889 research outputs found

    Sustainable business models: integrating employees, customers and technology

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    This Special Issue of the Journal of Business & Industrial Marketing has the same title as the 23rd International Conference CBIM 2018 (June 18-20, 2018, Madrid, Spain) “Sustainable Business Models: Integrating Employees, Customers and Technology”. In this edition of International Conference, following a competitive blind review process, papers from 126 authors and 25 countries were ultimately accepted. The best papers of the Conference were invited to submit to this Special Issue and we were also open to direct submissions from other authors. We present here the 17 accepted papers for publication in this Special Issue

    Design and construction of the western breakwater for the outer port at Punta Langosteira (A Coruña, Spain)

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    This paper describes the design process, hydraulic stability tests and construction of the Cubipod® armored Western breakwater at Punta Langosteira (Outer Port of A Coruña, Spain), located on the Atlantic coast of Spain. The environmental, geotechnical, economic and logistic conditions favored randomly-placed Cubipods for single-layer armoring of the trunk. 3D hydraulic stability tests were carried out to validate the final design of the Western Breakwater; two models were tested with single- and double-layer Cubipod armors in the trunk and roundhead, respectively. Single-layer 25- and 30-tonne Cubipod® armors were used for the trunk section and a double-layer 45-tonne Cubipod® armor was used for the roundhead. During this project, new challenges were overcome, such as constructing a transition between single and double-layer armors, and manufacturing and handling of 45-tonne Cubipods. The transition in the armor thickness was solved by modifying the filter thickness under the main armor, to ensure a homogeneous external armor profile. Breakwater construction finished in November 2016 with no significant problem or delay in the original schedule

    Design and construction of the western breakwater for the outer port at Punta Langosteira (A Coruña, Spain)

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    This paper describes the design process, hydraulic stability tests and construction of the Cubipod® armored Western breakwater at Punta Langosteira (Outer Port of A Coruña, Spain), located on the Atlantic coast of Spain. The environmental, geotechnical, economic and logistic conditions favored randomly-placed Cubipods for single-layer armoring of the trunk. 3D hydraulic stability tests were carried out to validate the final design of the Western Breakwater; two models were tested with single- and double-layer Cubipod armors in the trunk and roundhead, respectively. Single-layer 25- and 30-tonne Cubipod® armors were used for the trunk section and a double-layer 45-tonne Cubipod® armor was used for the roundhead. During this project, new challenges were overcome, such as constructing a transition between single and double-layer armors, and manufacturing and handling of 45-tonne Cubipods. The transition in the armor thickness was solved by modifying the filter thickness under the main armor, to ensure a homogeneous external armor profile. Breakwater construction finished in November 2016 with no significant problem or delay in the original schedule

    Single-Layer Cubipod Armored Breakwaters in Punta Langosteira (Spain)

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    This paper describes the design process, hydraulic stability tests and construction of two single-layer Cubipod armored breakwaters in the Port of Punta Langosteira (A Coruña, Spain), located on the Atlantic coast of Spain, the first single-layer armors of randomly placed massive concrete armor units. The environmental, geotechnical, economic and logistic conditions favored randomly-placed Cubipods in single-layer armoring. 3D hydraulic stability tests of single-layer Cubipod armored breakwaters proved useful to validate the final design with 15-tonne and 25-tonne Cubipod units

    Accesibilidad y administración pública: un análisis de la situación de la juventud

