardiac death. In future, other forms of PEST quantification together with more databases can be used to definitely conclude that PEST has no predictive power

Short-term effects of glyphosate and Roundup Transorb® formulation on the cyanobacteria Synechococcus elongatus

Glyphosate is an active ingredient used in herbicide formulations worldwide. However, besides glyphosate, these formulations have other components to facilitate glyphosate absorption by plants. These include the surfactants such as polyoxyethylene amine (POEA) present in the Roundup Transorb® (RT) formulation. Glyphosate formulations are potentially more toxic to non-target organisms than the pure active ingredient. In this work, we evaluated the toxicity (72 h) of pure glyphosate and RT for the cyanobacterium Synechococcus elongatus, based on biomass growth and cell viability. The formulation proved more toxic than pure glyphosate for both parameters analysed, with an IC50 (Inhibition concentration mean) based on biomass measured by optical density (750 nm) that was sixty times lower. Cell viability was not as sensitive as the biomass because, of the few cells left in the culture, most were viable. This indicates that there is a variation in tolerance between the cyanobacteria present in the inoculum. Thus, cell viability may underestimate the results of glyphosate and RT toxicity and be useful only in low concentrations of exposure