Firewood and timber exploitation during the 3rd and 2nd millennia BC in the Western façade of the Iberian Northwest: wooden resources, territories and chaîne opératoire

As sociedades humanas estabelecem toda uma série de estratégias produtivas destinadas a obter os meios materiais necessários para a sua existência, entre elas, o aprovisionamento de lenha e de madeira. Estas estratégias, além de estarem condicionadas pela oferta ambiental, são igualmente resultantes das características culturais e das capacidades técnicas. Os dados arqueobotânicos que se apresentam procedem de vários lugares de habitação do Calcolítico e da Idade do Bronze da fachada ocidental do Noroeste peninsular com cronologias que abarcam o III e parte do II milénios AC (Martin em preparação; Martín et al. no prelo; Figueiral e Bettencourt 2007). Os resultados obtidos permitiram identificar uma exploração diversificada dos recursos lenhosos que combinava a recolha de lenha e de madeira das áreas da floresta climácica com a proveniente das áreas de mato. As formaçãos arbóreas situadas nas margems dos cursos de água também constituíram fonte de aprovisionamento de combustíveis e, provavelmente, de madeira. A caracterização dos recursos usados em cada um dos casos de estudo permitiu-nos, igualmente, colocar hipóteses sobre o território de vivência, de circulação e de exploração de cada comunidade. A análise dendrológica das amostras registando o grau de curvatura dos anéis de crescimento anual, o diâmetro mínimo dos ramos ou troncos consumidos, a presença de tiloses e de depósitos de resina, a presença de madeira de reação, a conservação do floema e ou da casca, a presença ou a ausência de cicatrizes ou de anéis sinuosos, as mudanças no ritmo de crescimento, entre outras características, em inter-relação com determinados contextos arqueológicos (dimensões dos buracos de poste, por exemplo), proporcionaram, também, hipóteses relacionadas com a cadeia técnica-operativa dos recursos florestais. Ou seja, sobre a sucessão de operações realizadas pelas comunidades humanas desde a extração da matéria até à sua utilização final.This research was developed under the projects: A xestión do bosque e do monte dende a Idade do Ferro a época romana no noroeste da península Ibérica: consumo de combustibles e produción de manufacturas en madeira / Forest and scrubland management from Iron Age to roman period in the Northwest of the Iberian peninsula: firewood consumption and wooden manufacture production, IDEPatri-Deseño e desenvolvemento dun modelo de datos para unha IDE arqueolóxica da Idade do Ferro en Galicia /IDEPatri- Design and development of a data model for an archaeological SPI during the Galician Iron Age: (IDEPatri) 09SEC002CT. Xunta de Galicia, Paisagens da Idade do Bronze no ocidente peninsular / Bronze Age Landscapes in the West of Iberian Peninsula - SFRH/BSAB/986/10 e Geoindicators of natural and anthropogenic palaeoenvironmental evolution in the Portuguese NW, during de Holocene – 2010_CGUP/CCT/UM

Firewood and timber exploitation during the third and second millennia BC in Northwestern Iberia: wood resources, territories and chaîne opératoire

Human societies established productive strategies in order to obtain the material resources needed for their day‐to‐day life, including firewood and timber. These strategies were determined by the environmental supply, and also by the cultural characteristics and technical capacities of these communities. This paper presents charcoal analysis data from four Chalcolithic and Bronze Age open‐air settlements located in the northwest of the Iberian Peninsula and occupied during the third and second millennia BC. These results contribute to the knowledge of the exploitation of wooden resources, of the territories where these resources were collected, and of the firewood and timber production process. The identified wood taxa point to a diversified exploitation of the territory, where firewood and timber were collected and/or felled in the deciduous woodland, the river banks and scrubland areas. The characteristics of the wood elements used, the degree of growth ring curvature, the minimum diameter of twigs or logs, etc., as well as other data from archaeological contexts, such as the length of the postholes, were all taken into account to establish hypotheses related to the operative chaine of forest resources. The wooden resources consumed in each site allowed us to hypothesize about the territory of each community.As sociedades humanas estabelecem toda uma série de estratégias produtivas destinadas a obter os meios materiais necessários para a sua existência, entre elas, o aprovisionamento de lenha e de madeira. Estas estratégias, além de estarem condicionadas pela oferta ambiental, são igualmente resultantes das caraterísticas culturais e das capacidades técnicas das comunidades. Os dados arqueobotânicos que se apresentam procedem de vários lugares de habitação do Calcolítico e da Idade do Bronze da fachada ocidental do Noroeste peninsular com cronologias que abarcam o 3º e parte do 2º milénios AC. Os resultados obtidos permitiram identificar uma exploração diversificada dos recursos lenhosos que combinava a recolha de lenha e de madeira da floresta climácica com a proveniente das áreas de mato. As formações arbóreas situadas nas margens dos cursos de água também constituíram fonte de aprovisionamento de combustíveis e, provavelmente, de madeira. A análise dendrológica das amostras registando o grau de curvatura dos anéis de crescimento anual, o diâmetro mínimo dos ramos ou troncos consumidos, entre outras características, em inter‑relação com determinados contextos arqueológicos (dimensões dos buracos de poste, por exemplo), proporcionaram hipóteses relacionadas com a cadeia técnica‑operativa dos recursos florestais. A caracterização dos recursos usados em cada um dos casos de estudo permitiu, igualmente, colocar hipóteses sobre o território de vivência, de circulação e de exploração de cada comunidade.Fundação para a Ciência e Tecnologi

