45 research outputs found
Stability Properties of Underdominance in Finite Subdivided Populations
- Author
- A Bataille
- A Davison
- A Traulsen
- A Traulsen
- AB Soans
- Arne Traulsen
- B Skyrms
- BL Woodworth
- BO Bengtsson
- C Taylor
- CC Li
- CF Curtis
- DL Hartl
- DO McInnis
- Floyd A. Reed
- GD Snell
- H Gintis
- IA Boussy
- J Hofbauer
- J Ito
- J Pinto
- J Weibull
- JBS Haldane
- JBS Haldane
- JC Marshall
- K Magori
- LH Rieseberg
- MA Nowak
- MA Nowak
- MJ Eppstein
- MW Nachman
- N Goel
- NH Barton
- PAP Moran
- Philip Gerlee
- Philipp M. Altrock
- PM Altrock
- PM Altrock
- R Lande
- RA Fisher
- RE Warner
- S Charlat
- S Davis
- S Karlin
- S Karlin
- S Karlin
- S Redner
- S Wright
- S Wright
- T Antal
- T Clark
- V Kokoza
- WJ Ewens
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
In isolated populations underdominance leads to bistable evolutionary dynamics: below a certain mutant allele frequency the wildtype succeeds. Above this point, the potentially underdominant mutant allele fixes. In subdivided populations with gene flow there can be stable states with coexistence of wildtypes and mutants: polymorphism can be maintained because of a migration-selection equilibrium, i.e., selection against rare recent immigrant alleles that tend to be heterozygous. We focus on the stochastic evolutionary dynamics of systems where demographic fluctuations in the coupled populations are the main source of internal noise. We discuss the influence of fitness, migration rate, and the relative sizes of two interacting populations on the mean extinction times of a group of potentially underdominant mutant alleles. We classify realistic initial conditions according to their impact on the stochastic extinction process. Even in small populations, where demographic fluctuations are large, stability properties predicted from deterministic dynamics show remarkable robustness. Fixation of the mutant allele becomes unlikely but the time to its extinction can be long
Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment
- Author
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- Weiss K
- Welday B
- Welser-Sherrill L
- Wheeler G
- Whistler W
- White R
- Whitley H
- Whitman P
- Wickett M
- Widmann K
- Widmayer C
- Wiedwald J
- Wilcox R
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- Wisoff J
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- Wooten E
- Wootton A
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- Workman J
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- Wysocki F
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- Yang B
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- Yatabe J
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- Zobrist T
- Zuegel J
- Zylstra A
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Lawson criterion for ignition exceeded in an inertial fusion experiment
- Author
- Abu-Shawareb H
- Acree R
- Adams J
- Adams P
- Addis B
- Aden R
- Adrian P
- Afeyan BB
- Aggleton M
- Aghaian L
- Aguirre A
- Aikens D
- Akre J
- Albert F
- Albrecht M
- Albright BJ
- Albritton J
- Alcala J
- Alday C
- Alessi DA
- Alexander N
- Alfonso J
- Alfonso N
- Alger E
- Ali SJ
- Ali ZA
- Alley WE
- Amala P
- Amendt PA
- Amick P
- Ammula S
- Amorin C
- Ampleford DJ
- Anderson RW
- Anklam T
- Antipa N
- Appelbe B
- Aracne-Ruddle C
- Araya E
- Arend M
- Arnold P
- Arnold T
- Asay J
- Atherton LJ
- Atkinson D
- Atkinson R
- Auerbach JM
- Austin B
- Auyang L
- Awwal AS
- Ayers J
- Ayers S
- Ayers T
- Azevedo S
- Bachmann B
- Back CA
- Bae J
- Bailey DS
- Bailey J
- Baisden T
- Baker KL
- Baldis H
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- Barnes A
- Barnes CW
- Barrios MA
- Barty C
- Bass I
- Batha SH
- Baxamusa SH
- Bazan G
- Beagle JK
- Beale R
- Beck BR
- Beck JB
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- Beeler RG
- Beeler RG
- Behrendt W
- Belk L
- Bell P
- Belyaev M
- Benage JF
- Benedetti LR
- Benedict LX
- Bennett G
- Berger R
- Bernat T
- Bernstein LA
- Berry B
- Bertolini L
- Berzak Hopkins L
- Besenbruch G
- Betcher J
- Bettenhausen R
- Betti R
- Bezzerides B
- Bhandarkar SD
- Bickel R
- Biener J
- Biesiada T
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- Bigman V
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 06/07/2022
- Field of study
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37Â MJ of fusion for 1.92Â MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
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- Williamson IG
- Wilson AM
- Wilson KF
- Winther B
- Winther B
- Wise SK
- Wise SK
- Wise SK
- Wise SK
- Won HK
- Wong AYS
- Wong D
- Wong IW
- Wong IW
- Wong SJ
- Wood AJ
- Wood AJ
- Woodard T
- Woodhouse BM
- Woods CM
- Woodworth BA
- Woodworth BA
- Woodworth BA
- Woodworth BA
- Woodworth BA.
