An Examination Of Tax–Deductible Donations Made By Individual Australian Taxpayers In 2003-04

Each year QUT’s Centre of Philanthropy and Nonprofit Studies collects and analyses statistics on the amount and extent of tax-deductible donations made and claimed by Australians in their individual income tax returns to deductible gift recipients (DGRs). The information presented in this working paper is based on the amount and type of tax-deductible donations made and claimed by Australian individual taxpayers to DGRs for the period 1 July 2003 to 30 June 2004. This information has been extracted mainly from the Australian Taxation Office's publication Taxation Statistics 2003-04. The 2004 report is the latest report that has been made publicly available. It represents information in tax returns for the 2003-2004 year processed by the ATO as at 31 October 2005. This year we have also been able to divide tax deductible donations by gender based on the ATO statistics

Hydrogen bond networks facilitate the conversion of aliphatic aldehydes in the charged active site of S. cerevisiae transketolase

Naturally, transketolase (TK, E.C. 2.2.1.1) catalyzes asymmetric C-C bond formation in glycolysis derived metabolites to afford carbohydrates for nucleotide synthesis and the production of essential aromatic amino acids.[1] While results obtained earlier in our group showed that a decrease in active site polarity in S. cerevisiae transketolase was beneficial for the conversion of non-phosphorylated substrates,[2] the charged mutation D469E was counterintuitively found to promote the conversion of aliphatic aldehydes in E. coli transketolase.[3] Here we present a comparative study of the most beneficial single and double point mutants obtained from both reports for the conversion of aliphatic aldehydes using S. cerevisiae transketolase.[4] It was confirmed that a complete change of active site polarity is not required for the successful conversion of aliphatic aldehydes and surprisingly was found more beneficial than charge neutral mutations. These results were rationalized in docking studies, where a molecule of water was identified at the center of a hydrogen bond network, essential for substrate binding and correct orientation towards the cofactor, thus allowing the conversion of aliphatic aldehydes in the charged active site of transketolase. Please click Additional Files below to see the full abstract

Differences in peripheral noradrenergic function among actively drinking and abstinent alcohol-dependent individuals.

We examined whether excessive alcohol consumption was related to changes in plasma levels of noradrenaline (NA) and whether these changes recover following abstinence. We also explored whether there were differences in NA levels between Type I and Type II alcoholics and controls during active drinking and abstinence. Plasma concentrations of NA were determined in (1) 27 Caucasian men with alcohol dependence who were regularly drinking (active drinkers) within 24 hours of hospitalization, (2) 29 Caucasian alcohol-dependent men who were in remission (abstinent for a minimum of three months), and (3) 28 race- and gender-matched healthy controls. NA concentrations were significantly higher in actively drinking alcohol-dependent subjects compared to those in remission and controls. While Type I and Type II alcoholic individuals differed across clinical measures, NA levels were similar in the two subtypes. Both subtypes showed an elevation in NA levels during active drinking compared to controls, but NA levels did not differ between the two subtypes and controls during remission. The findings indicate that chronic exposure to alcohol may lead to disturbances in NA activity that may manifest in early abstinence. However, the changes in NA activity appears to normalize after a longer period of abstinence. Alterations in NA activity do not seem to be specific for Type I or Type II subtypes of alcoholism

Factors Affecting Sea Lamprey Egg Survival

Abstract.-Factors that affect recruitment of sea lampreys Petromyzon marinus are not well understood; for example, the majority (85%) of sea lamprey eggs are washed out of the nest, and the survival rate of these eggs is unknown. We examined the role of predation and substrate on egg survival in the laboratory and egg predation and dispersion of eggs outside the nest in the field. Substrate type did not influence the numbers of eggs consumed by predators, but the proportion of available eggs consumed was higher for crayfish Orconectes spp. (74%) and creek chub Semotilus atromaculatus (47%) than for white suckers Catostomus commersonii (9%) and logperch Percina caprodes (3%; F ¼ 11.12, df ¼ 3, P , 0.0001). Survival of eggs incubated on silt (69.2%) and sand (50.8%) in the laboratory was significantly higher than survival on gravel (19.1%). Stream sampling indicated that sea lamprey egg density outside of nests on gravel was low (1.9 eggs/ m 2 ) compared with egg density in depositional areas (105.7 eggs/m 2 ); eggs sampled outside the nest had near zero viability. In exclosure boxes seeded with sea lamprey eggs and deployed on gravel and silt for 7-10 d, egg retention was significantly greater on spawning gravel (31 6 3%; mean 6 SE) than on silt (6 6 3%; P 0.0001); egg retention was affected by the presence of a 0.5-cm-mesh cover. Stream discharge appeared to increase egg loss from nests. We conclude that predation rates on sea lamprey eggs outside the nest are high and that substrate type alone has little impact on egg hatching success. Given the low retention of eggs in nests, egg mortality is probably a primary determinant of year-class strength. Production of sea lampreys outside the nest likely occurs under low stream discharge conditions from eggs deposited on spawning gravel

