25 research outputs found
Effects of Maternal Fish Oil and/or 5-MethylTetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial
Recent studies have shown that maternal supplementation with folate and long-chain
polyunsaturated fatty acids (LC-PUFAs) during pregnancy may affect children’s brain development.
We aimed at examining the potential long-term effect of maternal supplementation with fish oil
(FO) and/or 5-methyl-tetrahydrofolate (5-MTHF) on the brain functionality of offspring at the age
of 9.5–10 years. The current study was conducted as a follow-up of the Spanish participants
belonging to the Nutraceuticals for a Healthier Life (NUHEAL) project; 57 children were divided
into groups according to mother’s supplementation and assessed through functional magnetic
resonance imaging (fMRI) scanning and neurodevelopment testing. Independent component analysis
and double regression methods were implemented to investigate plausible associations. Children
born to mothers supplemented with FO (FO and FO + 5-MTHF groups, n = 33) showed weaker
functional connectivity in the default mode (DM) (angular gyrus), the sensorimotor (SM) (motor and
somatosensory cortices) and the fronto-parietal (FP) (angular gyrus) networks compared to the No-FO
group (placebo and 5-MTHF groups, n = 24) (PFWE < 0.05). Furthermore, no differences were found
regarding the neuropsychological tests, except for a trend of better results in an object recall (memory)
test. Considering the No-FO group, the aforementioned networks were associated negatively with
attention and speed-processing functions. Mother’s FO supplementation during pregnancy seems
to be able to shape resting-state network functioning in their children at school age and appears to
produce long-term effects on children´s cognitive processing.European Union (EU)
212652
007036Commission of the European Community within the 5th Framework Program
QLK1-CT-1999-00888European Research Council (ERC)
322605 META-GROWTHSpanish Ministry of Science, Innovation and Universities
FJCI-2017-3339
Long-Chain Polyunsaturated Fatty Acids, Homocysteine at Birth and Fatty Acid Desaturase Gene Cluster Polymorphisms Are Associated with Children’s Processing Speed up to Age 9 Years
Both pre- and early postnatal supplementation with docosahexaenoic acid (DHA), arachidonic
acid (AA) and folate have been related to neural development, but their long-term effects
on later neural function remain unclear. We evaluated the long-term effects of maternal prenatal
supplementation with fish-oil (FO), 5-methyltetrahydrofolate (5-MTHF), placebo or FO + 5-MTHF,
as well as the role of fatty acid desaturase (FADS) gene cluster polymorphisms, on their offspring’s
processing speed at later school age. This study was conducted in NUHEAL children at 7.5 (n = 143)
and 9 years of age (n = 127). Processing speed tasks were assessed using Symbol Digit Modalities
Test (SDMT), Children Color Trails Test (CCTT) and Stroop Color andWord Test (SCWT). Long-chain
polyunsaturated fatty acids, folate and total homocysteine (tHcy) levels were determined at delivery
from maternal and cord blood samples. FADS and methylenetetrahydrofolate reductase (MTHFR)
677 C > T genetic polymorphisms were analyzed. Mixed models (linear and logistic) were performed.
There were significant differences in processing speed performance among children at different ages
(p < 0.001). The type of prenatal supplementation had no effect on processing speed in children
up to 9 years. Secondary exploratory analyses indicated that children born to mothers with higher
AA/DHA ratio at delivery (p < 0.001) and heterozygotes for FADS1 rs174556 (p < 0.05) showed better
performance in processing speed at 9 years. Negative associations between processing speed scores and maternal tHcy levels at delivery were found. Our findings suggest speed processing development
in children up to 9 years could be related to maternal factors, including AA/DHA and tHcy
levels, and their genetic background, mainly FADS polymorphism. These considerations support
that maternal prenatal supplementation should be quantitatively adequate and individualized to
obtain better brain development and mental performance in the offspring.European Commission
212652
007036
QLK1-CT-1999-00888European Commission
European Commission Joint Research Centre
DYNAHEALTH-633595
Lifecycle-733206European Research Council Advanced Grant META-GROWTH ERC-2012AdG
322605Erasmus Plus Programme Early Nutrition eAcademy Southeast Asia
573651EPP-1-2016-1-DE-EPPKA2-CBHE-JPErasmus Plus Programme Capacity Building to Improve Early Nutrition and Health in South Africa
598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JPEU Interreg Programme Focus in CD-CE111European Joint Programming Initiative Project NutriPROGRAM and EndObesityGerman Ministry of Education and Research, Berlin
01 GI 0825German Research Foundation (DFG)
Ko912/12-1
INST 409/224-1 FUGGElse Kroner-Fresenius-FoundationLMU University Hospital
Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE)
