New data from Orihuela and Callosa Mountains (Betic Internal Zone, Alicante, SE Spain). Implications for the “Almágride Complex” controversy

In this paper, we present the results of the stratigraphic and structural study of the Orihuela and Callosa Mountains (Alicante province, SE Spain), belonging to the Internal Betic Zone. The terrains cropping out in this area had been assigned by previous authors to the Ballabona-Cucharón Complex, lately redefi ned as the Almágride Complex. New data afforded in this work lead us to propose a new stratigraphic succesions, structural division, and geodynamic evolution. We also assign both mountains ranges to the lower Alpujarride Complex, confi rming that the Almágride Complex is not a singular element of the Betic Cordillera.En este trabajo presentamos los resultados del estudio estratigráfi co y estructural de las sierras de Orihuela y Callosa (provincia de Alicante, SE de España), pertenecientes ambas a la Zona Interna Bética. Estas sierras fueron asignadas por autores precedentes al Complejo Ballabona-Cucharón, más tarde redefi nido como Almágride. Los datos presentados en este trabajo nos llevan a proponer una nueva serie estratigráfi ca, división tectónica y evolución geodinámica del sector estudiado. Así mismo, asignamos las unidades reconocidas a la parte inferior del Complejo Alpujárride, confi rmando que el Complejo Almágride no debe ser considerado como elemento singular de la Zona Interna Bética

Polymerase chain reaction detection of rabbit DNA in food and animal feed

[EN] A polymerase chain reaction (PCR) based on oligonucleotide primers targeting the mitochondrial 12S rRNA gene was developed for the specific identification of rabbit DNA (Oryctolagus cuniculus) in food and feedstuffs. The specificity of the primers was verified by PCR analysis of DNA from 32 non-target species including mammals, birds, fish, and plant species. Analysis of experimental mixtures demonstrated the presence of rabbit-derived materials in the range of 0.1-100%. Prolonged heat treatment (up to 133ºC for 20 min at 300 kPa) applied to rabbit muscle/oats binary mixtures did not affect the performance of the method, which could therefore be said to be very useful for the accurate identification of rabbit materials in products submitted to denaturing technologies when other methods are not suitable.This study was supported by Grant Nº. AGL 2007-60077 from the Spanish Ministerio de Educación y Ciencia and the Programa de Vigilancia Sanitaria S-0505/AGR/000265 of the Comunidad de Madrid (Spain). Irene Martín is the recipient of a fellowship from the Universidad Complutense de Madrid (Spain). Violeta Fajardo and María Rojas are recipients of fellowships from the Ministerio de Educación y Ciencia (Spain).Martín, I.; García, T.; Fajardo, V.; Rojas, M.; Pegels, N.; Hernández, P.; González, I.... (2009). Polymerase chain reaction detection of rabbit DNA in food and animal feed. World Rabbit Science. 17(1):27-34. doi:10.4995/wrs.2009.667273417

Autentificación de carne y productos cárnicos procedentes de codorniz, faisán, perdiz y pintada mediante una técnica de PCR con cebadores especie-específicos

Polymerase chain reaction (PCR) based on oligonucleotide primers targeting the mitochondrial 12S rRNA gene has been applied to the specific identification of meats from quail (Coturnix coturnix), pheasant (Phasianus colchicus), partridge (Alectoris spp), and guinea fowl (Numida meleagris)

MLP-BASED SOURCE SEPARATION FOR MLP-LIKE NONLINEAR MIXTURES

In this paper, the nonlinear blind source separation problem is addressed by using a multilayer perceptron (MLP) as separating system, which is justified in the universal approximation property of MLP networks. An adaptive learning algorithm for a perceptron with two hidden-layers is presented. The algorithm minimizes the mutual information between the outputs of the MLP. The performance of the proposed method is illustrated by some experiments. 1. INTRODUCTION. Blind Source Separation (BSS) is a fundamental problem in signal processing. It consists of retrieving unobserved sources s1(t),..., sN (t), assumed to be statistically independent (which is phisically plausible when the source

Patients with severe mental illness and hepatitis C virus infection benefit from new pangenotypic direct-acting antivirals: Results of a literature review

