Controllability of protein-protein interaction phosphorylation-based networks: Participation of the hub 14-3-3 protein family

Posttranslational regulation of protein function is an ubiquitous mechanism in eukaryotic cells. Here, we analyzed biological properties of nodes and edges of a human protein-protein interaction phosphorylation-based network, especially of those nodes critical for the network controllability. We found that the minimal number of critical nodes needed to control the whole network is 29%, which is considerably lower compared to other real networks. These critical nodes are more regulated by posttranslational modifications and contain more binding domains to these modifications than other kinds of nodes in the network, suggesting an intra-group fast regulation. Also, when we analyzed the edges characteristics that connect critical and non-critical nodes, we found that the former are enriched in domain-to-eukaryotic linear motif interactions, whereas the later are enriched in domain-domain interactions. Our findings suggest a possible structure for protein-protein interaction networks with a densely interconnected and self-regulated central core, composed of critical nodes with a high participation in the controllability of the full network, and less regulated peripheral nodes. Our study offers a deeper understanding of complex network control and bridges the controllability theorems for complex networks and biological protein-protein interaction phosphorylation-based networked systems.Fil: Uhart, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Flores, Gabriel. Eventioz/eventbrite Company; ArgentinaFil: Bustos, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentin

Interpolative method for transport properties of quantum dots in the Kondo regime

We present an interpolative method for describing coherent transport through an interacting quantum dot. The idea of the method is to construct an approximate electron self-energy which becomes exact both in the limits of weak and strong coupling to the leads. The validity of the approximation is first checked for the case of a single (spin-degenerate) dot level. A generalization to the multilevel case is then discussed. We present results both for the density of states and the temperature dependent linear conductance showing the transition from the Kondo to the Coulomb blockade regime.Comment: 8 pages, 3 figures, includes lamuphys.sty, submitted to the Proceedings of the XVI Sitges Conference on Statistical Mechanic

Women in Senior Leadership Roles Career Mobility, Challenges, Success Stories and Need for Future Research

Women in Senior Leadership Roles Career Mobility, Challenges, Success Stories and Need for Future Research Women represent 57.4% of the US working population (~77M in 2019). From this, 51.8% held positions in managerial or professional roles. Although women represent over half of the working population and have demonstrated success in management and professional roles, they face challenges in attaining senior level leadership roles across multiple fields. Therefore, the purpose of this study was to look at how women respond to these challenges as they navigate their careers and ultimately the tools they used to successfully advance to senior level leadership roles. A qualitative approach was selected as my research method. It involved a personal narrative approach where the soliciting of participant stories were implemented via a formal semi-structured interview as the primary method of inquiry. This research approach allowed me to conduct a comprehensive analysis of the data gathered and understand via a first-person account how participants responded to barriers as they navigated through their careers. Barriers associated with structural and societal gender stereotypes ingrained in our culture and connected to patriarchal views that regardless of a woman’s experience, education or abilities, fosters the perception that women are less qualified and less competent than men. This perception deeming women less capable to master senior leadership roles across multiple fields. iii In addressing these barriers study participants highlight the tools they used to successfully advance to senior level leadership roles. Key tools that enabled them to take ownership of their careers, attained senior leadership roles and execute them successfully. These are resilient, transformational women that exercise their soft skills and lead with authenticity. Strong confident women that take risks and move barriers in spite of hearing “No” along the way. Women that in their leadership approach value the insights of others while empowering them to meet their full potential. These are inspirational leaders that understand the importance of elevating their voice and the voices of those that surround them. Most significantly, these are women who were once little girls that learned from their family and community they could accomplish anything they set their minds to

