Organic Molecules in the Galactic Center. Hot Core Chemistry without Hot Cores

We study the origin of large abundances of complex organic molecules in the Galactic center (GC). We carried out a systematic study of the complex organic molecules CH3OH, C2H5OH, (CH3)2O, HCOOCH3, HCOOH, CH3COOH, H2CO, and CS toward 40 GC molecular clouds. Using the LTE approximation, we derived the physical properties of GC molecular clouds and the abundances of the complex molecules.The CH3OH abundance between clouds varies by nearly two orders of magnitude from 2.4x10^{-8} to 1.1x10^{-6}. The abundance of the other complex organic molecules relative to that of CH3OH is basically independent of the CH3OH abundance, with variations of only a factor 4-8. The abundances of complex organic molecules in the GC are compared with those measured in hot cores and hot corinos, in which these complex molecules are also abundant. We find that both the abundance and the abundance ratios of the complex molecules relative to CH3OH in hot cores are similar to those found in the GC clouds. However, hot corinos show different abundance ratios than observed in hot cores and in GC clouds. The rather constant abundance of all the complex molecules relative to CH3OH suggests that all complex molecules are ejected from grain mantles by shocks. Frequent (similar 10^{5}years) shocks with velocities >6km/s are required to explain the high abundances in gas phase of complex organic molecules in the GC molecular clouds. The rather uniform abundance ratios in the GC clouds and in Galactic hot cores indicate a similar average composition of grain mantles in both kinds of regions. The Sickle and the Thermal Radio Arches, affected by UV radiation, show different relative abundances in the complex organic molecules due to the differentially photodissociation of these molecules.Comment: 18 pages, 10 Postscript figures, uses aa.cls, aa.bst, 10pt.rtx, natbib.sty, revsymb.sty revtex4.cls, aps.rtx and aalongtabl.sty. Accepted in A&A 2006. version 2. relocated figures and tables. Language editor suggestions. added reference

Armor Porosity and Hydraulic Stability of Mound Breakwaters

Armor porosity significantly affects construction costs and hydraulic stability of mound breakwaters; however, most hydraulic stability formulas do not include armor porosity or packing density as an explicative variable. 2D hydraulic stability tests of conventional randomly-placed double-layer cube armors with different armor porosities are analyzed. The stability number showed a significant 1.2-power relationship with the packing density, similar to what has been found in the literature for other armor units; thus, the higher the porosity, the lower the hydraulic stability. To avoid uncontrolled model effects, the packing density should be routinely measured and reported in small-scale tests and monitored at prototype scale.The authors are grateful for financial support from the Spanish Ministerio de Economía y Competitividad and FEDER (Grant BIA2012-33967) and CDTI (CUBIPOD and CLIOMAR Projects). The second author was funded through the FPU program (Formación del Profesorado Universitario, Grant AP2010-4366) by the Spanish Ministerio de Educación, Cultura y Deporte

Tensorial analisis of the superposed deformation in the easthern border of the Madrid basin

An analysis of Neogene brittle deformation using fault populatíon analysis methods has been carried out between the SW border of the Iberian Range and Altomira Range. Two main paleostress fields have been established: 1) N70E - N120E compression (Altomira paleostress field) ofLate Oligocene - Early Miocene age that induced the formation of the SW border of Iberian Range and Altomira - Pareja thrust belts with reverse and strike-slip faults. 2) N140-N160E compression (Guadarrama paleostress field) of Middle Aragonian - early Pleistocene age that reactivated previous faults with strikeslip movement along the Iberian Range. A superposition of two regional stress fields (Iberian and Guadarrama) is proposed to explain E-W compression that formed Altomira Range. Stress tensorial additions have been realized to check this hypothesis

Quantum optical signals in telecommunication networks

Introducción a una red óptica metropolitana cuántica donde señales cuánticas y convencionales son multiplexadas en longitud de onda utilizando bandas separadas del espectro óptico. El enrutado se realiza con componentes pasivos para no perturbar los qubits. Se estudian dos redes: red de acceso WDM-PON y red metropolitana completa con backbone DWDM y redes de acceso WDM-PON

