54 research outputs found
Unexpected Scaling of the Performance of Carbon Nanotube Transistors
We show that carbon nanotube transistors exhibit scaling that is
qualitatively different than conventional transistors. The performance depends
in an unexpected way on both the thickness and the dielectric constant of the
gate oxide. Experimental measurements and theoretical calculations provide a
consistent understanding of the scaling, which reflects the very different
device physics of a Schottky barrier transistor with a quasi-one-dimensional
channel contacting a sharp edge. A simple analytic model gives explicit scaling
expressions for key device parameters such as subthreshold slope, turn-on
voltage, and transconductance.Comment: 4 pages, 4 figure
How the central domain of dystrophin acts to bridge F-actin to sarcolemmal lipids
Dystrophin is a large intracellular protein that prevents sarcolemmal ruptures by providing a mechanical link between the intracellular actin cytoskeleton and the transmembrane dystroglycan complex. Dystrophin deficiency leads to the severe muscle wasting disease Duchenne Muscular Dystrophy and the milder allelic variant, Becker Muscular Dystrophy (DMD and BMD). Previous work has shown that concomitant interaction of the actin binding domain 2 (ABD2) comprising spectrin like repeats 11 to 15 (R11-15) of the central domain of dystrophin, with both actin and membrane lipids, can greatly increase membrane stiffness. Based on a combination of SAXS and SANS measurements, mass spectrometry analysis of cross-linked complexes and interactive low-resolution simulations, we explored in vitro the molecular properties of dystrophin that allow the formation of ABD2-F-actin and ABD2-membrane model complexes. In dystrophin we identified two subdomains interacting with F-actin, one located in R11 and a neighbouring region in R12 and another one in R15, while a single lipid binding domain was identified at the C-terminal end of R12. Relative orientations of the dystrophin central domain with F-actin and a membrane model were obtained from docking simulation under experimental constraints. SAXS-based models were then built for an extended central subdomain from R4 to R19, including ABD2. Overall results are compatible with a potential F-actin/dystrophin/membrane lipids ternary complex. Our description of this selected part of the dystrophin associated complex bridging muscle cell membrane and cytoskeleton opens the way to a better understanding of how cell muscle scaffolding is maintained through this essential protein
Aharonov-Bohm spectral features and coherence lengths in carbon nanotubes
The electronic properties of carbon nanotubes are investigated in the
presence of disorder and a magnetic field parallel or perpendicular to the
nanotube axis. In the parallel field geometry, the -periodic
metal-insulator transition (MIT) induced in metallic or semiconducting
nanotubes is shown to be related to a chirality-dependent shifting of the
energy of the van Hove singularities (VHSs). The effect of disorder on this
magnetic field-related mechanism is considered with a discussion of mean free
paths, localization lengths and magnetic dephasing rate in the context of
recent experiments.Comment: 22 pages, 6 Postscript figures. submitted to Phys. Rev.
M-theory, Cosmological Constant and Anthropic Principle
We discuss the theory of dark energy based on maximally extended supergravity
and suggest a possible anthropic explanation of the present value of the
cosmological constant and of the observed ratio between dark energy and energy
of matter.Comment: 8 pages, 6 figures, Introduction and Discussion are expande
Transport through the interface between a semiconducting carbon nanotube and a metal electrode
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Geologic Characterization of Fractures as an Aid to Hydrologic Modeling of the SCV Block at the Stripa Mine
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(NDC-16) Use of Integrated Geologic and Geophysical Information for Characterizing the Structure of Fracture Systems at the US/BK Site, Grimsel Laboratory, Switzerland
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