Computing All Isolated Invariant Sets at a Finite Resolution

Conley Index theory has inspired the development of rigorous computational methods to study dynamics. These methods construct outer approximations, combinatorial representations of the system, which allow us to represent the system as a combination of two graphs over a common vertex set. Invariant sets are sets of vertices and edges on the resulting digraph. Conley Index theory relies on isolated invariant sets, which are maximal invariant sets that meet an isolation condition, to describe the dynamics of the system. In this work, we present a computationally efficient and rigorous algorithm for computing all isolated invariant sets given an outer approximation. We improve upon an existing algorithm that “grows” iso- lated invariant sets individually and requires an input size of 2n, where n is the number of grid elements used for the outer approximation

MSB: Una aplicacion WWW para generación de resúmenes de comportamiento

La disponibilidad en Internet de grandes volúmenes de información en los que se basan decisiones relacionadas con el funcionamiento de sistemas dinámicos hace que cada vez sean más necesarios métodos efectivos de generación automáti-ca de resumen de información de comportamiento. En este artículo se describe la aplicación MSB (Multimedia Summari-zer of Behavior) como una herramienta software que genera presentaciones multimedia de resumen de comportamiento de sistemas dinámicos para ser presentadas en la Web. MSB usa como entrada datos de comportamiento de fuentes remo-tas (medidos por sensores) que pueden estar disponibles en diferentes servidores Web. Estas fuentes de información se interpretan y resumen usando métodos del campo de la Inteligencia Artificial simulando formas de razonamiento que realizan las personas al resumir información de interés. En el artículo se describe la arquitectura basada en el conocimien-to del sistema MSB y la aplicación desarrollada en el dominio de hidrología sobre comportamiento de cuencas hidrográ-ficas

Forecasting Salinity in the Laguna Madre Using Deep Learning

Salinity is an important metric in the Laguna Madre for establishing the long term health of the local ecological population. By utilizing Deep Learning (DL) techniques, the predicted and forecasted salinity in the Laguna Madre is generated from data provided by the Moderate Resolution Imaging Spectroradiometer (MODIS)-Aqua satellite. Currently, only one other DL model has been used to forecast Sea Surface Salinity (SSS), being a Recurrent Neural Network (RNN). However, the RNN model requires the prediction of a full area of salinity to function. As such, several model architectures were tested, with the best one, being a Multi-input MPNN, utilized to evaluate the feasibility of forecasting utilizing simpler DL models. The results show that a one-day forecast is plausible, while three and five-day forecasts would require a data-rich environment, unlike that of the Laguna Madre

Change in the North Atlantic circulation associated with the mid-Pleistocene transition

The southwestern Iberian margin is highly sensitive to changes in the distribution of North Atlantic currents and to the position of oceanic fronts. In this work, the evolution of oceanographic parameters from 812 to 530 ka (MIS20-MIS14) is studied based on the analysis of planktonic foraminifer assemblages from site IODP-U1385 (37 degrees 34.285' N, 10 degrees 7.562' W; 2585m b.s.l.). By comparing the obtained results with published records from other North Atlantic sites between 41 and 55 degrees N, basin-wide paleoceano-graphic conditions are reconstructed. Variations of assemblages dwelling in different water masses indicate a major change in the general North Atlantic circulation during MIS16, coinciding with the definite establishment of the 100 ky cyclicity associated with the mid-Pleistocene transition. At the surface, this change consisted in the redistribution of water masses, with the subsequent thermal variation, and occurred linked to the northwestward migration of the Arctic Front (AF), and the increase in the North Atlantic Deep Water (NADW) formation with respect to previous glacials. During glacials prior to MIS16, the NADW formation was very weak, which drastically slowed down the surface circulation; the AF was at a southerly position and the North Atlantic Current (NAC) diverted southeastwards, developing steep south-north, and east-west, thermal gradients and blocking the arrival of warm water, with associated moisture, to high latitudes. During MIS16, the increase in the meridional overturning circulation, in combination with the northwestward AF shift, allowed the arrival of the NAC to subpolar latitudes, multiplying the moisture availability for ice-sheet growth, which could have worked as a positive feedback to prolong the glacials towards 100 ky cycles.info:eu-repo/semantics/publishedVersio