7 research outputs found
Examining the immune signatures of SARS-CoV-2 infection in pregnancy and the impact on neurodevelopment: Protocol of the SIGNATURE longitudinal study.
The COVID-19 pandemic represents a valuable opportunity to carry out cohort studies that allow us to advance our knowledge on pathophysiological mechanisms of neuropsychiatric diseases. One of these opportunities is the study of the relationships between inflammation, brain development and an increased risk of suffering neuropsychiatric disorders. Based on the hypothesis that neuroinflammation during early stages of life is associated with neurodevelopmental disorders and confers a greater risk of developing neuropsychiatric disorders, we propose a cohort study of SARS-CoV-2-infected pregnant women and their newborns. The main objective of SIGNATURE project is to explore how the presence of prenatal SARS-CoV-2 infection and other non-infectious stressors generates an abnormal inflammatory activity in the newborn. The cohort of women during the COVID-19 pandemic will be psychological and biological monitored during their pregnancy, delivery, childbirth and postpartum. The biological information of the umbilical cord (foetus blood) and peripheral blood from the mother will be obtained after childbirth. These samples and the clinical characterisation of the cohort of mothers and newborns, are tremendously valuable at this time. This is a protocol report and no analyses have been conducted yet, being currently at, our study is in the recruitment process step. At the time of this publication, we have identified 1,060 SARS-CoV-2 infected mothers and all have already given birth. From the total of identified mothers, we have recruited 537 SARS-COV-2 infected women and all of them have completed the mental health assessment during pregnancy. We have collected biological samples from 119 mothers and babies. Additionally, we have recruited 390 non-infected pregnant women
Examining the immune signatures of SARS-CoV-2 infection in pregnancy and the impact on neurodevelopment: Protocol of the SIGNATURE longitudinal study
The COVID-19 pandemic represents a valuable opportunity to carry out cohort studies that allow us to advance our knowledge on pathophysiological mechanisms of neuropsychiatric diseases. One of these opportunities is the study of the relationships between inflammation, brain development and an increased risk of suffering neuropsychiatric disorders. Based on the hypothesis that neuroinflammation during early stages of life is associated with neurodevelopmental disorders and confers a greater risk of developing neuropsychiatric disorders, we propose a cohort study of SARS-CoV-2-infected pregnant women and their newborns. The main objective of SIGNATURE project is to explore how the presence of prenatal SARS-CoV-2 infection and other non-infectious stressors generates an abnormal inflammatory activity in the newborn. The cohort of women during the COVID-19 pandemic will be psychological and biological monitored during their pregnancy, delivery, childbirth and postpartum. The biological information of the umbilical cord (foetus blood) and peripheral blood from the mother will be obtained after childbirth. These samples and the clinical characterisation of the cohort of mothers and newborns, are tremendously valuable at this time. This is a protocol report and no analyses have been conducted yet, being currently at, our study is in the recruitment process step. At the time of this publication, we have identified 1,060 SARS-CoV-2 infected mothers and all have already given birth. From the total of identified mothers, we have recruited 537 SARS-COV-2 infected women and all of them have completed the mental health assessment during pregnancy. We have collected biological samples from 119 mothers and babies. Additionally, we have recruited 390 non-infected pregnant women.This work has received support from the FundaciĂłn Alicia Koplowitz to realize the epigenetic wide association study and to the clinical assessment to the children. This work has also received public support from the ConsejerĂa de Salud y Familias para la financiaciĂłn de la investigaciĂłn, desarrollo e innovaciĂłn (i + d + i) biomĂ©dica y en ciencias de la salud en AndalucĂa (CSyF 2021 - FEDER). Grant Grant number PECOVID- 0195-2020. Convocatoria financiada con Fondo Europeo de Desarrollo Regional (FEDER) al 80% dentro del Programa Operativo de AndalucĂa FEDER 2014-2020. AndalucĂa se mueve con Europa. NG-T received payment under Rio Hortega contract CM20-00015 with the Carlos III Health Institute.Peer reviewe
The Research Journey as a Challenge Towards New Trends
The academic community of the department of Risaralda, in its permanent interest in evidencing the results of the research processes that are carried out from the Higher Education Institutions and as a product of the VI meeting of researchers of the department of Risaralda held in November 2021 presents its work: âThe journey of research as a challenge towards new trendsâ, which reflects the result of the latest research and advances in different lines of knowledge in Agricultural Sciences, Health Sciences, Social Sciences and Technology and Information Sciences, which seek to solve and meet the demands of the different sectors.