- Workman AD
- Workman AD
- Workman AD
- Workman AD
- Workman AD
- Workman AD
- Wormald PJ
- Wormald PJ
- Wright ED
- Wu AW
- Wu AW
- Wu D
- Wu D
- Wu D
- Wu J
- Wu YâX
- Wuister AM
- WuokkoâLandĂ©n A
- Xia Z
- Xian M
- Xu J
- Xu JJ
- Xu M
- Xu Y
- Xu Z
- Yamada T
- Yamasaki A
- Yan C
- Yan CH
- Yan CH
- Yan CH
- Yan CH
- Yan CH
- Yan M
- Yan M
- Yancey KL
- Yancey KL
- Yang C
- Yang C
- Yaniv D
- Yaniv D
- Yao Y
- Yarmohammadi H
- Yatsunenko T
- Yayik AM
- Yel L
- Yelverton JC
- Yilmaz S
- Yip J
- Yip J
- Yohai RA
- Yoo F
- Yoo HS
- Yoon H
- Yoon HY
- Yoshida K
- Young J
- Young J
- Young Jang T
- Young LC
- Yousefi J
- Yu MS
- Yu X
- Yu XM
- Zabner J
- Zacharek M
- Zainine R
- Zajac AE
- Zalmanovici Trestioreanu A
- Zalmanovici Trestioreanu A
- Zariwala MA
- Zeiger J
- Zeng M
- Zeng M
- Zhai GT
- Zhang L
- Zhang ML
- Zhang N
- Zhang N
- Zhang N
- Zhang Q
- Zhang S
- Zhang S
- Zhang S
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhao CY
- Zhao K
- Zhao K
- Zhao L
- Zhao YC
- Zhao YC
- Zheng C
- Zheng Z
- Zhou B
- Zia S
- Ziegler CGK
- ZielinskaâBlizniewska H
- Zou L
- Zuckerman JD
- Zurlo JJ
- Zuskin E
- Äulig J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICARâRS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICARâRSâ2021 as well as updates to the original 140 topics. This executive summary consolidates the evidenceâbased findings of the document. Methods: ICARâRS presents over 180 topics in the forms of evidenceâbased reviews with recommendations (EBRRs), evidenceâbased reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICARâRSâ2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidenceâbased management algorithm is provided. Conclusion: This ICARâRSâ2021 executive summary provides a compilation of the evidenceâbased recommendations for medical and surgical treatment of the most common forms of RS
The content of African Keay 25 / Africana 3 amphorae: initial results of the CORONAM project.
- Author
- Publication venue
- Municipio de Esposende
- Publication date
- 12/09/2014
- Field of study
International audienc
Comparative Seasonal Fecundity of Four Neotropical Migrants in Middle Appalachia
- Author
- Alan B. Williams
- Barber
- Brawn
- Brittingham
- Donovan
- Dowdy
- Franzreb
- Gale
- George A. Gale
- Grzybowski
- Grzybowski
- Hanners
- Hensler
- Hines
- Holmes
- Hoover
- Jennifer A. Dececco
- Martin
- Martin
- Marvil
- Matthew R. Marshall
- May
- Mayfield
- Mayfield
- Nagy
- Nolan
- Nolan
- Pease
- Pulliam
- Ricklefs
- Robert J. Cooper
- Robinson
- Robinson
- Rodenhouse
- Roth
- Roth
- Sedgwick
- Southern
- Trine
- Woodworth
- Woodworth
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Development of the CDISC Pediatrics User Guide: A conect4children and CDISC Collaboration
- Author
- Publication venue
- Frontiers Media SA
- Publication date
- Field of study
The conect4children (c4c) project aims to facilitate efficient planning and delivery of paediatric clinical trials. One objective of c4c is data standardization and reuse. Interoperability and reusability of paediatric clinical trial data is challenging due to a lack of standardization. The Clinical Data Interchange Standards Consortium (CDISC) standards that are required or recommended for regulatory submissions in several countries lack paediatric specificity with limited awareness within academic institutions. To address this, c4c and CDISC collaborated to develop the Pediatrics User Guide (PUG) consisting of cross-cutting data items that are routinely collected in paediatric clinical trials, factoring in all paediatric age ranges.The development of the PUG consisted of six stages. During the scoping phase, subtopics (each containing several clinically relevant concepts) were suggested and debated for inclusion in the PUG. Ninety concepts were selected for the modelling phase. Concept maps describing the collection and representation procedure were developed for the 19 concepts that had no (or partial) previous modelling in CDISC. Next, metadata and implementation examples were developed for concepts. This was followed by a CDISC internal review and a public review. For both these review stages, the feedback comments were either implemented or rejected based on budget, timelines, expert review, and scope. The PUG was published on the CDISC website on February 23, 2023.The PUG is a first step in bridging the lack of child specific CDISC standards, particularly within academia. Several academic and industrial partners were involved in the development of the PUG, and c4c has undertaken multiple steps to publicize the PUG within its academic partner organizations â in particular, the European Reference Networks (ERNs) that are developing registries and dictionaries in 24 disease areas. In the long term, continued use of the PUG in paediatric clinical trials will enable the pooling of data from multiple trials, which is particularly important for medical domains with small populations
A systematic review of the endoscopic repair of cerebrospinal fluid leaks
- Author
- Bachert C
- Bernal-Sprekelsen M
- Briggs RJ
- Bumm K
- Carrau RL
- Castelnuovo P
- Castelnuovo PG
- Choi D
- Cui S
- Felisati G
- Forer B
- Gupta AK
- Harvey RJ
- Hegazy HM
- Ismail AS
- Lanza DC
- Lee DH
- Lescanne E
- Lindstrom DR
- Lloyd KM
- Locatelli D
- Lopatin AS
- Marks SC
- Marshall AH
- Marton E
- McCormack B
- McMains KC
- Meco C
- Mirza S
- Nyquist GG
- Park JI
- Peng A
- Placantonakis DG
- Purkey MT
- Schmerber S
- Seth R
- Shi JB
- Silva LR
- Stankiewicz JA
- Tabaee A
- Tolley NS
- Tosun F
- Wigand ME
- Wise SK
- Wise SK
- Woodworth BA
- Woodworth BA
- Wormald PJ
- Yadav JS
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/01/2012
- Field of study
Objectives: To provide an up-to-date review of the literature on the safety and efficacy of the endoscopic technique for cerebrospinal (CSF) leak repairs. Data Sources: PubMed, Medline/Old Medline, and Cochrane Central databases. Review Methods: Using the above outlined data sources, studies involving the endoscopic repair of CSF leaks were reviewed independently by 2 researchers. Studies included met the following criteria: full-text article written in the English language, at least 5 human patients undergoing purely endoscopic surgical repair of a CSF leak, and documented follow-up. Data extracted included leak etiology, presentation and location, the use of imaging, intrathecal fluorescein, and adjunctive measures as well as the success rate of the repair. Results: Fifty-five studies, involving 1778 fistulae repairs, were included for analysis. Spontaneous leaks were most prevalent, with the ethmoid roof and sphenoid the most common sites involved. The overall success rate of repair was high at 90% for primary and 97% for secondary repairs. A low complication rate of less than 0.03% was reported. Conclusion: The endoscopic repair of CSF fistula is both safe and effective and should be considered the standard of care for most cases. Evidence supporting adjunctive measures such as lumbar drains and antibiotics remains limited despite their common use.Alkis J. Psaltis, Rodney J. Schlosser, Caroline A. Banks, James Yawn, and Zachary M. Sole
A Systematic Review of the Endoscopic Repair of Cerebrospinal Fluid Leaks
- Author
- Bachert C
- Bernal-Sprekelsen M
- Briggs RJ
- Bumm K
- Carrau RL
- Castelnuovo P
- Castelnuovo PG
- Choi D
- Cui S
- Felisati G
- Forer B
- Gupta AK
- Harvey RJ
- Hegazy HM
- Ismail AS
- Lanza DC
- Lee DH
- Lescanne E
- Lindstrom DR
- Lloyd KM
- Locatelli D
- Lopatin AS
- Marks SC
- Marshall AH
- Marton E
- McCormack B
- McMains KC
- Meco C
- Mirza S
- Nyquist GG
- Park JI
- Peng A
- Placantonakis DG
- Purkey MT
- Schmerber S
- Seth R
- Shi JB
- Silva LR
- Stankiewicz JA
- Tabaee A
- Tolley NS
- Tosun F
- Wigand ME
- Wise SK
- Wise SK
- Woodworth BA
- Woodworth BA
- Wormald PJ
- Yadav JS
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study