Separated at Birth: An Inquiry on the Conceptual Independence of the Entrepreneurship and the Leadership Constructs

Entrepreneurship and leadership may flow from the same genealogical source and the appearance of separation of the two constructs may be due to differences in the contexts through which the root phenomenon flows. Entrepreneurship and leadership are figuratively different manifestations of the need to create. To better understand the origin of entrepreneurship and leadership, research must first focus on the combinations or hierarchy of traits that are necessary, but perhaps not sufficient, to stimulate the two constructs. Factors that trigger a drive to create or take initiative within the individual in the context of a particular circumstance should be identified, and the situational factors that move the individual toward more traditional leader or classic entrepreneurial-type behaviors need to be understood

Investigations of FFF 3D-printed zirconium dioxide implants = Untersuchungen an mittels FFF-3D-gedruckten Implantaten aus Zirkoniumdioxid

Stableandreliableboneanchorageiscrucialindentistry.Zirconiumdioxide(ZrO2)isapromisingalternativetotitaniumduetoitsaesthetics,highbiocompatibility,reducedbiofilmformation,lowerwear,andlessinflammation.FusedFilamentFabrication(FFF)3Dprintingoffersdesignflexibilityandcost-effectiveproduction.WeaimtouseFFFtocreatepatient-specific,root analogimplantstailoredtobonestructure,reducingtheneedforpredrilling.Furthermore,FFF3Dprintingallowsdirectintegrationofsurfacemodificationstoenhanceosteointegration,eliminatingextensivepost-processing

Ceramic fused filament fabrication (CF3^3) of zirconia implants by using flexible, partially water-soluble binder systems

Ceramic Fused Filament Fabrication offers a simple and cost-effective method to manufacture personalized ceramic implants. However, the lack of flexibility in highly filled filaments and the reduced accuracy compared to alternative additive manufacturing techniques limit the method’s widespread implementation. Therefore, an eco-friendly partially water-soluble binder system containing polyethylene glycol (PEG), poly(vinylbutyral) (PVB), and poly(methylmethacrylat) (PMMA) was investigated, along with the influence of the two additives acetyltributylcitrate (ATBC) and lauric acid (LA). The created feedstocks were characterized by comprehensive rheological analysis, which included capillary rheology and dynamic mechanical analysis. The production of filaments with a solid content of 50 vol% was successfully achieved, demonstrating exceptional flexibility and flow properties. Following the debinding and sintering processes, the optimal feedstock systems enabled the fabrication of defect-free components with a high level of detail and relative densities up to 100 %

Histological basis of laminar MRI patterns in high resolution images of fixed human auditory cortex

Functional magnetic resonance imaging (fMRI) studies of the auditory region of the temporal lobe would benefit from the availability of image contrast that allowed direct identification of the primary auditory cortex, as this region cannot be accurately located using gyral landmarks alone. Previous work has suggested that the primary area can be identified in magnetic resonance (MR) images because of its relatively high myelin content. However, MR images are also affected by the iron content of the tissue and in this study we sought to confirm that different MR image contrasts did correlate with the myelin content in the grey matter and were not primarily affected by iron content as is the case in the primary visual and somatosensory areas. By imaging blocks of fixed post-mortem cortex in a 7 Tesla scanner and then sectioning them for histological staining we sought to assess the relative contribution of myelin and iron to the grey matter contrast in the auditory region. Evaluating the image contrast in T2*-weighted images and quantitative R2* maps showed a reasonably high correlation between the myelin density of the grey matter and the intensity of the MR images. The correlation with T1-weighted phase sensitive inversion recovery (PSIR) images was better than with the previous two image types, and there were clearly differentiated borders between adjacent cortical areas in these images. A significant amount of iron was present in the auditory region, but did not seem to contribute to the laminar pattern of the cortical grey matter in MR images. Similar levels of iron were present in the grey and white matter and although iron was present in fibres within the grey matter, these fibres were fairly uniformly distributed across the cortex. Thus we conclude that T1- and T2*-weighted imaging sequences do demonstrate the relatively high myelin levels that are characteristic of the deep layers in primary auditory cortex and allow it and some of the surrounding areas to be reliably distinguished