This work would not have been possible without the help of each of the teachers, researchers and authors who presented their articles that make up each of the chapters of the book, to them our gratitude for their commitment, dedication and commitment, since their sole purpose is to contribute from the academy and science to scientific and technological development in the search for the solution of problems and thus contribute to transform the reality of our society and communities. We also wish to extend our
gratitude to the institutions of the Network that made this publication possible: UTP, UCP, UNAD, UNIREMINGTON; UNISARC, CIAF, Universidad Libre, Uniclaretiana, FundaciĂłn Universitaria Comfamiliar and UNIMINUTO, institutions that in one way or another allowed this work to become a reality, which we hope will be of interest to you.Preface............................................................................................................................7
Chapter 1. Technologies and Engineering
Towards a humanization in Engineering using soft skills in training
in Engineers.............................................................................................................11
Omar Ivån Trejos Buriticå1, Luis Eduardo Muñoz Guerrero
Innovative materials in construction: review from a bibliometric
analysis....................................................................................................................27
Cristian Osorio GĂłmez, Daniel AristizĂĄbal Torres, Alejandro Alzate Buitrago,
Cristhian Camilo Amariles LĂłpez
Bibliometric review of disaster risk management: progress, trends,
and challenges.........................................................................................................51
Alejandro Alzate Buitrago, Gloria Milena Molina Vinasco.
Incidence of land coverage and geology, in the unstability of lands
of the micro-basin of the Combia creek, Pereira, Risaralda....................................73
Alejandro Alzate Buitrago, Daniel AristizĂĄbal Torres.
Chapter 2. Arts, Humanities, and Social Sciences
Training experience with teachers teaching mathematics using the
inquiry methodology ...............................................................................................95
Vivian Libeth Uzuriaga LĂłpez, HĂ©ctor Gerardo SĂĄnchez Bedoya.
Interpretation of the multiple representations of the fears associated
to the boarding of limited visual patients in the elective I studentsâ written
productions and low vision ...................................................................................113
Eliana BermĂșdez Cardona, Ana MarĂa Agudelo Guevara, Caterine VillamarĂn Acosta.
The relevance of local knowledge in social sciences............................................131
Alberto Antonio BerĂłn Ospina, Isabel Cristina Castillo Quintero.
Basic education studentsâ conceptions of conflict a view from the peace
for the education....................................................................................................143
Astrid Milena CalderĂłn CĂĄrdenas,Carolina Aguirre Arias, Carolina Franco Ossa,
Martha Cecilia Gutiérrez Giraldo, Orfa Buitrago.
Comprehensive risk prevention in educational settings: an interdisciplinary
and socio-educational approach ............................................................................163
Olga MarĂa Henao Trujillo, Claudia MarĂa LĂłpez Ortiz.
Chapter 3. Natural and Agricultural Sciences
Physicochemical characterization of three substrates used in the deep
bedding system in swine .......................................................................................175
Juan Manuel SĂĄnchez Rubio, AndrĂ©s Felipe Arias Roldan, JesĂșs Arturo RincĂłn Sanz,
Jaime Andrés Betancourt Våsquez.
Periodic solutions in AFM models........................................................................187
Daniel Cortés Zapata, Alexander Gutiérrez Gutiérrez.
Phenology in flower and fruit of Rubus glaucus benth. Cv. Thornless
in Risaralda: elements for phytosanitary management .........................................199
Shirley Palacios Castro, AndrĂ©s Alfonso Patiño MartĂnez, James Montoya Lerma,
Ricardo Flórez, Harry Josué Pérez.
Socio-economic and technical characterization of the cultivation of
avocado (Persea americana) in Risaralda..............................................................217
AndrĂ©s Alfonso Patiño MartĂnez, Kelly Saudith Castañez Poveda, Eliana GĂłmez Correa.
Biosecurity management in backyard systems in Santa Rosa de Cabal,
Risaralda................................................................................................................227
Julia Victoria Arredondo Botero, Jaiver Estiben Ocampo Jaramillo, Juan SebastiĂĄn Mera Vallejo,
Ălvaro de JesĂșs Aranzazu HernĂĄndez.
CONTENTS
Physical-chemical diagnosis of soils in hillside areas with predominance
of Lulo CV. La Selva production system in the department of Risaralda.............241
Adriana Patricia Restrepo GallĂłn, MarĂa Paula Landinez Montes, Jimena TobĂłn LĂłpez.
Digestibility of three concentrates used in canine feeding....................................271
MarĂa Fernanda MejĂa Silva, Valentina Noreña SĂĄnchez, GastĂłn Adolfo Castaño JimĂ©nez.
Chapter 4. Economic, Administrative, and Accounting Sciences
Financial inclusion in households from socioeconomic strata 1 and 2 in
the city of Pereira ..................................................................................................285
Lindy Neth Perea Mosquera, Marlen Isabel Redondo RamĂrez, AngĂ©lica Viviana Morales.
