12,661 research outputs found

    ISO spectroscopy of compact HII regions in the Galaxy. II Ionization and elemental abundances

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    Based on the ISO spectral catalogue of compact HII regions by Peeters et al. (2001), we present a first analysis of the hydrogen recombination and atomic fine-structure lines originated in the ionized gas. The sample consists of 34 HII regions located at galactocentric distances between Rgal = 0 and 15 kpc. The SWS HI recombination lines between 2 and 8 mum are used to estimate the extinction law at these wavelengths for 14 HII regions. An extinction in the K band between 0 and ∌\sim 3 mag. has been derived. The fine-structure lines of N, O, Ne, S and Ar are detected in most of the sources. Most of these elements are observed in two different ionization stages probing a range in ionization potential up to 41 eV. The ISO data, by itself or combined with radio data taken from the literature, is used to derive the elemental abundances relative to hydrogen. The present data thus allow us to describe for each source its elemental abundance, its state of ionization and to constrain the properties of the ionizing star(s).Comment: Accepted in Astronomy and Astrophysics, 22 pages, 20 figures, 9 table

    Optical energies of AllnN epilayers

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    Optical energy gaps are measured for high-quality Al1−xInxN-on-GaN epilayers with a range of compositions around the lattice match point using photoluminescence and photoluminescence excitation spectroscopy. These data are combined with structural data to determine the compositional dependence of emission and absorption energies. The trend indicates a very large bowing parameter of 6 eV and differences with earlier reports are discussed. Very large Stokes' shifts of 0.4-0.8 eV are observed in the composition range 0.13<x<0.24, increasing approximately linearly with InN fraction despite the change of sign of the piezoelectric fiel

    Gene expression and fatty acid profiling in longissimus thoracis muscle, subcutaneous fat, and liver of light lambs in response to concentrate or alfalfa grazing

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    A better understanding of gene expression and metabolic pathways in response to a feeding system is critical for identifying key physiological processes and genes associated with polyunsaturated fatty acid (PUFA) content in lamb meat. The main objective of this study was to investigate transcriptional changes in L. thoracis (LT) muscle, liver, and subcutaneous fat (SF) of lambs that grazed alfalfa (ALF) and concentrate-fed (CON) slaughtered at 23 kg and using the Affymetrix Ovine Gene 1.1 ST whole-genome array. The study also evaluated the relationship between meat traits in LT muscle, including color, pigments and lipid oxidation during 7 days of display, a-tocopherol content, intramuscular fat (IMF) content and the fatty acid (FA) profile. Lambs that grazed on alfalfa had a greater a-tocopherol concentration in plasma than CON lambs (P 0.05). Grazing increased the a-tocopherol content (P < 0.001) and decreased lipid oxidation on day 7 of display (P < 0.05) in LT muscle. The ALF group contained a greater amount of conjugated linoleic acid (CLA), C18:3 n-3, C20:5 n-3, C22:5 n-3, and C22:6 n-3 than did the CON group (P < 0.05). We identified 41, 96 and four genes differentially expressed in LT muscle, liver, and subcutaneous fat, respectively. The most enriched biological processes in LT muscle were skeletal muscle tissue development, being the genes related to catabolic and lipid processes downregulated, except for CPT1B, which was upregulated in the ALF lambs. Animals grazing alfalfa had lower expression of desaturase enzymes in the liver (FADS1 and FADS2), which regulate unsaturation of fatty acids and are directly involved in the metabolism of n-3 PUFA series. The results found in the current study showed that ingesting diets richer in n-3 PUFA might have negative effects on the de novo synthesis of n-3 PUFA by downregulating the FADS1 and FADS2 expression. However, feeding diets poorer in n-3 PUFA can promote fatty acid desaturation, which makes these two genes attractive candidates for altering the content of PUFAs in meat

    How Trade Liberalization and Labor Development Could Coincide in the Philippines

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    As the world adapts to the rapid pace of globalization in the 21st century, countries ease trade restrictions by gradually removing tariffs and non-tariff barriers to incentivize the free flow of goods across nations. This prevalence of trade liberalization policies propelled policymakers and economists to investigate the relationship between trade reforms and economic outcomes including wage inequality around the world. They found that trade liberalization, on average, has had a positive impact on economic growth, but prior studies that examine the effects of trade liberalization on wage inequality in developing countries have found mixed results. Recently, Murakami (2021) examined the impact of trade liberalization on wage inequality in Chile through the reduction in effective tariffs brought about by the regional trade agreements of the country. Following his empirical strategy, we examine the impact of trade liberalization on wage inequality in the Philippines. In this policy brief, we provide insights on our findings and policy recommendations that the Philippines can undertak

    Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum.

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    Autosomal recessive hereditary spastic paraplegia (ARHSP) with thin corpus callosum (TCC) is a common and clinically distinct form of familial spastic paraplegia that is linked to the SPG11 locus on chromosome 15 in most affected families. We analyzed 12 ARHSP-TCC families, refined the SPG11 candidate interval and identified ten mutations in a previously unidentified gene expressed ubiquitously in the nervous system but most prominently in the cerebellum, cerebral cortex, hippocampus and pineal gland. The mutations were either nonsense or insertions and deletions leading to a frameshift, suggesting a loss-of-function mechanism. The identification of the function of the gene will provide insight into the mechanisms leading to the degeneration of the corticospinal tract and other brain structures in this frequent form of ARHSP

    A mutation in the melon Vacuolar Protein Sorting 41prevents systemic infection of Cucumber mosaic virus

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    [EN] In the melon exotic accession PI 161375, the gene cmv1, confers recessive resistance to Cucumber mosaic virus (CMV) strains of subgroup II. cmv1 prevents the systemic infection by restricting the virus to the bundle sheath cells and impeding viral loading to the phloem. Here we report the fine mapping and cloning of cmv1. Screening of an F2 population reduced the cmv1 region to a 132 Kb interval that includes a Vacuolar Protein Sorting 41 gene. CmVPS41 is conserved among plants, animals and yeast and is required for post-Golgi vesicle trafficking towards the vacuole. We have validated CmVPS41 as the gene responsible for the resistance, both by generating CMV susceptible transgenic melon plants, expressing the susceptible allele in the resistant cultivar and by characterizing CmVPS41 TILLING mutants with reduced susceptibility to CMV. Finally, a core collection of 52 melon accessions allowed us to identify a single amino acid substitution (L348R) as the only polymorphism associated with the resistant phenotype. CmVPS41 is the first natural recessive resistance gene found to be involved in viral transport and its cellular function suggests that CMV might use CmVPS41 for its own transport towards the phloem.The TILLING platform is supported by the Program Saclay Plant Sciences (SPS, ANR-10-LABX-40) and the European Research Council (ERC-SEXYPARTH). This work was supported by grants AGL2009-12698-C02-01 and AGL2012-40130-C02-01 from the Spanish Ministry of Science and Innovation, the Spanish Ministry of Econom and Competitiveness, through the "Severo Ochoa Programme for Centres of Excellence in R&D" 2016-2019 (SEV-2015-0533)" and the CERCA Programme/Generalitat de Catalunya.Giner, A.; Pascual, L.; Bourgeois, M.; Gyetvai, G.; Rios, P.; PicĂł Sirvent, MB.; Troadec, C.... (2017). 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Molecular Plant Pathology 16, 675–684, doi: 10.1111/mpp.12225 (2015).Guiu-AragonĂ©s, C. et al. The complex resistance to Cucumber mosaic cucumovirus (CMV) in the melon accession PI 161375 is governed by one gene and at least two quantitative trait loci. Molecular Breeding 34, 351–362, doi: 10.1007/s11032-014-0038-y (2014).Guiu-AragonĂ©s, C. et al. cmv1 is a gate for Cucumber mosaic virus transport from bundle sheath cells to phloem in melon. Mol. Plant Pathology 17, 973–984 (2016).Sanseverino, W. et al. Transposon Insertions, Structural Variations, and SNPs Contribute to the Evolution of the Melon Genome. Molecular Biology and Evolution 32, 2760–2774, doi: 10.1093/molbev/msv152 (2015).Pols, M. S., ten Brink, C., Gosavi, P., Oorschot, V. & Klumperman, J. The HOPS Proteins hVps41 and hVps39 Are Required for Homotypic and Heterotypic Late Endosome Fusion. Traffic 14, 219–232, doi: 10.1111/tra.12027 (2013).Asensio, C. S. et al. 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SNP genotyping in melons: genetic variation, population structure, and linkage disequilibrium. Theoretical and Applied Genetics 126, 1285–1303, doi: 10.1007/s00122-013-2053-5 (2013).Leida, C. et al. Variability of candidate genes, genetic structure and association with sugar accumulation and climacteric behavior in a broad germplasm collection of melon (Cucumis melo L.). BMC Genetics 16, 28, doi: 10.1186/s12863-015-0183-2 (2015).Balderhaar, H. Jk & Ungermann, C. CORVET and HOPS tethering complexes – coordinators of endosome and lysosome fusion. Journal of Cell Science 126, 1307–1316, doi: 10.1242/jcs.107805 (2013).Darsow, T., Katzmann, D. J., Cowles, C. R. & Emr, S. D. Vps41p Function in the Alkaline Phosphatase Pathway Requires Homo-oligomerization and Interaction with AP-3 through Two Distinct Domains. Molecular Biology of the Cell 12, 37–51 (2001).Ostrowicz, C. W. et al. Defined subunit arrangement and Rab interactions are required for functionality of the HOPS tethering complex. 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R. & Chan, A. P. Predicting the Functional Effect of Amino Acid Substitutions and Indels. PLoS ONE 7, e46688, doi: 10.1371/journal.pone.0046688 (2012).Li, B. et al. Automated inference of molecular mechanisms of disease from amino acid substitutions. Bioinformatics 25, 2744–2750, doi: 10.1093/bioinformatics/btp528 (2009).Earley, K. W. et al. Gateway-compatible vectors for plant functional genomics and proteomics. The Plant Journal 45, 616–629, doi: 10.1111/j.1365-313X.2005.02617.x (2006).Gonzalez-Ibeas, D. et al. MELOGEN: an EST database for melon functional genomics. BMC Genomics 8, 306 (2007).Pfaffl, M. W. A new mathematical model for relative quantification in real-time RT–PCR. Nucleic Acids Research 29, 2002–2007 (2001).Dalmais, M. et al. UTILLdb, a Pisum sativum in silico forward and reverse genetics tool. Genome Biology 9, R43–R43, doi: 10.1186/gb-2008-9-2-r43 (2008).SaladiĂ©, M. et al. 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    Effective Lagrangian for strongly coupled domain wall fermions