Crops on the edge of a cliff: Storage at Castro S. João das Arribas (Northwest Iberia) in the Late Antiquity

The site of Castro S. João das Arribas is placed on the edge of a cliff over the Douro river (Miranda do Douro, Northeast of Portugal). Archaeological interventions in its highest area uncovered a main occupation from Late Antiquity. On its western part a functional space was recorded, which included two small above-ground structures and abundant charred carpological remains. These were found inside ceramic vessels and spread throughout the area, suggesting its destruction occurred after a fire event. A radiocarbon date places such episode in some moment between the late 6th and the first half of the 7th century CE. Carpological results revealed an assemblage dominated by cereal grains, mostly rye (Secale cereale). Naked wheat (Triticum aestivum/durum), barley (Hordeum vulgare), common millet (Panicum miliaceum) and foxtail millet (Setaria italica) were also found but in smaller amounts. The large amount of carpological remains in the above-mentioned contexts, suggests the space was used for storage, at least between the 6th and 7th centuries CE. Although some uncertainties remain regarding how crops were stored, evidence points that they were kept in ceramic vessels, outside and inside the small storage facilities, but also in other types of containers, eventually made of perishable materials. At Castro S. João das Arribas, past communities chose a diversity of crops, however, most of them show undemanding features in terms of soil and climatic conditions. The agricultural choices could have been motivated by several factors, but cereals like rye were certainly well-suited to the environmental conditions around the settlement.LS was financially supported by a PhD grant (Norte-08-5369-FSE000057) from the University of Porto (Faculty of Sciences) and the European Social Fund, through the North Portugal Regional Operational Program “Norte 2020”, under the announcement “Aviso Norte-69-2015-15-Formaç˜ao Avançada (Programas Doutorais)”. MMS was funded by the Beatriz Galindo program as Junior Distinguished Researcher (BG20/00076). JPT was supported by national funds through the Foundationfor Science and Technology (FCT)

The introduction and spread of rye (Secale cereale) in the Iberian Peninsula

Some of the earliest Western European macroremains of rye (Secale cereale) have been recently recovered in Northwest Iberia. However, the chronological and cultural contexts of these remains have not been yet exhaustively analysed. To address this gap of research, previous and unpublished assemblages have been reviewed and analysed through an analytical set of methods: biometry, radiocarbon dates and integrating the remains of rye in the broad archaeobotanical record of the region. Results show the earliest macroremains of rye in the Iberian Peninsula date to a period between the 3rd century and the first half of the 1st century BCE. Rye was usually found in assemblages dominated by spelt and other cereals, in whose fields it was likely acting as a weed. There is no record of rye for about the two following centuries, after which it is probably reintroduced, now as a crop. It is found in several sites from the 3rd-4th centuries CE onwards, suggesting it is a staple crop as in other regions in Europe. Significant differences in grain size are only recorded in a 10th-11th century settlement, suggesting few changes in grain morphometry before Medieval times

Ab Initio Calculation of the Lattice Distortions induced by Substitutional Ag- and Cu- Impurities in Alkali Halide Crystals

An ab initio study of the doping of alkali halide crystals (AX: A = Li, Na, K, Rb; X = F, Cl, Br, I) by ns2 anions (Ag- and Cu-) is presented. Large active clusters with 179 ions embedded in the surrounding crystalline lattice are considered in order to describe properly the lattice relaxation induced by the introduction of substitutional impurities. In all the cases considered, the lattice distortions imply the concerted movement of several shells of neighbors. The shell displacements are smaller for the smaller anion Cu-, as expected. The study of the family of rock-salt alkali halides (excepting CsF) allows us to extract trends that might be useful at a predictive level in the study of other impurity systems. Those trends are presented and discussed in terms of simple geometric arguments.Comment: LaTeX file. 8 pages, 3 EPS pictures. New version contains calculations of the energy of formation of the defects with model clusters of different size