Internal marketing strategies as a competitive advantage for the company
Mobilautos SAS de Dosquebradas........................................................................303
InĂ©s Montoya SĂĄnchez, Sandra Patricia Viana Bolaños, Ana MarĂa Barrera RodrĂguez.
Uses of tourist marketing in the tourist sector of the municipality of Belén
de UmbrĂa, Risaralda.............................................................................................319
Ana MarĂa Barrera RodrĂguez, Paola Andrea Echeverri GutiĂ©rrez, MarĂa Camila Parra Buitrago,
Paola Andrea MartĂn Muñoz, Angy Paola Ăngel VĂ©lez, Luisa Natalia Trejos Ospina.
Territorial prospective of Risaralda department (Colombia), based on
the SDGS...............................................................................................................333
Juan Guillermo Gil GarcĂa, Samanta Londoño VelĂĄsquez.
Chapter 5. Health and Sports Sciences
Performance evaluation in times of pandemic. What do medical
students think?.......................................................................................................353
Samuel Eduardo Trujillo Henao, Rodolfo A. Cabrales Vega, GermĂĄn Alberto Moreno GĂłmez.
The relevance of the therapistâs self and self-reference in the training
of psychologists.....................................................................................................371
Maria Paula Marmolejo Lozano, Mireya Ospina Botero.
Habits related to oral health which influence lifestyle of elder people
in a wellness center for the elderly in Pereira 2020. .............................................387
Isadora Blanco PĂ©rez, Olga Patricia RamĂrez RodrĂguez, Ăngela MarĂa RincĂłn Hurtado.
Analysis of the suicide trend in the Coffee Region in Colombia during
the years 2012-2018 ..............................................................................................405
Germån Alberto Moreno Gómez, Jennifer Nessim Salazar, Jairo Franco Londoño,
Juan Carlos Medina Osorio.
Hind limb long bone fractures in canines and felines...........................................419
MarĂa Camila Cruz VĂ©lez, Valentina Herrera Morales, Alba Nydia Restrepo JimĂ©nez, Lina
Marcela Palomino, Gabriel Rodolfo Izquierdo Bravo.
Prevalence of overweight and obesity in children in the rural and urban
area of Risaralda....................................................................................................439
Angela MarĂa Ălvarez LĂłpez, Angela Liceth PĂ©rez RendĂłn, Alejandro GĂłmez Rodas,
Luis Enrique Isaza VelĂĄsquez.
Chapter 6. Architecture, Design and Advertising
The artisan crafts of Risaralda, characteristics, importance, and risks
within the Colombian Coffee Cultural Landscape, CCCL....................................457
Yaffa Nahir Ivette GĂłmez Barrera, Javier Alfonso LĂłpez Morales
UniĂłn Ibero-Americana, Año XXX, NĂșm. 4
48 pĂĄginasGRABADOS: Conjunto del Proyecto de Monumento de los Sres. Coullaut Valera y MartĂnez Zapatero premiado en el concurso abierto con motivo del tercer Centenario de la muerte de Cervantes.- D. Lorenzo Coullaut Valera.- D. Rafael MartĂnez Zapatero.- Conjunto de la Fuente del idioma en el Proyecto de Monumento a Cervantes.- ExcelentĂsimo Sr. Dr. Cecilio BĂĄez, ex Presidente de la RepĂșblica de Paraguay y entusiasta propagandista de la UniĂłn Ibero-Americana.- Peru: Vista panorĂĄmica de Lima.- Chile: Punta Arenas.- Guatemala: Teatro Nacional âArgentina (Buenos Aires): Mataderos pĂșblicos.
