Organizing Sustainably: Introduction to the Special Issue

To confront the climate crisis requires fundamental system change in order to break the convention of relentless economic exploitation of nature. In this Special Issue we extend understanding of the opportunities for an organizing perspective on sustainability in order that organization studies might contribute more effectively to the challenges of organizing sustainably. This organizing perspective is particularly sensitive to (1) a variety of forms and practices of sustainable organizing in different societal spheres and on different levels, (2) the social institutions, logics and value systems in which these forms and practices are embedded, (3) the power and politics of promoting (or blocking) sustainable organization, and (4) the ways in which work, voice, participation, and inclusion are organized and contribute to developing societal capabilities. These features formed the basis of our original call for papers and we review selected literature on sustainability, including the contribution of organization studies and the articles in this Special Issue, through this organizing perspective. In so doing we identify four key themes of a future research agenda that builds from the foundations of existing research and addresses key current limitations in both theory and practice: sustainability requires social justice; connecting local and global scale shifts; democratizing governance; and acting collectively. We conclude with some implications for our own scholarship in organization studies if we are to meet the twin challenges of the need for new theorizing in combination with devising practically relevant support for change

Crop-to-wild introgression in the European wild apple Malus sylvestris in Northern Britain 2 3 MARKUS RUHSAM

International audienc

Organizing sustainably: Introduction to the special issue

To confront the climate crisis requires fundamental system change in order to break the convention of relentless economic exploitation of nature. In this Special Issue we extend understanding of the opportunities for an organizing perspective on sustainability in order that organization studies might contribute more effectively to the challenges of organizing sustainably. This organizing perspective is particularly sensitive to (1) a variety of forms and practices of sustainable organizing in different societal spheres and on different levels, (2) the social institutions, logics and value systems in which these forms and practices are embedded, (3) the power and politics of promoting (or blocking) sustainable organization, and (4) the ways in which work, voice, participation, and inclusion are organized and contribute to developing societal capabilities. These features formed the basis of our original call for papers and we review selected literature on sustainability, including the contribution of organization studies and the articles in this Special Issue, through this organizing perspective. In so doing we identify four key themes of a future research agenda that builds from the foundations of existing research and addresses key current limitations in both theory and practice: sustainability requires social justice; connecting local and global scale shifts; democratizing governance; and acting collectively. We conclude with some implications for our own scholarship in organization studies if we are to meet the twin challenges of the need for new theorizing in combination with devising practically relevant support for change

Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage

Adefective response to DNA damage is observed in several human autosomal recessive ataxias with oculomotor apraxia, including ataxia-telangiectasia. We report that senataxin, defective in ataxia oculomotor apraxia (AOA) type 2, is a nuclear protein involved in the DNA damage response. AOA2 cells are sensitive to H2O2, camptothecin, and mitomycin C, but not to ionizing radiation, and sensitivity was rescued with full-length SETX cDNA. AOA2 cells exhibited constitutive oxidative DNA damage and enhanced chromosomal instability in response to H2O2. Rejoining of H2O2-induced DNA double-strand breaks (DSBs) was significantly reduced in AOA2 cells compared to controls, and there was no evidence for a defect in DNA single-strand break repair. This defect in DSB repair was corrected by full-length SETX cDNA. These results provide evidence that an additional member of the autosomal recessive AOA is also characterized by a defective response to DNA damage, which may contribute to the neurodegeneration seen in this syndrome

Inferring causation from time series in Earth system sciences

The heart of the scientific enterprise is a rational effort to understand the causes behind the phenomena we observe. In large-scale complex dynamical systems such as the Earth system, real experiments are rarely feasible. However, a rapidly increasing amount of observational and simulated data opens up the use of novel data-driven causal methods beyond the commonly adopted correlation techniques. Here, we give an overview of causal inference frameworks and identify promising generic application cases common in Earth system sciences and beyond. We discuss challenges and initiate the benchmark platform causeme.net to close the gap between method users and developers. © 2019, The Author(s)

ECCO Essential Requirements for Quality Cancer Care : Soft Tissue Sarcoma in Adults and Bone Sarcoma. A critical review

Background: ECCO essential requirements for quality cancer care (ERQCC) are checklists and explanations of organisation and actions that are necessary to give high-quality care to patients who have a specific tumour type. They are written by European experts representing all disciplines involved in cancer care. ERQCC papers give oncology teams, patients, policymakers and managers an overview of the elements needed in any healthcare system to provide high quality of care throughout the patient journey. References are made to clinical guidelines and other resources where appropriate, and the focus is on care in Europe. Sarcoma: essential requirements for quality care Sarcomas - which can be classified into soft tissue and bone sarcomas - are rare, but all rare cancers make up more than 20% of cancers in Europe, and there are substantial inequalities in access to high-quality care. Sarcomas, of which there are many subtypes, comprise a particularly complex and demanding challenge for healthcare systems and providers. This paper presents essential requirements for quality cancer care of soft tissue sarcomas in adults and bone sarcomas. High-quality care must only be carried out in specialised sarcoma centres (including paediatric cancer centres) which have both a core multidisciplinary team and an extended team of allied professionals, and which are subject to quality and audit procedures. Access to such units is far from universal in all European countries. It is essential that, to meet European aspirations for high-quality comprehensive cancer control, healthcare organisations implement the requirements in this paper, paying particular attention to multidisciplinarity and patient-centred pathways from diagnosis and follow-up, to treatment, to improve survival and quality of life for patients. Conclusion: Taken together, the information presented in this paper provides a comprehensive description of the essential requirements for establishing a high-quality service for soft tissue sarcomas in adults and bone sarcomas. The ECCO expert group is aware that it is not possible to propose a 'one size fits all' system for all countries, but urges that access to multidisciplinary teams is guaranteed to all patients with sarcoma. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.Peer reviewe