Birds of a feather locate together? Foursquare checkins and personality homophily

In this paper we consider whether people with similar personality traits have a preference for common locations. Due to the difficulty in tracking and categorising the places that individuals choose to visit, this is largely unexplored. However, the recent popularity of location-based social networks (LBSNs) provides a means to gain new insight into this question through checkins - records that are made by LBSN users of their presence at specific street level locations. A web-based participatory survey was used to collect the personality traits and checkin behaviour of 174 anonymous users, who, through their common check-ins, formed a network with 5373 edges and an approximate edge density of 35%. We assess the degree of overlap in personality traits for users visiting common locations, as detected by user checkins. We find that people with similar high levels of conscientiousness, openness or agreeableness tended to have checked-in locations in common. The findings for extraverts were unexpected in that they did not provide evidence of individuals assorting at the same locations, contrary to predictions. Individuals high in neuroticism were in line with expectations, they did not tend to have locations in common. Unanticipated results concerning disagreeableness are of particular interest and suggest that different venue types and distinctive characteristics may act as attractors for people with particularly selective tendencies. These findings have important implications for decision-making and location

The Effects of Thawing Procedure and Supplementation on the Motility and Viability of Frozen-thawed Boar Semen

The effect of two thawing procedures on frozen boar semen and supplementations to the fertilization media were studied. Frozen boar semen was thawed using either Percoll gradient or phosphate buffered saline (PBS)procedure. Supplementations were 1.0 mM L-glutamate, 1.0 mM N-acetylcysteine (NAC) , and 1.0 mM NAC-amide (NACA). Spermatozoa were analyzed for forward progressive motility (FPM) and viability every 0.5 h for 3 .0 h post-thawing. There were significantly (P \u3c 0.05) higher numbers of viable (76.0 ± 5.1 %) and FPM (30 .0 ± 2.4%) spermatozoa at 3.0 h post thawing using the PBS procedure compared to the Percoll gradient thawed spermatozoa (65.0 ± 3.9%; 10.0 ± 4.5 %, respectively). Supplementation of 1.0 mM L-glutamate, 1.0 mM NAC, or 1.0 mM NACA had no significant effect on spermatozoa viability regardless of the time post-thaw.Supplementation of 1.0 mM L-glutamate, 1.0 mM NAC , or 1.0 mM NACA had no significant effect on FPM up to 1.0 h post-thaw. Spermatozoa with no supplementation or 1.0 mM L-glutamate had significantly higher (P \u3c 0.05) FPM compared to the 1.0 mM NAC and 1.0 mM NACA supplemented groups at 1.5, 2.0, 2 .5, and 3.0 h post-thaw. There was no significant difference between no supplementation or 1.0 mM L-glutamate on FPM regardless of the time post-thaw. There was no significant difference between 1.0 mM NAC or 1.0 mM NACA on FPM regardless of the time post-thaw. These results indicate that thawing procedure has an effect on spermatozoa viability and FPM but supplementation does not have an effect on the overall viability of spermatozoa during thawing, but may reduce FPM

Personality and location-based social networks

Location-based social networks (LBSNs) are a recent phenomenon for sharing a presence at everyday locations with others and have the potential to give new insights into human behaviour. To date, due to barriers in data collection, there has been little research into how our personality relates to the categories of place that we visit. Using the Foursquare LBSN, we have released a web-based participatory application that examines the personality characteristics and checkin behaviour of volunteer Foursquare users. Over a four-month period, we examine the behaviour and the “Big Five” personality traits of 174 anonymous users who had collectively checked in 487,396 times at 119,746 venues. Significant correlations are found for Conscientiousness, Openness and Neuroticism. In contrast to some previous findings about online social networks, Conscientiousness is positively correlated with LBSN usage. Openness correlates mainly with location-based variables (average distance between venues visited, venue popularity, number of checkins at sociable venues). For Neuroticism, further negative correlations are found (number of venues visited, number of sociable venues visited). No correlations are found for the other personality traits, which is surprising for Extroversion. The study concludes that personality traits help to explain individual differences in LBSN usage and the type of places visited

Pediatric epilepsy surgery from 2000 to 2018: Changes in referral and surgical volumes, patient characteristics, genetic testing, and postsurgical outcomes

