8,461 research outputs found

    International Committee on Mental Health in Cystic Fibrosis: Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus statements for screening and treating depression and anxiety

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    Studies measuring psychological distress in individuals with cystic fibrosis (CF) have found high rates of both depression and anxiety. Psychological symptoms in both individuals with CF and parent caregivers have been associated with decreased lung function, lower body mass index, worse adherence, worse health-related quality of life, more frequent hospitalisations and increased healthcare costs. To identify and treat depression and anxiety in CF, the CF Foundation and the European CF Society invited a panel of experts, including physicians, psychologists, psychiatrists, nurses, social workers, a pharmacist, parents and an individual with CF, to develop consensus recommendations for clinical care. Over 18 months, this 22-member committee was divided into four workgroups: Screening; Psychological Interventions; Pharmacological Treatments and Implementation and Future Research, and used the Population, Intervention, Comparison, Outcome methodology to develop questions for literature search and review. Searches were conducted in PubMed, PsychINFO, ScienceDirect, Google Scholar, Psychiatry online and ABDATA by a methodologist at Dartmouth. The committee reviewed 344 articles, drafted statements and set an 80% acceptance for each recommendation statement as a consensus threshold prior to an anonymous voting process. Fifteen guideline recommendation statements for screening and treatment of depression and anxiety in individuals with CF and parent caregivers were finalised by vote. As these recommendations are implemented in CF centres internationally, the process of dissemination, implementation and resource provision should be closely monitored to assess barriers and concerns, validity and use

    Are these data real? Statistical methods for the detection of data fabrication in clinical trials.

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    OBJECTIVES: To test the application of statistical methods to detect data fabrication in a clinical trial. SETTING: Data from two clinical trials: a trial of a dietary intervention for cardiovascular disease and a trial of a drug intervention for the same problem. OUTCOME MEASURES: Baseline comparisons of means and variances of cardiovascular risk factors; digit preference overall and its pattern by group. RESULTS: In the dietary intervention trial, variances for 16 of the 22 variables available at baseline were significantly different, and 10 significant differences were seen in means for these variables. Some of these P values were extraordinarily small. Distributions of the final recorded digit were significantly different between the intervention and the control group at baseline for 14/22 variables in the dietary trial. In the drug trial, only five variables were available, and no significant differences between the groups for baseline values in means or variances or digit preference were seen. CONCLUSIONS: Several statistical features of the data from the dietary trial are so strongly suggestive of data fabrication that no other explanation is likely

    Automatic detection of potential buried archaeological sites in Saruq Al-Hadid, United Arab Emirates

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    The use of remote sensing in archaeological research allows the prospection of sub-surfaces in arid regions non- intrusively before the on-site investigation and excavation. While the actual detection method of expected buried archaeological structures is based on visual interpretation, this work provides a supporting archaeological guidance using remote sensing. The aim is to detect potential archaeological remains underneath the sand. This paper focuses on Saruq Al-Hadid surroundings, which is an archaeologist site discovered in 2002, located about 50 km south-east of Dubai, as archaeologists believe that other archaeological sites are potentially buried in the surroundings. The input data is derived from a combination of wavelength L-band Synthetic Aperture Radar (ALOS PALSAR), which is able to penetrate the sand, and multispectral optical images (Landsat 7). This paper develops a new strategy to help in the detection of suspected buried structures. The data fusion of surface roughness and spectral indices enables tackling the well-known limitation of SAR images and offers a set of pixels having an archaeological signature different from the manmade structures. The potential buried sites are then classified by performing a pixel-level unsupervised classification algorithm such as K-means cluster analysis. To test the performance of the proposed method, the results are compared with those obtained by visual interpretation

    Specificity of amino acid sequence and its role in secondary and supersecondary structure generation

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    Schematic presentation of loops (7 aa) linking two Ī²-strands (fragments of Ī²-sheets). The left one ā€“ helical form represents fuzzy oil drop distribution of hydrophobicity. The right one not able to generate the helical form represents the status recognized as amyloid seed in amyloids discussed in this work

    Pal Of My Cradle Days / music by Al Piantadosi; words by Marshall Montgomery

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    Key of Eb. Cover: a drawing of a woman rocking a Cradle; a photo inset of Harry Rappi; Publisher: Leo Feist Inc. (New York)https://egrove.olemiss.edu/sharris_d/1069/thumbnail.jp

    Understanding people: A course on qualitative and quantitative HCI research methods

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    This course will provide an introduction to methods used in Human-Computer Interaction (HCI) research. An equal focus will be given to both the quantitative and qualitative research traditions used to understand people and interactional contexts. We shall discuss these major research traditions along with their contemporary framings (e.g., in-the-wild research and Interaction Science). By the end of the course attendees will have a detailed understanding of how to select and apply methods to address a range of problems that are of concern to contemporary HCI researchers

    Research Methods for HCI: Understanding People Using Interactive Technologies

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    This course will provide an introduction to methods used in Human-Computer Interaction (HCI) research. An equal focus will be given to both the quantitative and qualitative research traditions used to understand people and interactional contexts. We shall discuss these major philosophical traditions along with their contemporary framings (e.g., in-the-wild research and Interaction Science). By the end of the course attendees will have a detailed understanding of how to select and apply methods to address a range of problems that are of concern to contemporary HCI researchers
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