Nanoformas de carbono moleculares quirales

Conferencias científicasCharla magistral sobre la química en fullerenos quirales y sus propiedades.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Vicerrectorado de Investigación de la Universidad de Málag

Fullerenes for Catalysis: Metallofullerenes in Hydrogen Transfer Reactions

[60]Fullerene hybrids have succesfully been used as catalysts in hydrogen transfer reactions, namely ketones reduction and Nalkylation with alcoholes. Due to the poor solubility in polar solvent, these hybrids behave as homogeneous/heterogeneous catalysts that can be mechanically separated and reused for several times while the final products do not need chromatographic separation

A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition

Multivalent ligand presentation is a powerful strategy for the development of specific binders and inhibitors. Peptide/[60]fullerene hybrids have now been synthesized that exploit the complete substitution of the fullerene scaffold to afford globular structures presenting twelve copies of a peptide ligand for the recognition of E-selectin. Fully substituted peptide/[60]fullerene hexakis-adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis-adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis-adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E-selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materialsThis work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [SAF2017-89890-R, PCI2019-103400, PID2020-117143RB-I00, PID2020-114653RB-I00 and PID2020-115120GB-I00], Xunta de Galicia (ED431C 2017/25 and Centro singular de investigación de Galicia accreditation 2019–2022, ED431G 2019/03) and the European Commission (EC) (European Regional Development Fund-ERDF). J.M. thanks the ERC-STG (DYNAP, 677786), ERC-POC (TraffikGene, 838002), Xunta de Galicia (Oportunius Program) and Human Frontier Science Programme Young Investigator Grant (RGY0066/2017) for funding. J.J.R. received a Beatriz Galindo Grant (BEAGAL18-00051) by the Spanish Ministerio de Universidades. I.G. received predoctoral fellowships (ED481A-2018/116 and FPU17/00941). J.C.-G. thanks the Comunidad de Madrid Atracción de Talento program (2018-T2/BMD-10275)S

An Ultra‐Long‐Lived Triplet Excited State in Water at Room Temperature: Insights on the Molecular Design of Tridecafullerenes

Suitably engineered molecular systems exhibiting triplet excited states with very long lifetimes are important for high-end applications in nonlinear optics, photocatalysis, or biomedicine. We report the finding of an ultra-long-lived triplet state with a mean lifetime of 93 ms in an aqueous phase at room temperature, measured for a globular tridecafullerene with a highly compact glycodendrimeric structure. A series of three tridecafullerenes bearing different glycodendrons and spacers to the C60 units have been synthesized and characterized. UV/Vis spectra and DLS experiments confirm their aggregation in water. Steady-state and time-resolved fluorescence experiments suggest a different degree of inner solvation of the multifullerenes depending on their molecular design. Efficient quenching of the triplet states by O2 but not by waterborne azide anions has been observed. Molecular modelling reveals dissimilar access of the aqueous phase to the internal structure of the tridecafullerenes, differently shielded by the glycodendrimeric shell

2011: ¿El comienzo de una nueva revolución química?

The International Year of Chemistry 2011 (IYC2011) is a worldwide celebration of the achievements of chemistry and its contributions to the well-being of humankind. Under the unifying theme �Chemistry: our life, our future�, the goals of the IYC2011 are to increase the public appreciation of chemistry in meeting world needs, to encourage interest in chemistry among young people, and to generate enthusiasm for the creative future of chemistry. The year 2011 coincides with the 100th anniversary of the Chemistry Nobel Prize awarded to Marie Curie, an opportunity to consider the contributions of women to science.El Año Internacional de la Química (AIQ2011) se ha proclamado para celebrar los logros de esta ciencia y mostrar al público sus contribuciones al bienestar de la humanidad. Bajo el lema �Química: nuestra vida, nuestro futuro�, los objetivos del AIQ2011 son incrementar la apreciación pública de la química como herramienta fundamental para satisfacer las necesidad de la sociedad, promover el interés por la química entre los jóvenes, y generar entusiasmo por el futuro creativo de la química. El año 2011 coincide además con el centenario de la concesión del Premio Nobel de Química a Marie Curie, una oportunidad para valorar la contribución de las mujeres a la ciencia