El fenómeno fan y los videojuegos publicitarios un caso de estudio de modding aplicado a los advergames

Comunicaciones del IV Congreso Internacional sobre análisis fílmico celebrado en la Universitat Jaume I de Castellón 4,5 y 6 de mayo de 201

Audiovisual and television content for mobile devices: an approach to the Spanish market

En el actual contexto mediático de convergencia digital y difusión multipantalla, los dispositivos móviles están adquiriendo un creciente protagonismo como punto de acceso a contenidos audiovisuales y televisivos, en especial aquellos contenidos relacionados con el entretenimiento. Este artículo examina las principales ventajas y limitaciones que presentan los dispositivos móviles como una nueva pantalla para la difusión de este tipo de contenidos. Para ello se ha realizado un análisis exploratorio de los contenidos audiovisuales de entretenimiento que han sido distribuidos en el mercado español desde los primeros formatos nativos del medio, como las moviseries y los realities shows, hasta la oferta actual de contenidos televisivos, así como las nuevas aplicaciones y contenidos surgidos con la consolidación de Internet móvil. La exploración realizada ha permitido identificar las principales tendencias y modelos de negocio surgidos en torno a estos contenidos, en especial aquellos relacionados con el emergente mercado de las aplicaciones para móviles. Del mismo modo ha permitido también señalar los principales factores, tanto tecnológicos como relativos al mercado, que pueden estar impidiendo un mayor uso de la telefonía móvil como plataforma de difusión de contenidos audiovisuales y televisivos.In nowadays media context of digital convergence and multi screen broadcast, mobile devices are playing an increasing role as a point of access to audiovisual and television contents, especially those related to entertainment. This paper analyzes the main advantages and limitations of mobile devices as a new screen through which broadcast these types of contents. In order to do this an exploratory analysis a Spanish market approach was conducted to reach those entertaining audiovisual contents broadcasted through the mobile platform, from the very first native formats —like moviseries and realities shows— to nowadays offer of television contents and brand new applications and contents which arise with the advent of the mobile Internet. This exploratory analysis has allowed identifying the main tendencies and business models which arise from these contents, especially those related to the emerging market of mobile application. Those main factors, both technological and market related, are also pointed as possible barriers for a greater use of mobile phones as a platform for broadcasting audiovisual and television contents

Nuevos formatos publicitarios y telefonía móvil: los "mobile advergames"

[EN] This paper analyzes mobile advergames in the context of advertising formats used in mobile marketing. Based on the features and functionality that define these formats, this paper iden tifies the predominant type of these formats in the Spanish market and emerging business models around them. It also identifies the main factors, both technological and market related that may be conditioning the short and medium term further development of video games in the mobile advertising.[ES] Este artículo examina los videojuegos para móviles con fines publicitarios (mobile advergames) en el marco de los nuevos formatos utilizados en el marketing móvil. A partir de las características y funcionalidades que definen estos formatos, este trabajo identifica la tipología predominante de estos formatos en el mercado español y los modelos de negocio surgidos en torno a los mismos. Asimismo, se indican los principales factores, tanto tecnológicos como relativos al mercado que pueden estar condicionando a corto y medio plazo un mayor desarrollo de videojuegos publicitarios en la telefonía móvil.[EU] Artikulu honek marketin mugikorrean erabilitako formatu berrien esparruan publizitate- xededun eskuko telefonoetarako bideo-jokoak (mobile advergames) ditu aztergai. Formatu hauek bereizten dituzten ezaugarri eta funtzionaltasunak abiapuntu hartuta, lan honek espainiar merkatuan aipatu formatuek duten tipologia nagusia eta euren inguruan sortutako negozio ereduak ere identifikatu egiten ditu. Orobat, telefonia mugikorrean epe labur zein ertainera bideo-joko publizitarioen garapen handiago bat baldintza dezaketen merkatu nahiz teknologia faktoreak ere adierazten diraAdelantado, E.; Martí Parreño, J. (2012). Nuevos formatos publicitarios y telefonía móvil: los "mobile advergames". Zer. Revista de estudios de comunicación. 17(33):31-45. http://hdl.handle.net/10251/51475S3145173