On the heating of source of the Orion KL hot core

We present images of the J=10-9 rotational lines of HC3N in the vibrationally excited levels 1v7, 1v6 and 1v5 of the hot core (HC) in Orion KL. The images show that the spatial distribution and the size emission from the 1v7 and 1v5 levels are different. While the J=10-9 1v7 line has a size of 4''x 6'' and peaks 1.1'' NE of the 3 mm continuum peak, the J=10--9 1v5 line emission is unresolved (<3'') and peaks 1.3'' south of the 3 mm peak. This is a clear indication that the HC is composed of condensations with very different temperatures (170 K for the 1v7 peak and $>230$ K for the 1v5 peak). The temperature derived from the 1v7 and 1v5 lines increases with the projected distance to the suspected main heating source I. Projection effects along the line of sight could explain the temperature gradient as produced by source I. However, the large luminosity required for source I, >5 10^5 Lsolar, to explain the 1v5 line suggests that external heating by this source may not dominate the heating of the HC. Simple model calculations of the vibrationally excited emission indicate that the HC can be internally heated by a source with a luminosity of 10^5 Lsolar, located 1.2'' SW of the 1v5 line peak (1.8'' south of source I). We also report the first detection of high-velocity gas from vibrationally excited HC3N emission. Based on excitation arguments we conclude that the main heating source is also driving the molecular outflow. We speculate that all the data presented in this letter and the IR images are consistent with a young massive protostar embedded in an edge-on disk.Comment: 13 pages, 3 figures, To be published in Ap.J. Letter

Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP

The transcriptional regulator YAP orchestrates many cellular functions, including tissue homeostasis, organ growth control, and tumorigenesis. Mechanical stimuli are a key input to YAP activity, but the mechanisms controlling this regulation remain largely uncharacterized. We show that CAV1 positively modulates the YAP mechanoresponse to substrate stiffness through actin-cytoskeleton-dependent and Hippo-kinase-independent mechanisms. RHO activity is necessary, but not sufficient, for CAV1-dependent mechanoregulation of YAP activity. Systematic quantitative interactomic studies and image-based small interfering RNA (siRNA) screens provide evidence that this actin-dependent regulation is determined by YAP interaction with the 14-3-3 protein YWHAH. Constitutive YAP activation rescued phenotypes associated with CAV1 loss, including defective extracellular matrix (ECM) remodeling. CAV1-mediated control of YAP activity was validated in vivo in a model of pancreatitis-driven acinar-to-ductal metaplasia. We propose that this CAV1-YAP mechanotransduction system controls a significant share of cell programs linked to these two pivotal regulators, with potentially broad physiological and pathological implications. Moreno-Vicente et al. report that CAV1, a key component of PM mechanosensing caveolae, mediates adaptation to ECM rigidity by modulating YAP activity through the control of actin dynamics and phosphorylation-dependent interaction of YAP with the 14-3-3-domain protein YWHAH. Cav1-dependent YAP regulation drives two pathophysiological processes: ECM remodeling and pancreatic ADM. © 2018 The Author

Fission of Highly Excited Nuclei:a Finite Temperature Description

An attempt to study the temperature dependence of fission in heavy nuclei using a microscopic theory. Application to two test nuclei. Gogny force. Reasonably big configuration space Axially deformed base. Breaking of reflection symmetry allowed: octupole de formation

R&amp;D Leadership Styles and Behaviors: A Review and Research Agenda

R&amp;D leaders are critical actors in creating and execut- ing organizational R&amp;D strategies and leading R&amp;D departments. R&amp;D leaders spearhead and manage innovation activities and efforts that are essential for organizational survival and growth. Despite the importance of the R&amp;D leader role, there is a scant focus on R&amp;D leadership styles and behaviors within the existing fragmented literature. Accordingly, in this article, the purpose is to address this deficit by examining R&amp;D leadership styles and behav- iors through a systematic literature review. Based on 60 articles, we identified three main themes: the influence of leadership style; R&amp;D leader behaviors; and R&amp;D leader human capital. We analyze and discuss these themes along with positing future research avenues for further understanding of R&amp;D leaders and leadership

A Trypanosoma cruzi Genome Tandem Repetitive Satellite DNA Sequence as a Molecular Marker for a LAMP Assay for Diagnosing Chagas' Disease

Chagas' disease is a neglected tropical disease caused by Trypanosoma cruzi which is endemic throughout Latin America and is spread by worldwide migration. Diagnosis is currently limited to serological and molecular techniques having variations regarding their sensitivity and specificity. This work was aimed at developing a new sensitive, applicable, and cost-effective molecular diagnosis technique for loop-mediated isothermal amplification-based detection of T. cruzi (Tc-LAMP). The results led to determining a highly homologous satellite repeat region (231 bp) among parasite strains as a molecular marker for diagnosing the disease. Tc-LAMP was performed correctly for detecting parasite DNA (5 fg for the CL Brener strain and 50 fg for the DM28, TcVI, and TcI strains). Assay results proved negative for DNA from 16 helminth species and 7 protozoa, including Leishmania spp. Tc-LAMP based on the highly repeated T. cruzi satellite region is thus proposed as an important alternative for diagnosing T. cruzi infection, overcoming other methods' limitations such as their analytic capability, speed, and requiring specialized equipment or highly trained personnel. Tc-LAMP could be easily adapted for point-of-care testing in areas having limited resources