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    Introducción. Las normas internacionales, como la Convención sobre los Derechos de las Personas con Discapacidad (CDPD), suponen un reconocimiento de los derechos sociales. Sin embargo, también implican una modificación de la legislación nacional para hacer efectivos estos derechos. A su vez, esto supone una complejización de la Administración, generando nuevos organismos e implicando nuevas disciplinas. Estos cambios no siempre resultan sencillos de comprender, precisando de adaptaciones para poder hacer efectivos los derechos reconocidos. Objetivo. Conocer cómo se ha aplicado el derecho a la accesibilidad universal, recogido en la CDPD, en las leyes relativas a los jóvenes con graves discapacidades incluidos en el sistema de dependencia aragonés. Método. Muestra: el período estudiado es de abril de 2008, fecha de ratificación de la CDPD por España, y marzo de 2020. Finalmente, tras una selección mediante criterios de inclusión/exclusión, la muestra fue de 36 leyes relacionadas con la discapacidad y la dependencia en Aragón. Instrumentos y procedimiento: Como técnica se utilizó un análisis de contenido deductivo. Se creó un libro de códigos con 31 variables para recoger el sistema de categorías. Por lo tanto, se definió la unidad de análisis como segmentos específicos del texto que se caracterizan por estar adscritos a una categoría específica. Los datos se dicotomizaron bajo criterios de presencia/ausencia dando lugar a una base de datos en SPSS. Resultados. Algunos de los resultados principales son: escasez de definiciones claras que disminuyan la arbitrariedad; pequeña presencia de referencias a la juventud y a grandes necesidades de apoyo; insuficiencia de legislación en lectura fácil. Conclusiones. A pesar de ciertos avances, la adaptación de la normativa no se ha consolidado, afectando a los derechos de las personas con discapacidad, especialmente en el caso de los jóvenes y de las personas con grandes necesidades de apoyo

    Sexual differences in hippocampal microglia of adult mice subjected to maternal separation stress.

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    Introduction: It is well known that early life adversities could a"ect brain development and increase the vulnerability to stress-related disorders later in adulthood. Nevertheless, the neurobiological mechanisms underlying this susceptibility have been poorly characterized and sex could be an important variable. Recently, microglia, which is involved in many neurodevelopmental processes such as neurogenesis and synaptic plasticity, has been proposed as a mediator of this stress response and early life stress could “prime” microglia to be over- responsive in future challenges. Objective: The analysis of hippocampal microglia morphology and distribution in the dentate gyrus (DG) of mice subjected to early stress. Methods: Female and male C57BL/6J mice were subjected to 3h daily maternal separation (MS) for 21 days. In postnatal day 60, adult mice undertook a single 2h restriction stress (RS). Accordingly, the experimental groups were as follows: CTRL, RS, MS, MS+RS. The DG was analyzed using immunohistochemistry techniques against Iba1 (microglia) following image analysis (ImageJ) to obtain morphological and distribution data of microglial somas and DG surface area. Results: Smaller DG surface area was observed in MS male mice compared with the CTRL group, but not in female. Furthermore, microglial soma area changed in a sex-dependent manner, having female mice from MS group an increased soma area than those of MS male mice. This was also observed to be region-specific, with a larger microglia soma in DG subgranular zone (SGZ) of MS female compared to MS male. Since microglia in this DG zone is involved in neurogenesis, this might suggest a possible change in the formation of new born neurons. Conclusion: These results revealed a di"erent microglial response to stress depending on the animal sex and open the door to a better understanding of neurobiological basis in pathologies like depression. .University of Málaga, the project PID2020-117464RB-I00 from Ministerio de Ciencia e Innovación (MCIN/AEI) Spain, awarded to Pedraza, C. and Pérez-Martín, M. ; the project P20_00460 from Consejería de Conocimiento, Investigación y Universidades, Junta de Andalucía awarded to Pedraza, C. and predoctoral fellowship FPU21/01318 awarded to Munoz- Martin, J. funded by MCIN/AEI, Spain. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

    Mild juvenile stress increases resilience to the development of anxious behaviors and prevents neurogenic reduction after stress exposure in adulthood.

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    Stress, especially during sensitive periods of development, can induce neuroplastic changes in brain regions such as the hippocampus, which increases vulnerability to the negative effects of a second stressor during adulthood, precipitating the development of depressive symptoms. For this reason, C57BL/6J mice were subjected to two stress protocols, the first in the juvenile period and the second in adulthood. Neurogenic and behavioral changes (saccharin preference test and social behavior test) were analyzed. The results revealed that juvenile stress increased basal saccharin preference in adulthood. However, animals subjected to stress in both juvenile and adulthood showed anhedonic behavior. In addition, stress in adulthood resulted in increased anxious behavior without affecting interest in social relationships. Stress in adulthood reduced neurogenesis. In contrast, juvenile stress prevented the development of anxious behavior and the reduction of hippocampal neurogenesis induced by stress in adulthood. In conclusion, juvenile stress increases the risk of developing anhedonia after exposure to a second stress, but, in contrast to our expectations, mild stress during the juvenile period increases resilience to the development of anxious behaviors and prevents neurogenic reduction after stress exposure in adulthoodUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech
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