A novel approach to antibiofilm susceptibility testing using a thermo-reversible matrix

Method: Pseudomonas aeruginosa (NCIMB 8626) was cultured in medium containing poloxamer 407 at 37°C for 24 hours to generate biofilms. The preparation was cooled to liquefy the poloxamer and allow recovery of the biofilm cells, which were then stained with SYTO9 to determine viability following exposure to four antimicrobials: polyhexanide, octenadine dihydrochloride, povidone-iodine and silver carbonate. Over an 8-minute time period, fluorescence levels were spectrophotometrically measured and compared with bacterial controls, cultured in the absence of poloxamer and without antimicrobial. Results: Untreated cells showed no reduction in viability over this period. Importantly, planktonic cells were more susceptible to test agents compared with those of a ‘biofilm’ phenotype cultured in poloxamer. Antibiofilm activity was evident for all of the test agents, with highest relative activity seen with octenadine dihydrochloride. Conclusion: In summary, a novel and relatively rapid approach to screen compounds for antibiofilm activity has been described. The method uses standard laboratory equipment and can be readily adapted to test a wide range of microorganisms and other antibiofilm compounds

Entanglement and replica symmetry breaking in a driven-dissipative quantum spin glass

We describe simulations of the quantum dynamics of a confocal cavity QED system that realizes an intrinsically driven-dissipative spin glass. A close connection between open quantum dynamics and replica symmetry breaking is established, in which individual quantum trajectories are the replicas. We observe that entanglement plays an important role in the emergence of replica symmetry breaking in a fully connected, frustrated spin network of up to fifteen spin-1/2 particles. Quantum trajectories of entangled spins reach steady-state spin configurations of lower energy than that of semiclassical trajectories. Cavity emission allows monitoring of the continuous stochastic evolution of spin configurations, while backaction from this projects entangled states into states of broken Ising and replica symmetry. The emergence of spin glass order manifests itself through the simultaneous absence of magnetization and the presence of nontrivial spin overlap density distributions among replicas. Moreover, these overlaps reveal incipient ultrametric order, in line with the Parisi RSB solution ansatz for the Sherrington-Kirkpatrick model. A nonthermal Parisi order parameter distribution, however, highlights the driven-dissipative nature of this quantum optical spin glass. This practicable system could serve as a testbed for exploring how quantum effects enrich the physics of spin glasses.Comment: 23 pages including 11 figures and 8 appendices; section V and appendix F are ne

An optical lattice with sound

Funding: We acknowledge funding support from the Army Research Office. Y.G. and B.M. acknowledge funding from the Stanford Q-FARM Graduate Student Fellowship and the NSF Graduate Research Fellowship, respectively. S.G. acknowledges support from NSF Grant No. DMR-1653271.Quantized sound waves—phonons—govern the elastic response of crystalline materials, and also play an integral part in determining their thermodynamic properties and electrical response (for example, by binding electrons into superconducting Cooper pairs). The physics of lattice phonons and elasticity is absent in simulators of quantum solids constructed of neutral atoms in periodic light potentials: unlike real solids, traditional optical lattices are silent because they are infinitely stiff. Optical-lattice realizations of crystals therefore lack some of the central dynamical degrees of freedom that determine the low-temperature properties of real materials. Here, we create an optical lattice with phonon modes using a Bose–Einstein condensate (BEC) coupled to a confocal optical resonator. Playing the role of an active quantum gas microscope, the multimode cavity QED system both images the phonons and induces the crystallization that supports phonons via short-range, photon-mediated atom–atom interactions. Dynamical susceptibility measurements reveal the phonon dispersion relation, showing that these collective excitations exhibit a sound speed dependent on the BEC–photon coupling strength. Our results pave the way for exploring the rich physics of elasticity in quantum solids, ranging from quantum melting transitions to exotic ‘fractonic’ topological defects in the quantum regime.PostprintPeer reviewe

Entanglement and replica symmetry breaking in a driven-dissipative quantum spin glass

Funding: We are grateful for funding support from the Army Research Office, NTT Research, and the Q-NEXT DOE National Quantum Information Science Research Center. Surya Ganguli acknowledges funding from NSF CAREER award #1845166. B.M. acknowledges funding from the Stanford QFARM Initiative and the NSF Graduate Research Fellowship.We describe simulations of the quantum dynamics of a confocal cavity QED system that realizes an intrinsically driven-dissipative spin glass. A close connection between open quantum dynamics and replica symmetry breaking is established, in which individual quantum trajectories are the replicas. We observe that entanglement plays an important role in the emergence of replica symmetry breaking in a fully connected, frustrated spin network of up to 15 spin-1/2 particles. Quantum trajectories of entangled spins reach steady-state spin configurations of lower energy than that of semiclassical trajectories. Cavity emission allows monitoring of the continuous stochastic evolution of spin configurations, while backaction from this projects entangled states into states of broken Ising and replica symmetry. The emergence of spin glass order manifests itself through the simultaneous absence of magnetization and the presence of nontrivial spin overlap density distributions among replicas. Moreover, these overlaps reveal incipient ultrametric order, in line with the Parisi replica symmetry breaking solution for the Sherrington-Kirkpatrick model. A nonthermal Parisi order parameter distribution, however, highlights the driven-dissipative nature of this quantum optical spin glass. This practicable system could serve as a test bed for exploring how quantum effects enrich the physics of spin glasses.Peer reviewe

