2,937 research outputs found
Study of the use of auxiliary electrodes in silver cells
Auxiliary electrodes in silver-cadmium and silver zinc cells for hydrogen and oxygen recombination, and hydrogen combination cell desig
Managing the patient with osteogenesis imperfecta: a multidisciplinary approach
Osteogenesis imperfecta (OI) is a heterogeneous heritable connective tissue disorder characterized by low bone density. The type and severity of OI are variable. The primary manifestations are fractures, bone deformity, and bone pain, resulting in reduced mobility and function to complete everyday tasks. OI affects not only the physical but also the social and emotional well-being of children, young people, and their families. As such, medical, surgical, and allied health professionals' assessments all play a role in the management of these children. The multidisciplinary approach to the treatment of children and young people living with OI seeks to provide well-coordinated, comprehensive assessments, and interventions that place the child and family at the very center of their care. The coordinated efforts of a multidisciplinary team can support children with OI to fulfill their potential, maximizing function, independence, and well-being
Troubles with Bayesianism: An introduction to the psychological immune system
A Bayesian mind is, at its core, a rational mind. Bayesianism is thus well-suited to predict and explain mental processes that best exemplify our ability to be rational. However, evidence from belief acquisition and change appears to show that we do not acquire and update information in a Bayesian way. Instead, the principles of belief acquisition and updating seem grounded in maintaining a psychological immune system rather than in approximating
a Bayesian processor
Origin Gaps and the Eternal Sunshine of the Second-Order Pendulum
The rich experiences of an intentional, goal-oriented life emerge, in an
unpredictable fashion, from the basic laws of physics. Here I argue that this
unpredictability is no mirage: there are true gaps between life and non-life,
mind and mindlessness, and even between functional societies and groups of
Hobbesian individuals. These gaps, I suggest, emerge from the mathematics of
self-reference, and the logical barriers to prediction that self-referring
systems present. Still, a mathematical truth does not imply a physical one: the
universe need not have made self-reference possible. It did, and the question
then is how. In the second half of this essay, I show how a basic move in
physics, known as renormalization, transforms the "forgetful" second-order
equations of fundamental physics into a rich, self-referential world that makes
possible the major transitions we care so much about. While the universe runs
in assembly code, the coarse-grained version runs in LISP, and it is from that
the world of aim and intention grows.Comment: FQXI Prize Essay 2017. 18 pages, including afterword on
Ostrogradsky's Theorem and an exchange with John Bova, Dresden Craig, and
Paul Livingsto
BIMODAL WHOLE-1 MOUNT IMAGING OF TENDON USING CONFOCAL MICROSCOPY AND X-RAY MICRO-COMPUTED TOMOGRAPHY
BACKGROUND:3-dimensional imaging modalities for optically dense connective tissues such as tendons are limited and typically have a single imaging methodological endpoint. Here, we have developed a bimodal procedure utilising fluorescence-based confocal microscopy and x-ray micro-computed tomography for the imaging of adult tendons to visualise and analyse extracellular sub-structure and cellular composition in small and large animal species.
RESULTS: Using fluorescent immunolabelling and optical clearing, we visualised the expression of the novel cross-species marker of tendon basement membrane, laminin-α4 in 3D throughout whole rat Achilles tendons and equine superficial digital flexor tendon 5 mm segments. This revealed a complex network of laminin-α4 within the tendon core that predominantly localises to the interfascicular matrix compartment. Furthermore, we implemented a chemical drying process capable of creating contrast densities enabling visualisation and quantification of both fascicular and interfascicular matrix volume and thickness by x-ray micro-computed tomography. We also demonstrated that both modalities can be combined using reverse clarification of fluorescently labelled tissues prior to chemical drying to enable bimodal imaging of a single sample.
CONCLUSIONS: Whole-mount imaging of tendon allowed us to identify the presence of an extensive network of laminin-α4 within tendon, the complexity of which cannot be appreciated using traditional 2D imaging techniques. Creating contrast for x-ray micro-computed tomography imaging of tendon using chemical drying is not only simple and rapid, but also markedly improves on previously published methods. Combining these methods provides the ability to gain spatio-temporal information and quantify tendon substructures to elucidate the relationship between morphology and function
Patterns of subnet usage reveal distinct scales of regulation in the transcriptional regulatory network of Escherichia coli
The set of regulatory interactions between genes, mediated by transcription
factors, forms a species' transcriptional regulatory network (TRN). By
comparing this network with measured gene expression data one can identify
functional properties of the TRN and gain general insight into transcriptional
control. We define the subnet of a node as the subgraph consisting of all nodes
topologically downstream of the node, including itself. Using a large set of
microarray expression data of the bacterium Escherichia coli, we find that the
gene expression in different subnets exhibits a structured pattern in response
to environmental changes and genotypic mutation. Subnets with less changes in
their expression pattern have a higher fraction of feed-forward loop motifs and
a lower fraction of small RNA targets within them. Our study implies that the
TRN consists of several scales of regulatory organization: 1) subnets with more
varying gene expression controlled by both transcription factors and
post-transcriptional RNA regulation, and 2) subnets with less varying gene
expression having more feed-forward loops and less post-transcriptional RNA
regulation.Comment: 14 pages, 8 figures, to be published in PLoS Computational Biolog
Judging the impact of leadership-development activities on school practice
The nature and effectiveness of professional-development activities should be judged in a way that takes account of
both the achievement of intended outcomes and the unintended consequences that may result. Our research project set out to create a robust approach that school staff members could use to assess the impact of
professional-development programs on leadership and management practice without being constrained in this judgment by the stated aims of the program. In the process,
we identified a number of factors and requirements relevant to a wider audience than that concerned with the development of leadership and management in England.
Such an assessment has to rest upon a clear understanding of educational leadership,a clearly articulated model of practice, and a clear model of potential forms of impact.
Such foundations, suitably adapted to the subject being addressed, are appropriate for assessing all teacher professional development
SB9: The Ninth Catalogue of Spectroscopic Binary Orbits
The Ninth Catalogue of Spectroscopic Binary Orbits
(http://sb9.astro.ulb.ac.be) continues the series of compilations of
spectroscopic orbits carried out over the past 35 years by Batten and
collaborators. As of 2004 May 1st, the new Catalogue holds orbits for 2,386
systems. Some essential differences between this catalogue and its predecessors
are outlined and three straightforward applications are presented: (1)
Completeness assessment: period distribution of SB1s and SB2s; (2) Shortest
periods across the H-R diagram; (3) Period-eccentricity relation.Comment: Accepte for publication in A&A, 6 pages, 6 figure
- …