TEXTO: EI tercer Centenario de la muerte de Cervantes, por Manuel de Saralegui y Medina.- Proyecto de Monumento a Miguel de Cervantes Saavedra, premiado en el concurso abierto en España con motivo del Tercer Centenario de la muerte del autor del Quijote.- Una obra meritoria, por BenjamĂn Barrios.- Del ilustre paraguayo Dr. Cecilio BĂĄez.- Nuestra raza. (De la_Estrella, de PanamĂĄ)-PanamĂĄ desde 1a emancipaciĂłn colonial, por Josep Pla.- D. Manuel Franco, ilustre Presidente de la RepĂșblica del Paraguay, por Federico GarcĂa.- El culto a la raza, por J. Francisco LĂłpez Escobar.- El peligro de las medicinas de patente, por el doctor Juan Antiga.- Anales de la escena española desde 1701 a 1730, por Narciso DĂaz de Escovar.- Americanos ilustres: Don Marco Fidel SuĂĄrez, por Ismael LĂłpez.- EI decĂĄlogo del padre, por el Dr. Manuel Tolosa y Latour.- La Cruz Roja (poesĂa), por VĂctor M. RendĂłn.- La instrucciĂłn en la RepĂșblica argentina, por Francisco Carbonell.- CatĂĄlogo de la ExposiciĂłn celebrada en el Archivo General de Indias en 1913 y 1914. PolĂtica econĂłmica hispano-americana: Conferencia dada en el Ateneo hispano-americano, de Buenos Aires, por el Sr. A. MartĂn JimĂ©nez.- EI cuento de la esclava Roxana, por Alfonso de Armiñån.- Noticias de España (Las CompañĂas de Seguros. Las armas de Elbar).- Lo que podrĂa ser un bachillerato para la raza hispanoamericana: Conferencia pronunciada en la UniĂłn lbero-Americana de Madrid, e1 14 de diciembre de 1915.- Biblioteca.- CatĂĄlogo de exportadores españoles.- Libros nacionales y extranjeros, por Antonio BalbĂn de Unquera.- Acepte V. la Biblioteca gratuita que se le ofrece.- Anuncios
Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry
Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER); Agencia Española del Medicamento; ConsejerĂa de Salud de AndalucĂa.Background & Aims: Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into the Spanish DILI Registry over a 20-year time period. Methods: Cases were identified, diagnosed and followed prospectively. Clinical features, drug information and outcome data were collected. Results: A total of 843 patients, with a mean age of 54 years (48% females), were enrolled up to 2018. Hepatocellular injury was associated with younger age (adjusted odds ratio [aOR] per year 0.983; 95% CI 0.974-0.991) and lower platelet count (aOR per unit 0.996; 95% CI 0.994-0.998). Anti-infectives were the most common causative drug class (40%). Liver-related mortality was more frequent in patients with hepatocellular damage aged â„65 years (p = 0.0083) and in patients with underlying liver disease (p = 0.0221). Independent predictors of liver-related death/transplantation included nR-based hepatocellular injury, female sex, higher onset aspartate aminotransferase (AST) and bilirubin values. nR-based hepatocellular injury was not associated with 6-month overall mortality, for which comorbidity burden played a more important role. The prognostic capacity of Hy's law varied between causative agents. Empirical therapy (corticosteroids, ursodeoxycholic acid and MARS) was prescribed to 20% of patients. Drug-induced autoimmune hepatitis patients (26 cases) were mainly females (62%) with hepatocellular damage (92%), who more frequently received immunosuppressive therapy (58%). Conclusions: AST elevation at onset is a strong predictor of poor outcome and should be routinely assessed in DILI evaluation. Mortality is higher in older patients with hepatocellular damage and patients with underlying hepatic conditions. The Spanish DILI Registry is a valuable tool in the identification of causative drugs, clinical signatures and prognostic risk factors in DILI and can aid physicians in DILI characterisation and management. Lay summary: Clinical information on drug-induced liver injury (DILI) collected from enrolled patients in the Spanish DILI Registry can guide physicians in the decision-making process. We have found that older patients with hepatocellular type liver injury and patients with additional liver conditions are at a higher risk of mortality. The type of liver injury, patient sex and analytical values of aspartate aminotransferase and total bilirubin can also help predict clinical outcomes
Delayed colorectal cancer care during covid-19 pandemic (decor-19). Global perspective from an international survey
Background
The widespread nature of coronavirus disease 2019 (COVID-19) has been unprecedented. We sought to analyze its global impact with a survey on colorectal cancer (CRC) care during the pandemic.
Methods
The impact of COVID-19 on preoperative assessment, elective surgery, and postoperative management of CRC patients was explored by a 35-item survey, which was distributed worldwide to members of surgical societies with an interest in CRC care. Respondents were divided into two comparator groups: 1) âdelayâ group: CRC care affected by the pandemic; 2) âno delayâ group: unaltered CRC practice.
Results
A total of 1,051 respondents from 84 countries completed the survey. No substantial differences in demographics were found between the âdelayâ (745, 70.9%) and âno delayâ (306, 29.1%) groups. Suspension of multidisciplinary team meetings, staff members quarantined or relocated to COVID-19 units, units fully dedicated to COVID-19 care, personal protective equipment not readily available were factors significantly associated to delays in endoscopy, radiology, surgery, histopathology and prolonged chemoradiation therapy-to-surgery intervals. In the âdelayâ group, 48.9% of respondents reported a change in the initial surgical plan and 26.3% reported a shift from elective to urgent operations. Recovery of CRC care was associated with the status of the outbreak. Practicing in COVID-free units, no change in operative slots and staff members not relocated to COVID-19 units were statistically associated with unaltered CRC care in the âno delayâ group, while the geographical distribution was not.
Conclusions
Global changes in diagnostic and therapeutic CRC practices were evident. Changes were associated with differences in health-care delivery systems, hospitalâs preparedness, resources availability, and local COVID-19 prevalence rather than geographical factors. Strategic planning is required to optimize CRC care
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)