Gaming methods as an educational instrument of project manager's competencies increase

The aim of presented paper is to present gaming methods to teach Management at the secondary schools towards the increase of the future project manager's competencies and his labor market placement.The concept is anticipated with the analysis of information sources describing gaming methods and their principles with an emphasison managerial competencies increase. Next in form of research we identify, if gaming methods are attractive for secondary school pupils and through the interviews with teachers of economical subjects we identify the possibilities of using these methods in the Management teaching on secondary schools with the impact on the increase of competencies of future project managers. The core of the work is the design of specific gaming methods for teaching the subject Management, which were actually implemented in the classroom. Questionnaire survey with pupils identifies strengths and weaknesses of the use of these methods and validates the use of these methods. © Serials Publications Pvt. Ltd

Vztahy mezi oscilacemi a jejich využití u adaptivní hluboké mozkové stimulace

Hluboká mozková stimulace (DBS) patří vedle dopaminergní léčby k nejvýznamnějším terapeutickým přístupům u Parkinsonovy nemoci (PN). Snaha potlačit některé limitace této terapie vede ke zvýšenému zájmu o přístupy jako je adaptivní DBS (aDBS). Stimulace s uzavřenou smyčkou řízená fluktuacemi výkonu v beta pásmu však nemusí být optimální pro všechny pacienty s PN. S cílem nalézt více senzitivní ukazatel než samotnou beta aktivitu byly analyzovány vztahy mezi jednotlivými oscilacemi v kontextu optimální stimulace subthalamického jádra (STN). Vztah fáze beta rytmu a amplitudy vysokofrekvenčních oscilací se jeví jako vhodný parametr pro cílení stimulace

Environmentalism in Czech Philosophy of 20th century

This thesis focuses on the role of the Czech philosophy in the 20th century and the way it affected the formation of an environmental approach. It unveils the mutual connections betweens the natural sciences and philosophy and highlights the importance of a close link between various ideas about man and the world. An analysis of the content of selected books by Erazim Kohák and Josef Šmajs emphasizes the existential threat arising from a critical relationship between man and the world at large. Finally, it reminds of the change in the scale of human values as well as the need for man to redefine his position in the world today

Pekárna

Import 20/04/2006Prezenční výpůjčkaVŠB - Technická univerzita Ostrava. Fakulta stavební. Katedra (225) pozemního stavitelstv

Klasifikace patentů a jejich vliv na rešeršní proces

Ústav informačních studií a knihovnictvíFilozofická fakult

The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates

Abstract Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson’s disease and the effect of DBS of the subthalamic nucleus (STN). The association between revealed spatiotemporal dynamics of brain networks and changes in oscillatory activity and clinical examination were assessed. Thirty-seven patients with Parkinson’s disease treated by STN-DBS underwent two sessions (OFF and ON stimulation conditions) of resting-state EEG. EEG microstates were analyzed in patient recordings and in a matched healthy control dataset. Microstate parameters were then compared across groups and were correlated with clinical and neuropsychological scores. Of the five revealed microstates, two differed between Parkinson’s disease patients and healthy controls. Another microstate differed between ON and OFF stimulation conditions in the patient group and restored parameters in the ON stimulation state toward to healthy values. The mean beta power of that microstate was the highest in patients during the OFF stimulation condition and the lowest in healthy controls; sources were localized mainly in the supplementary motor area. Changes in microstate parameters correlated with UPDRS and neuropsychological scores. Disease specific alterations in the spatiotemporal dynamics of large-scale brain networks can be described by EEG microstates. The approach can reveal changes reflecting the effect of DBS on PD motor symptoms as well as changes probably related to non-motor symptoms not influenced by DBS

Vztahy mezi oscilacemi a jejich využití u adaptivní hluboké mozkové stimulace

Hluboká mozková stimulace (DBS) patří vedle dopaminergní léčby k nejvýznamnějším terapeutickým přístupům u Parkinsonovy nemoci (PN). Snaha potlačit některé limitace této terapie vede ke zvýšenému zájmu o přístupy jako je adaptivní DBS (aDBS). Stimulace s uzavřenou smyčkou řízená fluktuacemi výkonu v beta pásmu však nemusí být optimální pro všechny pacienty s PN. S cílem nalézt více senzitivní ukazatel než samotnou beta aktivitu byly analyzovány vztahy mezi jednotlivými oscilacemi v kontextu optimální stimulace subthalamického jádra (STN). Vztah fáze beta rytmu a amplitudy vysokofrekvenčních oscilací se jeví jako vhodný parametr pro cílení stimulace

Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study

It has been suggested that slow oscillations in the subthalamic nucleus (STN) reflect top-down inputs from the medial prefrontal cortex, thus implementing behavior control. It is unclear, however, whether the STN oscillations are related to cortical activity in a bottom-up manner. To assess resting-state subcortico-cortical interactions, we recorded simultaneous scalp electroencephalographic activity and local field potentials in the STN (LFP-STN) in 11 patients with Parkinson’s disease implanted with deep brain stimulation electrodes in the on-medication state during rest. We assessed the cross-structural phase-amplitude coupling (PAC) between the STN and cortical activity within a wide frequency range of 1 to 100 Hz. The PAC was dominant between the δ/θ STN phase and β/γ cortical amplitude in most investigated scalp regions and between the δ cortical phase and θ/α STN amplitude in the frontal and temporal regions. The cross-frequency linkage between the slow oscillations of the LFP-STN activity and the amplitude of the scalp-recorded cortical activity at rest was demonstrated, and similar involvement of the left and right STNs in the coupling was observed. Our results suggest that the STN plays a role in both bottom-up and top-down processes within the subcortico-cortical circuitries of the human brain during the resting state. A relative left–right symmetry in the STN-cortex functional linkage was suggested. Practical treatment studies would be necessary to assess whether unilateral stimulation of the STN might be sufficient for treatment of Parkinson’s disease

Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS

Abstract Beta hypersynchrony was recently introduced into clinical practice in Parkinson’s disease (PD) to identify the best stimulation contacts and for adaptive deep brain stimulation (aDBS) sensing. However, many other oscillopathies accompany the disease, and beta power sensing may not be optimal for all patients. The aim of this work was to study the potential clinical usefulness of beta power phase-amplitude coupling (PAC) with high frequency oscillations (HFOs). Subthalamic nucleus (STN) local field potentials (LFPs) from externalized DBS electrodes were recorded and analyzed in PD patients (n = 19). Beta power and HFOs were evaluated in a resting-state condition; PAC was then studied and compared with the electrode contact positions, structural connectivity, and medication state. Beta-HFO PAC (mainly in the 200–500 Hz range) was observed in all subjects. PAC was detectable more specifically in the motor part of the STN compared to beta power and HFOs. Moreover, the presence of PAC better corresponds to the stimulation setup based on the clinical effect. PAC is also sensitive to the laterality of symptoms and dopaminergic therapy, where the greater PAC cluster reflects the more affected side and medication “off” state. Coupling between beta power and HFOs is known to be a correlate of the PD “off” state. Beta-HFO PAC seems to be more sensitive than beta power itself and could be more helpful in the selection of the best clinical stimulation contact and probably also as a potential future input signal for aDBS

The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study.

To study the involvement of the anterior nuclei of the thalamus (ANT) as compared to the involvement of the hippocampus in the processes of encoding and recognition during visual and verbal memory tasks.We studied intracerebral recordings in patients with pharmacoresistent epilepsy who underwent deep brain stimulation (DBS) of the ANT with depth electrodes implanted bilaterally in the ANT and compared the results with epilepsy surgery candidates with depth electrodes implanted bilaterally in the hippocampus. We recorded the event-related potentials (ERPs) elicited by the visual and verbal memory encoding and recognition tasks.P300-like potentials were recorded in the hippocampus by visual and verbal memory encoding and recognition tasks and in the ANT by the visual encoding and visual and verbal recognition tasks. No significant ERPs were recorded during the verbal encoding task in the ANT. In the visual and verbal recognition tasks, the P300-like potentials in the ANT preceded the P300-like potentials in the hippocampus.The ANT is a structure in the memory pathway that processes memory information before the hippocampus. We suggest that the ANT has a specific role in memory processes, especially memory recognition, and that memory disturbance should be considered in patients with ANT-DBS and in patients with ANT lesions. ANT is well positioned to serve as a subcortical gate for memory processing in cortical structures