4,305 research outputs found
Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease
Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were studied in postmortem brain tissue from patients with histopathologically confirmed Parkinson's disease and matched control subjects. Using washed membrane homogenates from the frontal cortex, hippocampus, caudate nucleus, and putamen, saturation analysis of specific receptor binding was performed for the total number of muscarinic receptors with [3H]quinuclidinyl benzilate, for muscarinic M1 receptors with [3H]pirenzepine, for muscarinic M2 receptors with [3H]oxotremorine-M, and for nicotinic receptors with (-)-[3H]nicotine. In comparison with control tissues, choline acetyl-transferase activity was reduced in the frontal cortex and hippocampus and unchanged in the caudate nucleus and putamen of parkinsonian patients. In Parkinson's disease the maximal binding site density for [3H]quinuclidinyl benzilate was increased in the frontal cortex and unaltered in the hippocampus, caudate nucleus, and putamen. Specific [3H]pirenzepine binding was increased in the frontal cortex, unaltered in the hippocampus, and decreased in the caudate nucleus and putamen. In parkinsonian patients Bmax values for specific [3H]oxotremorine-M binding were reduced in the cortex and unchanged in the hippocampus and striatum compared with controls. Maximal (-)-[3H]nicotine binding was reduced in both the cortex and hippocampus and unaltered in both the caudate nucleus and putamen. Alterations of the equilibrium dissociation constant were not observed for any ligand in any of the brain areas examined. The present results suggest that both the innominatocortical and the septohippocampal cholinergic systems degenerate in Parkinson's disease.(ABSTRACT TRUNCATED AT 250 WORDS
Observation of a possible superflare on Proxima Centauri
We report the observation on UT 2017 July 1 of an unusually powerful flare detected in near-infrared continuum photometry of Proxima Centauri. During a campaign monitoring the star for possible exoplanet transits, we identified an increase in Sloan i' flux leading to an observed peak at BJD 2457935.996 that was at least 10 per cent over pre-flare flux in this band. It was followed by a two-component rapid decline in the first 100 s that became a slower exponential decay with time constant of 1350 s. A smaller flare event 1300 s after the first added an incremental peak flux increase of 1 per cent of pre-flare flux. Since the onset of the flare was not fully time resolved at a cadence of 62 s, its actual peak value is unknown but greater than the time average over a single exposure of 20 s. The i' band is representative of broad optical and near-IR continuum flux over which the integrated energy of the flare is 100 times the stellar luminosity. This meets the criteria that established the concept of superflares on similar stars. The resulting implied ultraviolet flux and space weather could have had an extreme effect on the atmospheres of planets within the star's otherwise habitable zone
Brain muscarinic cholinergic receptors in Huntington's disease
Muscarinic cholinergic receptors and choline acetyltransferase (ChAT) activity were studied in postmortem brain tissue from patients with Huntington's disease and matched control subjects. In comparison with controls, reductions in ChAT activity were found in the hippocampus, but not in the temporal cortex in Huntington's disease. Patients with Huntington's disease showed reduced densities of the total number of muscarinic receptors and of M-2 receptors in the hippocampus while the density of M-1 receptors was unaltered. Muscarinic receptor binding was unchanged in the temporal cortex. These results indicate a degeneration in Huntington's disease of the septo-hippocampal cholinergic pathway, but no impairment of the innominato-cortical cholinergic system
Geometric Integration of Hamiltonian Systems Perturbed by Rayleigh Damping
Explicit and semi-explicit geometric integration schemes for dissipative
perturbations of Hamiltonian systems are analyzed. The dissipation is
characterized by a small parameter , and the schemes under study
preserve the symplectic structure in the case . In the case
the energy dissipation rate is shown to be asymptotically
correct by backward error analysis. Theoretical results on monotone decrease of
the modified Hamiltonian function for small enough step sizes are given.
Further, an analysis proving near conservation of relative equilibria for small
enough step sizes is conducted.
Numerical examples, verifying the analyses, are given for a planar pendulum
and an elastic 3--D pendulum. The results are superior in comparison with a
conventional explicit Runge-Kutta method of the same order
The Dynamics of a Rigid Body in Potential Flow with Circulation
We consider the motion of a two-dimensional body of arbitrary shape in a
planar irrotational, incompressible fluid with a given amount of circulation
around the body. We derive the equations of motion for this system by
performing symplectic reduction with respect to the group of volume-preserving
diffeomorphisms and obtain the relevant Poisson structures after a further
Poisson reduction with respect to the group of translations and rotations. In
this way, we recover the equations of motion given for this system by Chaplygin
and Lamb, and we give a geometric interpretation for the Kutta-Zhukowski force
as a curvature-related effect. In addition, we show that the motion of a rigid
body with circulation can be understood as a geodesic flow on a central
extension of the special Euclidian group SE(2), and we relate the cocycle in
the description of this central extension to a certain curvature tensor.Comment: 28 pages, 2 figures; v2: typos correcte
Magnetic fields and differential rotation on the pre-main sequence I: The early-G star HD 141943 - brightness and magnetic topologies
Spectroscopic and spectropolarimetric observations of the pre-main sequence
early-G star HD 141943 were obtained at four observing epochs (in 2006, 2007,
2009 and 2010). The observations were undertaken at the 3.9-m Anglo-Australian
Telescope using the UCLES echelle spectrograph and the SEMPOL
spectropolarimeter visitor instrument. Brightness and surface magnetic field
topologies were reconstructed for the star using the technique of least-squares
deconvolution to increase the signal-to-noise of the data.