A Kolmogorov theorem for nearly-integrable Poisson systems with asymptotically decaying time-dependent perturbation

The aim of this paper is to prove the Kolmogorov theorem of persistence of Diophantine flows for nearly-integrable Poisson systems associated to a real analytic Hamiltonian with aperiodic time dependence, provided that the perturbation is asymptotically vanishing. The paper is an extension of an analogous result by the same authors for canonical Hamiltonian systems; the flexibility of the Lie series method developed by A. Giorgilli et al., is profitably used in the present generalisation.Comment: 10 page

Head-to-head trials of antibiotics for bronchiectasis

Background The diagnosis of bronchiectasis is defined by abnormal dilation of the airways related to a pathological mechanism of progressive airway destruction that is due to a 'vicious cycle' of recurrent bacterial infection, inflammatory mediator release, airway damage, and subsequent further infection. Antibiotics are the main treatment option for reducing bacterial burden in people with exacerbations of bronchiectasis and for longer‐term eradication, but their use is tempered against potential adverse effects and concerns regarding antibiotic resistance. The comparative effectiveness, cost‐effectiveness, and safety of different antibiotics have been highlighted as important issues, but currently little evidence is available to help resolve uncertainty on these questions. Objectives To evaluate the comparative effects of different antibiotics in the treatment of adults and children with bronchiectasis. Search methods We identified randomised controlled trials (RCTs) through searches of the Cochrane Airways Group Register of trials and online trials registries, run 30 April 2018. We augmented these with searches of the reference lists of published studies. Selection criteria We included RCTs reported as full‐text articles, those published as abstracts only, and unpublished data. We included adults and children (younger than 18 years) with a diagnosis of bronchiectasis by bronchography or high‐resolution computed tomography who reported daily signs and symptoms, such as cough, sputum production, or haemoptysis, and those with recurrent episodes of chest infection; we included studies that compared one antibiotic versus another when they were administered by the same delivery method. Data collection and analysis Two review authors independently assessed trial selection, data extraction, and risk of bias. We assessed overall quality of the evidence using GRADE criteria. We made efforts to collect missing data from trial authors. We have presented results with their 95% confidence intervals (CIs) as mean differences (MDs) or odds ratios (ORs). Main results Four randomised trials were eligible for inclusion in this systematic review ‐ two studies with 83 adults comparing fluoroquinolones with β‐lactams and two studies with 55 adults comparing aminoglycosides with polymyxins. None of the included studies reported information on exacerbations ‐ one of our primary outcomes. Included studies reported no serious adverse events ‐ another of our primary outcomes ‐ and no deaths. We graded this evidence as low or very low quality. Included studies did not report quality of life. Comparison between fluoroquinolones and β‐lactams (amoxicillin) showed fewer treatment failures in the fluoroquinolone group than in the amoxicillin group (OR 0.07, 95% CI 0.01 to 0.32; low‐quality evidence) after 7 to 10 days of therapy. Researchers reported that Pseudomonas aeruginosa infection was eradicated in more participants treated with fluoroquinolones (Peto OR 20.09, 95% CI 2.83 to 142.59; low‐quality evidence) but provided no evidence of differences in the numbers of participants showing improvement in sputum purulence (OR 2.35, 95% CI 0.96 to 5.72; very low‐quality evidence). Study authors presented no evidence of benefit in relation to forced expiratory volume in one second (FEV₁). The two studies that compared polymyxins versus aminoglycosides described no clear differences between groups in the proportion of participants with P aeruginosa eradication (OR 1.40. 95% CI 0.36 to 5.35; very low‐quality evidence) or improvement in sputum purulence (OR 0.16, 95% CI 0.01 to 3.85; very low‐quality evidence). The evidence for changes in FEV₁ was inconclusive. Two of three trials reported adverse events but did not report the proportion of participants experiencing one or more adverse events, so we were unable to interpret the information. Authors' conclusions Limited low‐quality evidence favours short‐term oral fluoroquinolones over beta‐lactam antibiotics for patients hospitalised with exacerbations. Very low‐quality evidence suggests no benefit from inhaled aminoglycosides verus polymyxins. RCTs have presented no evidence comparing other modes of delivery for each of these comparisons, and no RCTs have included children. Overall, current evidence from a limited number of head‐to‐head trials in adults or children with bronchiectasis is insufficient to guide the selection of antibiotics for short‐term or long‐term therapy. More research on this topic is needed

Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents.