Visualization of the small RNA transcriptome using seqclusterViz

The study of small RNAs provides us with a deeper understanding of the complexity of gene regulation within cells. Of the different types of small RNAs, the most important in mammals are miRNA, tRNA fragments and piRNAs. Using small RNA-seq analysis, we can study all small RNA types simultaneously, with the potential to detect novel small RNA types. We describe SeqclusterViz, an interactive HTML-javascript webpage for visualizing small noncoding RNAs (small RNAs) detected by Seqcluster. The SeqclusterViz tool allows users to visualize known and novel small RNA types in model or non-model organisms, and to select small RNA candidates for further validation. SeqclusterViz is divided into three panels: i) query-ready tables showing detected small RNA clusters and their genomic locations, ii) the expression profile over the precursor for all the samples together with RNA secondary structures, and iii) the mostly highly expressed sequences. Here, we show the capabilities of the visualization tool and its validation using human brain samples from patients with Parkinson's disease

Audiovisual and television content for mobile devices: an approach to the Spanish market

[ES] En el actual contexto mediático de convergencia digital y difusión multipantalla, los dispositivos móviles están adquiriendo un creciente protagonismo como punto de acceso a contenidos audiovisuales y televisivos, en especial aquellos contenidos relacionados con el entretenimiento. Este artículo examina las principales ventajas y limitaciones que presentan los dispositivos móviles como una nueva pantalla para la difusión de este tipo de contenidos. Para ello se ha realizado un análisis exploratorio de los contenidos audiovisuales de entretenimiento que han sido distribuidos en el mercado español desde los primeros formatos nativos del medio, como las moviseries y los realities shows, hasta la oferta actual de contenidos televisivos, así como las nuevas aplicaciones y contenidos surgidos con la consolidación de Internet móvil. La exploración realizada ha permitido identificar las principales tendencias y modelos de negocio surgidos en torno a estos contenidos, en especial aquellos relacionados con el emergente mercado de las aplicaciones para móviles. Del mismo modo ha permitido también señalar los principales factores, tanto tecnológicos como relativos al mercado, que pueden estar impidiendo un mayor uso de la telefonía móvil como plataforma de difusión de contenidos audiovisuales y televisivos.[EN] In nowadays media context of digital convergence and multi screen broadcast, mobile devices are playing an increasing role as a point of access to audiovisual and television contents, especially those related to entertainment. This paper analyzes the main advantages and limitations of mobile devices as a new screen through which broadcast these types of contents. In order to do this an exploratory analysis a Spanish market approach was conducted to reach those entertaining audiovisual contents broadcasted through the mobile platform, from the very first native formats ¿like moviseries and realities shows¿ to nowadays offer of television contents and brand new applications and contents which arise with the advent of the mobile Internet. This exploratory analysis has allowed identifying the main tendencies and business models which arise from these contents, especially those related to the emerging market of mobile application. Those main factors, both technological and market related, are also pointed as possible barriers for a greater use of mobile phones as a platform for broadcasting audiovisual and television contents.Los resultados presentados en este texto forman parte de los trabajos realizados en el marco de dos proyectos de investigación: “La industria de los contenidos audiovisuales ante su mutación digital. Búsqueda de las claves de decisión del nuevo consumidor” financiado por el Ministerio de Cultura, la Agencia IDEA de Andalucía y la Plataforma de servicios en movilidad Cartuja ‘93 (Proyecto Minerva); y el proyecto “Evolución del medio móvil en España: actores, contenidos, modelos de negocio y percepción de los usuarios” (CSO2009-07108 subprograma SOCI), financiado por el Plan Nacional de I+D+I del Ministerio de Ciencia e Innovación.Adelantado Mateu, ME.; Martí, J. (2011). Contenidos audiovisuales y televisivos para dispositivos móviles: una aproximación al mercado español. AdComunica: revista científica de estrategias, tendencias e innovación en comunicación. (1):99-113. http://hdl.handle.net/10251/29598S99113