OBJECTIVE: Neurosurgery is a safe and effective form of treatment for select children with drug-resistant epilepsy. Still, there is concern that it remains underutilized, and that seizure freedom rates have not improved over time. We investigated referral and surgical practices, patient characteristics, and postoperative outcomes over the past two decades. METHODS: We performed a retrospective cohort study of children referred for epilepsy surgery at a tertiary center between 2000 and 2018. We extracted information from medical records and analyzed temporal trends using regression analyses. RESULTS: A total of 1443 children were evaluated for surgery. Of these, 859 (402 females) underwent surgical resection or disconnection at a median age of 8.5 years (interquartile range [IQR] = 4.6-13.4). Excluding palliative procedures, 67% of patients were seizure-free and 15% were on no antiseizure medication (ASM) at 1-year follow-up. There was an annual increase in the number of referrals (7%, 95% confidence interval [CI] = 5.3-8.6; p < .001) and surgeries (4% [95% CI = 2.9-5.6], p < .001) over time. Duration of epilepsy and total number of different ASMs trialed from epilepsy onset to surgery were, however, unchanged, and continued to exceed guidelines. Seizure freedom rates were also unchanged overall but showed improvement (odds ratio [OR] 1.09, 95% CI = 1.01-1.18; p = .027) after adjustment for an observed increase in complex cases. Children who underwent surgery more recently were more likely to be off ASMs postoperatively (OR 1.04, 95% CI = 1.01-1.08; p = .013). There was a 17% annual increase (95% CI = 8.4-28.4, p < .001) in children identified to have a genetic cause of epilepsy, which was associated with poor outcome. SIGNIFICANCE: Children with drug-resistant epilepsy continue to be put forward for surgery late, despite national and international guidelines urging prompt referral. Seizure freedom rates have improved over the past decades, but only after adjustment for a concurrent increase in complex cases. Finally, genetic testing in epilepsy surgery patients has expanded considerably over time and shows promise in identifying patients in whom surgery is less likely to be successful

Human content filtering in Twitter: The influence of metadata

Social micro-blogging systems such as Twitter are designed for rapid and informal communication from a large potential number of participants. Due to the volume of content received, human users must typically skim their timeline of received content and exercise judgement in selecting items for consumption, necessitating a selection process based on heuristics and content meta-data. This selection process is not well understood, yet is important due to its potential use in content management systems. In this research we have conducted an open online experiment in which participants are shown quantitative and qualitative meta-data describing two pieces of Twitter content. Without revealing the text of the tweet, participants are asked to make a selection. We observe the decisions made from 239 surveys and discover insights into human behaviour on decision making for content selection. We find that for qualitative meta-data consumption decisions are driven by online friendship and for quantitative meta-data the largest numerical value presented influences choice. Overall, the ‘number of retweets’ is found to be the most influential quantitative meta-data, while displaying multiple cues about an author's identity provides the strongest qualitative meta-data. When both quantitative and qualitative meta-data is presented, it is the qualitative meta-data (friendship information) that drives selection. The results are consistent with application of the Recognition heuristic, which postulates that when faced with constrained decision-making, humans will tend to exercise judgement based on cues representing familiarity. These findings are useful for future interface design for content filtering and recommendation systems

Model-Informed Target Morning 17α-Hydroxyprogesterone Concentrations in Dried Blood Spots for Pediatric Congenital Adrenal Hyperplasia Patients

Monitoring cortisol replacement therapy in congenital adrenal hyperplasia (CAH) patients is vital to avoid serious adverse events such as adrenal crises due to cortisol underexposure or metabolic consequences due to cortisol overexposure. The less invasive dried blood spot (DBS) sampling is an advantageous alternative to traditional plasma sampling, especially in pediatric patients. However, target concentrations for important disease biomarkers such as 17α-hydroxyprogesterone (17-OHP) are unknown using DBS. Therefore, a modeling and simulation framework, including a pharmacokinetic/pharmacodynamic model linking plasma cortisol concentrations to DBS 17-OHP concentrations, was used to derive a target morning DBS 17-OHP concentration range of 2–8 nmol/L in pediatric CAH patients. Since either capillary or venous DBS sampling is becoming more common in the clinics, the clinical applicability of this work was shown by demonstrating the comparability of capillary and venous cortisol and 17-OHP concentrations collected by DBS sampling, using a Bland-Altman and Passing-Bablok analysis. The derived target morning DBS 17-OHP concentration range is a first step towards providing improved therapy monitoring using DBS sampling and adjusting hydrocortisone (synthetic cortisol) dosing in children with CAH. In the future, this framework can be used to assess further research questions, e.g., target replacement ranges for the entire day

Executive control in older Welsh monolinguals and bilinguals

Evidence for a bilingual advantage in executive control has led to the suggestion that being bilingual might protect against late-life cognitive decline. We assessed the performance of socially homogeneous groups of older (≥ 60 years) bilingual Welsh/English (n = 50) and monolingual English (n = 49) speakers on a range of executive control tasks yielding 17 indices for comparison. Effect sizes (> .2) favoured monolinguals on 10 indices, with negligible differences observed on the remaining 7 indices. Univariate analyses indicated that monolinguals performed significantly better on two of 17 indices. Multivariate analysis indicated no significant overall differences between the two groups in performance on executive tasks. Older Welsh bilinguals do not show a bilingual advantage in executive control, and where differences are observed, these tend to favour monolinguals. A possible explanation may lie in the nature of the sociolinguistic context and its influence on cognitive processing in the bilingual group

β-lactam hypersensitivity involves expansion of circulating and skin-resident Th22 cells

Background: β-lactam hypersensitivity has been classified according to the phenotype and function of drug-specific T-cells; however, new T-cell subsets have not been considered. Objective: The objective of this study was use piperacillin as a model of β-lactam hypersensitivity to study the nature of the drug-specific T-cell response induced in the blood and skin of hypersensitive patients and healthy volunteers. Methods: Drug-specific T-cells were cloned from blood and inflamed skin and cellular phenotype and function was explored. Naïve T cells from healthy volunteers were primed to piperacillin, cloned and subjected to the similar analyses. Results: PBMC and T-cell clones (n=570, 84% CD4+) from blood of piperacillin hypersensitive patients proliferated and secreted Th1/2 cytokines alongside IL-22 following drug stimulation. IL-17A secretion was not detected. Drug-specific clones from inflamed skin (n=96, 83% CD4+) secreted a similar profile of cytokines, but displayed greater cytolytic activity, secreting perforin, granzyme B and Fas L when activated. Blood- and skin-derived clones expressed high levels of skin-homing chemokine receptors and migrated in the presence of the ligands CCL17 and CCL27. Piperacillin-primed naïve T-cells from healthy volunteers also secreted IFN-γ, IL-13, IL-22 and cytolytic molecules. Aryl hydrocarbon (ArH) receptor blockade prevented differentiation of the naïve T-cells into antigen-specific Il-22 secreting cells. Conclusion: Together our results reveal that circulating and skin resident antigen-specific IL-22 secreting T-cells are detectable in patients with β-lactam hypersensitivity. Furthermore, differentiation of naïve T-cells into antigen-specific Th22 cells is dependent on ArH receptor signalling

Validation of a digital photographic method for assessment of dietary quality of school lunch sandwiches brought from home.

Background: It is a challenge to assess children&#x0027;s dietary intake. The digital photographic method (DPM) may be an objective method that can overcome some of these challenges. Objective: The aim of this study was to evaluate the validity and reliability of a DPM to assess the quality of dietary intake from school lunch sandwiches brought from home among children aged 7&#x2013;13 years. Design: School lunch sandwiches (n=191) were prepared to represent randomly selected school lunch sandwiches from a large database. All components were weighed to provide an objective measure of the composition. The lunches were photographed using a standardised DPM. From the digital images, the dietary components were estimated by a trained image analyst using weights or household measures and the dietary quality was assessed using a validated Meal Index of Dietary Quality (Meal IQ). The dietary components and the Meal IQ obtained from the digital images were validated against the objective weighed foods of the school lunch sandwiches. To determine interrater reliability, the digital images were evaluated by a second image analyst. Results: Correlation coefficients between the DPM and the weighed foods ranged from 0.89 to 0.97. The proportion of meals classified in the same or an adjacent quartile ranged from 98% (starch) to 100% (fruits, vegetables, fish, whole grain, and Meal IQ). There was no statistical difference between fish, fat, starch, whole grains, and Meal IQ using the two methods. Differences were found for fruits and vegetables; Bland&#x2013;Altman analyses showed a tendency to underestimate high amounts of these variables using the DPM. For interrater reliability, kappa statistics ranged from 0.59 to 0.82 across the dietary components and Meal IQ. Conclusions: The standardised DPM is a valid and reliable method for assessing the dietary quality of school lunch sandwiches brought from home