1,267 research outputs found

    El compás del baile entre la arquitectura y el sistema de información y comunicación de una organización

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    Este ensayo pretende destacar la necesidad de un sistema de información y comunicación en los diferentes entes económicos locales, tanto del sector público como del privado. Por medio de la relación del tema analizado con un baile armónico, se busca plantear que ese mundo económico no puede dejar de incluir la parte emocional del ser y que pese a que se desarrollen sistemas, metodologías, modelos y parámetros, las organizaciones siempre deberán tener en cuenta que la cultura será transformada por la capacidad de los visionarios que logran interiorizar, analizar y diluir los deseos de otros seres humanos

    The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines

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    Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of the user (“set”) and the surroundings (“setting”). The observation of cross-tolerance and a series of empirical studies in humans and animal models support agonism at the serotonin (5-HT)2A receptor as a common mechanism for the action of psychedelics. The diversity of subjective effects elicited by different compounds has been attributed to the variables of “set” and “setting,” to the binding affinities for other 5-HT receptor subtypes, and to the heterogeneity of transduction pathways initiated by conformational receptor states as they interact with different ligands (“functional selectivity”). Here we investigate the complementary (i.e., not mutually exclusive) possibility that such variety is also related to the binding affinity for a range of neurotransmitters and monoamine transporters including (but not limited to) 5-HT receptors. Building on two independent binding affinity datasets (compared to “in silico” estimates) in combination with natural language processing tools applied to a large repository of reports of psychedelic experiences (Erowid’s Experience Vaults), we obtained preliminary evidence supporting that the similarity between the binding affinity profiles of psychoactive substituted phenethylamines and tryptamines is correlated with the semantic similarity of the associated reports. We also showed that the highest correlation was achieved by considering the combined binding affinity for the 5-HT, dopamine (DA), glutamate, muscarinic and opioid receptors and for the Ca+ channel. Applying dimensionality reduction techniques to the reports, we linked the compounds, receptors, transporters and the Ca+ channel to distinct fingerprints of the reported subjective effects. To the extent that the existing binding affinity data is based on a low number of displacement curves that requires further replication, our analysis produced preliminary evidence consistent with the involvement of different binding sites in the reported subjective effects elicited by psychedelics. Beyond the study of this particular class of drugs, we provide a methodological framework to explore the relationship between the binding affinity profiles and the reported subjective effects of other psychoactive compounds.Fil: Zamberlan, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Sanz, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Martínez Vivot, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Pallavicini, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Erowid, Fire. Grass Valley; Estados UnidosFil: Erowid, Earth. Grass Valley; Estados UnidosFil: Tagliazucchi, Enzo Rodolfo. Institut du cerveau et de la moelle épinière; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentin

    Perception and enterprise communication networks to improve the requirements elicitation process

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    The requirements elicitation phase of software development projects is characterised by the intensity and importance of communication activities. Requirements elicitation is a traditional exploratory phase in which context is analysed and an abstraction is performed as a consequence. However, exploratory processes are characterised by a deep interaction with environmental factors. In this paper, we present a process for managing communication during the requirements elicitation phase. Our process would help get well-defined requirements by using knowledge inside organisations and a classification of requirements perception based on how environment is controlled by stakeholders. Our approach can be used to guide the elicitation process as well as to validate the requirements.Eje: Procesamiento Concurrente, Paralelo y DistribuidoRed de Universidades con Carreras en Informática (RedUNCI

    Active Q-switching of a fiber laser using a modulated fiber Fabry-Perot filter and a fiber bragg grating

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    Abstract:We propose and demonstrate a simple and robust actively Q-switched Erbium-doped fiber ring cavity laser. The Q-switching is based on dynamic spectral overlapping of two filters, namely a fiber Bragg grating based filter and a fiber Fabry – Perot tunable filter. Using 3.5 meters of Erbium-doped fiber and a pump power of only 60 mW, Q-switched pulses with a peak power of 9.7 W and a pulse duration of 500 ns were obtained. A pulse repetition rate can be continuously varied from a single shot to a few KHz

    Madres y padres de familia sumu-tuahka en las actividades escolares de sexto grado, escuela bilingüe: Ronas Dolares, comunidad de Wasakin, primer cuatrimestre del 2008