Hepatitis C virus (HCV) infection is a global health problem that can results in cirrhosis, hepatocellular carcinoma and even death. HCV infection is 3–20-fold more prevalent among patients with versus without severe mental illness (SMI), such as major depressive disorder, personality disorder, bipolar disorder and schizophrenia. Treatment options for HCV were formerly based on pegylated interferon alpha, which is associated with neuropsychiatric adverse events, and this contributed to the exclusion of patients with SMI from HCV treatment, elimination programmes, and clinical trials. Moreover, the assumption of poor adherence, scant access to healthcare and the stigma and vulnerability of this population emerged as barriers and contributed to the low rates of treatment and efficacy. This paper reviews the literature published between December 2010 and December 2020 exploring the epidemiology of HCV in patients with SMI, and vice versa, the effect of HCV infection, barriers to the management of illness in these patients, and benefits of new therapeutic options with pangenotypic direct antiviral agents (DAAs). The approval of DAAs has changed the paradigm of HCV infection treatment. DAAs have proven to be an equally efficacious and safe option that improves quality of life (QoL) in patients SMI. Knowledge of the consequences of the HCV infection and the benefits of treatment with new pangenotypic DAAs among psychiatrists can increase screening, referral and treatment of HCV infection in patients with SM

Oral Anticoagulant Adequacy in Non-Valvular Atrial Fibrillation in Primary Care: A Cross-Sectional Study Using Real-World Data (Fantas-TIC Study)

Background: Oral anticoagulants (OAs) are the treatment to prevent stroke in atrial fibrillation (AF). Anticoagulant treatment choice in non-valvular atrial fibrillation (NVAF) must be individualized, taking current guidelines into account. Adequacy of anticoagulant therapy under the current criteria for NVAF in real-world primary care is presented. Methods: Cross-sectional study, with real-world data from patients treated in primary care (PC). Data were obtained from the System for the Improvement of Research in Primary Care (SIDIAP) database, covering 60,978 NVAF-anticoagulated patients from 287 PC centers in 2018. Results: In total, 41,430 (68%) were treated with vitamin K antagonists (VKAs) and 19,548 (32%) NVAF with direct-acting oral anticoagulants (DOACs). Inadequate prescription was estimated to be 36.0% and 67.6%, respectively. Most DOAC inadequacy (77.3%) was due to it being prescribed as a first-line anticoagulant when there was no history of thromboembolic events or intracranial hemorrhage (ICH). A total of 22.1% had missing estimated glomerular filtration rate (eGFR) values. Common causes of inadequate VKA prescription were poor control of time in therapeutic range (TTR) (98.8%) and ICH (2.2%). Conclusions: Poor adequacy to current criteria was observed, being inadequacy higher in DOACs than in VKAs. TTR and GFR should be routinely calculated in electronic health records (EHR) to facilitate decision-making and patient safety

Clinical and laboratory features of anti-MAG neuropathy without monoclonal gammopathy

Antibodies against myelin-associated glycoprotein (MAG) almost invariably appear in the context of an IgM monoclonal gammopathy associated neuropathy. Very few cases of anti-MAG neuropathy lacking IgM-monoclonal gammopathy have been reported. We investigated the presence of anti-MAG antibodies in 69 patients fulfilling diagnostic criteria for CIDP. Anti-MAG antibodies were tested by ELISA and confirmed by immunohistochemistry. We identified four (5.8%) anti-MAG positive patients without detectable IgM-monoclonal gammopathy. In two of them, IgM-monoclonal gammopathy was detected at 3 and 4-year follow-up coinciding with an increase in anti-MAG antibodies titers. In conclusion, anti-MAG antibody testing should be considered in chronic demyelinating neuropathies, even if IgM-monoclonal gammopathy is not detectable

Influencia de la adición, en diferentes proporciones, de rocas silíceas opalinas al cemento portland

En este trabajo se estudia la influencia de la presencia de rocas silíceas opalinas, procedentes de las provincias de Salamanca, Zamora y Avila, en las propiedades de los cementos mixtos fabricados con cemento portland y proporciones variables de estas rocas utilizadas como adiciones activas. La caracterización de estos materiales y el estudio de las propiedades de los cementos preparados revelan la capacidad puzolánica de las rocas opalinas, y su singularidad respecto a otras puzolanas naturales, así como su posibilidad de empleo en la fabricación de cementos con adiciones.En este trabajo se estudia la influencia de la presencia de rocas silíceas opalinas, procedentes de las provincias de Salamanca, Zamora y Avila, en las propiedades de los cementos mixtos fabricados con cemento portland y proporciones variables de estas rocas utilizadas como adiciones activas. La caracterización de estos materiales y el estudio de las propiedades de los cementos preparados revelan la capacidad puzolánica de las rocas opalinas, y su singularidad respecto a otras puzolanas naturales, así como su posibilidad de empleo en la fabricación de cementos con adiciones

The VVV Templates Project. Towards an Automated Classification of VVV Light-Curves. I. Building a database of stellar variability in the near-infrared

Context. The Vista Variables in the V\'ia L\'actea (VVV) ESO Public Survey is a variability survey of the Milky Way bulge and an adjacent section of the disk carried out from 2010 on ESO Visible and Infrared Survey Telescope for Astronomy (VISTA). VVV will eventually deliver a deep near-IR atlas with photometry and positions in five passbands (ZYJHK_S) and a catalogue of 1-10 million variable point sources - mostly unknown - which require classifications. Aims. The main goal of the VVV Templates Project, that we introduce in this work, is to develop and test the machine-learning algorithms for the automated classification of the VVV light-curves. As VVV is the first massive, multi-epoch survey of stellar variability in the near-infrared, the template light-curves that are required for training the classification algorithms are not available. In the first paper of the series we describe the construction of this comprehensive database of infrared stellar variability. Methods. First we performed a systematic search in the literature and public data archives, second, we coordinated a worldwide observational campaign, and third we exploited the VVV variability database itself on (optically) well-known stars to gather high-quality infrared light-curves of several hundreds of variable stars. Results. We have now collected a significant (and still increasing) number of infrared template light-curves. This database will be used as a training-set for the machine-learning algorithms that will automatically classify the light-curves produced by VVV. The results of such an automated classification will be covered in forthcoming papers of the series.Comment: 12 pages, 16 figures, 3 tables, accepted for publication in A&A. Most of the data are now accessible through http://www.vvvtemplates.org

Are there any risk factors for developing complications with the use of retrievable vena cava filters in orthopaedic surgery?

Background: In high-risk patients, common prophylaxis may be insufficient to prevent thromboembolic events after orthopaedic procedures. In this scenario, a retrievable vena cava filter (VCF) could be considered as an alternative, although it's use remains controversial. Therefore, we asked: (1) what is the overall mechanical complication rate associated with the use of retrievable VCFs in orthopaedic surgery?, (2) what is the association with thromboembolic disease (TED) recurrence, post-thrombotic syndrome and/or major bleeding according to different surgical characteristics?, (3) What is the overall mortality rate attributed to VCF use?Methods: We retrospectively analyzed a cohort of 68 patients who underwent orthopaedic surgery with a previous diagnosis of TED, in whom a retrievable VCF was placed. Permanent filters were excluded. We studied the filter’s mechanical complications and considered as possible outcomes death and 3 hematologic complications: TED recurrence, post-thrombotic syndrome and major bleeding. To estimate association with risk factors, we subclassified surgeries into 5 groups: 1, arthroplasty/non-arthroplasty; 2, primary/revision; 3, elective/urgent; 4, oncologic/non-oncologic; 5, preoperative/postoperative filter.Results: Mechanical complications were 16% and required a filter revision. Sixty-four percent of the revised VCFs developed a mechanical failure and could not be retrieved. Overall prevalence of TED recurrence, post-thrombotic syndrome and hemorrhage was 33%, 15% and 4.5%, respectively. Spinal surgeries were a risk factor for developing TED recurrences.  Only 4% of patients died of a TED recurrence.Conclusions: Orthopaedic procedures had a high risk of mechanical and hematologic complications after using a retrievable VCF. However, mortality was low due to these complications.</p