Analysis of the Localization Error for Capsule Endoscopy Applications at UWB Frequencies

Localization for Wireless Capsule Endoscopy (WCE) in the Ultra-Wideband frequency band is a very active field of investigation due to its potential advantages in future endoscopy applications. Received Signal Strength (RSS) based localization is commonly preferred due to its simplicity. Previous studies on Ultra-Wideband (UWB) RSS-based localization showed that the localization accuracy depends on the average ranging error related to the selected combination of receivers, which not always is the one experiencing the highest level of received power. In this paper the tendency of the localization error is further investigated through supplementary software simulations and previously conducted laboratory measurements. Two-dimensional (2D) and three-dimensional (3D) positioning are performed and the trend of the localization error compared in both cases. Results shows that the distribution of the selected path loss values, corresponding to the receivers used for localization, around the in-body position to estimate also affects the localization accuracy.This work was supported by the H2020:MSCA:ITN program for the “Wireless In-body Environment Communication- WiBEC” project under the grant agreement no. 675353. This work was also supported by the European Union’s H2020:MSCA:ITN program for the ”mmWave Communications in the Built Environments - WaveComBE” project under the grant agreement no. 766231.Barbi, M.; Pérez-Simbor, S.; Garcia-Pardo, C.; Cardona Marcet, N. (2019). Analysis of the Localization Error for Capsule Endoscopy Applications at UWB Frequencies. IEEE. https://doi.org/10.1109/ISMICT.2019.8743813

Long term application of a constructed wetland for phytoremediation of domestic wastewater: macrofauna biodiversity assessment

Constructed wetlands (CW) are engineered systems, phytoremediation based, that mimic several processes (physical, biological, and chemical) that occur in natural wetlands. They comprise several components, impermeabilization liners and substrate, and as the key elements the plants and their associated microorganisms. They were thought primarily for wastewater treatment but nowadays are considered a nature-based solution of excellence in terms of flexibility of their application and services provided. In the present study, the phytoremediation potential of a real scale constructed wetland to treat wastewater from a tourism unity is addressed. The CW was implemented in 2010 at Paço de Calheiros, a tourism house integrated in a rural area. The CW was designed to be placed after a previously installed septic tank that acted as the main treatment before the CW was established. It is a horizontal subsurface flow system planted with a polyculture of Agapanthus africanus, Canna flaccida, Zantedeschia aethiopica, Canna indica, and Watsonia borbonica. The aim of the study is to monitor the efficiency of a CW, after long term operation, based on phytoremediation processes, to treat the wastewater from the tourism unit. Wastewater quality will be assessed through the analysis of physic-chemical and microbiological parameters towards its reuse for irrigation purposes. The biodiversity of macrofauna communities associated to the rhizosphere of selected plants and substrate will be studied.info:eu-repo/semantics/publishedVersio

Role of tissue and circulating microRNA and DNA as biomarkers in medullary thyroid cancer

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor comprising hereditary or sporadic form with frequent mutations in the rearranged during transfection (RET) or RAS genes. Diagnosis is based on presence of thyroid tumor mass with altered levels of calcitonin (Ctn) and carcinoembryonal antigen (CEA) in the serum and/or in the cytological smears from fine needle aspiration biopsies. Treatment consists of total thyroidectomy, followed by tyrosine kinase inhibitors (TKi) in case of disease persistence. During TKi treatment, Ctn and CEA levels can fluctuate regardless of tumor volume, metastasis or response to therapy. Research for more reliable non-invasive biomarkers in MTC is still underway. In this context, circulating nucleic acids, namely circulating microRNAs (miRNAs) and cell free DNA (cfDNA), have been evaluated by different research groups. Aiming to shed light on whether miRNAs and cfDNA are suitable as MTC biomarkers we searched three different databases, PubMed, Scopus, WOS and reviewed literature. We classified 83 publications fulfilling our search criteria and summarized the results. We report data on miRNA and cfDNA that can be evaluated for validation in independent studies and clinical application

Quels sont les facteurs environnementaux à prendre en compte pour améliorer le vécu de l'hospitalisation d'une personne en situation de handicap communicationnel ?: travail de Bachelor

Thème : Notre recherche aborde les facteurs environnementaux qui influencent l’hospitalisation d’une personne en situation de handicap présentant un trouble de la communication. Contenus : Après un point de situation sur le handicap et sur la communication, nous analyserons notre thématique sous l’angle du modèle théorique de Callista Roy. Puis, nous traiterons par thème notre recension des écrits. Pour finir, nous tenterons d’émettre des recommandations pour la pratique infirmière. Discussion : L’évolution des concepts du handicap (médical à social) et des classifications internationales du handicap montrent une envie de réintroduire la population en situation de handicap dans la société en déplaçant le problème sur l’environnement inadéquat. Il est nécessaire que la discipline infirmière suive cette évolution en passant d’un modèle comportementaliste à une approche systémique

Neuropsychiatric performance and treatment of hepatitis C with direct-acting antivirals: a prospective study

Background: Since direct-acting antivirals (DAAs) have been approved for the treatment of hepatitis C virus (HCV) infection, a small series of patients with new-onset neuropsychiatric alterations have been referred to us. We therefore set out to study neuropsychiatric function in relation to DAAs prospectively. Methods: Ten patients with cirrhosis and 12 post-liver transplant (post-LT) patients were enrolled. All underwent wake electroencephalography (EEG) and a neuropsychological evaluation (paper and pencil battery, simple/choice reaction times, working memory task) at baseline, at the end of treatment with DAAs and after 6 months. At the same time points, full blood count, liver/kidney function tests, quantitative HCV RNA, ammonia and immunosuppressant drug levels were obtained, as appropriate. Results: Patients with cirrhosis were significantly older than post-LT patients (65\ub112 vs 55\ub17 years; P<0.05). Neuropsychological performance and wake EEG were comparable in the two groups at baseline. At the end of a course of treatment with DAAs, a significant slowing in choice reaction times and in the EEG (increased relative delta power) was observed in patients with cirrhosis, which resolved after 6 months. In contrast, no significant changes over time were observed in the neuropsychiatric performance of post-LT patients. No significant associations were observed between neuropsychiatric performance and stand-alone/combined laboratory variables. Conclusion: Some degree of neuropsychiatric impairment was observed in relation to treatment with DAAs in patients with cirrhosis, but not in post-LT patients, suggesting that the former may be sensitive to mild DAA neurotoxicity

Initial UWB in-body channel characterization using a novel multilayer phantom measurement setup

[EN] Wireless Body Area Networks (WBANs) are a promising technology for medical purposes. Currently the WBAN are classified into: implanted (in-), surface (on-) or outside (off-) body communications regarding the location of the devices with reference to the human body. The Ultra Wide-Band (UWB) frequency band is growing as a band of interest for implanted communications because of its high data rate and low power consumption among other benefits. Software simulations, in-vivo measurements and experimental phantom measurements are common methods to properly characterize the propagation channel. Nevertheless, up to now, experimental phantoms measurements presented in the literature show some inconveniences, i.e., the accuracy of the phantoms compared with the real human tissues or the testbed used for the measurements. This paper aims at overcoming these issues using accurate phantoms designed for the purpose of implanted communications in the UWB frequency band. In addition, a multilayer phantom container was developed. This container has capacity for two different phantoms, emulating a heterogeneous propagation medium for in-body measurements. Moreover, a novel setup was built for in-body phantom measurements. As a result, an experimental path loss model is presented from the measurements obtained with phantoms. Besides, software simulations mimicking the experimental setup are performed in order to validate the previous results obtainedThis work was supported by the European Union's H2020:MSCA:ITN program for the "Wireless In-body Environment Communication-WiBEC" project under the grant agreement no. 675353. this work was also funded by the Programa de Ayudas de Investigación y Desarrollo 8PAID-01-16) from Univeristat Politècnica de València and by the Ministerio de Economía y Competitividad, Spain (TEC2014-60258-C2-1-R), by the European FEDER funds.Pérez-Simbor, S.; Barbi, M.; Garcia-Pardo, C.; Castelló-Palacios, S.; Cardona Marcet, N. (2018). Initial UWB in-body channel characterization using a novel multilayer phantom measurement setup. IEEE. 384-389. https://doi.org/10.1109/WCNCW.2018.8369011S38438

Estimating moisture content and hydraulic properties of unsaturated sandy soils of Tiber River (Central Italy): integrating data from calibrated PR2/6 probe and hydraulic property estimator

The correct estimation of soil moisture data is essential in soil-water management and estimating the hydraulic properties of unsaturated soils. The increased use of Multi-Sensor Capacitance Probes (MCAPs) requires careful calibration. Without accurate calibration, the use of MCAPs leads to incorrect water content estimation, making them of no practical use. This work presents the specific calibration equations for the correct use of the PR2/6 profile probe on sands of different nature. As the iron oxides content of the Tiber River basin sands increases, the calibration lines slope increases, allowing the understanding of the different electromagnetic responses. As for other sands worldwide, sands with high iron oxides content show a relative high specific surface than quartz or calcareous sands, responsible for more adhesive water (e.g., high permittivity values). The water content data are integrated with a hydraulic property estimator allowing the estimation of the hydraulic conductivity of soils. Applying the manufacturer equation of the PR2/6 profile probe instead of the specific equation leads to an overestimation of the hydraulic conductivity values up to two orders of magnitude, making therefore rather incorrect the understanding of the phenomena occurring in the unsaturated zone

Opportunities and Limits of Conventional IVF versus ICSI: It Is Time to Come off the Fence

Conventional IVF (c-IVF) is one of the most practiced assisted reproductive technology (ART) approaches used worldwide. However, in the last years, the number of c-IVF procedures has dropped dramatically in favor of intracytoplasmic sperm injection (ICSI) in cases of non-male-related infertility. In this review, we have outlined advantages and disadvantages associated with c-IVF, highlighting the essential steps governing its success, its limitations, the methodology differences among laboratories and the technical progress. In addition, we have debated recent insights into fundamental questions, including indications regarding maternal age, decreased ovarian reserve, endometriosis, autoimmunity, single oocyte retrieval-cases as well as preimplantation genetic testing cycles. The “overuse” of ICSI procedures in several clinical situations of ART has been critically discussed. These insights will provide a framework for a better understanding of opportunities associated with human c-IVF and for best practice guidelines applicability in the reproductive medicine field

A Comprehensive Sequencing-Based Analysis of Allelic Methylation Patterns in Hemostatic Genes in Human Liver

Characterizing the relationship between genetic, epigenetic (e.g., deoxyribonucleic acid [DNA] methylation), and transcript variation could provide insights into mechanisms regulating hemostasis and potentially identify new drug targets. Several hemostatic factors are synthesized in the liver, yet high-resolution DNA methylation data from human liver tissue is currently lacking for these genes. Single-nucleotide polymorphisms (SNPs) can influence DNA methylation in cis which can affect gene expression. This can be analyzed through allele-specific methylation (ASM) experiments. We performed targeted genomic DNA- and bisulfite-sequencing of 35 hemostatic genes in human liver samples for SNP and DNA methylation analysis, respectively, and integrated the data for ASM determination. ASM-associated SNPs (ASM-SNPs) were tested for association to gene expression in liver using in-house generated ribonucleic acid-sequencing data. We then assessed whether ASM-SNPs associated with gene expression, plasma proteins, or other traits relevant for hemostasis using publicly available data. We identified 112 candidate ASM-SNPs. Of these, 68% were associated with expression of their respective genes in human liver or in other human tissues and 54% were associated with the respective plasma protein levels, activity, or other relevant hemostatic genome-wide association study traits such as venous thromboembolism, coronary artery disease, stroke, and warfarin dose maintenance. Our study provides the first detailed map of the DNA methylation landscape and ASM analysis of hemostatic genes in human liver tissue, and suggests that methylation regulated by genetic variants in cis may provide a mechanistic link between noncoding SNPs and variation observed in circulating hemostatic proteins, prothrombotic diseases, and drug response

Multi criteria decision analysis for prospective sustainability assessment of alternative technologies and fuels for individual motorized transport

Reducing greenhouse gas (GHG) emissions in the transport sector is one of the biggest challenges in the German energy transition. Furthermore, sustainable development does not stop with reducing GHG emissions. Other environmental, social and economic aspects should not be neglected. Thus, here a comprehensive sustainability assessment for passenger vehicles is conducted for 2020 and 2050. The discussed options are an internal combustion engine vehicle (ICEV) fuelled with synthetic biofuel and fossil gasoline, a battery electric vehicle (BEV) with electricity from wind power and electricity mix Germany and a fuel cell electric vehicle (FCEV) with hydrogen from wind power. The life cycle-based assessment entails 13 environmental indicators, one economic and one social indicator. For integrated consideration of the different indicators, the MCDA method Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) is chosen. For the assessment, a consistent assessment framework, i.e. background scenario and system boundaries, and a detailed modelling of vehicle production, fuel supply and vehicle use are the cornerstones. The BEV with wind power is the most sustainable option in 2020 as well as in 2050. While in 2020, the second rank is taken by the ICEV with synthetic biofuel from straw and the last rank by the FCEV, in 2050 the FCEV is the runner-up. With the help of MCDA, transparent and structured guidance for decision makers in terms of sustainability assessment of motorized transport options is provided