The reconstructed brightness maps show that HD 141943 had a weak polar spot
and a significant amount of low latitude features, with little change in the
latitude distribution of the spots over the 4 years of observations. The
surface magnetic field was reconstructed at three of the epochs from a high
order (l <= 30) spherical harmonic expansion of the spectropolarimetric
observations. The reconstructed magnetic topologies show that in 2007 and 2010
the surface magnetic field was reasonably balanced between poloidal and
toroidal components. However we find tentative evidence of a change in the
poloidal/toroidal ratio in 2009 with the poloidal component becoming more
dominant. At all epochs the radial magnetic field is predominantly
non-axisymmetric while the azimuthal field is predominantly axisymmetric with a
ring of positive azimuthal field around the pole similar to that seen on other
active stars.Comment: 18 pages, 17 figures, accepted by MNRA
Un-reduction
This paper provides a full geometric development of a new technique called
un-reduction, for dealing with dynamics and optimal control problems posed on
spaces that are unwieldy for numerical implementation. The technique, which was
originally concieved for an application to image dynamics, uses Lagrangian
reduction by symmetry in reverse. A deeper understanding of un-reduction leads
to new developments in image matching which serve to illustrate the
mathematical power of the technique.Comment: 25 pages, revised versio
The first magnetic maps of a pre-main sequence binary star system - HD 155555
We present the first maps of the surface magnetic fields of a pre-main
sequence binary system. Spectropolarimetric observations of the young, 18 Myr,
HD 155555 (V824 Ara, G5IV + K0IV) system were obtained at the Anglo-Australian
Telescope in 2004 and 2007. Both datasets are analysed using a new binary
Zeeman Doppler imaging (ZDI) code. This allows us to simultaneously model the
contribution of each component to the observed circularly polarised spectra.
Stellar brightness maps are also produced for HD 155555 and compared to
previous Doppler images. Our radial magnetic maps reveal a complex surface
magnetic topology with mixed polarities at all latitudes. We find rings of
azimuthal field on both stars, most of which are found to be non-axisymmetric
with the stellar rotational axis. We also examine the field strength and the
relative fraction of magnetic energy stored in the radial and azimuthal field
components at both epochs. A marked weakening of the field strength of the
secondary star is observed between the 2004 and 2007 epochs. This is
accompanied by an apparent shift in the location of magnetic energy from the
azimuthal to radial field. We suggest that this could be indicative of a
magnetic activity cycle. We use the radial magnetic maps to extrapolate the
coronal field (by assuming a potential field) for each star individually - at
present ignoring any possible interaction. The secondary star is found to
exhibit an extreme tilt (~75 deg) of its large scale magnetic field to that of
its rotation axis for both epochs. The field complexity that is apparent in the
surface maps persists out to a significant fraction of the binary separation.
Any interaction between the fields of the two stars is therefore likely to be
complex also. Modelling this would require a full binary field extrapolation.Comment: 17 pages, 12 figures, accepted for publication in MNRA
Magnetic cycles of the planet-hosting star tauBootis
We have obtained new spectropolarimetric observations of the planet-hosting
star tauBootis, using the ESPaDOnS and NARVAL spectropolarimeters at the
Canada-France-Hawaii Telescope and Telescope Bernard-Lyot. With this data set,
we are able to confirm the presence of a magnetic field at the surface of
tauBoo and map its large-scale structure over the whole star. The overall
polarity of the magnetic field has reversed with respect to our previous
observation (obtained a year before), strongly suggesting that tauBoo is
undergoing magnetic cycles similar to those of the Sun. This is the first time
that a global magnetic polarity switch is observed in a star other than the
Sun; we speculate that the magnetic cycle period of tauBoo is much shorter than
that of the Sun.
Our new data also allow us to confirm the presence of differential rotation
from the latitudinal shearing that the magnetic structure is undergoing. The
differential rotation surface shear that tauBoo experiences is found to be 6 to
10 times larger than that of the Sun. We propose that the short magnetic cycle
period is due to the strong level of differential rotation. With a rotation
period of 3.0 and 3.9 d at the equator and pole respectively, tauBoo appears as
the first planet-hosting star whose rotation (at intermediate latitudes) is
synchronised with the orbital motion of its giant planet (period 3.3 d).
Assuming that this synchronisation is not coincidental, it suggests that the
tidal effects induced by the giant planet can be strong enough to force the
thin convective enveloppe (though not the whole star) into corotation and thus
to play a role in the activity cycle of tauBoo.Comment: MNRAS, in pres
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