Two-Way Quantum Time Transfer: A Method for Daytime Space-Earth Links

Remote clock synchronization is crucial for many classical and quantum network applications. Current state-of-the-art remote clock synchronization techniques achieve femtosecond-scale clock stability utilizing frequency combs, which are supplementary to quantum-networking hardware. Demonstrating an alternative, we synchronize two remote clocks across our freespace testbed using a method called two-way quantum time transfer (QTT). In one second we reach picosecond-scale timing precision under very lossy and noisy channel conditions representative of daytime space-Earth links with commercial off-the-shelf quantum-photon sources and detection equipment. This work demonstrates how QTT is potentially relevant for daytime space-Earth quantum networking and/or providing high-precision secure timing in GPS-denied environments.Comment: arXiv admin note: text overlap with arXiv:2211.0073

Understanding Others' Regret: A fMRI Study

Previous studies showed that the understanding of others' basic emotional experiences is based on a “resonant” mechanism, i.e., on the reactivation, in the observer's brain, of the cerebral areas associated with those experiences. The present study aimed to investigate whether the same neural mechanism is activated both when experiencing and attending complex, cognitively-generated, emotions. A gambling task and functional-Magnetic-Resonance-Imaging (fMRI) were used to test this hypothesis using regret, the negative cognitively-based emotion resulting from an unfavorable counterfactual comparison between the outcomes of chosen and discarded options. Do the same brain structures that mediate the experience of regret become active in the observation of situations eliciting regret in another individual? Here we show that observing the regretful outcomes of someone else's choices activates the same regions that are activated during a first-person experience of regret, i.e. the ventromedial prefrontal cortex, anterior cingulate cortex and hippocampus. These results extend the possible role of a mirror-like mechanism beyond basic emotions

Summary Report of PQRI Workshop on Nanomaterial in Drug Products: Current Experience and Management of Potential Risks

At the Product Quality Research Institute (PQRI) Workshop held last January 14-15, 2014, participants from academia, industry, and governmental agencies involved in the development and regulation of nanomedicines discussed the current state of characterization, formulation development, manufacturing, and nonclinical safety evaluation of nanomaterial-containing drug products for human use. The workshop discussions identified areas where additional understanding of material attributes, absorption, biodistribution, cellular and tissue uptake, and disposition of nanosized particles would continue to inform their safe use in drug products. Analytical techniques and methods used for in vitro characterization and stability testing of formulations containing nanomaterials were discussed, along with their advantages and limitations. Areas where additional regulatory guidance and material characterization standards would help in the development and approval of nanomedicines were explored. Representatives from the US Food and Drug Administration (USFDA), Health Canada, and European Medicines Agency (EMA) presented information about the diversity of nanomaterials in approved and newly developed drug products. USFDA, Health Canada, and EMA regulators discussed the applicability of current regulatory policies in presentations and open discussion. Information contained in several of the recent EMA reflection papers was discussed in detail, along with their scope and intent to enhance scientific understanding about disposition, efficacy, and safety of nanomaterials introduced in vivo and regulatory requirements for testing and market authorization. Opportunities for interaction with regulatory agencies during the lifecycle of nanomedicines were also addressed at the meeting. This is a summary of the workshop presentations and discussions, including considerations for future regulatory guidance on drug products containing nanomaterials

Proceedings from the Ice Hockey Summit III: Action on Concussion

Objectives The Ice Hockey Summit III provided updated scientific evidence on concussions in hockey to inform these five objectives: (1) describe sport related concussion (SRC) epidemiology, (2) classify prevention strategies, (3) define objective, diagnostic tests, (4) identify treatment and (5) integrate science and clinical care into prioritized action plans and policy. Methods Our action plan evolved from 40 scientific presentations. The 155 attendees (physicians, athletic trainers, physical therapists, nurses, neuropsychologists, scientists, engineers, coaches and officials) voted to prioritize these action items in the final Summit session. Results (1) establish a national and international hockey data base for SRCs at all levels; (2) eliminate body checking in Bantam youth hockey games; (3) expand a behavior modification program (Fair Play) to all youth hockey levels; (4) enforce game ejection penalties for fighting in Junior A and professional hockey leagues; (5) establish objective tests to diagnose concussion at point of care (POC); and (6) mandate baseline testing to improve concussion diagnosis for all age groups. Conclusions Expedient implementation of the Summit III prioritized action items is necessary to reduce the risk, severity and consequences of concussion in the sport of ice hockey