Lattice Distortions Around a Tl+ Impurity in NaI:Tl+ and CsI:Tl+ Scintillators. An Ab Initio Study Involving Large Active Clusters

Ab initio Perturbed Ion cluster-in-the-lattice calculations of the impurity centers NaI:Tl+ and CsI:Tl+ are pressented. We study several active clusters of increasing complexity and show that the lattice relaxation around the Tl+ impurity implies the concerted movement of several shells of neighbors. The results also reveal the importance of considering a set of ions that can respond to the geometrical displacements of the inner shells by adapting selfconsistently their wave functions. Comparison with other calculations involving comparatively small active clusters serves to assert the significance of our conclusions. Contact with experiment is made by calculating absorption energies. These are in excellent agreement with the experimental data for the most realistic active clusters considered.Comment: 7 pages plus 6 postscript figures, LaTeX. Submmited to Phys, Rev.

Dating the setting of a late prehistoric statue-menhir at Cruz de Cepos, NE Portugal

The emergence of ‘standing stone’ monuments within the European Late Prehistoric landscape is considered to be associated with a pivotal human cultural transition from hunting and gathering to agriculture and permanent settlement, being the earliest monuments currently dated by radiocarbon to the 5th millennium BCE. However, many standing stones were first erected, subsequently collapsed, and then re-erected during the following three millennia. The excavation of the site of an apparently in situ statue-menhir at Cruz de Cepos in NE Portugal provided the rare opportunity in Iberian prehistory to apply radiocarbon and luminescence techniques to establish the date of construction. On the basis of the iconography, the standing stone was assigned to a sculptural tradition of north-western and western Iberia, loosely dated to the Early/Middle Bronze Age (ca. 2000/1900–1250 BCE). The optically stimulated luminescence (OSL) and dosimetry characteristics of quartz extracted from sediment samples taken from locations associated with the socket pit and surrounding backfilling deposits were examined, producing OSL single grain ages at eight locations. Comparison of the OSL and calibrated radiocarbon ages shows very good agreement, with the mid-3rd millennium BCE dates confirming original erection during the Copper Age and not a much later transformation of the monument. These encouraging results indicate that OSL has the potential to provide reliable dating of depositional processes related to the construction process and is suitable for wider application to megalithic monuments of this type

An optimized MNK1b aptamer, apMNKQ2, and its potential use as a therapeutic agent in breast cancer

16 pags., 8 figs.Breast cancer is the most commonly diagnosed and leading cause of cancer death among women worldwide. Mitogen-activated protein kinase-interacting kinases (MNKs) promote the expression of several oncogenic proteins and are overexpressed in several types of cancer. In human cells, there are four isoforms of MNKs. The truncated isoform MNK1b, first described in our laboratory, has a higher basal activity and is constitutively active. Aptamers are emerging in recent years as potential therapeutic agents that show significant advantages over drugs of other nature. We have previously obtained and characterized a highly specific aptamer against MNK1b, named apMNK2F, with a dissociation constant in the nanomolar range, which produces significant inhibition of proliferation, migration, and colony formation in breast cancer cells. Furthermore, its sequence analysis predicted two G-quadruplex structures. In this work, we show the optimization process of the aptamer to reduce its size, improving its stability. The obtained aptamer, named apMNKQ2, is able to inhibit proliferation, colony formation, migration, and invasion in breast cancer cells. In murine models of breast cancer, apMNKQ2 has demonstrated its efficacy in reducing tumor volume and the number of metastases. In conclusion, apMNKQ2 could be used as an anti-tumor drug in the future.C.P.-D. was supported by grant RTC-2014-1986-1 from the Ministry of Economy and Competitiveness (Spain). R.F.-M... by predoctoral contract (PEJD-2018-BMD-4416) from the Community of Madrid (Spain) and FPU19/02929 from the Ministry of Science, Innovation and Universities (Spain). R.C.-B. for predoctoral contracts (PEJD 2016-BMD-2145 and 2018-BMD-9201) from the Community of Madrid and grant RTC2019-07227-1. M. EM., and V.M.G. are researchers at FIBio-HRC. Supported by grants RTC2019-07227-1, PID2020-116620GB-T.I.00, and PID2019-105417RB-I00, funded by MCIN/ AEI /10.13039/501100011033 (Ministry of Economy and Competitiveness, Spain).Peer reviewe

Evaluación de la intervención educativa enfermera y adherencia terapéutica a los inmunosupresores en pacientes trasplantados de corazón

[Resumen] Introducción. El seguimiento clínico de pacientes trasplantados de corazón es complejo y requiere que la enfermera trasmita conocimientos según necesidades para fomentar el autocuidado y adherencia terapéutica. El objetivo fue evaluar la intervención educativa enfermera en pacientes trasplantados.Metodología. Se realizó un estudio observacional-descriptivo-transversal de los pacientes trasplantados de corazón en 2019 y 2020 (n=41) en la Unidad de Insuficiencia Cardiaca Avanzada del Hospital Universitario de A Coruña, a través de cuestionarios de conocimientos, evaluación y adherencia BAASIS©.Resultados. Participaron 41 pacientes con una edad media de 60,5 (±6,9), hombres el 80,5%. Según prioridad fueron 53,7% electivo. Respondieron correctamente a las 15 preguntas de conocimientos el 36,8%. Las preguntas con más errores fueron las relativas a los síntomas del rechazo.Todos los pacientes consideraron la información recibida útil y un 92,7% refirieron que les ayudó a mejorar la ansiedad y el miedo.El 87,2% tomaron tres fármacos inmunosupresores: tacrolimus 100%, de los cuales el 84,6% en una sola toma por la mañana, prednisona 97,4%, micofenolato de mofetilo 79,5% y everolimus 10,3%. Ningún paciente dejó de tomar los inmunosupresores por completo en el último año. Durante el último mes olvidaron o modificaron una vez la dosis pautada dos pacientes.El 69,2% de los pacientes puntuaron con el máximo su conducta sobre la toma de medicamentos inmunosupresores. Conclusiones. Los resultados obtenidos muestran que los pacientes mantienen, durante el primer año del trasplante de corazón, un nivel de conocimientos aceptable, buena adherencia a los inmunosupresores y consideran útil la intervención educativa-enfermera.[Abstract] Introduction. The clinical follow up of heart transplant patients is complex and requires the nurse to transmit knowledge according to needs to promote self-care and therapeutic adherence. The objective was to evaluate the nurse educational intervention in transplanted patients.Methodology. An observational-descriptive-transversal study was performed of patients who received heart transplants in 2019 and 2020 (n=41) at the Advanced Heart Failure Unit of the University Hospital of A Coruña using knowledge, assessment, and adherence questionnaires (BAASIS).Results. Forty-one patients participated with a mean age of 60.5 (±6.9), 80.5% were male. According to priority, 53.7% were elective. The 15 knowledge questions were answered correctly by 36.8%. The questions with more failures were those related to rejection symptoms.All patients considered the information received to be useful and 92.7% reported that it helped them improve their anxiety and fear.Three immunosuppressive drugs were taken by 87.2%: Tacrolimus 100%, of which 84.6% in a single morning dose, prednisone 97.4%, mycophenolate mofetil 79.5%, and everolimus 10.3%. No patient fully stopped taking immunosuppressants in the last year. During the last month, two patients forgot or changed the prescribed dose once.The maximum score was achieved by 69.2% of patients for their behavior regarding taking immunosuppressive drugs.Conclusions. The results obtained show that during the first year after heart transplantation, patients maintain an acceptable level of knowledge, good adherence to immunosuppressants, and consider the nurse educational intervention useful

Desarrollo de un suero equino hiperinmune para el tratamiento de COVID-19 en Argentina

