Functional and patient-centered treatment outcomes with mandibular overdentures retained by two immediate or conventionally loaded Implants: A randomized clinical Trial

[ES]Este estudio tiene como objetivo evaluar los resultados del tratamiento (funcionales y subjetivos) de sobredentaduras mandibulares retenidas sobre dos implantes con o sin un protocolo de carga inmediata. En este ensayo clínico aleatorizado, veinte pacientes completamente edéntulos fueron tratados con una sobredentadura mandibular retenida por dos implantes y una dentadura maxilar nueva completa. En la mitad de la muestra, los implantes se cargaron inmediatamente mediante pilares VulkanLoc® tras la colocación del implante, pero en las contralaterales, estos pilares VulkanLoc® se conectaron a los implantes dos meses después de la cirugía (protocolo convencional), y hasta ese momento las dentaduras postizas fueron retenidas por pilares de cicatrización. Los resultados del tratamiento se evaluaron a los dos, seis y doce meses después de la cirugía. Los resultados funcionales se calcularon según el rendimiento masticatorio, estimado por la fracción mixta de un chicle bicolor después de cinco, diez y quince golpes de masticación, por la fuerza oclusal registrada por las láminas sensibles a la presión y por la actividad muscular bioeléctrica. Los resultados subjetivos del tratamiento se evaluaron utilizando tanto la escala de satisfacción oral (escala visual analógica) como la versión española del Oral Health Impact Profile (OHIP-20). Los hallazgos del presente estudio muestran que las nuevas dentaduras postizas completas dieron como resultado mejoras significativas en la capacidad de masticación, la satisfacción del paciente y la calidad de vida relacionada con la salud bucal y que las posteriores sobredentaduras implantosoportadas produjeron mejoras significativas adicionales y más rápidas. El protocolo de carga puede influir en esos resultados positivos auto-informados en lugar de las evaluaciones funcionales objetivas[EN]This study aims to assess the treatment outcomes (functional and subjective) of mandibular overdentures retained on two implants with or without an immediate loading protocol. In this randomized clinical trial, twenty fully edentulous patients were treated with a mandibular twoimplant-retained overdenture and a complete new maxillary denture. In half of the sample, the implants were loaded immediately by means of VulkanLoc® abutments after emplacement of the implant, but in the counterparts, these VulkanLoc® abutments were connected to implants two months after the surgery (conventional protocol), and until that time the dentures were retained by healing abutments. Treatment outcomes were assessed at two, six, and twelve months after surgery. Functional outcomes were calculated according to masticatory performance, estimated by the mixed fraction of a two-coloured chewing gum after five, ten, and fifteen chewing strokes, by the occlusal force recorded by pressure-sensitive sheets, and by the bioelectrical muscular activity. The subjective outcomes of the treatment were assessed using both the oral satisfaction scale (visual analogue scale) and the Spanish version of the Oral Health Impact Profile (OHIP-20). The findings of the present study show that new complete dentures resulted in significant improvements in chewing ability, patient satisfaction, and oral health-related quality of life and that subsequent implant-retained overdentures produced further and faster significant improvements. The loading protocol may influence those positive self-reported outcomes rather than the objective functional evaluations

Clinical Outcomes of the Double Lateral Sliding Bridge Flap Technique with Simultaneous Connective Tissue Graft in Sextant V Recessions: Three-Year Follow-Up Study

The presence of isolated or multiple gingival recessions in the mandibular anterior region is a challenge for the clinician, as they may be associated with a shallow vestibule, high frenum insertion and/or little or no attached gingiva. Only limited evidence is available on the use of the double lateral sliding bridge flap technique with connective tissue graft (CTG) technique for treating gingival recessions in the mandibular anterior region. The aim of this study was to describe and evaluate the clinical and esthetic outcomes of the double lateral sliding bridge flap technique with CTG on isolated and multiple gingival recessions at the level of the mandibular incisors. Nine patients required treatment of gingival recessions in the mandibular incisors at the University of Salamanca (Spain) (seven females, two males; mean age: 27.9 ± 6.9) with a total of 14 isolated (42.9%) and multiple (57.1%) Miller class II and III gingival recessions. After a mean follow-up of 36 months, the mean percentage of root coverage was 80.5% for all treated recessions. Statistically significant differences (p < 0.05), were observed for reduction in recession depth, increased width of keratinized tissue and increased gingival thickness, this being dependent on the Miller class. The esthetic outcome was acceptable, with a final mean esthetic score of 7.4 out of 10. The double lateral sliding bridge flap surgical technique with CTG is an effective procedure for the coverage of isolated and multiple gingival recessions in the anterior mandibular region, as it offers satisfactory esthetic results

