Effects of basic infrastructure on ENLACE Test of High School Technology Mexican

Bajo la teoría de capital humano, la educación se concibe como auspiciadora de capital humano y económico. La inversión en capital humano puede reflejarse a mediano plazo en el logro académico de los estudiantes. El logro académico es un indicador de la eficacia de las políticas educativas, sin embargo, en Latino América hay pocos estudios que analicen los efectos que tienen los insumos o el gasto de inversión en el desempeño de los estudiantes. En el presente estudio se analizó una muestra de 538 escuelas de educación media superior con el fin de evaluar los efectos que tiene el número de alumnos por grupo y el número de alumnos por clase sobre el logro académico. Se realizó análisis factorial confirmatorio y un modelo estandarizado con análisis de senderos por Máxima Verosimilitud para infraestructura y logro académico. Se encontró que el incremento de alumnos por grupo y el número de alumnos por clase aumenta la cantidad de alumnos que obtienen niveles de ejecución elemental tanto en habilidad lectora como en habilidad matemática. Así también, disminuye el número de alumnos con desempeño excelente en ambas habilidades. Estos resultados respaldan la evidencia que indica que la infraestructura escolar afecta el desempeño o logro educativo.Under human capital theory, education is seen as sponsor of human and economic capital. Investment in human capital in the medium term may be reflected in the students' academic achievement. Academic achievement is an indicator of the effectiveness of education policies, however, in Latin America there are few studies analyzing effects of inputs or investment spending on student performance. In this study were considered 538 high schools (vocational School) in order to assess effects of number of students per classroom and number of students per class in academic achievement. We carry out a confirmatory factorial analysis and a structural model by Maximum-likelihood Paths for infrastructure and academic achievement. Was found that increase of students per classroom and per class have negative effects because these increase on quantity of students with low levels on reading and mathematical abilities. Also, was reducing the number of students with excellent performance in both skills. These results support the evidence that scholar infrastructure has effects on academic achievement

Clinical Data, Comorbidities, and Mortality of COVID-19 in the State of Guanajuato, Mexico until May 20, 2020

Introduction: In December 2019, cases of pneumonia of unknown cause arose in Wuhan, China. The causative agent was subsequently identified as 2019-nCoV and later called SARS-CoV-2. In Mexico, since January 2020 when the first cases were reported, the spread of the infection has occurred throughout the country. The state of Guanajuato, which is located in the center of the country, has taken isolation measures and closed public places in March 2020. The objective of this study was to analyze the evolution, symptoms, co-morbidities and deaths due to confirmed cases of COVID-19.Methods: An ecological study was designed from the database of confirmed cases of COVID-19 in the state of Guanajuato. Odds ratios and 95% confidence intervals were calculated for symptoms and co-morbidities in deaths of confirmed cases. Logistic regression models were generated adjusting for age group and gender.Results: Among the 838 confirmed cases in the state, cases with dyspnea and cyanosis showed more significant effect on death. Age group and gender had little involvement as confounders. For practically all comorbidities (including diabetes, hypertension, cardiovascular disease, chronic kidney disease, and immunosuppression), there was a significant effect (odds ratio greater than 2) on mortality from COVID-19. Age group showed a confounding effect on comorbidities and death, but not gender.Conclusion: The confirmed cases had more than twice the possibility of having comorbidities, compared with those who did not die

Formation of the University Faculty in Methodological Stategies to Incorporation of E-Learning in European Space of Higher Education

El documento que presentamos, es una síntesis de una propuesta que presentamos al Ministerio de Educación español, y se acoge a la línea de trabajo sobre «el proceso de aprendizaje en el marco del EEES: estrategias universitarias», centrándonos más concretamente en el desarrollo de nuevas metodologías docentes y del evaluación del aprendizaje así como en el análisis y creación de estrategias para la docencia universitaria orientadas al desarrollo del aprendizaje electrónico.The document that present, is a synthesis of a proposal that present to Department of Spanish Education, and is received to the line of work on the «process of learning in Europe Space for Higher Education: university strategies», centering us more concretely in the development educational of new methodologies and of the evaluation of the learning as well as in the analysis and creation of strategies for the university teaching oriented toward development of the electronic learning

Aerosol radiative forcing efficiency in the UV region over southeastern Mediterranean: VELETA2002 campaign

Atmospheric aerosol effects on spectral global UV irradiance were evaluated during the VELETA2002 field campaign between 8 and 19 July 2002 in southeast Spain. In the first stage, seven UV spectroradiometer and six CIMEL Sun photometer measurements were carried out simultaneously, allowing them to be calibrated and intercompared. The mean ratio obtained for the global irradiance between the spectroradiometers, with regards to a reference instrument, ranges from 0.98 up to 1.04 with standard deviations that oscillate between ±0.01 and ±0.17. In particular, the two spectroradiometers used to obtain the aerosol forcing efficiencies have a ratio of 1.000 ± 0.001. The aerosol optical depth (AOD) obtained with the CIMEL Sun photometers has a standard deviation of lower than ±0.01 for all the channels. Under clear sky conditions, the diurnal aerosol forcing efficiency (DDFe) and fractional diurnal forcing efficiency (DFDFe) was calculated for two Mediterranean stations: Armilla (691 m.a.s.l.) within the boundary layer and Sabinas (2200 m.a.s.l) on the lower limit of the free troposphere and 25 km away from the first station. The DDFe values obtained at Armilla range between _2.72 ± 0.45 W m_2/t380 and _2.88 ± 0.45 W m_2/t440 and between _3.22 ± 0.61 W m_2/t380 and _3.40 ± 0.62 W m_2/t440 at Sabinas station; the DFDFe values range from _8.0 ± 1.4%/t380 to _8.6 ± 1.3%/t440 and _12.0 ± 2.3%/t380 to _12.6 ± 2.3%/t440 at the two stations, respectively. Also, an experimental aerosol transmittance factor, CT, used to obtain UV satellite derived products was found as a result of the dependence of the global irradiance with the AOD, under cloudless conditions. The average aerosol attenuation factor, h, obtained from the CT, is 6 ± 2% under weakly absorbing aerosols, with a negligible spectral dependence.This work was supported by CICYT–MCYT through the coordinated projects CGL2004-05984-C07-05 and CGL2005-03428-C04-02

Introducción al patrimonio geológico de interés turístico de la Red Española de Reservas de la Biosfera

160 p.Esta publicación se ha realizado con el objetivo de describir el origen y formación de una buena parte del patrimonio geológico de interés turístico de la Red Española de Reservas de la Biosfera para que éste sea conocido y pueda ser utilizado como motor de desarrollo económico local. La necesidad de dar a conocer este sorprendente patrimonio natural de la Red español de Reservas de la Biosfera fue constatada por su Consejo de Gestores que encargó el trabajo a su Consejo Científico. La publicación tiene la vocación de ser accesible para todos los públicos. Sin embargo, parte de un trabajo bibliográfico profundo abordado con una rigurosa metodología científica. Es además el fruto de una continua colaboración de los editores con las personas gestoras de las Reservas de la Biosfera españolas, así como con varios miembros de su Consejo Científico asesor.Instituto Geológico y Minero de España, Españ

The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent.

