The Spanish Pancreatic Club recommendations for the diagnosis and treatment of chronic pancreatitis: Part 1 (diagnosis)

Chronic pancreatitis (CP) is a relatively uncommon, complex and heterogeneous disease. The absence of a gold standard applicable to the initial phases of CP makes its early diagnosis difficult. Some of its complications, particularly chronic pain, can be difficult to manage. There is much variability in the diagnosis and treatment of CP and its complications amongst centers and professionals. The Spanish Pancreatic Club has developed a consensus on the management of CP. Two coordinators chose a multidisciplinary panel of 24 experts on this disease. A list of questions was drafted, and two experts reviewed each question. Then, a draft was produced and shared with the entire panel of experts and discussed in a face-to-fac

The Spanish Pancreatic Club's recommendations for the diagnosis and treatment of chronic pancreatitis: Part 2 (treatment)

Chronic pancreatitis (CP) is a complex disease with a wide range of clinical manifestations. This range comprises from asymptomatic patients to patients with disabling symptoms or complications. The management of CP is frequently different between geographic areas and even medical centers. This is due to the paucity of high quality studies and clinical practice guidelines regarding its diagnosis and treatment. The aim of the Spanish Pancreatic Club was to give current evidence-based recommendations for the management of CP. Two coordinators chose a multidisciplinary panel of 24 experts on this disease. These experts were selected according to clinical and research experience in CP. A list of questions was made and two experts reviewed each question. A draft was later produced and discussed with the entire panel of experts in a face-to-face meeting. The level of evidence was based on the ratings given by the Oxford Centre for Evidence-Based Medicine. In the second part of the consensus, recommendations were given regarding the management of pain, pseudocysts, duodenal and biliary stenosis, pancreatic fistula and ascites, left portal hypertension, diabetes mellitus, exocrine pancreatic insufficiency, and nutritional support in CP

Heat Shock Response in Yeast Involves Changes in Both Transcription Rates and mRNA Stabilities

We have analyzed the heat stress response in the yeast Saccharomyces cerevisiae by determining mRNA levels and transcription rates for the whole transcriptome after a shift from 25°C to 37°C. Using an established mathematical algorithm, theoretical mRNA decay rates have also been calculated from the experimental data. We have verified the mathematical predictions for selected genes by determining their mRNA decay rates at different times during heat stress response using the regulatable tetO promoter. This study indicates that the yeast response to heat shock is not only due to changes in transcription rates, but also to changes in the mRNA stabilities. mRNA stability is affected in 62% of the yeast genes and it is particularly important in shaping the mRNA profile of the genes belonging to the environmental stress response. In most cases, changes in transcription rates and mRNA stabilities are homodirectional for both parameters, although some interesting cases of antagonist behavior are found. The statistical analysis of gene targets and sequence motifs within the clusters of genes with similar behaviors shows that both transcriptional and post-transcriptional regulons apparently contribute to the general heat stress response by means of transcriptional factors and RNA binding proteins

The miniJPAS survey: Identification and characterization of galaxy populations with the J-PAS photometric system

Full list of authors: González Delgado, R. M.; Díaz-García, L. A.; de Amorim, A.; Bruzual, G.; Cid Fernandes, R.; Pérez, E.; Bonoli, S.; Cenarro, A. J.; Coelho, P. R. T.; Cortesi, A.; García-Benito, R.; López Fernández, R.; Martínez-Solaeche, G.; Rodríguez-Martín, J. E.; Magris, G.; Mejía-Narvaez, A.; Brito-Silva, D.; Abramo, L. R.; Diego, J. M. ; Dupke, R. A.; Hernán-Caballero, A.; Hernández-Monteagudo, C.; López-Sanjuan, C.; Marín-Franch, A.; Marra, V.; Moles, M.; Montero-Dorta, A.; Queiroz, C.; Sodré, L.; Varela, J.; Vázquez Ramió, H.; Vílchez, J. M.; Baqui, P. O.; Benítez, N.; Cristóbal-Hornillos, D.; Ederoclite, A.; Mendes de Oliveira, C.; Civera, T.; Muniesa, D.; Taylor, K.; Tempel, E.; J-PAS Collaboration.The Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS) will soon start imaging thousands of square degrees of the northern sky with its unique set of 56 filters (spectral resolution of R - 60). Before the arrival of the final instrument, we observed 1 deg2 on the AEGIS field with an interim camera with all the J-PAS filters. Taking advantage of these data, dubbed miniJPAS, we aim at proving the scientific potential of the J-PAS to derive the stellar population properties of galaxies via fitting codes for spectral energy distributions (SEDs), with the ultimate goal of performing galaxy evolution studies across cosmic time. One parametric (BaySeAGal) and three non-parametric (MUFFIT, AlStar, and TGASPEX) SED-fitting codes are used to constrain the stellar mass, age, metallicity, extinction, and rest-frame and dust-corrected (u-r) colours of a complete flux-limited sample (rSDSS - 22.5 AB) of miniJPAS galaxies that extends up to z = 1. We generally find consistent results on the galaxy properties derived from the different codes, independently of the galaxy spectral type or redshift; this is remarkable considering that 25% of the J-spectra have signal-to-noise ratios (S/N) -3. For galaxies with S=N - 10, we estimate that the J-PAS photometric system will allow us to derive the stellar population properties of rest-frame (u - r) colour, stellar mass, extinction, and mass-weighted age with a precision of 0:04 - 0:02 mag, 0:07 - 0:03 dex, 0:2 - 0:09 mag, and 0:16 - 0:07 dex, respectively. This precision is equivalent to that obtained with spectroscopic surveys of similar S/N. By using the dust-corrected (u - r) colour mass diagram, a powerful proxy for characterizing galaxy populations, we find: (i) that the fraction of red and blue galaxies evolves with cosmic time, with red galaxies being -38% and -18% of the whole population at z = 0:1 and z = 0:5, respectively, and (ii) consistent results between codes for the average intrinsic (u-r) colour, stellar mass, age, and stellar metallicity of blue and red galaxies and their evolution up to z = 1. At all redshifts, the more massive galaxies belong to the red sequence, and these galaxies are typically older and more metal-rich than their counterparts in the blue cloud. Our results confirm that with J-PAS data we will be able to analyse large samples of galaxies up to z - 1, with galaxy stellar masses above log(M?=M-) - 8:9, 9.5, and 9.9 at z = 0:3, 0.5, and 0.7, respectively. The star formation history of a complete sub-sample of galaxies selected at z - 0:1 with log(M=M-) > 8:3 constrains the cosmic evolution of the star formation rate density up to z - 3, in good agreement with results from cosmological surveys. © ESO 2021.Acknowledgements. R.G.D., L.A.D.G., R.G.B., G.M.S., J.R.M., and E.P. acknowledge financial support from the State Agency for Research of the Spanish MCIU through the “Center of Excellence Severo Ochoa” award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709), and to the AYA2016-77846-P and PID2019-109067-GB100. L.A.D.G. also acknowledges financial support by the Ministry of Science and Technology of Taiwan (grant MOST 106-2628-M-001-003-MY3) and by the Academia Sinica (grant AS-IA-107-M01). G.B. acknowledges financial support from the National Autonomous University of México (UNAM) through grant DGAPA/PAPIIT IG100319 and from CONACyT through grant CB2015-252364. SB acknowledges PGC2018-097585-B-C22, MINECO/FEDER, UE of the Spanish Ministerio de Econo-mia, Industria y Competitividad. L.S.J. acknowledges support from Brazilian agencies FAPESP (2019/10923-5) and CNPq (304819/201794). P.O.B. acknowledges support from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001. P.R.T.C. acknowledges financial support from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) process number 2018/05392-8 and Conselho Nacional de Desenvolvi-mento Científico e Tecnológico (CNPq) process number 310041/2018-0. V.M. thanks CNPq (Brazil) for partial financial support. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 888258. E.T. acknowledges support by ETAg grant PRG1006 and by EU through the ERDF CoE grant TK133. Based on observations made with the JST/T250 telescope and PathFinder camera for the miniJPAS project at the Observatorio Astrofísico de Javalambre (OAJ), in Teruel, owned, managed, and operated by the Centro de Estudios de Física del Cosmos de Aragón (CEFCA). We acknowledge the OAJ Data Processing and Archiving Unit (UPAD) for reducing and calibrating the OAJ data used in this work. Funding for OAJ, UPAD, and CEFCA has been provided by the Governments of Spain and Aragón through the Fondo de Inver-siones de Teruel; the Aragón Government through the Research Groups E96, E103, and E16_17R; the Spanish Ministry of Science, Innovation and Universities (MCIU/AEI/FEDER, UE) with grant PGC2018-097585-B-C21; the Spanish Ministry of Economy and Competitiveness (MINECO/FEDER, UE) under AYA2015-66211-C2-1-P, AYA2015-66211-C2-2, AYA2012-30789, and ICTS-2009-14; and European FEDER funding (FCDD10-4E-867, FCDD13-4E-2685).Peer reviewe

Analysis of the immune system of multiple myeloma patients achieving long-term disease control by multidimensional flow cytometry

Spanish Myeloma Group (GEM) and Grupo Castellano-Leones de Gammapatias Monoclonales, cooperative study groups: et al.Multiple myeloma remains largely incurable. However, a few patients experience more than 10 years of relapsefree survival and can be considered as operationally cured. Interestingly, long-term disease control in multiple myeloma is not restricted to patients with a complete response, since some patients revert to having a profile of monoclonal gammopathy of undetermined significance. We compared the distribution of multiple compartments of lymphocytes and dendritic cells in the bone marrow and peripheral blood of multiple myeloma patients with long-term disease control (n=28), patients with newly diagnosed monoclonal gammopathy of undetermined significance (n=23), patients with symptomatic multiple myeloma (n=23), and age-matched healthy adults (n=10). Similarly to the patients with monoclonal gammopathy of undetermined significance and symptomatic multiple myeloma, patients with long-term disease control showed an expansion of cytotoxic CD8 + T cells and natural killer cells. However, the numbers of bone marrow T-regulatory cells were lower in patients with long-term disease control than in those with symptomatic multiple myeloma. It is noteworthy that B cells were depleted in patients with monoclonal gammopathy of undetermined significance and in those with symptomatic multiple myeloma, but recovered in both the bone marrow and peripheral blood of patients with long-term disease control, due to an increase in normal bone marrow B-cell precursors and plasma cells, as well as pre-germinal center peripheral blood B cells. The number of bone marrow dendritic cells and tissue macrophages differed significantly between patients with long-term disease control and those with symptomatic multiple myeloma, with a trend to cell count recovering in the former group of patients towards levels similar to those found in healthy adults. In summary, our results indicate that multiple myeloma patients with long-term disease control have a constellation of unique immune changes favoring both immune cytotoxicity and recovery of B-cell production and homing, suggesting improved immune surveillance.This work was supported by the Cooperative Research Thematic Network (RTICCs; RD06/0020/0006 and G03/136), Instituto de Salud Carlos III/ Subdirección General de Investigación Sanitaria (FIS: PI060339; 06/1354; 02/0905; 01/0089/01-02; PS09/01897/01370) and Consejeria de Educacion (GR37) and Consejería de Sanidad, Junta de Castilla y León, Valladolid, Spain (557/A/10). The authors also thank the Fundación Carolina-BBVA for supporting and promoting the exchange of medical researchers from Latin America to Spain.Peer Reviewe

Introducción al patrimonio geológico de interés turístico de la Red Española de Reservas de la Biosfera

160 p.Esta publicación se ha realizado con el objetivo de describir el origen y formación de una buena parte del patrimonio geológico de interés turístico de la Red Española de Reservas de la Biosfera para que éste sea conocido y pueda ser utilizado como motor de desarrollo económico local. La necesidad de dar a conocer este sorprendente patrimonio natural de la Red español de Reservas de la Biosfera fue constatada por su Consejo de Gestores que encargó el trabajo a su Consejo Científico. La publicación tiene la vocación de ser accesible para todos los públicos. Sin embargo, parte de un trabajo bibliográfico profundo abordado con una rigurosa metodología científica. Es además el fruto de una continua colaboración de los editores con las personas gestoras de las Reservas de la Biosfera españolas, así como con varios miembros de su Consejo Científico asesor.Instituto Geológico y Minero de España, Españ

Differences in nutrient composition of sea fennel (Crithmum maritimum) grown in different habitats and optimally controlled growing conditions

10 páginas.- 1 figura.- 5 tablas.- referenciasCrithmum maritimum L. is an edible halophyte with large potential in human nutrition field. However, it is unclear whether its nutritional value is maintained throughout the contrasting habitats where it commonly grows (cliffs, sandy and rocky beaches) and the nutritional profile of cultivated plants still remains uncertain. In this work, we provided for the first time a comparison of the nutritional profile of C. maritimum across its different type of habitats in the south of Spain and between wild plants and plant material under optimal growing conditions. The protein, amino acids, lipids, fatty acids, minerals composition and phenolic content of plants were analysed. Plants under field conditions exhibited a nutritionally balanced composition (3.8–6.2 g protein/100 g DW, 4.9–7.5 mg lipids/g WW, 3.9–5.0 g Na/100 g DW), with high phenolic content (30.2–48.0 mg/g DW) regardless of the variability of the contrasting habitats. In contrast, under optimal conditions, C. maritimum showed a greater protein and lipid content (10.2 g/100 g DW and 9.6 mg/g WW, respectively), and lower sodium accumulation (1.2 g/100 g DW), allowing a greater consumption of this halophyte without exceeding the daily intake recommendations. Conversely, phenolics were strongly decreased in these plants (6.1 mg/g DW) likely due to the absence of stress factors. © 2021 Elsevier Inc.This work was financially supported by two grants from the Spanish Ministry of Science, Innovation and Universities (RTI2018-099260-A- I00 to J. Cambroll é and RTI2018-099322-B-100 to X. Moreira).Peer reviewe