Abstract Background: Maternal overweight, obesity, and gestational diabetes (GD) have been negatively associated with offspring development. Further knowledge regarding metabolic and nutritional alterations in these mother and their offspring are warranted. Methods: In an observational cohort study we included 331 pregnant women from Granada, Spain. The mothers were categorized into four groups according to BMI and their GD status; overweight (n:56), obese (n:64), GD (n:79), and healthy normal weight controls (n:132). We assessed maternal growth and nutritional biomarkers at 24 weeks (n = 269), 34 weeks (n = 310) and at delivery (n = 310) and the perinatal characteristics including cord blood biomarkers. Results: Obese and GD mothers had significantly lower weight gain during pregnancy and infant birth weight, waist circumference, and placental weight were higher in the obese group, including a significantly increased prevalence of macrosomia. Except for differences in markers of glucose metabolism (glucose, HbA1c, insulin and uric acid) we found at some measures that overweight and/or obese mothers had lower levels of transferrin saturation, hemoglobin, Vitamin B12 and folate and higher levels of C-reactive protein, erythrocyte sedimentation rate, ferritin, and cortisol. GD mothers had similar differences in hemoglobin and C-reactive protein but higher levels of folate. The latter was seen also in cord blood. Conclusions: We identified several metabolic alterations in overweight, obese and GD mothers compared to controls. Together with the observed differences in infant anthropometrics, these may be important biomarkers in future research regarding the programming of health and disease in children. Trial registration: The trial was registered at clinicaltrials.gov, identifier (NCT01634464). Keywords: Pregnancy, Maternal overweight, Maternal obesity, Gestational diabetes, Offspring, Fetal nutrition, Early programming, Vitamin B12, Folate, Iron status, Glucose metabolis
The impact of GPU/Multicore in Signal Processing: a quantitative approach
[EN] This paper presents a meaningful practical performance comparison between the last generation
of Graphics Processing Units (GPUs) and the last generation multi-core CPUs when they are
used to solve given Signal Processing algorithms. Two kinds of tests were considered: when GPU
pre-designed computational libraries were available, and when the GPU code was developed by
the authors. Results show that GPUs offer great possibilities, but its programming is still hard
and high performances can be obtained only if the algorithm can be adapted to the GPU programming model.This work was financially supported by the Spanish Ministerio de Ciencia e InnovaciĂłn (Projects TIN2008-06570-C04-02, TEC2009-13741 and
CAPAP-H3 TIN2010-12011-E), Universitat Politècnica de València through “Programa de Apoyo a la Investigación y Desarrollo (PAID-05-10)” and
Generalitat Valenciana through project PROMETEO/2009/013.GarcĂa Mollá, VM.; Gonzalez, A.; González GarcĂa, CY.; MartĂnez ZaldĂvar, FJ.; Ramiro Sánchez, C.; Roger Varea, S.; Vidal Maciá, AM. (2011). The impact of GPU/Multicore in Signal Processing: a quantitative approach. Waves. (3):96-106. http://hdl.handle.net/10251/47425S96106
New gall-associated species of Allorhogas (Hymenoptera: Braconidae), including a natural enemy of the weed Miconia calvescens (Melastomataceae)
Nine species of the gall-associated doryctine genus Allorhogas Gahan (Hymenoptera: Braconidae) are described from Brazil (A. clidemiae MartĂnez and ZaldĂvar-RiverĂłn new species, A. granivorus ZaldĂvar-RiverĂłn and MartĂnez new species, A. mineiro ZaldĂvar-RiverĂłn and MartĂnez new species, and A. vulgaris ZaldĂvar-RiverĂłn and MartĂnez new species) and Costa Rica (A. brevithorax ZaldĂvar-RiverĂłn and MartĂnez new species, A. pallidus MartĂnez and ZaldĂvarRiverĂłn new species, A. psychotria ZaldĂvar-RiverĂłn and MartĂnez new species, A. punctatus MartĂnez and ZaldĂvar-RiverĂłn new species, and A. tico MartĂnez and ZaldĂvar-RiverĂłn new species). We provide host plant records for the described species, including information that reveals that at least three of them feed on seeds. Allorhogas granivorus had previously been confirmed to represent a natural enemy of the invasive weed Miconia calvescens de Candolle (Melastomataceae). Updated keys to the species of Allorhogas from Brazil and Costa Rica are provided.Fil: ZaldĂvar RiverĂłn, Alejandro. Universidad AutĂłnoma del Estado de MĂ©xico; MĂ©xicoFil: MartĂnez, Juan JosĂ©. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias BiolĂłgicas; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Hanson, Paul E.. Universidad de Costa Rica; Costa RicaFil: Mayorga MartĂnez, Cristina. Universidad AutĂłnoma del Estado de MĂ©xico; MĂ©xicoFil: Salinas Ramos, Valeria B.. Universidad AutĂłnoma del Estado de MĂ©xico; MĂ©xicoFil: Faria, Lucas D. B.. Universidade Federal de Lavras; Brasi
Applyng geophysical methods to evaluate natural hazards in karst systems: a case of study in the surroundings of the Nerja Cave
Workshop Alboran domain and Gibraltar Arc: geological research and natural hazards, Granada (Spain), 16-18 october, 201
The impacts of maternal iron deficiency and being overweight during pregnancy on neurodevelopment of the offspring.
Both maternal Fe deficiency (ID) and being overweight or obese (Ow/Ob, BMI≥25 kg/m2) may negatively affect offspring brain development. However, the two risk factors correlate and their independent effects on infant neurodevelopment are unclear. PREOBE is a prospective observational study that included 331 pregnant Spanish women, of whom 166 had pre-gestational Ow/Ob. Fe status was analysed at 34 weeks and at delivery, and babies were assessed using Bayley III scales of neurodevelopment at 18 months. In confounder-adjusted analyses, maternal ID at 34 weeks was associated with lower composite motor scores at 18 months (mean 113·3 (sd 9·9) v. 117·1 (sd 9·2), P=0·039). Further, the offspring of mothers with ID at delivery had lower cognitive scores (114·0 (sd 9·7) v. 121·5 (sd 10·9), P=0·039) and lower receptive, expressive and composite (99·5 (sd 8·6) v. 107·6 (sd 8·3), P=0·004) language scores. The negative associations between maternal ID at delivery and Bayley scores remained even when adjusting for maternal Ow/Ob and gestational diabetes. Similarly, maternal Ow/Ob correlated with lower gross motor scores in the offspring (12·3 (sd 2·0) v. 13·0 (sd 2·1), P=0·037), a correlation that remained when adjusting for maternal ID. In conclusion, maternal ID and pre-gestational Ow/Ob are both negatively associated with Bayley scores at 18 months, but independently and on different subscales. These results should be taken into account when considering Fe supplementation for pregnant women
Early nutrition in combination with polymorphisms in fatty acid desaturase gene cluster modulate fatty acid composition of cheek cells’ glycerophospholipids in school-age children
Benzothiazole-based LRRK2 inhibitors as Wnt enhancers and promoters of oligodendrocytic fate
63 p.-15 fig.-1 tab.-2 schem.Leucine Rich Repeat Kinase 2 (LRRK2) is an enigmatic enzyme and a relevant target for Parkinson’s Disease (PD). However, despite the significant amount of research done in the last decade, the precise function of LRRK2 remains largely unknown. Moreover, the therapeutic potential of its inhibitors is in its infancy with the first clinical trial having just started. In the present work the molecular mechanism of LRRK2 in the control of neurogenesis or gliogenesis was investigated. We designed and synthesized novel benzothiazole-based LRRK2 inhibitors and showed that they can modulate the Wnt/β-catenin signaling pathway. Furthermore, compounds 5 and 14 were able to promote neural progenitors proliferation and drive their differentiation towards neuronal and oligodendrocytic cell fates. These results suggest potential new avenues for the application of LRRK2 inhibitors in demyelinating diseases in which oligodendrocyte cell-death is one of the pathological features.This work was supported by MINECO (grant SAF2016-76693-R to A.M. and SAF2017-85717-R to A.V.M.), CIBERNED (CB18/05/00040 to A.M.), MECD
(FPU13-003262 to J.Z.-D.), CEU-Banco Santander (Scholarships for the Research
Mobility Program CEU-BANCO SANTANDER to J.Z.-D.), FundaciĂłn Alicia
Koplowitz (Research Project, 2018 to A.V.M.) and Tau Consortium and Stuart &
Suzanne Steele MGH Research Scholar Award to S.J.HPeer reviewe