SoK : Remote Power Analysis

In recent years, numerous attacks have appeared that aim to steal secret information from their victim using the power side-channel vector, yet without direct physical access. These attacks are called Remote Power Attacks or Remote Power Analysis, utilizing resources that are natively present inside the victim environment. However, there is no unified definition about the limitations that a power attack requires to be defined as remote. This paper aims to propose a unified definition and concrete threat models to clearly differentiate remote power attacks from non-remote ones. Additionally, we collect the main remote power attacks performed so far from the literature, and the principal proposed countermeasures to avoid them. The search of such countermeasures denoted a clear gap in preventing remote power attacks at the technical level. Thus, the academic community must face an important challenge to avoid this emerging threat, given the clear room for improvement that should be addressed in terms of defense and security of devices that work with private information.acceptedVersionPeer reviewe

Attestation Waves : Platform Trust via Remote Power Analysis

Attestation is a strong tool to verify the integrity of an untrusted system. However, in recent years, different attacks have appeared that are able to mislead the attestation process with treacherous practices as memory copy, proxy, and rootkit attacks, just to name a few. A successful attack leads to systems that are considered trusted by a verifier system, while the prover has bypassed the challenge. To mitigate these attacks against attestation methods and protocols, some proposals have considered the use of side-channel information that can be measured externally, as it is the case of electromagnetic (EM) emanation. Nonetheless, these methods require the physical proximity of an external setup to capture the EM radiation. In this paper, we present the possibility of performing attestation by using the side-channel information captured by a sensor or peripheral that lives in the same System-on-Chip (SoC) than the processor system (PS) which executes the operation that we aim to attest, by only sharing the Power Distribution Network (PDN). In our case, an analog-to-digital converter (ADC) that captures the voltage fluctuations at its input terminal while a certain operation is taking place is suitable to characterize itself and to distinguish it from other binaries. The resultant power traces are enough to clearly identify a given operation without the requirement of physical proximity.acceptedVersionPeer reviewe

Critical review of technologies for the on-site treatment of hospital wastewater: From conventional to combined advanced processes

In this work, a raw and low cost mineral, ilmenite (FeTiO3), has been tested for the first time as a photocatalyst paired with peroxymonosulfate (HSO5-; PMS) for the inactivation of Enterococcus faecalis as an alternative to conventional treatments to disinfect wastewater for reuse. The influence of some operational parameters such as reagent dosage, catalyst concentration, initial pH, or flow rate was also studied and optimized. After several tests, the scarce pure photoactivity under UV-A was remarked by ilmenite because of its high iron content, which favors photogenerated charge recombination. However, ilmenite activity was highly promoted when combined with low concentrations of PMS and UV-A light, reaching total inactivation of Enterococcus faecalis in 120 min. Quenching tests were performed using methanol, tert-butyl alcohol, furfuryl alcohol, and Cu(II) to assess the main reactive species involved in the disinfection process determining the critical role of both HO·and SO4·- radicals in the process. Finally, the influence of the water matrix was also evaluated by studying the effect of water hardness and the presence of nutrients on the system. Overall, the PMS/Ilmenite/UV-A system yielded promising results with a total removal of Enterococcus faecalis in 120 min. However, it also showed the need for further study and understanding of the disinfection mechanism to achieve the same level of performance in real wastewaterThe "Comunidad de Madrid" supported this research through REMTAVARES S2013/MAE-2716 and S2018/EMT-434

Un examen actualizado de la percepción de las barreras para la implementación de la farmacogenómica y la utilidad de los pares fármaco/gen en América Latina y el Caribe

