Type-D Personality in Unemployed Subjects: Prevalence, Self-Efficacy and Heart Rate Variability/Autonomic Response

Background: Unemployment may impair mental and physical health. The influencing factors causing such negative effects are relevant from an individual and public health perspective. The personality as one possible influencing factor was discussed. This study investigated the prevalence of the type-D personality in an unemployed population and its connections to socio-demographic, psychological and heart rate variability (HRV) parameters. Methods: A questionnaire set including socio-demographics, type-D scale (DS14), Complaint list (BL), Beck-Depression-Inventory II (BDI-II) and the General Self-Efficacy Scale (GSE) was handed out to 203 unemployed individuals [126 females, mean age ± SD: 42.36 ± 11.08]. For HRV assessment (RMSSD), a subsample of 83 participants [50 females, median age ± IQR: 47.00 ± 17.00] passed the “stress-tests” (timed breathing, d2-attention-stress-test, math test) while heart frequency (HF) was acquired via the Stressball software (BioSign GmbH, Ottenhofen, Germany). Results: 53% of the unemployed had a type-D personality. Compared to non-type-D individuals, type-D individuals had rarely children and by trend a lower educational level; they showed significantly higher scores in the BDI-II and lower scores in the GSE and BL. No differences were observed in mean HF or RMSSD during all the stress-tests. Conclusion: The HRV of individuals with a type-D personality is no worse than that of individuals without a type-D personality. Type-D personality was significantly associated with negative health effects regarding depressiveness, self-efficacy and physical complaints. Our main findings implicate that the DS14 could serve as a short and reliable screening instrument to select concerned unemployed individuals who might be at risk for negative health effects for adequate intervention

Flows, Fragmentation, and Star Formation. I. Low-mass Stars in Taurus

The remarkably filamentary spatial distribution of young stars in the Taurus molecular cloud has significant implications for understanding low-mass star formation in relatively quiescent conditions. The large scale and regular spacing of the filaments suggests that small-scale turbulence is of limited importance, which could be consistent with driving on large scales by flows which produced the cloud. The small spatial dispersion of stars from gaseous filaments indicates that the low-mass stars are generally born with small velocity dispersions relative to their natal gas, of order the sound speed or less. The spatial distribution of the stars exhibits a mean separation of about 0.25 pc, comparable to the estimated Jeans length in the densest gaseous filaments, and is consistent with roughly uniform density along the filaments. The efficiency of star formation in filaments is much higher than elsewhere, with an associated higher frequency of protostars and accreting T Tauri stars. The protostellar cores generally are aligned with the filaments, suggesting that they are produced by gravitational fragmentation, resulting in initially quasi-prolate cores. Given the absence of massive stars which could strongly dominate cloud dynamics, Taurus provides important tests of theories of dispersed low-mass star formation and numerical simulations of molecular cloud structure and evolution.Comment: 32 pages, 9 figures: to appear in Ap

L-arginine: A unique amino acid for improving depressed wound immune function following hemorrhage

Objective: To determine whether L-arginine has any salutary effects on wound immune cell function following trauma-hemorrhage. Background. Depressed wound immune function contributes to an increased incidence of wound infections following hemorrhage. Although administration of L-arginine has been shown to restore depressed cell-mediated immune responses following hemorrhage potentially by maintaining organ blood flow, it remains unknown whether Larginine has any salutary effects on the depressed local immune response at the wound site. Methods: Male mice were subjected to a midline laparotomy and polyvinyl sponges were implanted subcutaneously in the abdominal wound prior to hemorrhage (35 +/- 5 mm Hg for 90 min and resuscitation) or sham operation. During resuscitation mice received 300 mg/kg body weight L-arginine or saline (vehicle). Sponges were harvested 24 h thereafter, wound fluid collected and wound immune cells cultured for 24 h in the presence of LPS. Pro- (IL-1beta, IL-6) and anti-inflammatory (IL-10) cytokines were determined in the supernatants and the wound fluid. In addition, wounds were stained for IL-6 immunohistochemically. In a separate set of animals, skin and muscle blood flow was determined by microspheres. Results: The capacity of wound immune cells to release IL-1beta and IL-6 in vitro was significantly depressed in hemorrhaged mice receiving vehicle. Administration of L-arginine, however, improved wound immune cell function. In contrast, in vivo the increased IL-6 release at the wound site was decreased in L-arginine-treated mice following hemorrhage. Moreover, IL-10 levels were significantly increased in the wound fluid in hemorrhaged animals receiving L-arginine compared to vehicle-treated mice. In addition, the depressed skin and muscle blood flow after hemorrhage was restored by L-arginine. Conclusions: Thus, L-arginine might improve local wound cell function by decreasing the inflammatory response at the wound site. Since L-arginine protected wound immune cell function this amino acid might represent a novel and useful adjunct to fluid resuscitation for decreasing wound complications following hemorrhage. Copyright beta 2002 S. Karger AG, Basel

