Conformational restrained peptides

Die vorliegende Arbeit beschreibt die Synthese und Untersuchung der Struktur-Wirkungsbeziehung von konformationell eingeschränkten, cyclischen Peptidliganden von tumorassoziierten Zellrezeptoren (avb3-Integrine, Urokinase(uPA)- und Somatostatin-Rezeptor). Durch die Verwendung von enantioselektiv synthetisierten Cyclohexen-beta-aminosäuren und linearen beta-turn-Mimetika wurden bioaktive Cyclen mit definierter Raumstruktur erhalten, die mit NMR- und MD-Techniken strukturell aufgeklärt wurden. Für die Synthese von Templatpeptiden und funktionalisierten Liganden mussten darüber hinaus eine Reihe von trifunktionellen Aminosäuren, Cyclisierungs- und Fragmentkupplungskonzepte für die Festphasensynthese entwickelt werden.This thesis describes the synthesis and analysis of the structure-activity relationship of conformational restrained, cyclic peptide ligands for tumor associated cell receptors (avb3-integrines, urokinase(uPA)- und somatostatin-receptors). By usage of cyclohexene-beta-amino acids, which were synthesized in a enantioselective manner, and linear beta-turn-mimetics bioactive cycles were obtained. Their defined 3D-structure were determined by NMR and modeling techniques. Moreover, for the synthesis of template peptides and functionalized ligands a number of trifunctional amino acids, cyclisation methods and concepts for fragment condensations on solid phase had to be worked out

A conceptual framework for predicting the effects of urban environments on floras.

1 With the majority of people now living in urban environments, urbanization is arguably the most intensive and irreversible ecosystem change on the planet. 2 Urbanization transforms floras through a series of filters that change: (i) habitat availability; (ii) the spatial arrangement of habitats; (iii) the pool of plant species; and (iv) evolutionary selection pressures on populations persisting in the urban environment. 3 Using a framework based on mechanisms of change leads to specific predictions of floristic change in urban environments. Explicitly linking drivers of floristic change to predicted outcomes in urban areas can facilitate sustainable management of urban vegetation as well as the conservation of biodiversity. 4 Synthesis. We outline how the use of our proposed framework, based on environmental filtering, can be used to predict responses of floras to urbanization. These floristic responses can be assessed using metrics of taxonomic composition, phylogenetic relatedness among species, plant trait distributions or plant community structure. We outline how this framework can be applied to studies that compare floras within cities or among cities to better understand the various floristic responses to urbanization.The working group was funded by the ARC‐NZ Research Network for Vegetation Function. Financial support was also provided by The Baker Foundation

Cultural appropriation of spaces and things

This proceedings volume gathers papers presented at the symposium “Cultural Appropriation of Spaces and Things” held in Siegen, Germany in October 2019. All over the world, children are confronted with an increasingly complicated and fast-moving world. Children need elementary cultural techniques and skills to shape their own lives and enable them to find individual interpretations of meaning. In addition to the acquisition of classical cultural techniques such as arithmetic, writing and reading, the competent handling of spaces and things – through manifold processes of appropriation and reflection – is crucial. It forms the basis and prerequisite for the development of competences or abilities that are suitable for understanding the dimensions, the complexity and changeability of their world and enable them to critically deal with associated problems and find appropriate solutions. The aim of the conference was to find suitable ways for children all over the world for a methodically and didactically guided examination of their natural, social and technical environment. At the same time, the aim was to achieve a mutual enrichment of monodisciplinary research accesses. It also included a self-critical reflection of one’s own culturally shaped approaches of research.Contents: Martin Gröger, Christian Prust, Alexandra Flügel: Preface LECTURES Alexandre Avelino Giffoni Junior, Sebastião Lázaro Pereira, Alberto Barella Netto: Haus Früher Hilfen UniRV: A historic building in process in the heart of Brazil Hyeongjoo Kim: Designing and Applying the Moral Turing Test for Korean Children Karen Barfod and Peer Daugbjerg: Teaching Science and Mathematics Outside the Classroom, a pilot study on assessing inquiry-based practices Jan Höper: Towards integrated science education by using mobile technologies outdoors WORKSHOPS Mareike Janssen: Exploring the things of life: First insights into chemical processes with sparkling water as an example Julia Gaffron, Martin Gröger: Children like to experiment, many teachers apparently do not Volker Heck: Alexander von Humboldt - The Voyage to the Americas as an approach to science in Primary School Thomas Sukopp: Interculturality in Philosophy Education: Challenges and Prospects of Education for Sustainable Development in Primary Schools POSTERS André Dorn, Martin Gröger: ESD in general studies -prospective general studies teachers deal with the educational concept of ESD in a student-oriented and cooperative manner Andree Georg: From Carlowitz to Sustainable Development and Education for Sustainable Development Irina Landrock: Children at NS Memorial Sites Dr. Markus Schaal: Martha Muchow in the Context of the New Sociology of Childhood What Can a Classic Still Teach Us Today? Martin Gröger: Open air laboratory FLEX – Starting to learn chemistry in a near-natural learning environment Martin Gröger: FoodLAB - a molecular gastronomic experimental laboratory in teacher training Martin Gröger: How Alexander von Humboldt saw the world from a chemist’s point of view Matthias Weipert: Extracurricular learning locations in the historical perspective of general studies - the example of the Wendener Hütte Mirko Schommer: Spatial Orientation - Competence expectations and common misconceptions based on map projections Sarah Gaubitz: Options for handling complex problems of global change from the perspective of primary school children Swaantje Brill: Museum Field Trips in Primary School: An Approach to Children’s Perspectives Urs Gießelmann and Uta Birkhölzer: The “Hauberg” as an extracurricular learning locatio

