Discrimination of the effects on zebrafish reproduction from pollutans in drinking water via female , via male and/or via fecundation water

[EN] The lack of preventive policy legislation and the low removal rate of organic pollutants in conventional potabilization treatments lead to some of them being present in drinking water. The problem arises because some of these substances have detrimental effects on human reproduction health, via females, via males or even both. In this work, we established the zebrafish as a bioindicator of these types of substances with the goal of discriminating the effects through three different pathways: male, female or water where the fertilization took place. For this purpose, four parameters were analysed: fertility rate, hatching rate and survival and abnormalities rates. So, for each parameter two groups were formed, according to whether adult males or females were reared in bottled spring water (Z) or tap water (B) and if the in vitro fertilization took place in water Z or B. Results revealed a decline in the fertility and hatching rate in water B, due to a water effect. The most plausible explanation could be the presence of substances which affect the micropyle and chorion. Moreover, a decrease in the fertility rate due to an effect over the female was also observed, but in this case by an alteration of the oocyte quality.Martínez-Sales, MI.; García Ximenez, F.; Espinos Gutierrez, FJ. (2016). Discrimination of the effects on zebrafish reproduction from pollutans in drinking water via female , via male and/or via fecundation water. Zygote. 24(4):563-567. doi:10.1017/S0967199415000532S56356724

Zebrafish as a possible bioindicator of organic pollutans in drinking waters with effects on reproduction: are effects accumulative or reversible ?

[EN] Due to inefficient detection and removal treatments, organic pollutants are present in drinking waters. For this reason, zebrafish is proposed as a complementary control measure in conventional potabilization treatments. According to the most sensitive parameters (hatching rate, fertility rate and underdeveloped specimens) detected in our previous work, in the current work we attempt to study, in these parameters, the possible cumulative effect of environmental pollutants likely present in drinking waters, between generations, when specimens are cultured in the same water in both generations and/or the possible reversibility of these effects when cultured in control water. To this end, batches of 20 embryos with the chorion intact were cultured in 3 drinking waters from different sources (A, B and C) and in one control water up to 5 months, in 20 l tanks. Four replicates were performed in all water groups, with a total of 28 aquariums. Results in water C revealed a non-reversible effect on fertility rate, and also in water C an alteration of sex ratio towards females, although in this case the alteration was reversible. A transgenerational alteration in the germline via epigenetic mechanism from the previous generation is proposed as the most plausible explanation to this effect.Martínez-Sales, MI.; García Ximenez, F.; Espinos Gutierrez, FJ. (2016). Zebrafish as a possible bioindicator of organic pollutans in drinking waters with effects on reproduction: are effects accumulative or reversible ?. Zygote. 24(5):692-699. doi:10.1017/S0967199415000702S69269924

Zebrafish as a possible bioindicator of organic pollutants with effects on reproduction in drinking waters

[EN] Organic contaminants can be detected at low concentrations in drinking water, raising concerns for human health, particularly in reproduction. In this respect, we attempted to use the zebrafish as a bioindicator to detect the possible presence of these substances in drinking water, aiming to define the most relevant parameters to detect these substances, which particularly affect the development and reproduction of zebrafish. To this end, batches of 30 embryos with the chorion intact were cultured in drinking waters from different sources, throughout their full life-cycle up to 5 months, in 20 L tanks. Six replicates were performed in all water groups, with a total of 24 aquariums. Two generations (F0 and Fl) were studied and the following parameters were tested: in the F0 generation, survival and abnormality rates evaluated at 5 dpf (days post-fertilization) and at 5 mpf (months post-fertilization), the onset of spawning and the fertility rate from 3 mpf to 5 mpf, and the sex ratio and underdeveloped specimens at 5 mpf. Furthermore, in the F0 offspring (F1), survival and abnormality rates were evaluated at 5 dpf and the hatching rate at 72 hpf. These results revealed that the hatching rate is the most sensitive parameter to distinguish different levels of effects between waters during the early life stages, whereas the rate of underdeveloped specimens is more suitable at later life stages. Regarding adult reproduction, fertility rate was the most sensitive parameter. The possible reversibility or accumulative nature of such effects will be studied in future work. (C) 2015 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.Martínez-Sales, MI.; García Ximenez, F.; Espinos Gutierrez, FJ. (2015). Zebrafish as a possible bioindicator of organic pollutants with effects on reproduction in drinking waters. Journal of Environmental Sciences. 33(1):254-260. doi:10.1016/j.jes.2014.11.012S25426033

Ecocardiografía; visión de un cardiólogo en formación y opinión del experto

La ecocardiografía es una herramienta imprescindible para la cardiología contemporánea. Su aprendizaje constituye un reto para los residentes de cardiología. Se exponen algunas consideraciones de un cardiólogo en formación y las de un experto en imagen cardíaca sobre este proceso de formación en ecocardiografía.