HIV latency in resting CD4+ T cell represents a key barrier preventing cure of the infection with antiretroviral drugs alone. Latency reversing agents (LRAs) can activate HIV expression in latently infected cells, potentially leading to their elimination through virus-mediated cytopathic effects, host immune responses, and/or therapeutic strategies targeting cells actively expressing virus. We have recently described several structurally simplified analogs of the PKC modulator LRA bryostatin (termed bryologs) designed to improve synthetic accessibility, tolerability in vivo, and efficacy in inducing HIV latency reversal. Here we report the comparative performance of lead bryologs, including their effects in reducing cell surface expression of HIV entry receptors, inducing proinflammatory cytokines, inhibiting short-term HIV replication, and synergizing with histone deacetylase inhibitors to reverse HIV latency. These data provide unique insights into structure-function relationships between A- and B-ring bryolog modifications and activities in primary cells, and suggest that bryologs represent promising leads for preclinical advancement

Objective cough frequency, airway inflammation, and disease control in asthma

Background Cough is recognized as an important troublesome symptom in the diagnosis and monitoring of asthma. Asthma control is thought to be determined by the degree of airway inflammation and hyperresponsiveness but how these factors relate to cough frequency is unclear. The goal of this study was to investigate the relationships between objective cough frequency, disease control, airflow obstruction, and airway inflammation in asthma. Methods Participants with asthma underwent 24-h ambulatory cough monitoring and assessment of exhaled nitric oxide, spirometry, methacholine challenge, and sputum induction (cell counts and inflammatory mediator levels). Asthma control was assessed by using the Global Initiative for Asthma (GINA) classification and the Asthma Control Questionnaire (ACQ). The number of cough sounds was manually counted and expressed as coughs per hour (c/h). Results Eighty-nine subjects with asthma (mean ± SD age, 57 ± 12 years; 57% female) were recruited. According to GINA criteria, 18 (20.2%) patients were classified as controlled, 39 (43.8%) partly controlled, and 32 (36%) uncontrolled; the median ACQ score was 1 (range, 0.0-4.4). The 6-item ACQ correlated with 24-h cough frequency (r = 0.40; P < .001), and patients with uncontrolled asthma (per GINA criteria) had higher median 24-h cough frequency (4.2 c/h; range, 0.3-27.6) compared with partially controlled asthma (1.8 c/h; range, 0.2-25.3; P = .01) and controlled asthma (1.7 c/h; range, 0.3-6.7; P = .002). Measures of airway inflammation were not significantly different between GINA categories and were not correlated with ACQ. In multivariate analyses, increasing cough frequency and worsening FEV1 independently predicted measures of asthma control. Conclusions Ambulatory cough frequency monitoring provides an objective assessment of asthma symptoms that correlates with standard measures of asthma control but not airflow obstruction or airway inflammation. Moreover, cough frequency and airflow obstruction represent independent dimensions of asthma control

Topological changes in the magnetic field of LQ Hya during an activity minimum

Aims. Previous studies have related surface temperature maps, obtained with the Doppler imaging (DI) technique, of LQ Hya with long-term photometry. Here, we compare surface magnetic field maps, obtained with the Zeeman Doppler imaging (ZDI) technique, with contemporaneous photometry, with the aim of quantifying the star's magnetic cycle characteristics. Methods. We inverted Stokes IV spectropolarimetry, obtained with the HARPSpol and ESPaDOnS instruments, into magnetic field and surface brightness maps using a tomographic inversion code that models high signal-to-noise ratio mean line profiles produced by the least squares deconvolution (LSD) technique. The maps were compared against long-term ground-based photometry acquired with the T3 0.40 m Automatic Photoelectric Telescope (APT) at Fairborn Observatory, which offers a proxy for the spot cycle of the star, as well as with chromospheric Ca II H&K activity derived from the observed spectra. Results. The magnetic field and surface brightness maps reveal similar patterns relative to previous DI and ZDI studies: nonaxisymmetric polar magnetic field structure, void of fields at mid-latitudes, and a complex structure in the equatorial regions. There is a weak but clear tendency of the polar structures to be linked with a strong radial field and the equatorial ones with the azimuthal field. We find a polarity reversal in the radial field between 2016 and 2017 that is coincident with a spot minimum seen in the long-term photometry, although the precise relation of chromospheric activity to the spot activity remains complex and unclear. The inverted field strengths cannot be easily related with the observed spottedness, but we find that they are partially connected to the retrieved field complexity. Conclusions. This field topology and the dominance of the poloidal field component, when compared to global magnetoconvection models for rapidly rotating young suns, could be explained by a turbulent dynamo, where differential rotation does not play a major role (so-called alpha(2)Omega(2) or alpha(2) dynamos) and axi- and non-axisymmetric modes are excited simultaneously. The complex equatorial magnetic field structure could arise from the twisted (helical) wreaths often seen in these simulations, while the polar feature would be connected to the mostly poloidal non-axisymmetric component that has a smooth spatial structure.Peer reviewe

A New Limit on the Antiproton Lifetime

Measurements of the cosmic ray pbar/p ratio are compared to predictions from an inhomogeneous disk-diffusion model of pbar production and propagation within the Galaxy, combined with a calculation of the modulation of the interstellar cosmic ray spectra as the particles propagate through the heliosphere to the Earth. The predictions agree with the observed pbar/p spectrum. Adding a finite pbar lifetime to the model, we obtain the limit tau_pbar > 0.8 Myr (90 % C.L.).Comment: 13 pages, 3 encapsulated Postscript figures, uses AASTeX; accepted by Astrophysical Journal; minor change