Közművelődési jelenségek és jelentések. Az ÁMK

Many classroom climate studies suffer from 2 critical problems: They (a) treat climate as a student-level (L1) variable in single-level analyses instead of a classroom-level (L2) construct in multilevel analyses; and (b) rely on manifest-variable models rather than on latent-variable models that control measurement error at L1 and L2, and sampling error in the aggregation of L1 ratings to form L2 constructs. On the basis of an analysis of 2,541 students in Grades 5 or 6 from 89 classrooms, the authors demonstrate doubly latent multilevel structural equation models that overcome both of these problems. The results show that L2 classroom climate (a higher-order factor representing classroom mastery goal orientation, challenge, and teacher caring) had positive effects on self-efficacy and achievement. The authors conclude with a discussion of related issues (e.g., the meaning of L2 constructs vs. L1 residuals, the dimensionality of climate constructs at L2) and guidelines for future research

Enhancing associative memory recall and storage capacity using confocal cavity QED

Funding: Y.G. and B.M. acknowledgefunding from the Stanford Q-FARM Graduate Student Fellowship and the NSF Graduate Research Fellowship, respectively. J.K. acknowledges support from the Leverhulme Trust (IAF-2014-025), and S.G. acknowledges funding from the James S. McDonnell and Simons Foundations and an NSF Career Award.We introduce a near-term experimental platform for realizing an associative memory. It can simultaneously store many memories by using spinful bosons coupled to a degenerate multimode optical cavity. The associative memory is realized by a confocal cavity QED neural network, with the modes serving as the synapses, connecting a network of superradiant atomic spin ensembles,which serve as the neurons. Memories are encoded in the connectivity matrix between the spins and can be accessed through the input and output of patterns of light. Each aspect of the scheme is based on recently demonstrated technology using a confocal cavity and Bose-condensed atoms. Our scheme has two conceptually novel elements. First, it introduces a new form of random spin system that interpolates between a ferromagnetic and a spin glass regime as a physical parameter is tuned—the positions of ensembles within the cavity. Second, and more importantly, the spins relax via deterministic steepest-descent dynamics rather than Glauber dynamics. We show that this nonequilibrium quantum-optical scheme has significant advantages for associative memory over Glauber dynamics: These dynamics can enhance the network’s ability to store and recall memories beyond that of the standard Hopfield model. Surprisingly, the cavity QED dynamics can retrieve memories even when the system is in the spin glass phase. Thus, the experimental platform provides a novel physical instantiation of associative memories and spin glasses as well as provides an unusual form of relaxational dynamics that is conducive to memory recall even in regimes where it was thought to be impossible.Publisher PDFPeer reviewe

The Influence of Overbuilt Versus Game-Permitted American Football Facemasks on Peripheral Visuomotor Ability in NCAA Division I Football Athletes

Topics in Exercise Science and Kinesiology Volume 2: Issue 1, Article 9, 2021. Heavier facemask reinforcement has been shown to impair reaction time. While overbuilt facemasks are illegal for gameplay at all levels of competition, empirical rationale for this has not be realized and it is unknown if overbuilt facemasks are worse for peripheral vision than permitted ones. Thus, the purpose of this study was to investigate the effects of wearing an overbuilt facemask versus game permitted facemasks on peripheral visuomotor ability in collegiate football players. Male NCAA Division I football players (n=18) completed a 60-second peripheral visuomotor test on a Dynavision D2 visuomotor board under the following conditions: 1) Baseline (No helmet), 2) Helmet + Light reinforced facemask, 3) Helmet + Medium reinforced facemask, 4) Helmet + Heavy reinforced facemask, 5) Helmet + Overbuilt facemask. Overall peripheral reaction time (PRT) and PRT separated by rings and quadrants were analyzed. Points of application: 1) Regardless of facemask reinforcement, wearing protective headgear impairs peripheral reaction time (PRT) compared to baseline with no helmet. Addition of an overbuilt facemask significantly impairs PRT compared to NCAA permitted facemasks. 2) An overbuilt facemask exhibits the most visuomotor decrement in far peripheral visual fields. 3) Decreases in visuomotor ability while wearing an overbuilt facemask are most pronounced in lower regions of visual field

The role of religion in the longer-range future, April 6, 7, and 8, 2006

This repository item contains a single issue of the Pardee Conference Series, a publication series that began publishing in 2006 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future. This conference that took place during April 6, 7, and 8, 2006. Co-organized by David Fromkin, Director, Frederick S. Pardee Center for the Study of the Longer-Range Future, and Ray L. Hart, Dean ad interim Boston University School of TheologyThe conference brought together some 40 experts from various disciplines to ponder upon the “great dilemma” of how science, religion, and the human future interact. In particular, different panels looked at trends in what is happening to religion around the world, questions about how religion is impacting the current political and economic order, and how the social dynamics unleashed by science and by religion can be reconciled.Carnegie Council on Ethics and International Affair

The Utility of Video Diaries for Organizational Research

This article assesses the utility of video diaries as a method for organization studies. While it is frequently suggested that video-based research methodologies have the capacity to capture new data about the minutiae of complex organizational affairs, as well as offering new forms of dissemination to both academic and professional audiences, little is known about the specific benefits and drawbacks of video diaries. We compare video diaries with two established and “adjacent” methods: traditional diary studies (written or audio) and other video methods. We evaluate each in relation to three key research areas: bodily expressions, identity, and practice studies. Our assessment of video diaries suggests that the approach is best used as a complement to other forms of research and is particularly suited to capturing plurivocal, asynchronous accounts of organizational phenomena. We use illustrations from an empirical research project to exemplify our claims before concluding with five points of advice for researchers wishing to employ this method