Thermodynamic Properties for the Simulation of Crude Oil Primary Refining

Commonly, the use of simulators in the industry is performed without having a proper theoretical support. Sometimes this situation is a consequence of both, lack of time and the dairy dynamism required in the refinery industries. Particularly, the application of thermodynamic models is often not properly considered for the specific process under analysis. An undesirable fact can appear, for example, when a wrong properties package is chosen or even more when this selection step is completely ignored. The aim of this article is to prove that the habitual selection of the thermodynamic models is appropriate or not for the primary refining process. For the purpose, two available simulation softwares and thermodynamic models have been analyzed. The research paper focuses on establishing a guide for plant operators with information that has been previously proven, with theoretical support. In particular, for the oil crude atmospheric distillation (Topping), engineers use almost by default the Peng– Robinson thermodynamic package in Aspen Hysys simulator and Chao–Seader in Aspen Plus. Although the use of the thermodynamic property packages involves a whole theoretical support, this is not considered at the time of their election.Fil: Gutierrez, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación para la Industria Química (i); ArgentinaFil: Benitez, Leonel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); ArgentinaFil: Martínez, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación para la Industria Química (i); ArgentinaFil: Ale Ruiz, Liliana. Universidad Nacional de Salta. Facultad de Ingenieria; ArgentinaFil: Erdmann, Eleonora. Instituto Tecnologico de Buenos Aires; Argentin

Sarcoma de Ewing extraóseo en cabeza y cuello: revisión de la literatura a propósito de un caso

ResumenIntroducciónEl sarcoma de Ewing extraesquelético (SEE) es un tumor maligno muy poco frecuente. La región de la cabeza y el cuello es una localización primaria inusual para este tipo de tumor.Material y métodosEl objetivo de esta revisión es identificar las principales localizaciones dentro de cabeza y cuello. Para ello se realizó una búsqueda en la base de datos MEDLINE. Se analizaron múltiples variables. Se realiza la revisión a propósito un caso clínico de un paciente con SEE en la mejilla.ResultadosDe un total de 31 pacientes, se reportan 18 casos en cabeza y 13 en cuello.ConclusionesEn nuestra revisión no pudimos determinar ninguna localización que sea de mayor frecuencia en esta región. Las pruebas de imagen son útiles para estadificar, y son necesarios estudios anatomopatológicos para confirmar el diagnóstico. El tratamiento intensivo es el de mayor eficacia.AbstractIntroductionExtraskeletal Ewing's sarcoma (EES) is a rare malignant neoplasm. It is a highly unusual finding in the head and neck region.Material and methodsThe aim of this review is to identify the main sites in the head and neck region, by searching in the MEDLINE database. A wide range of variables were analysed. This review was carried out due to a case report of a patient with EES of the cheek.ResultsOut of a total of 31 patients, there were 18 cases in the head and 13 in the neck.ConclusionsIn our review it was not possible to determine a more frequent head and neck location. The imaging studies are useful for staging, and the histology to confirm the diagnosis. An aggressive treatment has demonstrated to be more effective

Propuesta de Método Delphi en Políticas Públicas de Innovación

En este artículo se presenta una propuesta de análisis y priorización de políticas públicas de innovación a través de la aplicación del método Delphi, el propósito fundamental es el de brindar elementos para responder a la pregunta: ¿existen buenas prácticas en políticas de innovación en Colombia? Para aportar a este cuestionamiento, se realizó un método de consulta a expertos anónima – Delphi con 92 variables en dos rondas, el cual fue enviado a representantes de universidades, empresas gobierno y entidades de interfaz de Colombia, con el fin de que priorizaran las políticas de innovación de Colombia al 2025. El documento está dividido en varias secciones, se presenta una revisión sobre los conceptos de política de innovación, posteriormente se hace una revisión de políticas públicas de innovación en los tigres asiáticos y en algunos países de la OCDE así como un análisis del marco legal de la innovación en Colombia, el estudio termina con la aplicación del método Delphi en políticas públicas de innovación en Colombia al 2025

Bridging universities and industry through cleaner production activities. Experiences from the Cleaner Production Center at the University of Cienfuegos, Cuba

The involvement of universities is crucial to identify how Cleaner Production strategies are formed in practice so that companies integrate sustainability into their strategies. This paper discusses the experience of establishing and operating the Cleaner Production Center at the University of Cienfuegos. From 2008 to 2011, the University of Cienfuegos, the Free University of Brussels (Belgium) and the University of Leuven (Belgium) implemented a project, financially supported by the Flemish Interuniversity Council (Belgium) allowing establishing a Cleaner Production Center at the University of Cienfuegos. This first project was followed by a second University of Cienfuegos - University of Leuven one. So far, the collaboration allowed to establish a master program on Cleaner Production that constitutes a bridge between the university and the production and service sector, allowing to promote and implement cleaner production strategies. 34 master students graduated during two graduations and a third one is ongoing. Among the most important results of the master thesis were the yearly reduction of the emission of 60 000 t/a of carbon dioxide equivalent and of the electricity consumption by 400 MWh/a at a cement plant. Research activities on Cleaner Production were upgraded through the collaboration resulting in several publications in peer-reviewed journals with impact factor. This type of North-South cooperation aided establishing and developing the center, by transferring expertise and experience and by providing part of the necessary funding which is difficult to raise by developing economies. This case study offers an interesting practice example about developing academic (training, research) values on Cleaner Production