La farmacogenómica (PGx) se considera un campo emergente en los países en desarrollo. La investigación sobre PGx en la región de América Latina y el Caribe (ALC) sigue siendo escasa, con información limitada en algunas poblaciones. Por lo tanto, las extrapolaciones son complicadas, especialmente en poblaciones mixtas. En este trabajo, revisamos y analizamos el conocimiento farmacogenómico entre la comunidad científica y clínica de ALC y examinamos las barreras para la aplicación clínica. Realizamos una búsqueda de publicaciones y ensayos clínicos en este campo en todo el mundo y evaluamos la contribución de ALC. A continuación, realizamos una encuesta regional estructurada que evaluó una lista de 14 barreras potenciales para la aplicación clínica de biomarcadores en función de su importancia. Además, se analizó una lista emparejada de 54 genes/fármacos para determinar una asociación entre los biomarcadores y la respuesta a la medicina genómica. Esta encuesta se comparó con una encuesta anterior realizada en 2014 para evaluar el progreso en la región. Los resultados de la búsqueda indicaron que los países de América Latina y el Caribe han contribuido con el 3,44% del total de publicaciones y el 2,45% de los ensayos clínicos relacionados con PGx en todo el mundo hasta el momento. Un total de 106 profesionales de 17 países respondieron a la encuesta. Se identificaron seis grandes grupos de obstáculos. A pesar de los continuos esfuerzos de la región en la última década, la principal barrera para la implementación de PGx en ALC sigue siendo la misma, la "necesidad de directrices, procesos y protocolos para la aplicación clínica de la farmacogenética/farmacogenómica". Las cuestiones de coste-eficacia se consideran factores críticos en la región. Los puntos relacionados con la reticencia de los clínicos son actualmente menos relevantes. Según los resultados de la encuesta, los pares gen/fármaco mejor clasificados (96%-99%) y percibidos como importantes fueron CYP2D6/tamoxifeno, CYP3A5/tacrolimus, CYP2D6/opioides, DPYD/fluoropirimidinas, TMPT/tiopurinas, CYP2D6/antidepresivos tricíclicos, CYP2C19/antidepresivos tricíclicos, NUDT15/tiopurinas, CYP2B6/efavirenz y CYP2C19/clopidogrel. En conclusión, aunque la contribución global de los países de ALC sigue siendo baja en el campo del PGx, se ha observado una mejora relevante en la región. La percepción de la utilidad de las pruebas PGx en la comunidad biomédica ha cambiado drásticamente, aumentando la concienciación entre los médicos, lo que sugiere un futuro prometedor en las aplicaciones clínicas de PGx en ALC.Pharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx in the Latin American and the Caribbean (LAC) region remains scarce, with limited information in some populations. Thus, extrapolations are complicated, especially in mixed populations. In this paper, we reviewed and analyzed pharmacogenomic knowledge among the LAC scientific and clinical community and examined barriers to clinical application. We performed a search for publications and clinical trials in the field worldwide and evaluated the contribution of LAC. Next, we conducted a regional structured survey that evaluated a list of 14 potential barriers to the clinical implementation of biomarkers based on their importance. In addition, a paired list of 54 genes/drugs was analyzed to determine an association between biomarkers and response to genomic medicine. This survey was compared to a previous survey performed in 2014 to assess progress in the region. The search results indicated that Latin American and Caribbean countries have contributed 3.44% of the total publications and 2.45% of the PGx-related clinical trials worldwide thus far. A total of 106 professionals from 17 countries answered the survey. Six major groups of barriers were identified. Despite the region’s continuous efforts in the last decade, the primary barrier to PGx implementation in LAC remains the same, the “need for guidelines, processes, and protocols for the clinical application of pharmacogenetics/pharmacogenomics”. Cost-effectiveness issues are considered critical factors in the region. Items related to the reluctance of clinicians are currently less relevant. Based on the survey results, the highest ranked (96%–99%) gene/drug pairs perceived as important were CYP2D6/tamoxifen, CYP3A5/tacrolimus, CYP2D6/opioids, DPYD/fluoropyrimidines, TMPT/thiopurines, CYP2D6/tricyclic antidepressants, CYP2C19/tricyclic antidepressants, NUDT15/thiopurines, CYP2B6/efavirenz, and CYP2C19/clopidogrel. In conclusion, although the global contribution of LAC countries remains low in the PGx field, a relevant improvement has been observed in the region. The perception of the usefulness of PGx tests in biomedical community has drastically changed, raising awareness among physicians, which suggests a promising future in the clinical applications of PGx in LAC

Association of insularity and body condition to cloacal bacteria prevalence in a small shorebird

Do islands harbour less diverse disease communities than mainland? The island biogeography theory predicts more diverse communities on mainland than on islands due to more niches, more diverse habitats and availability of greater range of hosts. We compared bacteria prevalences ofCampylobacter,ChlamydiaandSalmonellain cloacal samples of a small shorebird, the Kentish plover (Charadrius alexandrinus) between two island populations of Macaronesia and two mainland locations in the Iberian Peninsula. Bacteria were found in all populations but, contrary to the expectations, prevalences did not differ between islands and mainland. Females had higher prevalences than males forSalmonellaand when three bacteria genera were pooled together. Bacteria infection was unrelated to bird's body condition but females from mainland were heavier than males and birds from mainland were heavier than those from islands. Abiotic variables consistent throughout breeding sites, like high salinity that is known to inhibit bacteria growth, could explain the lack of differences in the bacteria prevalence between areas. We argue about the possible drivers and implications of sex differences in bacteria prevalence in Kentish plovers

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Handbook of Active Ageing and Quality of Life: From Concepts to Applications

La edición de este libro estuvo a cargo de Fermina Rojo-Pérez y Gloria Fernández-Mayoralas.El documento adjunto contiene la cubierta, portada e índice del libro.This handbook presents an overview of studies on the relationship of active ageing and quality of life. It addresses the new challenges of ageing from the paradigm of positive ageing (active, healthy and successful) for a better quality of life. It provides theoretical perspectives and empirical studies, including scientific knowledge as well as practical experiences about the good ageing and the quality of later life around the world, in order to respond to the challenges of an aged population. The handbook is structured in 4 sections covering theoretical and conceptual perspectives, social policy issues and research agenda, methods, measurement instrument-scales and evaluations, and lastly application studies including domains and geographical contexts.Peer reviewe

VLSI Design of Trusted Virtual Sensors

This work presents a Very Large Scale Integration (VLSI) design of trusted virtual sensors providing a minimum unitary cost and very good figures of size, speed and power consumption. The sensed variable is estimated by a virtual sensor based on a configurable and programmable PieceWise-Affine hyper-Rectangular (PWAR) model. An algorithm is presented to find the best values of the programmable parameters given a set of (empirical or simulated) input-output data. The VLSI design of the trusted virtual sensor uses the fast authenticated encryption algorithm, AEGIS, to ensure the integrity of the provided virtual measurement and to encrypt it, and a Physical Unclonable Function (PUF) based on a Static Random Access Memory (SRAM) to ensure the integrity of the sensor itself. Implementation results of a prototype designed in a 90-nm Complementary Metal Oxide Semiconductor (CMOS) technology show that the active silicon area of the trusted virtual sensor is 0.86 mm 2 and its power consumption when trusted sensing at 50 MHz is 7.12 mW. The maximum operation frequency is 85 MHz, which allows response times lower than 0.25 μ s. As application example, the designed prototype was programmed to estimate the yaw rate in a vehicle, obtaining root mean square errors lower than 1.1%. Experimental results of the employed PUF show the robustness of the trusted sensing against aging and variations of the operation conditions, namely, temperature and power supply voltage (final value as well as ramp-up time)

A Configurable RO-PUF for Securing Embedded Systems Implemented on Programmable Devices

Improving the security of electronic devices that support innovative critical services (digital administrative services, e-health, e-shopping, and on-line banking) is essential to lay the foundations of a secure digital society. Security schemes based on Physical Unclonable Functions (PUFs) take advantage of intrinsic characteristics of the hardware for the online generation of unique digital identifiers and cryptographic keys that allow to ensure the protection of the devices against counterfeiting and to preserve data privacy. This paper tackles the design of a configurable Ring Oscillator (RO) PUF that encompasses several strategies to provide an efficient solution in terms of area, timing response, and performance. RO-PUF implementation on programmable logic devices is conceived to minimize the use of available resources, while operating speed can be optimized by properly selecting the size of the elements used to obtain the PUF response. The work also describes the interface added to the PUF to facilitate its incorporation as hardware Intellectual Property (IP)-modules into embedded systems. The performance of the RO-PUF is proven with an extensive battery of tests, which are executed to analyze the influence of different test strategies on the PUF quality indexes. The configurability of the proposed RO-PUF allows establishing the most suitable “cost/performance/security-level” trade-off for a certain applicationPeer reviewe

Timing-Attack-Resistant Acceleration of NTRU Round 3 Encryption on Resource-Constrained Embedded Systems

The advent of quantum computing with high processing capabilities will enable brute force attacks in short periods of time, threatening current secure communication channels. To mitigate this situation, post-quantum cryptography (PQC) algorithms have emerged. Among the algorithms evaluated by NIST in the third round of its PQC contest was the NTRU cryptosystem. The main drawback of this algorithm is the enormous amount of time required for the multiplication of polynomials in both the encryption and decryption processes. Therefore, the strategy of speeding up this algorithm using hardware/software co-design techniques where this operation is executed on specific hardware arises. Using these techniques, this work focuses on the acceleration of polynomial multiplication in the encryption process for resource-constrained devices. For this purpose, several hardware multiplications are analyzed following different strategies, taking into account the fact that there are no possible timing information leaks and that the available resources are optimized as much as possible. The designed multiplier is encapsulated as a fully reusable and parametrizable IP module with standard AXI4-Stream interconnection buses, which makes it easy to integrate into embedded systems implemented on programmable devices from different manufacturers. Depending on the resource constraints imposed, accelerations of up to 30–45 times with respect to the software-level multiplication runtime can be achieved using dedicated hardware, with a device occupancy of around 5%