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    The present investigation values ​​the participation of Sumu – tuahka parents, in the school activities of the sixth grade students, Ronas Dolores Bilingual School, Wasakin Community. The cultural practice of Sumo – tuahka indigenous peoples differs with mestizo culture and other ethnic groups. This is linked to the worldview and the way in which ancestral knowledge is transmitted. This study is qualitative of a descriptive type. The study population are parents, students, teachers, principals, School Council and community leaders. The techniques used were interviews, observation and group discussion. Most fathers do not make follow-up visits at school, this work falls almost exclusively on mothers. Among the argued reasons are: little support from parents to their children, poverty, little time and illiteracy. There is ignorance of the role played by the School Council and the community leaders who do not assume their role for the educational benefit of children in school. The perception of the parents is that: "The responsibility of guaranteeing the care of the center and keeping the infrastructure in good condition corresponds to the leaders, nevertheless, they are not interested in education but they only care about their own benefit". The low participation of parents affects the children morally, this is reflected in the academic performance, which is better in those students whose parents are more aware of their performance in the school.La presente investigación valora la participación de madres y padres de familia sumu tuahka, en las actividades escolares de los estudiantes del sexto grado, escuela bilingüe: “Ronas Dolores”, comunidad de Wasakin. La práctica cultural de los pueblos indígenas sumo - tuahka difiere con la cultura mestiza y otros grupos étnicos. Esto está vinculado con la cosmovisión y la forma en que se transmiten los conocimientos ancestrales. Este estudio es cualitativo de tipo descriptivo. La población de estudio son madres y padres de familia, estudiantes, docentes, directores, Consejo Escolar y líderes comunales. Las técnicas empleadas fueron entrevistas, observación y discusión grupal. La mayoría de los padres de familia no hacen visitas de seguimiento en la escuela, esta labor recae casi exclusivamente en las madres. Dentro de las razones que se argumentan son: el poco apoyo de los padres a sus hijos, la pobreza, el poco tiempo y el analfabetismo. Hay desconocimiento del papel que juega el Consejo Escolar y los líderes comunales no asumen su rol para el beneficio educativo de la niñez en la escuela. La percepción de los padres y madres es que: “La responsabilidad de garantizar el cuido del centro y mantener en buenas condiciones la infraestructura corresponde a los líderes. Pero, a éstos no les interesa la educación sino que sólo les importa su propio beneficio”. La poca participación de las madres y padres de familia afecta moralmente a la niñez, eso se refleja en el rendimiento académico, el cual es mejor en aquellos estudiantes cuyos padres están más pendientes de su desempeño en el centro escolar

    Wavelength and power stabilization of a three wavelength erbium doped fiber laser using a Nonlinear Optical Loop Mirror

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    Abstract: This paper describes the use of a Nonlinear Loop Mirror to achieve wavelength and power stabilization in a three wavelength Erbium doped fiber ring laser. The laser uses three fiber Bragg grating reflectors as the oscillation wavelength selecting filters. The influence of the length of the Nonlinear Loop Mirror (NOLM) on the laser stability both in terms of wavelength and laser output power was investigated. The laser performance was improved by changing the length of the Loop Mirror to an optimal length and three simultaneous wavelength oscillations with acceptable power and wavelength stability were achieved

    Chunky graphite in spheroidal graphite iron: review of recent results and definition of an predicting index

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    International audienceGraphite degeneracy in heavy-section spheroidal graphite cast irons is mostly associated with the formation of chunky graphite which consists of large eutectic cells with interconnected graphite strings. At low level, appearance of chunky graphite is limited to its non-aesthetic effect on machined surfaces, while at higher level it is detrimental for mechanical properties of the components. Chunky graphite is often related to high silicon levels and too high cerium additions during the spheroidization treatment. The appearance of this defect may be limited by controlled additions of antimony that is thought to tight the excess of cerium, but other impurities and low level elements may have to be considered during melt preparation. This contribution proposes a review of recent results and approaches on chunky graphite appearance, primarily but not exclusively in the case of heavy-section cast irons. Based on this literature review and series of experimental data, a predictive index for evaluating the risk of chunky graphite appearance is proposed. Lines for further research work aimed at a better understanding of graphite degeneracy are finally suggested. Introduction The need for melt control before casting of spheroidal graphite cast irons have led for long to look for graphite degeneracy as resulting from melt chemistry. Thielemann developed a trace element evaluation number S b for assessing the ability of the charge to give well-formed nodules [1]

    Discurso al asumir el rectorado de la Universidad

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