Constrained subspace estimation via convex optimization

Given a collection of M experimentally measured subspaces, and a model-based subspace, this paper addresses the problem of finding a subspace that approximates the collection, under the constraint that it intersects the model-based subspace in a predetermined number of dimensions. This constrained subspace estimation (CSE) problem arises in applications such as beamforming, where the model-based subspace encodes prior information about the direction-of-arrival of some sources impinging on the array. In this paper, we formulate the constrained subspace estimation (CSE) problem, and present an approximation based on a semidefinite relaxation (SDR) of this non-convex problem. The performance of the proposed CSE algorithm is demonstrated via numerical simulation, and its application to beamforming is also discussed.This work has been supported by the Ministerio de Economía, Industria y Competitividad (MINECO) of Spain, and AEI/FEDER funds of the E.U., under grants TEC2013-47141-C4-R (RACHEL), TEC2016-75067-C4-4-R (CARMEN) and TEC2016-81900-REDT (KERMES), and by the National Science Foundation under Grant No. IIS-1633830

Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease

Funded by Parkinson's UK National Institute for Health Research (NIHR) DeNDRoN network NIHR Newcastle Biomedical Research Unit Newcastle University NIHR funded Biomedical Research Centre in CambridgePeer reviewedPublisher PD

Tracking Parkinson's : Study Design and Baseline Patient Data

Peer reviewedPublisher PD

The flesh of painting: Caillebotte’s Modern Olympia

The language of putrefaction, often applied through a culinary analogy, appeared consistently in the critical reception of modern-life and Impressionist painting. For example, two critics used the term faisandé, referring to well-hung meat, to describe Manet’s nude figure of Olympia in 1865. The analogies that they posed between morgue bodies, female figures, meat, and fleshy paint material became central modes of denigrating Impressionist paintings of women in the ensuing decades. Gustave Caillebotte’s Veal in a Butcher’s Shop (c. 1882), depicting anthropomorphized, gendered, and sexualized animal flesh, can be considered in this context. In my reading, the painting enacts the critical responses to his colleagues’ figures, foregrounding the violent operations through which bodies might be reduced to meat, whether literal or metaphorical. In their comparisons to rotting flesh, nineteenth-century critics expressed a visceral reaction to works of art that Veal in a Butcher’s Shop demands

Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease.

BACKGROUND: There are currently no treatments that stop or slow the progression of Parkinson's disease (PD). Case-control genome-wide association studies have identified variants associated with disease risk, but not progression. The objective of the current study was to identify genetic variants associated with PD progression. METHODS: We analyzed 3 large longitudinal cohorts: Tracking Parkinson's, Oxford Discovery, and the Parkinson's Progression Markers Initiative. We included clinical data for 3364 patients with 12,144 observations (mean follow-up 4.2 years). We used a new method in PD, following a similar approach in Huntington's disease, in which we combined multiple assessments using a principal components analysis to derive scores for composite, motor, and cognitive progression. These scores were analyzed in linear regression in genome-wide association studies. We also performed a targeted analysis of the 90 PD risk loci from the latest case-control meta-analysis. RESULTS: There was no overlap between variants associated with PD risk, from case-control studies, and PD age at onset versus PD progression. The APOE ε4 tagging variant, rs429358, was significantly associated with composite and cognitive progression in PD. Conditional analysis revealed several independent signals in the APOE locus for cognitive progression. No single variants were associated with motor progression. However, in gene-based analysis, ATP8B2, a phospholipid transporter related to vesicle formation, was nominally associated with motor progression (P = 5.3 × 10-6 ). CONCLUSIONS: We provide early evidence that this new method in PD improves measurement of symptom progression. We show that the APOE ε4 allele drives progressive cognitive impairment in PD. Replication of this method and results in independent cohorts are needed. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Funding sources: Parkinson’s U

Immersive Insights: A Hybrid Analytics System for Collaborative Exploratory Data Analysis

In the past few years, augmented reality (AR) and virtual reality (VR) technologies have experienced terrific improvements in both accessibility and hardware capabilities, encouraging the application of these devices across various domains. While researchers have demonstrated the possible advantages of AR and VR for certain data science tasks, it is still unclear how these technologies would perform in the context of exploratory data analysis (EDA) at large. In particular, we believe it is important to better understand which level of immersion EDA would concretely benefit from, and to quantify the contribution of AR and VR with respect to standard analysis workflows. In this work, we leverage a Dataspace reconfigurable hybrid reality environment to study how data scientists might perform EDA in a co-located, collaborative context. Specifically, we propose the design and implementation of Immersive Insights, a hybrid analytics system combining high-resolution displays, table projections, and augmented reality (AR) visualizations of the data. We conducted a two-part user study with twelve data scientists, in which we evaluated how different levels of data immersion affect the EDA process and compared the performance of Immersive Insights with a state-of-the-art, non-immersive data analysis system.Comment: VRST 201

Proceedings of the Third Caldwell Conference, St. Catherines Island, Georgia, May 9-11, 2008

341 p. : ill. (some col.), maps (some col.) ; 26 cm. "Issued June 23, 2010." Includes bibliographical references (p. 303-341).The late Archaic of the American Southeast is typically described as a time of population growth, innovative developments in subsistence strategies, and increased social complexity. Although it is difficult to generalize, many early Woodland communities are characterized as relatively small scale, fairly mobile foragers organized into unranked or minimally ranked lineages and clans. Early Woodland groups also seem to be more socially isolated than their late Archaic predecessors, with a decline in regional exchange networks. The papers in this volume were presented at a conference entitled "What Happened in the Late Archaic?" which was co-sponsored by the American Museum of Natural History and the St. Catherines Island Foundation and held on St. Catherines Island (Georgia), May 9-11, 2008. The Third Caldwell Conference invited the participants to engage the appropriate archaeological data from the American Southeast, specifically addressing the nature of change during the late Archaic-early Woodland transition. This volume consists of a dozen substantive papers, followed by three discussant contributions. TABLE OF CONTENTS: Trend, tradition, and transition at the end of the Archaic / Tristram R. Kidder -- "Nothing but the river's flood" : late Archaic diaspora or disengagement in the lower Mississippi Valley and southeastern North America / Jon L. Gibson -- The two rings of St. Catherines Island : some preliminary results from the St. Catherines and McQueen shell rings / Matthew C. Sanger and David Hurst Thomas -- Two late Archaic period shell rings, St. Simon's Island, Georgia / Rochelle A. Marrinan -- The Archaic above Choctawhatchee Bay : hydrodynamics, adaptation, and abandonment / Rebecca Saunders -- Prehistoric landscapes of complexity : Archaic and Woodland period shell works, shell rings, and tree islands of the Everglades, South Florida / Margo Schwadron -- Shell rings and other settlement features as indicators of cultural continuity between the late Archaic and Woodland periods of coastal Florida / Michael Russo -- "What happened to the southeastern Archaic?" : a perspective from St. Catherines Island / David Hurst Thomas -- Leaving the rings : shell ring abandonment and the end of the late Archaic / Matthew C. Sanger -- The rhythms of space-time and the making of monuments and places during the Archaic / Victor D. Thompson -- Getting from the late Archaic to early Woodland in three middle valleys (those being the Savannah, St. Johns, and Tennessee) / Kenneth E. Sassaman -- Late Archaic? : what the hell happened to the middle Archaic? / Joe Saunders -- Thoughts on the late Archaic-early Woodland transition on the Georgia and South Carolina coasts / Chester B. DePratter -- Mounds, middens, and rapid climate change during the Archaic-Woodland transition in the southeastern United States / William H. Marquardt -- The end of the southeastern Archaic : regional interaction and archaeological interpretation / David G. Anderson

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Real-Time Omnidirectional Stereo Rendering: Generating 360° Surround-View Panoramic Images for Comfortable Immersive Viewing

Surround-view panoramic images and videos have become a popular form of media for interactive viewing on mobile devices and virtual reality headsets. Viewing such media provides a sense of immersion by allowing users to control their view direction and experience an entire environment. When using a virtual reality headset, the level of immersion can be improved by leveraging stereoscopic capabilities. Stereoscopic images are generated in pairs, one for the left eye and one for the right eye, and result in providing an important depth cue for the human visual system. For computer generated imagery, rendering proper stereo pairs is well known for a fixed view. However, it is much more difficult to create omnidirectional stereo pairs for a surround-view projection that work well when looking in any direction. One major drawback of traditional omnidirectional stereo images is that they suffer from binocular misalignment in the peripheral vision as a user\u27s view direction approaches the zenith / nadir (north / south pole) of the projection sphere. This paper presents a real-time geometry-based approach for omnidirectional stereo rendering that fits into the standard rendering pipeline. Our approach includes tunable parameters that enable pole merging - a reduction in the stereo effect near the poles that can minimize binocular misalignment. Results from a user study indicate that pole merging reduces visual fatigue and discomfort associated with binocular misalignment without inhibiting depth perception