Schriftenschau

In der Schriftenschau zum Kochia-Band 5 werden 12 für die Flora von Deutschland relevante Neuerscheinungen aus den Jahren 2009 bis 2010 besprochen

Free‑floating medial meniscus implant kinematics do not change after simulation of medial open‑wedge high tibial osteotomy and notchplasty

Purpose The purpose of this in-vitro study was to examine the kinematics of an artificial, free-floating medial meniscus replacement device under dynamic loading situations and different knee joint states. Methods A dynamic knee simulator was used to perform dynamic loading exercises on three neutrally aligned and three 10° valgus aligned (simulating a medial openwedge high tibial osteotomy - MOWHTO) left human cadaveric knee joints. The knee joints were tested in three states (intact, conventional notchplasty, extended notchplasty) while 11 randomised exercises were simulated (jump landing, squatting, tibial rotation and axial ground impacts at 10°, 30° and 60° knee joint flexion) to investigate the knee joint and implant kinematics by means of rigidly attached reflective marker sets and an according motion analysis. Results The maximum implant translation relative to the tibial plateau was < 13 mm and the maximum implant rotation was < 19° for all exercises. Both, the notchplasties and the valgus knee alignment did not affect the device kinematics. Conclusions The results of the present in-vitro study showed that the non-anchored free-floating device remains within the medial knee joint gap under challenging dynamic loading situations without indicating any luxation tendencies. This also provides initial benchtop evidence that the device offers suitable stability and kinematic behaviour to be considered a potential alternative to meniscus allograft transplantation in combination with an MOWHTO, potentially expanding the patient collective in the future

Free‐floating medial meniscus implant kinematics do not change after simulation of medial open‐wedge high tibial osteotomy and notchplasty

Abstract Purpose The purpose of this in‐vitro study was to examine the kinematics of an artificial, free‐floating medial meniscus replacement device under dynamic loading situations and different knee joint states. Methods A dynamic knee simulator was used to perform dynamic loading exercises on three neutrally aligned and three 10° valgus aligned (simulating a medial openwedge high tibial osteotomy ‐ MOWHTO) left human cadaveric knee joints. The knee joints were tested in three states (intact, conventional notchplasty, extended notchplasty) while 11 randomised exercises were simulated (jump landing, squatting, tibial rotation and axial ground impacts at 10°, 30° and 60° knee joint flexion) to investigate the knee joint and implant kinematics by means of rigidly attached reflective marker sets and an according motion analysis. Results The maximum implant translation relative to the tibial plateau was < 13 mm and the maximum implant rotation was < 19° for all exercises. Both, the notchplasties and the valgus knee alignment did not affect the device kinematics. Conclusions The results of the present in‐vitro study showed that the non‐anchored free‐floating device remains within the medial knee joint gap under challenging dynamic loading situations without indicating any luxation tendencies. This also provides initial benchtop evidence that the device offers suitable stability and kinematic behaviour to be considered a potential alternative to meniscus allograft transplantation in combination with an MOWHTO, potentially expanding the patient collective in the future