Social application with Pepper Robot

Pepper robot is a social robot with the ability of maintaining a dynamic communication with people. The aim of this project is to develop a system based on face detection and recognition as a kind of interactive app for people, especially for kids and children with disabilities. The robot has to be able to recognize the person who is in front of it, performing predefined movements and holding a basic real-time conversation based on the children's preferences (favourite color, hobbies, etc.)

Real-time data quality control applied at OBSEA

The expandable seafoor observatory OBSEA (https://obsea.es) is located at 4 Km of Vilaonva i la Geltrú (Catalonia, Spain) at 20 m depth. This cabled observatory obtains diferent environmental data from a meteorological station, CTD sensor, hydrophone, ADCP, buoy and seismometer. Previously, the quality control of the acquired data was not in real-time and oversighted erroneous data values guiding to a misunderstanding of the environment. Accounting that the data collected from the OBSEA observatory needs to comply with the Copernicus Marine Environment Monitoring Service (CMEMS) In Situ Thematic Assembly Center (INS TAC) procedures and the inefciency of the previous data quality control processes, a new automatic realtime data quality control system has been developed. The quality control consists of a set of automatic tests according to the manual for real-time quality control of in-situ temperature and salinity data of the Quality Assurance/Quality Control of Real Time Oceanographic Data (QARTOD, https://ioos.noaa.gov/project/qartod) project of the Integrated Ocean Observing System (IOOS, https://ioos.noaa.gov). The follow-through of the QARTOD manual for the development of the tests was made considering the community acceptance, notability and previous work of the IOOS.Peer Reviewe

Study of optimization design criteria for stand-alone hybrid renewable power systems

Hybrid renewable power systems integrate two or more sources of energy, one of which is renewable, optionally a storage system and typically work in stand-alone mode. They are being considered more and more and we should increment their usage taking advantage of their positive benefits: free of charge resource availability, CO2 emissions reductions and subsidies. Dealing with their inconveniences: variability of renewable resources availability and cost acquisition, through the optimization of the design and the control of the system. The optimal design of hybrid renewable power systems is usually defined by economic criteria. But there are also technical and environmental criteria to be taken into account to improve decision-making. In this paper a discussion on different criteria will introduce the non-economical perspectives in addition to the economic criteria. A case study of a PV-Wind-Diesel-Battery system for a Telecommunication station in Catalonia is discussed. Availability of renewable energy sources is obtained with RETScreen and PVSyst. Analysis and simulations of various hybrid power systems have been done in HOMER resulting on a comparison of different scenarios. Optimal scenario taking into account the best results of all three types of criteria: economic, technical and environmental, is a trade-off of the economic optimum.Postprint (published version

Examining Topoisomers of a Snake-Venom-Derived Peptide for Improved Antimicrobial and Antitumoral Properties

Ctn[15-34], the C-terminal section of crotalicidin (Ctn), a cathelicidin from a South American pit viper, is an antimicrobial and antitumoral peptide with remarkably longer stability in human serum than the parent Ctn. In this work, a set of topoisomers of both Ctn and Ctn[15-34], including the retro, enantio, and retroenantio versions, were synthesized and tested to investigate the structural requirements for activity. All topoisomers were as active as the cognate sequences against Gram-negative bacteria and tumor cells while slightly more toxic towards normal cells. More importantly, the enhanced serum stability of the D-amino-acid-containing versions suggests that such topoisomers must be preferentially considered as future antimicrobial and anticancer peptide leads

A Kinematic Sensor and Algorithm to Detect Motor Fluctuations in Parkinson Disease : Validation Study Under Real Conditions of Use

A new algorithm has been developed, which combines information on gait bradykinesia and dyskinesia provided by a single kinematic sensor located on the waist of Parkinson disease (PD) patients to detect motor fluctuations (On- and Off-periods). The goal of this study was to analyze the accuracy of this algorithm under real conditions of use. This validation study of a motor-fluctuation detection algorithm was conducted on a sample of 23 patients with advanced PD. Patients were asked to wear the kinematic sensor for 1 to 3 days at home, while simultaneously keeping a diary of their On- and Off-periods. During this testing, researchers were not present, and patients continued to carry on their usual daily activities in their natural environment. The algorithm's outputs were compared with the patients' records, which were used as the gold standard. The algorithm produced 37% more results than the patients' records (671 vs 489). The positive predictive value of the algorithm to detect Off-periods, as compared with the patients' records, was 92% (95% CI 87.33%-97.3%) and the negative predictive value was 94% (95% CI 90.71%-97.1%); the overall classification accuracy was 92.20%. The kinematic sensor and the algorithm for detection of motor-fluctuations validated in this study are an accurate and useful tool for monitoring PD patients with difficult-to-control motor fluctuations in the outpatient setting

Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism

[EN] Diclofenac (DCF) can cause adverse reactions such as gastrointestinal, renal and cardiovascular disorders; therefore, topical administration may be an attractive alternative to the management of local pain in order to avoid these side effects. However, previous studies have shown that DCF, in combination with sunlight, displays capability to induce photosensitivity disorders. In humans, DCF is biotransformed into hydroxylated metabolites at positions 4¿ and 5 (4¿OH-DCF and 5OH-DCF), and this chemical change produces non negligible alterations of the drug chromophore, resulting in a significant modification of its light-absorbing properties. In the present work, 5OH-DCF exhibited higher photo(geno)toxic potential than the parent drug, as shown by several in vitro assays (3T3 NRU phototoxicity, DNA ssb gel electrophoresis and COMET), whereas 4¿OH-DCF did not display significant photo(geno)toxicity. This could be associated, at least partially with their more efficient UV-light absorption by 5OH-DCF metabolite and with a higher photoreactivity. Interestingly, most of the cellular DNA damage photosensitized by DCF and 5OH-DCF was repaired by the cells after several hours, although this effect was not complete in the case of 5OH-DCF.This work was supported by the Carlos III Institute of Health (Grants: RD16/0006/0030, PI16/01877), by the MINECO (Grants: CTQ2013-47872, CTQ2016-78875), and by the Generalitat Valenciana (Prometeo 2017/075).García -Laínez, G.; Ana M Marínez-Reig; Limones Herrero, D.; Jiménez Molero, MC.; Miranda Alonso, MÁ.; Andreu Ros, MI. (2018). Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism. Toxicology and Applied Pharmacology. 341:51-55. https://doi.org/10.1016/j.taap.2018.01.005S515534

Predictive and Prognostic Brain Metastases Assessment in Luminal Breast Cancer Patients: FN14 and GRP94 from Diagnosis to Prophylaxis

FN14 has been implicated in many intracellular signaling pathways, and GRP94 is a well-known endoplasmic reticulum protein regulated by glucose. Recently, both have been associated with metastasis progression in breast cancer patients. We studied the usefulness of FN14 and GRP94 expression to stratify breast cancer patients according their risk of brain metastasis (BrM) progression. We analyzed FN14 and GRP94 by immunohistochemistry in a retrospective multicenter study using tissue microarrays from 208 patients with breast carcinomas, of whom 52 had developed BrM. Clinical and pathological characteristics and biomarkers expression in Luminal and non-Luminal patients were analyzed using a multivariate logistic regression model adjusted for covariates, and brain metastasis-free survival (BrMFS) was estimated using the Kaplan–Meier method and the Cox proportional hazards model. FN14 expression was associated with BrM progression mainly in Luminal breast cancer patients with a sensitivity (53.85%) and specificity (89.60%) similar to Her2 expression (46.15 and 89.84%, respectively). Moreover, the likelihood to develop BrM in FN14-positive Luminal carcinomas increased 36.70-fold (3.65–368.25, p = 0.002). Furthermore, the worst prognostic factor for BrMFS in patients with Luminal carcinomas was FN14 overexpression (HR = 8.25; 95% CI: 2.77–24.61; p = 0.00015). In these patients, GRP94 overexpression also increased the risk of BrM (HR = 3.58; 95% CI: 0.98–13.11; p = 0.054—Wald test). Therefore, FN14 expression in Luminal breast carcinomas is a predictive/prognostic biomarker of BrM, which combined with GRP94 predicts BrM progression in non-Luminal tumors 4.04-fold (1.19–8.22, p = 0.025), suggesting that both biomarkers are useful to stratify BrM risk at early diagnosis. We propose a new follow-up protocol for the early prevention of clinical BrM of breast cancer patients with BrM risk

Resource pulse in shallow waters: characterization of the scavenger community associated with a dolphin carcass

OCEANS 2023, 05-08 June 2023, Limerick.-- 5 pages, 3 figures, 3 tables.-- © 20XX IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other worksNumerous studies have focused on the scavenger communities that feed on the carcasses of large marine animals, such as whales, in deep-sea habitats. Yet, there are far fewer studies in shallow water ecosystems and especially in the Mediterranean. Here, we performed an artificial cetacean fall in shallow waters in the northwestern Mediterranean. The cetacean carcass was monitored by via 30-min time-lapse photos using a fixed camera. We observed that bony fish were the main scavenger taxa. In addition, different species arrived at different times perhaps reflecting their role as scavengers or active predatorsWe thank the financial support from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)Peer reviewe