Gene-Gene Interaction between APOA5 and USF1: Two Candidate Genes for the Metabolic Syndrome

Objective: The metabolic syndrome, a major cluster of risk factors for cardiovascular diseases, shows increasing prevalence worldwide. Several studies have established associations of both apolipoprotein A5 (APOA5) gene variants and upstream stimulatory factor 1 (USF1) gene variants with blood lipid levels and metabolic syndrome. USF1 is a transcription factor for APOA5. Methods: We investigated a possible interaction between these two genes on the risk for the metabolic syndrome, using data from the German population-based KORA survey 4 (1,622 men and women aged 55-74 years). Seven APOA5 single nucleotide polymorphisms (SNPs) were analyzed in combination with six USF1 SNPs, applying logistic regression in an additive model adjusting for age and sex and the definition for metabolic syndrome from the National Cholesterol Education Program's Adult Treatment Panel III (NCEP (AIII)) including medication. Results: The overall prevalence for metabolic syndrome was 41%. Two SNP combinations showed a nominal gene-gene interaction (p values 0.024 and 0.047). The effect of one SNP was modified by the other SNP, with a lower risk for the metabolic syndrome with odds ratios (ORs) between 0.33 (95% CI = 0.13-0.83) and 0.40 (95% CI = 0.15-1.12) when the other SNP was homozygous for the minor allele. Nevertheless, none of the associations remained significant after correction for multiple testing. Conclusion: Thus, there is an indication of an interaction between APOA5 and USF1 on the risk for metabolic syndrome

Promoting future teachers' evidence-informed reasoning scripts: effects of different forms of instruction after problem-solving

Pre-service teachers face difficulties when dealing with problem situations in the classroom if their evidence-informed reasoning script (EIRS) is not adequately developed. An EIRS might be promoted by demonstrating how to implement evidence-informed reasoning after a problem-solving activity on an authentic case. However, it is unclear what form of instruction is appropriate to promote pre-service teachers in the development of an EIRS. The present 2×3-factorial experimental intervention study investigated how different forms of instruction on functional procedures (example-free vs. example-based) and on dysfunctional procedures (without vs. example-free vs. example-based) affect the development of an EIRS. N = 384 pre-service teachers worked on a written case vignette of a problem situation in a problem-solving phase, in which the crucial steps of the EIRS were prompted externally. In the subsequent instruction phase, the participants compared their own solution with an example-free or example-based instruction on functional procedures, which was either supplemented by an example-free or example-based instruction on typical dysfunctional procedures or not at all. The participants’ learning success (declarative EIRS; near and far transfer problem-solving performance) and error awareness were assessed. The results revealed that the example-based instruction on functional procedures led to a higher learning success than the example-free instruction. Both forms of instruction on dysfunctional procedures improved learning success compared to learning without one. During learning, error awareness was higher for learners who worked with an example-free instruction on dysfunctional procedures. In order to promote the development of an EIRS in pre-service teachers, it is promising to provide instruction after problem-solving that presents a functional example of evidence-informed reasoning for the given problem and that also points out typical dysfunctional approaches to solving the problem. The results highlight the importance of selecting appropriate scaffolds in case-based learning approaches that aim to develop cognitive schemata. The mechanisms that explain when and why instructions on dysfunctional procedures work need to be further explored

Assessment of the Effects of Active Immunisation against Respiratory Syncytial Virus (RSV) using Decision-Analytic Models: A Systematic Review with a Focus on Vaccination Strategies, Modelling Methods and Input Data

Background: Several vaccine and antibody candidates are currently in development for the prevention of lower respiratory tract infections caused by the respiratory syncytial virus (RSV). Methods: We searched MEDLINE, Embase, and SCOPUS and included model-based evaluations of RSV vaccinations. Two reviewers performed the selection, data extraction, and quality evaluation with EVIDEM. Cost-effectiveness (CE) estimates were converted to $US purchasing power parity (PPP), year 2018 values. Potential economic and epidemiological outcomes were summarised for maternal, infant, children, and elderly vaccinations. The PROSPERO identifier is CRD42019122570. Results: In total, 22 model-based studies were reviewed. On average, a potential 27$US1766–5857 PPP 2018/disability-adjusted life-years (DALYs) for Global Alliance for Vaccines and Immunisation (Gavi)-eligible countries. For England, the maximum cost-effective price of maternal vaccination was estimated at $US81.5 PPP 2018. Infant vaccination was associated with higher CE ratios in low- and high-income settings. Vaccination of neonates born before the RSV season was the most cost effective in high-income settings. Higher values for vaccine effectiveness, duration of protection, and vaccine uptake increased the benefits. Due to indirect effects, the vaccination of school-age children and a cocooning strategy were effective alternatives to protect infants, and the vaccination of children aged < 5 years had a beneficial impact on the elderly. Conclusion: RSV vaccines with anticipated characteristics may reduce a sizeable proportion of the RSV burden. The results are subject to uncertainty because of the limited epidemiological and clinical data. Data on RSV incidence and hospitalisation risk for granular age strata should be prioritised to facilitate the evaluation of RSV interventions and decision making.Peer Reviewe

A Case Study of Low-Mass Star Formation

This article synthesizes observational data from an extensive program aimed toward a comprehensive understanding of star formation in a low-mass star-forming molecular cloud. New observations and published data spanning from the centimeter wave band to the near infrared reveal the high and low density molecular gas, dust, and pre-main sequence stars in L1551.Comment: 24 pages, 21 figures, ApJS accepte

Food security in developing countries: Gender and spatial interactions

This brief summarizes findings of a project entitled “Food Security in Developing Countries: Gender and Spatial Interactions’” undertaken by researchers from the University of Alberta. The project uses a large cross-sectional dataset from the Integrated Modelling Platform for Mixed Animal Crop systems (IMPACT) Lite collected by Climate Change, Agriculture, and Food Security (CCAFS) from 2010 to late 2012. This dataset surveyed 1,500 households located across seven countries in Africa and Asia. The project focused on estimating three spatial effects on food security: i) a spatial autoregressive effect that measures how neighbors’ food security influences a farmer’s food security; ii) how these spatial effects differ for male and female-headed households; and iii) how the food security of neighbors of the same gender affect their own food security

The Spitzer c2d Survey of Weak-line T Tauri Stars II: New Constraints on the Timescale for Planet Building

One of the central goals of the Spitzer Legacy Project ``From Molecular Cores to Planet-forming Disks'' (c2d) is to determine the frequency of remnant circumstellar disks around weak-line T Tauri stars (wTTs) and to study the properties and evolutionary status of these disks. Here we present a census of disks for a sample of over 230 spectroscopically identified wTTs located in the c2d IRAC (3.6, 4.5, 4.8, and 8.0 um) and MIPS (24 um) maps of the Ophiuchus, Lupus, and Perseus Molecular Clouds. We find that ~20% of the wTTs in a magnitude limited subsample have noticeable IR-excesses at IRAC wavelengths indicating the presence of a circumstellar disk. The disk frequencies we find in these 3 regions are ~3-6 times larger than that recently found for a sample of 83 relatively isolated wTTs located, for the most part, outside the highest extinction regions covered by the c2d IRAC and MIPS maps. The disk fractions we find are more consistent with those obtained in recent Spitzer studies of wTTs in young clusters such as IC 348 and Tr 37. From their location in the H-R diagram, we find that, in our sample, the wTTs with excesses are among the younger part of the age distribution. Still, up to ~50% of the apparently youngest stars in the sample show no evidence of IR excess, suggesting that the circumstellar disks of a sizable fraction of pre-main-sequence stars dissipate in a timescale of ~1 Myr. We also find that none of the stars in our sample apparently older than ~10 Myrs have detectable circumstellar disks at wavelengths < 24 um. Also, we find that the wTTs disks in our sample exhibit a wide range of properties (SED morphology, inner radius, L_DISK/L*, etc) which bridge the gaps observed between the cTTs and the debris disk regimes.Comment: 54 pages, 13 figures, Accepted by Ap