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    We derive the effective Lagrangian for mesons in lattice gauge theory with domain-wall fermions in the strong-coupling and large-N_c limits. We use the formalism of supergroups to deal with the Pauli-Villars fields, needed to regulate the contributions of the heavy fermions. We calculate the spectrum of pseudo-Goldstone bosons and show that domain wall fermions are doubled and massive in this regime. Since we take the extent and lattice spacing of the fifth dimension to infinity and zero respectively, our conclusions apply also to overlap fermions.Comment: 26 pp. RevTeX and 3 figures; corrected error in symmetry breaking scheme and added comments to discussio

    UV to IR SEDs of UV selected galaxies in the ELAIS fields: evolution of dust attenuation and star formation activity from z=0.7 to z=0.2

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    We study the ultraviolet to far-infrared (hereafter UV-to-IR) SEDs of a sample of intermediate redshift (0.2 < z < 0.7) UV-selected galaxies from the ELAIS-N1 and ELAIS-N2 fields by fitting a multi-wavelength dataset to a library of GRASIL templates. Star formation related properties of the galaxies are derived from the library of models by using the Bayesian statistics. We find a decreasing presence of galaxies with low attenuation and low total luminosity as redshift decreases, which does not hold for high total luminosity galaxies. In addition the dust attenuation of low mass galaxies increases as redshift decreases, and this trend seems to disappear for galaxies with M* > 10^11 M_sun. This result is consistent with a mass dependent evolution of the dust to gas ratio, which could be driven by a mass dependent efficiency of star formation in star forming galaxies. The specific star formation rates (SSFR) decrease with increasing stellar mass at all redshifts, and for a given stellar mass the SSFR decreases with decreasing redshift. The differences in the slope of the M*--SSFR relation found between this work and others at similar redshift could be explained by the adopted selection criteria of the samples which, for a UV selected sample, favours blue, star forming galaxies.Comment: 21 figures, accepted for publication in Ap
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