Derecho penal económico y de la empresa

Presentación (pp. 37 - 38). -- Tema 1: Introducción al derecho penal económico y de la empresa / Adán Nieto Martín (pp. 39 - 60). -- Tema 2: Derecho penal de la empresa y económico europeo e internacional / Adán Nieto Martín (pp. 61 - 85). -- Tema 3: La responsabilidad penal individual en los delitos de empresa / Juan Antonio Lascuraín Sánchez (pp. 87 - 128). -- Tema 4: La responsabilidad penal de las personas jurídicas / Jacobo Dopico Gómez-Aller (pp. 129 - 168). -- Tema 5: Estafas y otros fraudes en el ámbito empresarial / Jacobo Dopico Gómez-Aller (pp. 169 - 235). -- Tema 6: Administración desleal y apropiación indebida / Adán Nieto Martín (pp. 237 - 284). -- Tema 7: Delitos de frustación de la ejecución y delitos de insolvencia / Norberto J. de la Mata Barranco (pp. 285 - 325). -- Tema 8: Delitos contra la propiedad intelectual e industrial y violación de secretos de empresa / Norberto J. de la Mata Barranco (pp. 327 - 366). -- Tema 9: Protección penal de la competencia y del mercado de valores / Adán Nieto Martín (pp. 367 - 414). -- Tema 10: Corrupción en los negocios / Adán Nieto Martín (pp. 415 - 445). -- Tema 11: Delitos contra los consumidores (publicidad engañosa y facturación automática fraudulenta). Piratería de servicios de comunicación / Jacobo Dopico Gómez-Aller y Juan Antonio Lascuraín Sánchez (pp. 447 - 467). -- Tema 12: Delitos societarios / Juan Antonio Lascuraín Sánchez (pp. 469 - 492). -- Tema 13: Blanqueo de capitales / Juan Antonio Lascuraín Sánchez (pp. 493 - 527). -- Tema 14: Delitos contra la Hacienda Pública y la Seguridad Social / Norberto J. de la Mata Barranco (pp. 529 - 591). -- Tema 15: Delitos contra los derechos de los trabajadores / Juan Antonio Lascuraín Sánchez (pp. 593 - 628). -- Tema 16: Delitos contra el urbanismo y la ordenación del territorio y delitos contra el ambiente / Norberto J. de la Mata Barranco (pp. 629 - 684). -- Tema 17: Falsedades en la empresa / Adán Nieto Martín (pp. 685 - 726). -- Tema 18: Delitos contra los sistemas de información / Norberto J. de la Mata Barranco (pp. 727 - 759

Treatment of children obesity and diabetes through gamification

Childhood obesity is nowadays a global epidemic. This illness sometimes comes with another associated problem, like Diabetes type II. In this paper we present a case of study about the results of the application of a gamified educational program. A 3-year longitudinal and prospective study was conducted a patient with obesity and diabetes. Different assessments regarding the health state of the patient have been developed (family background, physical/medical, emotional state and physical activity). Using Positive outcomes have been obtained in their medical registers and also, in their health habits. Thus, the application of gamification strategies in the educational program has positive impact in the health

Anisotropy studies around the galactic centre at EeV energies with the Auger Observatory

Data from the Pierre Auger Observatory are analyzed to search for anisotropies near the direction of the Galactic Centre at EeV energies. The exposure of the surface array in this part of the sky is already significantly larger than that of the fore-runner experiments. Our results do not support previous findings of localized excesses in the AGASA and SUGAR data. We set an upper bound on a pointlike flux of cosmic rays arriving from the Galactic Centre which excludes several scenarios predicting sources of EeV neutrons from Sagittarius A. Also the events detected simultaneously by the surface and fluorescence detectors (the ‘hybrid’ data set), which have better pointing accuracy but are less numerous than those of the surface array alone, do not show any significant localized excess from this direction.Facultad de Ciencias Exacta

Anisotropy studies around the galactic centre at EeV energies with the Auger Observatory

Data from the Pierre Auger Observatory are analyzed to search for anisotropies near the direction of the Galactic Centre at EeV energies. The exposure of the surface array in this part of the sky is already significantly larger than that of the fore-runner experiments. Our results do not support previous findings of localized excesses in the AGASA and SUGAR data. We set an upper bound on a pointlike flux of cosmic rays arriving from the Galactic Centre which excludes several scenarios predicting sources of EeV neutrons from Sagittarius A. Also the events detected simultaneously by the surface and fluorescence detectors (the ‘hybrid’ data set), which have better pointing accuracy but are less numerous than those of the surface array alone, do not show any significant localized excess from this direction.Facultad de Ciencias Exacta

PROVITAO: a research program based on active games for help the abulatory treatment of childhood obesity

Childhood obesity is the most prevalent chronic disease in developed and developing countries. Recent studies showed that the Canary Islands are the Spanish region with the highest rate of childhood obesity. However, this disease is easy to prevent, educating children from healthy habits, and, the ICT in general and videogames in particular, represent an opportunity to work towards change. Therefore, this paper presents the design of an educational intervention program to help the ambulatory treatment of childhood obesity. This program is intended for children 8 to 12 years of age with obesity and who come for the first time to the Pediatric Service of the University Hospital of Canaries, and is currently being validated. The partial results show that the satisfaction of the minors with the program is high, emphasizing the focus in games

Evidence of association of the NLRP1 gene with giant cell arteritis

Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity. NLRP1 provides a scaffold for the assembly of the inflammasome that activates caspases 1 and 5, required for processing and activation of the proinflammatory cytokines interleukin 1β (IL-1β), IL-18 and IL-33 and promoting inflammation

Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis

Cytokines signalling pathway genes are crucial factors of the genetic network underlying the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence of the interleukin (IL)33- IL1 receptor like (IL1RL)1 signalling pathway on the increased risk of several immune-mediated diseases has been described. Accordingly, we assessed whether the IL33-IL1RL1 pathway represents a novel genetic risk factor for IgAV. Three tag polymorphisms within IL33 (rs3939286, rs7025417 and rs7044343) and three within IL1RL1 (rs2310173, rs13015714 and rs2058660), that also were previously associated with several inflammatory diseases, were genotyped in 380 Caucasian IgAV patients and 845 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when IL33 and IL1RL1 variants were analysed independently. Likewise, no statistically significant differences were found in IL33 or IL1RL1 genotype and allele frequencies when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when IL33 and IL1RL1 haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that the IL33-IL1RL1 signalling pathway does not contribute to the genetic network underlying IgAV.Acknowledgements: We are indebted to the patients and healthy controls for their essential collaboration to this study. We also thank the National DNA Bank Repository (Salamanca) for supplying part of the control samples. This study was supported by European Union FEDER funds and `Fondo de Investigaciones Sanitarias´ (Grant PI18/00042) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). DP-P is a recipient of a Río Hortega programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, `Investing in your future´) (Grant Number CM20/00006). SR-M is supported by funds of the RETICS Program (RD16/0012/0009) (ISCIII, cofunded by the European Regional Development Fund (ERDF)). VP-C is supported by a pre-doctoral grant from IDIVAL (PREVAL 18/01). BA-M is a recipient of a `López Albo´ Post-Residency Programme funded by Servicio Cántabro de Salud. LL-G is supported by funds from IDIVAL (INNVAL20/06). OG is staff personnel of Xunta de Galicia (Servizo Galego de Saude (SERGAS)) through a research-staff stabilization contract (ISCIII/SERGAS) and his work is funded by ISCIII and the European Union FEDER fund (Grant Numbers RD16/0012/0014 (RIER) and PI17/00409). He is beneficiary of project funds from the Research Executive Agency (REA) of the European Union in the framework of MSCA-RISE Action of the H2020 Programme, project 734899—Olive-Net. RL-M is a recipient of a Miguel Servet type I programme fellowship from the ISCIII, co-funded by ESF (`Investing in your future´) (Grant Number CP16/00033)

IgA vasculitis: influence of CD40, BLK and BANK1 gene polymorphisms

CD40, BLK and BANK1 genes involved in the development and signaling of B-cells are identified as susceptibility loci for numerous inflammatory diseases. Accordingly, we assessed the potential influence of CD40, BLK and BANK1 on the pathogenesis of immunoglobulin-A vasculitis (IgAV), predominantly a B-lymphocyte inflammatory condition. Three genetic variants within CD40 (rs1883832, rs1535045, rs4813003) and BLK (rs2254546, rs2736340, rs2618476) as well as two BANK1 polymorphisms (rs10516487, rs3733197), previously associated with inflammatory diseases, were genotyped in 382 Caucasian patients with IgAV and 955 sex- and ethnically matched healthy controls. No statistically significant differences were observed in the genotype and allele frequencies of CD40, BLK and BANK1 when IgAV patients and healthy controls were compared. Similar results were found when CD40, BLK and BANK1 genotypes or alleles frequencies were compared between patients with IgAV stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations. Moreover, no CD40, BLK and BANK1 haplotype differences were disclosed between patients with IgAV and healthy controls and between patients with IgAV stratified according to the clinical characteristics mentioned above. Our findings indicate that CD40, BLK and BANK1 do not contribute to the genetic background of IgAV.Funding: This study was supported by European Union FEDER funds and “Fondo de Investigaciones Sanitarias” (grants PI18/00042 and PI21/00042) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain). D.P.-P. is a recipient of a Río Hortega program fellowship from the ISCIII, co-funded by the European Social Fund (ESF, “Investing in your future”) (grant number CM20/00006). F.G. is supported by funds of the RICORS Program from ISCIII, co-funded by the European Union (grant number RD21/0002/0025). V.P.-C. is supported by funds of PI18/00042. S.R.-M. is supported by funds of the RETICS Program (RD16/0012/0009) (ISCIII, co-funded by the European Regional Development Fund (ERDF)). O.G. is a staff member of Xunta de Galicia (Servizo Galego de Saude (SERGAS)) through a research-staff stabilization contract (ISCIII/SERGAS) and his work is funded by ISCIII and the European Union FEDER fund (grant numbers RD16/0012/0014 (RIER) and PI17/00409). He is a beneficiary of project funds from the Research Executive Agency (REA) of the European Union in the framework of MSCA-RISE Action of the H2020 Program, project 734899—Olive-Net. R.L.-M. is a recipient of a Miguel Servet type II program fellowship from the ISCIII, co-funded by ESF (“Investing in your future”) (grant number CPII21/00004). Acknowledgments: We are indebted to the patients and healthy controls for their essential collaboration on this study. We also thank the National DNA Bank Repository (Salamanca) for supplying part of the control samples