Nuevos formatos publicitarios y telefonía móvil: los "mobile advergames"

This paper analyzes mobile advergames in the context of advertising formats used in mobile marketing. Based on the features and functionality that define these formats, this paper identifies the predominant type of these formats in the Spanish market and emerging business models around them. It also identifies the main factors, both technological and market related that may be conditioning the short and medium term further development of video games in the mobile advertising.; Este artículo examina los videojuegos para móviles con fines publicitarios (mobile advergames) en el marco de los nuevos formatos utilizados en el marketing móvil. A partir de las características y funcionalidades que definen estos formatos, este trabajo identifica la tipología predominante de estos formatos en el mercado español y los modelos de negocio surgidos en torno a los mismos. Asimismo, se indican los principales factores, tanto tecnológicos como relativos al mercado que pueden estar condicionando a corto y medio plazo un mayor desarrollo de videojuegos publicitarios en la telefonía móvil.; Artikulu honek marketin mugikorrean erabilitako formatu berrien esparruan publizitate-xededun eskuko telefonoetarako bideo-jokoak (mobile advergames) ditu aztergai. Formatu hauek bereizten dituzten ezaugarri eta funtzionaltasunak abiapuntu hartuta, lan honek espainiar merkatuan aipatu formatuek duten tipologia nagusia eta euren inguruan sortutako negozio ereduak ere identifikatu egiten ditu. Orobat, telefonia mugikorrean epe labur zein ertainera bideo-joko publizitarioen garapen handiago bat baldintza dezaketen merkatu nahiz teknologia faktoreak ere adierazten dira

Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction

Accumulating evidence has suggested that neurotrophins participate in the pathophysiology of mood disorders. We have developed transgenic mice overexpressing the full-length neurotrophin-3 receptor TrkC (TgNTRK3) in the central nervous system. TgNTRK3 mice show increased anxiety-like behavior and enhancement of panic reaction in the mouse defense test battery, along with an increase in the number and density of catecholaminergic (tyrosine hydroxylase positive) neurons in locus coeruleus and substantia nigra. Furthermore, treatment of TgNTRK3 mice with diazepam significantly attenuated the anxiety-like behaviors in the plus maze. These results provide evidence for the involvement of TrkC in the development of noradrenergic neurons in the central nervous system with consequences on anxiety-like behavior and panic reaction. Thus, changes in TrkC expression levels could contribute to the phenotypic expression of panic disorder through a trophic effect on noradrenergic neurons in the locus coeruleus. Our results demonstrate that the elevated NT3-TrkC tone via overexpression of TrkC in the brain may constitute a molecular mechanism for the expression of anxiety and anxiety

A crowdsourcing database for the copy-number variation of the Spanish population

Background: Despite being a very common type of genetic variation, the distribution of copy-number variations (CNVs) in the population is still poorly understood. The knowledge of the genetic variability, especially at the level of the local population, is a critical factor for distinguishing pathogenic from non-pathogenic variation in the discovery of new disease variants. Results: Here, we present the SPAnish Copy Number Alterations Collaborative Server (SPACNACS), which currently contains copy number variation profiles obtained from more than 400 genomes and exomes of unrelated Spanish individuals. By means of a collaborative crowdsourcing effort whole genome and whole exome sequencing data, produced by local genomic projects and for other purposes, is continuously collected. Once checked both, the Spanish ancestry and the lack of kinship with other individuals in the SPACNACS, the CNVs are inferred for these sequences and they are used to populate the database. A web interface allows querying the database with different filters that include ICD10 upper categories. This allows discarding samples from the disease under study and obtaining pseudo-control CNV profiles from the local population. We also show here additional studies on the local impact of CNVs in some phenotypes and on pharmacogenomic variants. SPACNACS can be accessed at: http://csvs.clinbioinfosspa.es/spacnacs/. Conclusion: SPACNACS facilitates disease gene discovery by providing detailed information of the local variability of the population and exemplifies how to reuse genomic data produced for other purposes to build a local reference database

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p < 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics