A useful form of the recurrence relation between relativistic atomic matrix elements of radial powers

Recently obtained recurrence formulae for relativistic hydrogenic radial matrix elements are cast in a simpler and perhaps more useful form. This is achieved with the help of a new relation between the $r^a$ and the $\beta r^b$ terms ($\beta$ is a $4\times 4$ Dirac matrix and $a, b$ are constants) in the atomic matrix elements.Comment: 7 pages, no figure

Nutrición parenteral e identificación de subpoblaciones con necesidades nutricionales similares

[email protected] disponibilidad de formulaciones parenterales normalizadas en relación a los aportes de nutrientes, plantea la problemática de su idoneidad en relación a las necesidades nutritivas de los pacientes. El objetivo de este trabajo es identificar subpoblaciones de pacientes con necesidades calórico-proteicas similares y valorar su adecuación a formulaciones normalizadas. Con este fin, se evaluaron, de forma prospectiva las necesidades calórico- proteicas de 100 pacientes adultos metabólicamente estables en tratamiento con nutrición parenteral total. Los aportes calóricos se estudiaron por Harris-Benedict (con corrección de Long) y los aportes proteicos se calcularon en función del grado de estrés. Las necesidades calórico-proteicas se analizaron mediante un análisis de cluster mediante el algoritmo de partición alrededor de los mediodes. Se consideró que cuando la formulación de nutrición parenteral contenía aportes equivalentes a ± 20% de las necesidades medias de cada subpoblación era adecuada para satisfacer los requerimientos calórico- proteicos de los pacientes. El porcentaje de pacientes, en función del número de subpoblaciones identificadas, que recibirían aportes adecuados a sus requerimientos se tomó como variable de estudio comparativo. En el caso de dos subpoblaciones, para la subpoblación 1 (N = 35), las necesidades de glucosa, lípidos y aminoácidos son: 275 (IC 95%: 265-285) g, 83 (IC 95%: 78- 88) g y 89 (IC 95%: 86-92) y para la subpoblación 2 (N = 65), 195 (IC 95%: 187-203) g, 58 (IC 95%: 56-61) g y 74 (IC 95%: 72-77) g, respectivamente. En el caso de tres subpoblaciones, estas mismas necesidades de nutrientes son para la subpoblación 1 (N = 19): 295 (IC 95%: 283- 306) g, 91 (IC 95%: 84-97) g y 91 (IC 95%: 86-95); para la subpoblación 2 (N = 45), 234 (IC 95%: 227-240) g, 67 (IC 95%: 64-70) g, y 84 (IC 95%: 82-86) g; y para la subpoblación 3 (N = 36): 172 (IC 95%: 165-179) g, 55 (IC 95%: 52-57) g y 68 (IC 95%: 64-71) g, respectivamente. La utilización de una, dos o tres formulaciones, que contengan aportes equivalentes a ± 20% de las necesidades medias de cada subpoblación, satisfacen los requerimientos de glucosa, lípidos y proteínas en el 45% (IC 95%: 36% a 55%), 74% (IC 95%: 65% a 83) y 82% (IC 95%: 74% a 89%) de los pacientes, respectivamente. En suma, el desarrollo de tres formulaciones normalizadas de nutrición parenteral permite satisfacer las necesidades nutricionales de al menos el 74% de los pacientes adultos metabólicamente estables subsidiarios de nutrición parenteral total.The aim of this study is to identify patients subpopulations with similar caloric and proteic needs (CPN) and developing and assessing the utility of standarized formulations of total parenteral nutrition (TPN) with equivalents supplies to the average patients needs of each identified subpopulation. CPN of one hundred metabolically stables adults patients in treatment with TPN were evaluated consecutively. Caloric supplies were calculated with the Harris-Benedict equation, with the Long corrections and proteics supplies were evaluated according to stress level. The identification of patients subpopulation according to the CPN was made through the cluster analysis with partitioning around mediods algorithm. We considered the formulation with equivalent supplies to the average needs of each subpopulation was adequated to the patients caloric-proteic requirements when their difference was lower than 20%. The percentage of patients who received adequated supplies were compared between the subpopulations identified. In case of two subpopulations, glucose, lipids and amino acid needs are: 275 (CI 95%: 265-285) g, 83 (CI 95%: 78-88) g and 89 (CI 95%: 86-92) g in subpopulation 1 (N = 35), and 195 (CI 95%: 187-203) g, 58 (CI 95%: 56-61) g and 74 (CI 95%: 72-77) g in subpopulation 2 (N = 65), respectively. In case of three subpopulations, in subpopulation 1 (N = 19), glucose, lipids and amino acid needs are: 295 (CI 95%: 283-306) g, 91 (CI 95%: 84-97) g and 91 (CI 95%: 86-95); 234 (CI 95%: 227-240) g, 67 (CI 95%: 64-70) g and 84 (CI 95%: 82-86) g to the subpopulation 2 (N = 45) and 172 (CI 95%: 165- 179) g, 55 (CI 95%: 52-57) g, and 68 (CI 95%: 64-71) g to the subpopulation 3 (N = 36) respectively. In general, caloric and proteic supplies are equal to the patients needs, but there was a tendendy to overfeeding in patients with lower CPN. The utilization of one, two or three formulations with equivalent supplies to the average needs of each subpopulation was adequated to the patients in the 45% (CI 95%: 36%-55%), 75% (CI 95%: 65%- 83%) and 82% (CI 95%: 74%-89%), respectively. Therefore, the development of three normalized formulations of total parenteral nutrition allows to satisfy the patients nutritional needs at least the 74% of the patients

Molecular and Functional Characterization of Novel Fructosyltransferases and Invertases from Agave tequilana

Fructans are the main storage polysaccharides found in Agave species. The synthesis of these complex carbohydrates relies on the activities of specific fructosyltransferase enzymes closely related to the hydrolytic invertases. Analysis of Agave tequilana transcriptome data led to the identification of ESTs encoding putative fructosyltransferases and invertases. Based on sequence alignments and structure/function relationships, two different genes were predicted to encode 1-SST and 6G-FFT type fructosyltransferases, in addition, 4 genes encoding putative cell wall invertases and 4 genes encoding putative vacuolar invertases were also identified. Probable functions for each gene, were assigned based on conserved amino acid sequences and confirmed for 2 fructosyltransferases and one invertase by analyzing the enzymatic activity of recombinant Agave protein s expressed and purified from Pichia pastoris. The genome organization of the fructosyltransferase/invertase genes, for which the corresponding cDNA contained the complete open reading frame, was found to be well conserved since all genes were shown to carry a 9 bp mini-exon and all showed a similar structure of 8 exons/7 introns with the exception of a cell wall invertase gene which has 7 exons and 6 introns. Fructosyltransferase genes were strongly expressed in the storage organs of the plants, especially in vegetative stages of development and to lower levels in photosynthetic tissues, in contrast to the invertase genes where higher levels of expression were observed in leaf tissues and in mature plants

Peroxidase expression in a cereal cyst nematode (Heterodera avenae) resistant hexaploid wheat line.

The incompatible interaction between plant and pathogen is often determined by the hypersensitive reaction (HR). This response is associated with accumulation of reactive oxygen species (ROS), which results in adverse growth conditions for pathogens. Two major mechanisms involving either NADPH oxidases or peroxidases have been proposed for generation of ROS. Peroxidases (PER, EC 1.11.1.7), present in all land plants, are members of a large multigenic family with high number of isoforms involved in a broad range of physiological processes. PER genes, which are expressed in nematode feeding sites, have been identified in several plant species (Zacheo et al. 1997). A strong correlation between HR and PER activities at four and seven days post nematode infection, was detected in roots of wheat lines carrying Cre2, Cre5 (from Ae. ventricosa) or Cre7 (from Ae. triuncialis) Heterodera avenae resistance genes (Andrés et al. 2001; Montes et al. 2003, 2004). We have studied changes in root of peroxidase mRNAs levels after infection by H. avenae of a wheat/Ae. ven¬tricosa introgression line (H-93-8) carrying Cre2 (Delibes et al. 1993). We also report and classify the predicted protein sequences derived from complete peroxidase transcripts

Whole-nanoparticle atomistic modelling of the schwertmannite structure from total scattering data

Schwertmannite is a poorly crystalline nanometric iron sulfate oxyhydroxide. This mineral shows a structural variability under different environments. Because of that, the determination of its structure and, consequently, of its physical–chemical properties is quite challenging. This article presents a detailed structural investigation of the structure of schwertmannite conducted under different approaches: X-ray absorption spectroscopy, Rietveld refinement, and a combined reverse Monte Carlo and Debye function analysis of the whole nanoparticle structure. The schwertmannite model presented here is, to the auhors' knowledge, the most complete model so far reported.This work has been supported by a grant from Labex OSUG@2020 (Investissements d'avenir - ANR10 LABX56). SC was partially funded by a 'Nano Espagne' fellowship (Campus France)

Design and manufacture of a customised temporomandibular prosthesis

In this work, design, manufacture and surgical success of a personalised temporomandibular prosthesis is featured. A fused deposition modelling technique and Die forging process constitute the methodology used in a patient who had an amputation in the upper third branch of the mandible, without considering the joint capsule. The implant was designed using a processed resection image of a computational tomography and using the methodology of Özkaya and Nordin. The jaw operating conditions were simulated by the finite element method (FEM). The main considered factors were the morphological geometry of the patient, implant fixation in the first third of the branch, implant fixation on the chin, dental post for placement of the teeth, and the form of the sub-lingual fossa weight optimisation. Special consideration was to preserve the patients facial aesthetics.Peer Reviewe

Estudio de las diferencias en aspectos psicomotores, perceptivo motores y afectivo relacionales con respecto a variables personales en niños de 5 años.

La psicomotricidad es la interacción que se produce entre la actividad cognitiva y la función motriz del cuerpo. El análisis del desarrollo psicomotríz es el estudio del progreso de dicha interacción en los niños. Actualmente es un tema muy importante en la educación infantil pues existe una gran dependencia entre el desarrollo motor, afectivo y cognitivo. Es por este motivo que el objetivo del presente trabajo es analizar la influencia de características personales (si ha sido un niño prematuro y su género); familiares (si es un hijo único o por el contrario tiene hermanos) y educativas (tipo de colegio en el que estudia y si realiza actividades extraescolares deportivas) sobre tres factores del desarrollo psicomotríz en niños de 5 años.2017-1

Propuesta de Investigación-Acción Participativa para los Menores Desmovilizados mediante el Muro Virtual

En Colombia, la guerrilla de las FARC ha reclutado entre 9000 y 15000 niños según el Instituto Colombiano de Bienestar Familiar (ICBF), de los cuales la mayoría está ya desmovilizado después del proceso de paz desarrollado en la Habana. Es de suma importancia que las instituciones promuevan la participación eficaz de estos menores desmovilizados ya que tienen mucho que decir, además, el fortalecimiento de la comunicación es de suma importancia tras un proceso de desmovilización como el que se ha vivido en el país, además de ser un derecho fundamental en la infancia (Save the Children, 2006; Sauri, 2009). Para fomentar la participación de estos menores es necesario detectar sus necesidades, debilidades, fortalezas y así poder ejecutar propuestas de intervención realistas. Los menores desmovilizados deben desarrollar competencias para participar de forma activa en la sociedad. Diversas investigaciones han encontrado que la participación de los menores en el ámbito social no suele ser muy alta (Jackson, 1991) se encuentran con muchas barreras a la hora de participar como miedos a expresarse (posibles represalias), falta de espacio y tiempo para reunirse, timidez, desconfianza o un clima que no favorece la participación. Otra de las dificultades que refieren es que no ven la utilidad de la participación y creen que sus propuestas no serán consideradas y que no producirán ningún efecto o cambio concretado en acciones (Granizo, 2011). Es por estos motivos que el objetivo de la presente ponencia es presentar una propuesta de investigación-acción para escuchar las voces de los niños y jóvenes desmovilizados del conflicto armado en Colombia mediante la mediante la utilización del muro virtual.2017-1

Regulation and role of the PP2A-B56 holoenzyme family in cancer

Protein phosphatase 2A (PP2A) inactivation is common in cancer, leading to sustained activation of pro-survival and growth-promoting pathways. PP2A consists of a scaffolding A-subunit, a catalytic C-subunit, and a regulatory B-subunit. The functional complexity of PP2A holoenzymes arises mainly through the vast repertoire of regulatory B-subunits, which determine both their substrate specificity and their subcellular localization. Therefore, a major challenge for developing more effective therapeutic strategies for cancer is to identify the specific PP2A complexes to be targeted. Of note, the development of small molecules specifically directed at PP2A-B56α has opened new therapeutic avenues in both solid and hematological tumors. Here, we focus on the B56/PR61 family of PP2A regulatory subunits, which have a central role in directing PP2A tumor suppressor activity. We provide an overview of the mechanisms controlling the formation and regulation of these complexes, the pathways they control, and the mechanisms underlying their deregulation in cancer