A Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study

Metabolically unhealthy obesity (MUO) is a regular state in people with primary hypertension (HTN), obesity, and who are physically inactive. To achieve and maintain a metabolically healthy overweight/obese (MHO) state should be a main treatment goal. The aims of the study were (1) to determine differences in metabolic profiles of overweight/obese, physically inactive individuals with HTN following a 16-week (POST) supervised aerobic exercise training (SupExT) intervention with an attentional control (AC) group, and (2) to determine whether the changes observed were maintained following six months (6 M) of unsupervised time. Participants (n = 219) were randomly assigned into AC or SupExT groups. All participants underwent a hypocaloric diet. At POST, all participants received diet and physical activity advice for the following 6 M, with no supervision. All measurements were assessed pre-intervention (PRE), POST, and after 6 M. From PRE to POST, MUO participants became MHO with improved (p < 0.05) total cholesterol (TC, ∆ = −12.1 mg/dL), alanine aminotransferase (∆ = −8.3 U/L), glucose (∆ = −5.5 mg/dL), C-reactive protein (∆ = −1.4 mg/dL), systolic blood pressure (SBP), and cardiorespiratory fitness (CRF) compared to unhealthy optimal cut-off values. However, after 6 M, TC, glucose, and SBP returned to unhealthy values (p < 0.05). In a non-physically active population with obesity and HTN, a 16-week SupExT and diet intervention significantly improves cardiometabolic profile from MUO to MHO. However, after 6 M of no supervision, participants returned to MUO. The findings of this study highlight the need for regular, systematic, and supervised diet and exercise programs to avoid subsequent declines in cardiometabolic health.P.C., A.M.A.-B., and I.G.-A. were supported by the Basque Government with predoctoral grants. This study was supported by the University of the Basque Country (EHU14/08, PPGA18/15)

Proteomic identification of s-nitrosylated proteins in arabidopsis thaliana in response to pathogen infection

Comunicaciones a congreso

Increasing the sensivity of proteomic identification of s-nitrosylated proteins: towards the S-nitrosoproteomes in (patho)physiological settings

Comunicaciones a congreso

Why the sea doesn’t escape if it has only got sand holding it? Inquiry at the beach

En el presente artículo mostramos el diseño de una secuencia de indagación basada en modelos para Primaria para pensar, hacer, hablar y sentir sobre la playa. Esta secuencia surge de la reflexión de una educadora ambiental tras desarrollar el típico activismo de limpieza de costas o juegos motrices sobre biodiversidad, impactos o pesca.In the current paper the design of a teaching sequence through Model-Based Inquiry for Primary School is presented. Primary school students are engaged to think, do, talk, and feel science at the beach. This sequence arises from an environmental educator reflections after participating in the common activism activities of coast-cleaning or games on fishing and its environmental impacts on biodiversity.

Criteria for spectral classification of cool stars using high-resolution spectra

We have compiled a large number of optical spectra of cool stars taken with different high-resolution echelle spectrographs (R ≃ 40 000). Many of those are available as spectral libraries (Montes et al. 1997, 1998, 1999,

KEOPS project: Research on sustainable high-added value alkali-activated concretes based on industrial waste

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The CRISPR conundrum: evolve and maybe die, or survive and risk stagnation

CRISPR-Cas represents a prokaryotic defense mechanism against invading genetic elements. Although there is a diversity of CRISPR-Cas systems, they all share similar, essential traits. In general, a CRISPR-Cas system consists of one or more groups of DNA repeats named CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), regularly separated by unique sequences referred to as spacers, and a set of functionally associated cas (CRISPR associated) genes typically located next to one of the repeat arrays. The origin of spacers is in many cases unknown but, when ascertained, they usually match foreign genetic molecules. The proteins encoded by some of the cas genes are in charge of the incorporation of new spacers upon entry of a genetic element. Other Cas proteins participate in generating CRISPR-spacer RNAs and perform the task of destroying nucleic acid molecules carrying sequences similar to the spacer. In this way, CRISPR-Cas provides protection against genetic intruders that could substantially affect the cell viability, thus acting as an adaptive immune system. However, this defensive action also hampers the acquisition of potentially beneficial, horizontally transferred genes, undermining evolution. Here we cover how the model bacterium Escherichia coli deals with CRISPR-Cas to tackle this major dilemma, evolution versus survival.The authors are supported by grants BIO2014-53029-P (Ministerio de Economía y Competitividad, Spain), 291815 Era-Net ANIHWA (7th Framework Programme, European Commission) and PROMETEO/2017/129 (Conselleria d'Ed-ucació, Investigació, Cultura i Esport, Generalitat Valenciana, Spain)

Prediciendo reingresos hospitalarios no planificados antes de 15 días: una aplicación de la regresión logística

Hospital readmission is considered a key research area for improving care coordination and achieving potential savings. This is important because hospital readmissions can have negative consequences in terms of good health and recovery for patients. It is thus important to significantly reduce such readmissions. Unfortunately, there isn't a one-size-fits-all solution to preventing hospital readmissions. There are many variables outside of hospitals' direct control, such as social determinants and patient lifestyle factors, impacting readmissions. Although several studies have been undertaken to investigate 30-day readmissions, predicting revisits in shorter intervals (e.g., within 15 days after discharge) is highly needed to capture hospital-attributable returns better and develop more effective improvement plans. Hence, the aim of this paper is three-fold: i) to develop a comprehensive experimental study for identifying factors affecting 15-day readmission risk, ii) to classify patients according to the risk of 15-day readmission using logistic regression, and iii) provide general recommendations to reduce the 15-day readmission risk considering different predictors. To this end, the patients' characteristics were first described. Then, the significance of potential predictors, their interactions, and their effects were assessed. After this, a logistic regression model was derived to predict the likelihood of 15-day readmission in each patient. Finally, general recommendations were provided to reduce 15-day revisits. A real case study in Colombia was considered to validate the proposed methodology

También las publicaciones deben comprometerse con el impacto social

Recientemente el gobierno español ha modifi-cado los criterios de evaluación del profesorado universitario, introduciendo el valor cualitativo a la hora de determinar el peso de las publicaciones. Hasta ahora y desde hace más de una década se venía haciendo exclusivamente a través de un indicador indirecto: el Factor de Impacto que reciben las revistas científicas. Aunque tímidamente, el nue-vo criterio supone una ruptura al menos conceptual: al exigir a los académicos que muestren la repercu-sión bibliométrica de algunas de sus publicaciones, se está lanzando el mensaje de que lo importante es el impacto social del conocimiento,2 más que la producción acumulada del mismo. De alguna ma-nera se pone de manifiesto la preocupación que nuestras autoridades tienen sobre la escasa capaci-dad competitiva de nuestra actividad investigadora