El fondeadero de Getares (Algeciras)

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Turismo y Patrimonio en la Antártida

Se presenta a continuación una reflexión sobre el turismo en la Antártida desde un punto de vista cultural y patrimonial. A este respecto se realiza también un recorrido por las principales actuaciones de recuperación y conservación de dicho patrimonio en este continente, llevadas a cabo por diferentes países

Turismo y Patrimonio en la Antártida

The present in the following article a reflection on the tourism in the Antactic lined to the ultural eritage. e also analize the main recovery and preservation campaigns carried out by different countries in the continent.Se presenta a continuación una reflexión sobre el turismo en la Antártida desde un punto de vista cultural y patri monial. A este respecto se realiza también un recorrido por las principales actuaciones de recuperación y conser vación de dicho patrimonio en este continente, llevadas a cabo por diferentes países

El patrimonio arqueológico de A Coruña y su aprovechamiento turístico

Se presenta un recorrido histórico de los primeros asentamientos y habitantes de la actual A Coruña y cómo el turista que llega a la ciudad puede conocer su historia a través de los legados de esos primeros pobladores

Effects of advertising on problem gambling: Neural-cue reactivity as a possible underlying mechanism

Problem gambling has recently been reclassified as a non-substance-associated behavioral addiction. To the associated vital impact (family, social, labor, and economic), we must add its increasing incidence in recent years, which has led to prioritizing the problem from the point of view of public health. Although the effects of advertising on gambling behavior have been explored since the second half of the twentieth century, there is a lack of research regarding its underlying mechanisms. Thus, the objective of this review is to present an update on the effects of advertisements on gambling attitudes and behavioral intentions, as well as to present the neurobiological correlates of gambling-related cues as a possible hypothesis for this effect. Advertisements in various formats may act both as a precipitating factor and as a maintenance factor for the gambling disorder, changing both attitudes and beliefs about gambling. Activation of brain areas related to reward, such as accumbens nucleus, to memory, such as hippocampus or amygdala, and to executive functions could be the underlying mechanism of this effect. Also, ads promoting responsible gambling do not appear to be effective in reducing behavior or encouraging self-control, but the available evidence is scarce. Therefore, the number of studies on this topic needs to increase. In addition, the available evidence questions the effectiveness of responsible gambling policies to promote self-control in this population, as well as to reduce the negative impact of this disorder, so future research on neural-cue reactivity to gambling-related stimuli may serve to improve the design of advertising strategies that increase the impact of these messages

Patrimonio arqueológico urbano: conflictos entre investigadores y administración

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Evolutionary fates of universal stress protein paralogs in Platyhelminthes

Background Universal stress proteins (USPs) are present in all domains of life. Their expression is upregulated in response to a large variety of stress conditions. The functional diversity found in this protein family, paired with the sequence degeneration of the characteristic ATP-binding motif, suggests a complex evolutionary pattern for the paralogous USP-encoding genes. In this work, we investigated the origin, genomic organization, expression patterns and evolutionary history of the USP gene family in species of the phylum Platyhelminthes. Results Our data showed a cluster organization, a lineage-specific distribution, and the presence of several pseudogenes among the USP gene copies identified. The absence of a well conserved -CCAATCA- motif in the promoter region was positively correlated with low or null levels of gene expression, and with amino acid changes within the ligand binding motifs. Despite evidence of the pseudogenization of various USP genes, we detected an important functional divergence at several residues, mostly located near sites that are critical for ligand interaction. Conclusions Our results provide a broad framework for the evolution of the USP gene family, based on the emergence of new paralogs that face very contrasting fates, including pseudogenization, subfunctionalization or neofunctionalization. This framework aims to explain the sequence and functional diversity of this gene family, providing a foundation for future studies in other taxa in which USPs occur

Leges Romanae on‐line: diseño colaborativo y multidisciplinar de recursos educativos en abierto

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Potential Benefits of Non-Pharmacological Therapies in Fibromyalgia

Fibromyalgia (FM) is an incurable common syndrome of non-articular origin, and with no effective treatment by now. A great deal of research has sought to assess the efficacy of different therapies, especially non-pharmacological and low-cost ones, in the reduction of the intensity of symptoms. Despite the availability of a wide range of alternative therapies nowadays, there is little scientific evidence of the potential benefits of most of them, with results being contradictories. The purpose of this paper is to review some of the less well known alternative therapies in FM treatment, to describe the more relevant clinical studies published in this matter, and to analyze the potential effects of the main alternative therapies, in order to verify their efficacy