La enfermedad denominada COVID-19 es causada por el coronavirus SARS-CoV-2 y es actualmente considerada una pandemia a nivel global. El desarrollo de vacunas es sin duda la mejor estrategia a largo plazo, pero debido a la emergencia sanitaria, existe una necesidad urgente de encontrar soluciones rápidas y efectivas para el tratamiento de la enfermedad. Hasta la fecha, el uso de plasma de convalecientes es la única inmunoterapia disponible para pacientes hospitalizados con COVID-19. El uso de anticuerpos policlonales equinos (EpAbs) es otra alternativa terapéutica interesante. La nueva generación de EpAbs incluyen el procesamiento y purificación de los mismos y la obtención de fragmentos F(ab’)2 con alta pureza y un excelente perfil de seguridad en humanos. Los EpAbs son fáciles de producir, lo cual permite el desarrollo rápido y la elaboración a gran escala de un producto terapéutico. En este trabajo mostramos el desarrollo de un suero terapéutico obtenido luego de la inmunización de caballos utilizando el receptor-binding domain de la glicoproteína Spike del virus. Nuestro producto mostró ser alrededor de 50 veces más potente en ensayos de seroneutralización in vitro que el promedio de los plasmas de convalecientes. Estos resultados nos permitirían testear la seguridad y eficacia de nuestro producto en ensayos clínicos de fase 2/3 a realizarse a partir de julio de 2020 en la zona metropolitana de Buenos Aires, Argentina.The disease named COVID-19, caused by the SARS-CoV-2 coronavirus, is currently generating a global pandemic. Vaccine development is no doubt the best long-term immunological approach, but in the current epidemiologic and health emergency there is a need for rapid and effective solutions. Convalescent plasma is the only antibody-based therapy available for COVID-19 patients to date. Equine polyclonal antibodies (EpAbs) put forward a sound alternative. The new generation of processed and purified EpAbs containing highly purified F(ab’)2 fragments demonstrated to be safe and well tolerated. EpAbs are easy to manufacture allowing a fast development and scaling up for a treatment. Based on these ideas, we present a new therapeutic product obtained after immunization of horses with the receptor-binding domain of the viral Spike glycoprotein. Our product shows around 50 times more potency in in vitro seroneutralization assays than the average of convalescent plasma. This result may allow us to test the safety and efficacy of this product in a phase 2/3 clinical trial to be conducted in July 2020 in the metropolitan area of Buenos Aires, Argentina.Fil: Zylberman, Vanesa. Inmunova; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sanguineti, Santiago. Inmunova; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pontoriero, Andrea. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Higa, Sandra V.. Instituto Biológico Argentino S.A.I.C.; ArgentinaFil: Cerutti, Maria Laura. Universidad Nacional de San Martín. Centro de Rediseño e Ingeniería de Proteínas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Morrone Seijo, Susana María. Inmunova; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pardo, Romina Paola. Inmunova; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Muñoz, Luciana. Inmunova; ArgentinaFil: Acuña Intieri, María Eugenia. Universidad Nacional de San Martín. Centro de Rediseño e Ingeniería de Proteínas; ArgentinaFil: Alzogaray, Vanina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Avaro, Martín M.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Benedetti, Estefanía. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Berguer, Paula Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Bocanera, Laura. mAbxience; ArgentinaFil: Bukata, Lucas. Inmunova; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bustelo, Marina S.. Inmunova; ArgentinaFil: Campos, Ana M.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Colonna, Mariana. Inmunova; ArgentinaFil: Correa, Elisa. mAbxience; ArgentinaFil: Cragnaz, Lucí­a. mAbxience; ArgentinaFil: Dattero, María E.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Dellafiore, María Andrea. mAbxience; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Foscaldi, Sabrina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: González, Joaquí­n V.. Inmunova; ArgentinaFil: Guerra, Luciano Lucas. mAbxience; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Klinke, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Labanda, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Lauché, Constanza Elena. Inmunova; ArgentinaFil: López, Juan C.. Instituto Biológico Argentino S.A.I.C.; ArgentinaFil: Martínez, Anabela M.. Instituto Biológico Argentino S.A.I.C.; ArgentinaFil: Otero, Lisandro Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Peyric, Elías H.. Instituto Biológico Argentino S.A.I.C.; ArgentinaFil: Ponziani, Pablo F.. Instituto Biológico Argentino S.A.I.C.; ArgentinaFil: Ramondino, Romina. Inmunova; ArgentinaFil: Rinaldi, Jimena Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Rodrí­guez, Santiago. mAbxience; ArgentinaFil: Russo, Javier E.. Instituto Biológico Argentino S.A.I.C.; ArgentinaFil: Russo, Mara Laura. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Saavedra, Soledad Lorena. Instituto Biológico Argentino S.A.I.C.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Seigelchifer, Mauricio. mAbxience; ArgentinaFil: Sosa, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Vilariño, Claudio. Universidad Nacional de San Martín. Centro de Rediseño e Ingeniería de Proteínas; ArgentinaFil: López Biscayart, Patricia. Instituto Biológico Argentino S.A.I.C.; ArgentinaFil: Corley, Esteban. mAbxience; ArgentinaFil: Spatz, Linus. Inmunova; ArgentinaFil: Baumeister, Elsa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Goldbaum, Fernando Alberto. Universidad Nacional de San Martín. Centro de Rediseño e Ingeniería de Proteínas; Argentina. Inmunova; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentin