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Biomimetic hierarchical micro/nano texturing of TiAlV alloys by femtosecond laser processing for the control of cell adhesion and migration

The control of the interaction between materials and biological tissues is a key factor to optimize the overall performance of implants and prostheses integrated into the body. With this objective in mind, biomimetic hierarchical one- and two-dimensional surface patterns textured at the micro and nano scales were fabricated on titanium alloys using femtosecond laser processing. The experimental results show that laser irradiation promotes surface oxidation together with a polarization-dependent nano-ripple formation. Human mesenchymal stem cells were subsequently cultured on different surface patterns aiming at determining their response to the underlying micro and nano structures. The ripple topography was demonstrated to induce a nonfouling behavior, which could be exploited in the fabrication of biomimetic hierarchical surface patterns to develop cell-trapping modulesThe authors are grateful for funding provided by Ministerio de Economía y Competitividad (Spain), under project reference numbers MAT2014-54826-C2-1-R and MAT2014-54826-C2-2-R and NanoNeuroDev (Grant No. 2017/EEUU/11) from Santander-Universida

Active case-finding for TB among incarcerated women in Peru

Carta al editorRevisión por pare

Lack of sex-related analysis and reporting in Cochrane Reviews : a cross-sectional study

Background: Sex-specific analysis and reporting may allow a better understanding of intervention effects and can support the decision-making process. Well-conducted systematic reviews (SRs), like those carried out by the Cochrane Collaboration, provide clinical responses transparently and stress gaps of knowledge. This study aimed to describe the extent to which sex is analysed and reported in a cross-section of Cochrane SRs of interventions, and assess the association with the gender of main authorships. Methods: We searched SRs published during 2018 within the Cochrane Database of Systematic Reviews. An investigator appraised the sex-related analysis and reporting across sections of SRs and collected data on gender and country of affiliation of the review first and last authors, and a second checked for accuracy. We conducted descriptive statistics and bivariate logistic regression to explore the association between the gender of the authors and sex-related analysis and reporting. Results: Six hundred and ten Cochrane SRs were identified. After removing those that met no eligibility criteria, 516 reviews of interventions were included. Fifty-six reviews included sex-related reporting in the abstract, 90 considered sex in their design, 380 provided sex-disaggregated descriptive data, 142 reported main outcomes or performed subgroup analyses by sex, and 76 discussed the potential impact of sex or the lack of such on the interpretations of findings. Women represented 53.1 and 42.2% of first and last authorships, respectively. Women authors (in first and last position) had a higher possibility to report sex in at least one of the review sections (OR 2.05; CI 95% 1.12-3.75, P=0.020) than having none. Conclusions: Sex consideration amongst Cochrane SRs was frequently missing. Structured guidance to sex-related analysis and reporting is needed to enhance the external validity of findings. Likewise, including gender diversity within the research workforce and relevant authorship positions may foster equity in the evidence generated

Motion of CMS detector and mechanical structures during Magnet Cycles and Stability Periods from 2008 to 2013 as observed by the Link Alignment System

Magnet Cycles and Stability Periods of the CMS Experiment are studied with the Alignment Link System data recorded along the 2008-2013 years of operation. The motions of the mechanical structures due to the magnetic field forces are studied and the mechanical stability of the detector during the physics data taking periods is verified.Peer Reviewe

Observation of two excited Bc+ states and measurement of the Bc+ (2S) mass in pp collisions at √s = 13 TeV

CMS Collaboration: et al.Signals consistent with the Bc+(2S) and Bc∗+(2S) states are observed in proton-proton collisions at √s = 13 TeV, in an event sample corresponding to an integrated luminosity of 143 fb-1, collected by the CMS experiment during the 2015-2018 LHC running periods. These excited bc states are observed in the Bc+π+π- invariant mass spectrum, with the ground state Bc+ reconstructed through its decay to J/ψπ+. The two states are reconstructed as two well-resolved peaks, separated in mass by 29.1±1.5(stat)±0.7(syst) MeV. The observation of two peaks, rather than one, is established with a significance exceeding five standard deviations. The mass of the Bc+(2S) meson is measured to be 6871.0±1.2(stat)±0.8(syst)±0.8(Bc+) MeV, where the last term corresponds to the uncertainty in the world-average Bc+ mass

Fine synchronization of the CMS muon drift-tube local trigger using cosmic rays

33 páginas, 12 figuras.-- Open Access.-- CMS Collaboration: et al.The CMS experiment uses self-triggering arrays of drift tubes in the barrel muon trigger to perform the identification of the correct bunch crossing. The identification is unique only if the trigger chain is correctly synchronized. In this paper, the synchronization performed during an extended cosmic ray run is described and the results are reported. The random arrival time of cosmic ray muons allowed several synchronization aspects to be studied and a simple method for the fine synchronization of the Drift Tube Local Trigger at LHC to be developed.Individuals have received support from the Marie-Curie IEF program (European Union); the Leventis Foundation; the A. P. Sloan Foundation; and the Alexander von Humboldt Foundation.Peer reviewe

Commissioning and performance of the CMS silicon strip tracker with cosmic ray muons

46 páginas, 17 figuras, 8 tablas.-- Open Access.-- CMS Collaboration: et al.During autumn 2008, the Silicon Strip Tracker was operated with the full CMS experiment in a comprehensive test, in the presence of the 3.8 T magnetic field produced by the CMS superconducting solenoid. Cosmic ray muons were detected in the muon chambers and used to trigger the readout of all CMS sub-detectors. About 15 million events with a muon in the tracker were collected. The efficiency of hit and track reconstruction were measured to be higher than 99% and consistent with expectations from Monte Carlo simulation. This article details the commissioning and performance of the Silicon Strip Tracker with cosmic ray muons.Individuals have received support from the Marie-Curie IEF program (European Union); the Leventis Foundation; the A. P. Sloan Foundation; and the Alexander von Humboldt Foundation.Peer reviewe

Search for Low-Mass Quark-Antiquark Resonances Produced in Association with a Photon at s =13 TeV

A search for narrow low-mass resonances decaying to quark-antiquark pairs is presented. The search is based on proton-proton collision events collected at 13 TeV by the CMS detector at the CERN LHC. The data sample corresponds to an integrated luminosity of 35.9 fb-1, recorded in 2016. The search considers the case where the resonance has high transverse momentum due to initial-state radiation of a hard photon. To study this process, the decay products of the resonance are reconstructed as a single large-radius jet with two-pronged substructure. The signal would be identified as a localized excess in the jet invariant mass spectrum. No evidence for such a resonance is observed in the mass range 10 to 125 GeV. Upper limits at the 95% confidence level are set on the coupling strength of resonances decaying to quark pairs. The results obtained with this photon trigger strategy provide the first direct constraints on quark-antiquark resonance masses below 50 GeV obtained at a hadron collider