BACKGROUND AND AIMS Alcohol-associated liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial dysfunction is one of the earliest manifestations of alcohol-induced injury, restoring mitochondrial activity remains a problematic strategy due to oxidative stress. Here, we identify methylation-controlled J protein (MCJ) as a mediator for ALD progression and hypothesize that targeting MCJ may help in recovering mitochondrial fitness without collateral oxidative damage. APPROACH AND RESULTS C57BL/6 mice [wild-type (Wt)] Mcj knockout and Mcj liver-specific silencing (MCJ-LSS) underwent the NIAAA dietary protocol (Lieber-DeCarli diet containing 5% (vol/vol) ethanol for 10 days, plus a single binge ethanol feeding at day 11). To evaluate the impact of a restored mitochondrial activity in ALD, the liver, gut, and pancreas were characterized, focusing on lipid metabolism, glucose homeostasis, intestinal permeability, and microbiota composition. MCJ, a protein acting as an endogenous negative regulator of mitochondrial respiration, is downregulated in the early stages of ALD and increases with the severity of the disease. Whole-body deficiency of MCJ is detrimental during ALD because it exacerbates the systemic effects of alcohol abuse through altered intestinal permeability, increased endotoxemia, and dysregulation of pancreatic function, which overall worsens liver injury. On the other hand, liver-specific Mcj silencing prevents main ALD hallmarks, that is, mitochondrial dysfunction, steatosis, inflammation, and oxidative stress, as it restores the NAD + /NADH ratio and SIRT1 function, hence preventing de novo lipogenesis and improving lipid oxidation. CONCLUSIONS Improving mitochondrial respiration by liver-specific Mcj silencing might become a novel therapeutic approach for treating ALD.This work was supported by grants from Ministerio de Ciencia e Innovación, Programa Retos-Colaboración RTC2019-007125-1 (for Jorge Simon and Maria Luz Martinez-Chantar); Ministerio de Economía, Industria y Competitividad, Retos a la Sociedad AGL2017- 86927R (for F.M.); Instituto de Salud Carlos III, Proyectos de Investigación en Salud DTS20/00138 and DTS21/00094 (for Jorge Simon and Maria Luz Martinez-Chantar, and Asis Palazon. respectively); Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias co-founded by European Regional Development Fund/European Social Fund, “Investing in your future” PI19/00819, “Una manera de hacer Europa” FIS PI20/00765, and PI21/01067 (for Jose J. G. Marin., Pau Sancho-Bru,. and Mario F. Fraga respectively); Departamento de Industria del Gobierno Vasco (for Maria Luz Martinez-Chantar); Asturias Government (PCTI) co-funding 2018-2023/ FEDER IDI/2021/000077 (for Mario F. Fraga.); Ministerio de Ciencia, Innovación y Universidades MICINN: PID2020-117116RB-I00, CEX2021-001136-S PID2020-117941RB-I00, PID2020-11827RB-I00 and PID2019-107956RA-100 integrado en el Plan Estatal de Investigación Científica y Técnica y Innovación, cofinanciado con Fondos FEDER (for Maria Luz Martinez-Chantar, Francisco J Cubero., Yulia A Nevzorova and Asis Palazon); Ayudas Ramón y Cajal de la Agencia Estatal de Investigación RY2013-13666 and RYC2018- 024183-I (for Leticia Abecia and Asis Palazon); European Research Council Starting Grant 804236 NEXTGEN-IO (for Asis Palazon); The German Research Foundation SFB/TRR57/P04, SFB1382-403224013/ A02 and DFG NE 2128/2-1 (for Francisco J Cubero and Yulia A Nevzorova); National Institute of Health (NIH)/National Institute of Alcohol Abuse and Alcoholism (NIAAA) 1U01AA026972-01 (For Pau Sancho-Bru); Junta de Castilla y León SA074P20 (for Jose J. G. Marin); Junta de Andalucía, Grupo PAIDI BIO311 (for Franz Martin); CIBERER Acciones Cooperativas y Complementarias Intramurales ACCI20-35 (for Mario F. Fraga); Ministerio de Educación, Cultura y Deporte FPU17/04992 (for Silvia Ariño); Fundació Marato TV3 201916-31 (for Jose J. G. Marin.); Ainize Pena-Cearra is a fellow of the University of the Basque Country (UPV/ EHU); BIOEF (Basque Foundation for Innovation and Health Research); Asociación Española contra el Cáncer (Maria Luz Martinez-Chantar and Teresa C. Delgado.); Fundación Científica de la Asociación Española Contra el Cáncer (AECC Scientific Foundation) Rare Tumor Calls 2017 (for Maria Luz Martinez-Chantar); La Caixa Foundation Program (for Maria Luz Martinez-Chantar); Proyecto Desarrollo Tecnologico CIBERehd (for Maria Luz Martinez-Chantar); Ciberehd_ISCIII_MINECO is funded by the Instituto de Salud Carlos III.S

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO

Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO

Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary file